2025
White Matter, Cognition, and Electrophysiological Variables in Bipolar Disorder: Using Multimodal Integration of Biomarker Variables Associated With Bipolar Disorder to Elucidate Deficits
Berardi A, Brown J, Jackson B, Huang L, Trotti R, Parker D, Hill S, Ivleva E, Pearlson G, Tamminga C, Keshavan M, Keedy S, Gershon E, Sweeney J, Clementz B, McDowell J. White Matter, Cognition, and Electrophysiological Variables in Bipolar Disorder: Using Multimodal Integration of Biomarker Variables Associated With Bipolar Disorder to Elucidate Deficits. Bipolar Disorders 2025, 27: 205-216. PMID: 40084552, PMCID: PMC12169086, DOI: 10.1111/bdi.70010.Peer-Reviewed Original ResearchConceptsEvent-related potentialsStop signal taskBipolar disorderBrief Assessment of CognitionLongitudinal fasciculusFractional anisotropyBrain electrophysiological measuresRight inferior longitudinal fasciculusIntermediate Phenotypes consortiumMeasures of white matter microstructureBilateral superior longitudinal fasciculusAssessment of CognitionAuditory event-related potentialsBilateral anterior thalamic radiationIntrinsic brain activitySuperior longitudinal fasciculusWhite matter integrityInferior longitudinal fasciculusCingulum cingulate gyrusWhite matter microstructureAnterior thalamic radiationRadial diffusivityWhite matter variabilitySignal taskBrief AssessmentBrain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease
Ramsingh N, Lin H, Ouyang Y, Ravona‐Springer R, Livny A, Soleimani L, Bendlin B, Matatov A, Niv T, Shamir T, Ganmore I, Heymann A, Sano M, Azuri J, Beeri M. Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease. International Journal Of Geriatric Psychiatry 2025, 40: e70060. PMID: 40050014, DOI: 10.1002/gps.70060.Peer-Reviewed Original ResearchConceptsSuperior longitudinal fasciculusCortical volumeCortical brain volumesWhite matterAlzheimer's Prevention studyEarly cognitive declineBrain signaturesBrain regionsCognitive changesWM microstructureMiddle-aged adultsBrain volumeLongitudinal fasciculusCognitive declinePreclinical cognitive changesOffspring of peopleBrain tractsPatient's offspringTarget individualsEarly interventionCorpus callosumParental historyBrainAlzheimer's diseaseLinear regression modelsBrain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors
Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors. Translational Psychiatry 2025, 15: 61. PMID: 39979292, PMCID: PMC11842717, DOI: 10.1038/s41398-025-03288-5.Peer-Reviewed Original ResearchConceptsImaging-derived phenotypesBrain imaging-derived phenotypesAlcohol drinkingBrain structuresProcessing of social cuesCorrelates of smoking behaviorRelationship of brain structureSequencing Consortium of AlcoholGlobal genetic correlationsSmoking behaviorSuperior longitudinal fasciculusAssociated with smoking initiationTobacco smokeTobacco smoking behaviorLatent causal variable approachesNicotine useBrain regionsPremotor cortexSocial cuesWhite matter hyperintensitiesLongitudinal fasciculusChemosensory processingCortical thicknessMendelian randomizationPleiotropic mechanisms
2024
Immunosenescence-related T cell phenotypes and white matter in schizophrenia patients with tardive dyskinesia
Li N, Li Y, Yu T, Gou M, Chen W, Wang X, Tong J, Chen S, Tan S, Wang Z, Tian B, Li C, Tan Y. Immunosenescence-related T cell phenotypes and white matter in schizophrenia patients with tardive dyskinesia. Schizophrenia Research 2024, 269: 36-47. PMID: 38723519, DOI: 10.1016/j.schres.2024.04.017.Peer-Reviewed Original ResearchCD95+ T cellsTardive dyskinesiaT-cell phenotypeT cell subpopulationsBrain structural abnormalitiesT cellsSchizophrenia patientsFractional anisotropyCD95+Distribution of T cell phenotypesStructural abnormalitiesAssociated with brain structural abnormalitiesMemory T-cell subpopulationsCD8+ T cellsLevels of IFN-gInferior fronto-occipital fasciculusLevels of cytokinesSuperior longitudinal fasciculusFronto-occipital fasciculusChoroid plexus volumeIntracellular levelsWhite matter tractsOrofacial TDPallidum volumesPublished routinesSniffing out meaning: Chemosensory and semantic neural network changes in sommeliers
Carreiras M, Quiñones I, Chen H, Vázquez‐Araujo L, Small D, Frost R. Sniffing out meaning: Chemosensory and semantic neural network changes in sommeliers. Human Brain Mapping 2024, 45: e26564. PMID: 38339911, PMCID: PMC10823763, DOI: 10.1002/hbm.26564.Peer-Reviewed Original ResearchConceptsNeural circuitsFractional anisotropyRight superior longitudinal fasciculusSuperior longitudinal fasciculusRelevant sensory inputNeural network changesBrain responsesSemantic narrativesSemantic knowledgeMediation analysisPerceptual informationOlfactory circuitsLongitudinal fasciculusSensory processingChemosensory processingSensory neural circuitsVerbal descriptionsSemantic networkWine complexitySensory inputSemantic operationsWine tastingWine consumersTasting wineWine
2022
Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study
Chiang H, Tseng W, Tseng W, Tung Y, Hsu Y, Chen C, Gau S. Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study. Asian Journal Of Psychiatry 2022, 79: 103358. PMID: 36481569, DOI: 10.1016/j.ajp.2022.103358.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderInferior fronto-occipital fasciculusGeneralized fractional anisotropyAttention performanceWhite matter microstructureDevelopmental trajectoriesComputerized continuous performance testAtypical developmental trajectoriesContinuous Performance TestDiffusion spectrum imagingFrontal aslant tractWhite matter tractsInattention symptomsAtypical developmentADHD symptomsHyperactivity disorderSuperior longitudinal fasciculusPrefrontal cortexFrontostriatal tractsImaging studiesArcuate fasciculusDevelopmental changesFronto-occipital fasciculusNeuroplastic processesDiagnosis interactionWhite matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions
Barch D, Hua X, Kandala S, Harms M, Sanders A, Brady R, Tillman R, Luby J. White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions. Depression And Anxiety 2022, 39: 881-890. PMID: 36321433, PMCID: PMC10848013, DOI: 10.1002/da.23294.Peer-Reviewed Original ResearchConceptsDepression severityCingulum bundleReduced FAFractional anisotropyCurrent depression severityPreschool Depression StudyWhite matter microstructural differencesFunctional connectivity differencesDorsal cingulum bundleEstimates of fractional anisotropySuperior longitudinal fasciculusWhite matter differencesMean diffusivityAxial diffusivityAssociated with depressionIncreased RDRadial diffusivityWhite matter structuresEmotion dysregulationDepression StudyLifetime diagnosisConcurrent depressionCurrent depressionConnectivity differencesBrain regions
2020
Altered striatum centered brain structures in SHANK3 deficient Chinese children with genotype and phenotype profiling
Liu C, Li D, Yang H, Li H, Xu Q, Zhou B, Hu C, Li C, Wang Y, Qiao Z, Jiang YH, Xu X. Altered striatum centered brain structures in SHANK3 deficient Chinese children with genotype and phenotype profiling. Progress In Neurobiology 2020, 200: 101985. PMID: 33388374, PMCID: PMC8572121, DOI: 10.1016/j.pneurobio.2020.101985.Peer-Reviewed Original ResearchConceptsTract-based spatial statisticsVoxel-based morphometryUnderlying neuropathological mechanismsNeuropathological mechanismsDeficient childrenBrain structuresMiddle cerebral peduncleAutism spectrum disorderAbnormal neural circuitsPosterior thalamic radiationGray matter volumeFunctional connectivity studiesSuperior longitudinal fasciculusStudy of subjectsCerebral peduncleInternal capsuleRisk factorsDental abnormalitiesCorpus callosumCommissural fibersHematological problemsCorona radiataDorsal striatumNeurobehavioral evaluationAnteverted nares
2018
Structural and functional brain imaging in acute HIV
Samboju V, Philippi CL, Chan P, Cobigo Y, Fletcher JLK, Robb M, Hellmuth J, Benjapornpong K, Dumrongpisutikul N, Pothisri M, Paul R, Ananworanich J, Spudich S, Valcour V, 010/RV254 S, teams R. Structural and functional brain imaging in acute HIV. NeuroImage Clinical 2018, 20: 327-335. PMID: 30101063, PMCID: PMC6082997, DOI: 10.1016/j.nicl.2018.07.024.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAcute HIV infectionAntiretroviral treatmentDiffusion tensor imagingAHI groupNPZ-4HIV RNARadial diffusivityFractional anisotropyCerebrospinal fluidHigher CD4 cell countsParahippocampal cortexHigher resting-state functional connectivityCombination antiretroviral treatmentHIV disease variablesLeft parahippocampal cortexMean CD4 countPlasma HIV RNACD4 cell countCopies/mLNeuropsychological testing performanceMicrostructural white matterFunctional brain integrityMiddle frontal gyrusSuperior longitudinal fasciculusComprehensive Investigation of White Matter Tracts in Professional Chess Players and Relation to Expertise: Region of Interest and DMRI Connectometry
Mayeli M, Rahmani F, Aarabi M. Comprehensive Investigation of White Matter Tracts in Professional Chess Players and Relation to Expertise: Region of Interest and DMRI Connectometry. Frontiers In Neuroscience 2018, 12: 288. PMID: 29773973, PMCID: PMC5943529, DOI: 10.3389/fnins.2018.00288.Peer-Reviewed Original ResearchInferior longitudinal fasciculusSuperior longitudinal fasciculusRaven's progressive matricesUncinate fasciculusFractional anisotropyStructural connectivityChess playersLongitudinal fasciculusProfessional chess playersBilateral SLFHigher fractional anisotropyRaven's progressive matrices scoreDiffusion MRI connectometryWhite matter tractsNeural underpinningsProgressive matricesCingulate gyrusBilateral UFChess expertiseWhite matter regionsBilateral cingulumFunctional connectivityConnectometry analysisWhite matter fibersIncreased connectivityT182. SHARED AND DISTINCT ALTERATIONS IN THE WHITE MATTER TRACTS OF REMITTED AND NON-REMITTED PATIENTS WITH SCHIZOPHRENIA
Hwang T, Huang J, Liu C, Chen Y, Hsu Y, Hwu H, Lin Y, Hsieh M, Liu C, Chien Y, Tseng W. T182. SHARED AND DISTINCT ALTERATIONS IN THE WHITE MATTER TRACTS OF REMITTED AND NON-REMITTED PATIENTS WITH SCHIZOPHRENIA. Schizophrenia Bulletin 2018, 44: s186-s187. PMCID: PMC5888289, DOI: 10.1093/schbul/sby016.458.Peer-Reviewed Original ResearchGeneralized fractional anisotropy valuesGeneralized fractional anisotropyBilateral temporal polesWhite matter tract integrityGray matter volumeUncinate fasciculusLimbic systemTemporal poleNon-remission groupBilateral amygdalaBilateral fornixBilateral hippocampiMatter volumeTract integrityReduced gray matter volumeTreatment outcomesCallosal fibersSchizophrenia Working GroupGray matter reductionsBilateral uncinate fasciculusGray matter alterationsTract-based spatial statisticsSuperior longitudinal fasciculusTesla magnetic resonance imaging scannerWhite matter tract alterations
2017
White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine
Morie KP, Yip SW, Zhai ZW, Xu J, Hamilton KR, Sinha R, Mayes LC, Potenza MN. White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine. Drug And Alcohol Dependence 2017, 174: 23-29. PMID: 28292689, PMCID: PMC5555052, DOI: 10.1016/j.drugalcdep.2017.01.011.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureSuperior longitudinal fasciculusPCE adolescentsCrossing-fiber modelsGroup differencesWhole-brain investigationNon-exposed youthWhole-brain analysisSignificant group differencesAltered white matter developmentLeft superior longitudinal fasciculusRisk-taking behaviorNeurobiological underpinningsWhite matter developmentWhite matter microstructureSubstance useWhite matter differencesWhite matter regionsAdolescentsDiffusion-weighted imaging dataCocaine exposureLongitudinal cohortBilateral cingulumCorpus callosumROI analysis
2011
Diffusion Tensor Imaging in Autism Spectrum Disorders: Preliminary Evidence of Abnormal Neural Connectivity
Jou RJ, Jackowski AP, Papademetris X, Rajeevan N, Staib LH, Volkmar FR. Diffusion Tensor Imaging in Autism Spectrum Disorders: Preliminary Evidence of Abnormal Neural Connectivity. Australian & New Zealand Journal Of Psychiatry 2011, 45: 153-162. PMID: 21128874, PMCID: PMC3123660, DOI: 10.3109/00048674.2010.534069.Peer-Reviewed Original ResearchConceptsInferior fronto-occipital fasciculusFronto-occipital fasciculusLongitudinal fasciculusInferior longitudinal fasciculusSuperior longitudinal fasciculus
2010
A Multimodal Assessment of the Genetic Control over Working Memory
Karlsgodt KH, Kochunov P, Winkler AM, Laird AR, Almasy L, Duggirala R, Olvera RL, Fox PT, Blangero J, Glahn DC. A Multimodal Assessment of the Genetic Control over Working Memory. Journal Of Neuroscience 2010, 30: 8197-8202. PMID: 20554870, PMCID: PMC2894480, DOI: 10.1523/jneurosci.0359-10.2010.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnisotropyBrainBrain MappingDiffusion Magnetic Resonance ImagingFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMemory, Short-TermMexican AmericansMiddle AgedNerve Fibers, MyelinatedNeural PathwaysNeuropsychological TestsOxygenPedigreeYoung AdultConceptsMemory performanceComplex cognitive functionsHigher-level processesGray matter densityWorking memoryCognitive measuresResponse taskStructural magnetic resonanceGeneral intelligenceSuperior longitudinal fasciculusHuman participantsWhite matter tractsCognitive functionCognitive deficitsOnly performanceMultimodal assessmentBrain regionsMemoryCommon genetic factorsLongitudinal fasciculusMajor white matter tractsLevel processesMeasuresGray matter regionsCore component
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