2025
Tobacco smoking is associated with attenuated error monitoring
Stam C, van der Veen F, Steele V, Franken I. Tobacco smoking is associated with attenuated error monitoring. Biological Psychology 2025, 109075. PMID: 40562349, DOI: 10.1016/j.biopsycho.2025.109075.Peer-Reviewed Original ResearchError-related negativityBlunted error-related negativityError monitoringEvent-related oscillationsEvent-related thetaEriksen-Flanker taskSubstance use disordersTobacco smokeGender-balanced sampleRobust deficitsBehavioral performanceSubstance addictionError positivityNeurophysiological deficitsSmoking participationGroup differencesDelta band powerNon-smoking participantsInternational goalsAddictionSmoking tobaccoBand powerDeficitsThetaParticipantsCognitive bias modification for individuals with opioid use disorder and chronic pain did not predict changes in clinical outcomes.
Wolkowicz N, Pittman B, Schrader S, Wesolowicz D, Sofuoglu M, Heapy A, MacLean R. Cognitive bias modification for individuals with opioid use disorder and chronic pain did not predict changes in clinical outcomes. Journal Of Studies On Alcohol And Drugs 2025 PMID: 40536409, DOI: 10.15288/jsad.25-00057.Peer-Reviewed Original ResearchCognitive bias modificationAttentional biasOpioid cravingBias modificationCBM effectsSubstance use disordersPain severityChronic painClinical outcomesAddiction severityOpioid use disorderUse disorderNaturalistic settingsNeutral-cueOpioid withdrawalPain cuesCravingDiverse sampleSalient outcomesSubstance typePreliminary effectivenessPrimary clinical outcomePain catastrophizingModerate painPain intensityCriminal Justice-Involved Veterans Not Engaged in Primary Care in the Veterans Health Administration.
Tsai J, Lampros A, Clark S, Dunn A, O'Toole T. Criminal Justice-Involved Veterans Not Engaged in Primary Care in the Veterans Health Administration. Journal Of Primary Care & Community Health 2025, 16: 21501319251348134. PMID: 40525421, PMCID: PMC12174793, DOI: 10.1177/21501319251348134.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationPrimary care visitsPrimary careJustice-involved veteransCare visitsHealth AdministrationVeterans Health Administration medical recordsMental health/substance use treatmentVeterans Health Administration facilitiesIntegrated care initiativesVA primary careOutpatient medical careMilitary sexual traumaCare initiativesService useAssociated with useCriminal justice systemHealthcare needsService utilizationNon-HispanicRetrospective cohort studySubstance use disordersBehavioral healthcareMental healthSociodemographic characteristicsLong-term, bidirectional associations between depressive symptom severity and opioid use among people with HIV: A prospective cohort study
Macmadu A, Li Y, Bhondoekhan F, Chang C, Bahji A, Crystal S, Gordon K, Kerns R, Vickers-Smith R, Edelman E, Marshall B. Long-term, bidirectional associations between depressive symptom severity and opioid use among people with HIV: A prospective cohort study. Addictive Behaviors Reports 2025, 22: 100619. PMID: 40547483, PMCID: PMC12182372, DOI: 10.1016/j.abrep.2025.100619.Peer-Reviewed Original ResearchDepressive symptom severityVeterans Aging Cohort StudySymptom severityOpioid useCohort studySubstance use disordersPrescription opioid useProspective cohort studyOpioid use disorderAging Cohort StudyMental health servicesDose-response patternGeneralized estimating equation modelsVeterans Health Administration sitesUse disorderClinical characteristicsProspective cohortBidirectional associationsFollow-upStudy entryOpioidHarm reduction servicesBidirectional relationshipPLHIVAdministration siteCommon neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis
Zhang X, Zhang H, Shao Y, Li Y, Zhang F, Zhang H. Common neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis. Translational Psychiatry 2025, 15: 190. PMID: 40467551, PMCID: PMC12137653, DOI: 10.1038/s41398-025-03396-2.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexSuperior frontal gyrusMedian cingulate gyrusInferior frontal gyrusResting-state functional connectivityBrain reward circuitsReward circuitSUD patientsPrefrontal cortexFamily-wise errorFrontal gyrusUse disorderCortical-striatal-thalamic-cortical circuitWhole-brain rs-fMRI studiesReduced resting-state functional connectivityDorsal anterior cingulate cortexResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingHealthy controlsPatterns of substance use disordersAssociated with impulsivityStages of addictionSubstance use disordersRs-fMRI studiesBackgroundSubstance use disordersMental Health, Substance Use, and Tuberculosis Preventive Therapy in People With HIV: A Prospective Cohort Study
Johnson A, Chimoyi L, Shenoi S, Brault M, Forastiere L, Charalambous S, Chihota V, Davis J. Mental Health, Substance Use, and Tuberculosis Preventive Therapy in People With HIV: A Prospective Cohort Study. Open Forum Infectious Diseases 2025, 12: ofaf303. PMID: 40567997, PMCID: PMC12188208, DOI: 10.1093/ofid/ofaf303.Peer-Reviewed Original ResearchTuberculosis preventive therapyUnhealthy alcohol useMental healthDepressive symptomsAlcohol useTobacco useAssociation of mental healthInfluence of mental healthCohort studyMeasure symptoms of anxietyNegatively associated with adherenceDeductive content analysisMixed methods studySubstance useLongitudinal cohort studyPsychological support servicesSymptoms of anxietySymptoms of depressionPreventive therapyProspective cohort studyAntiretroviral therapyHIV mortalityMultivariate regression modelSubstance use disordersMethods studyKappa opioid receptor antagonism restores phosphorylation, trafficking and behavior induced by a disease-associated dopamine transporter variant
Mayer F, Stewart A, Varman D, Moritz A, Foster J, Owens A, Areal L, Gowrishankar R, Velez M, Wickham K, Phelps H, Katamish R, Rabil M, Jayanthi L, Vaughan R, Daws L, Blakely R, Ramamoorthy S. Kappa opioid receptor antagonism restores phosphorylation, trafficking and behavior induced by a disease-associated dopamine transporter variant. Molecular Psychiatry 2025, 1-14. PMID: 40442453, DOI: 10.1038/s41380-025-03055-4.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderKappa-opioid receptor antagonismKappa-opioid receptorsAnomalous DA effluxDA transporterAutism spectrum disorderBipolar disorderDAT Val559D-amphetamineDA releaseAbuse liabilityTreatment of attention-deficit/hyperactivity disorderDopamine transporter variantsModulate DA releaseDA transporter functionSubstance use disordersTargeting kappa opioid receptorsKappa-opioid receptor stimulationHuman DA transporterKOR antagonismDA effluxAberrant dopamineAttention-deficit/hyperactivityDA neuronsSpectrum disorderThe Potential Use of Cannabidiol in the Treatment of Opioid Use Disorder: A Systematic Review
Shafie M, Ing K, Rostam‐Abadi Y, Weleff J, Griffin M, Ranganathan M, Aghaei A, Pratt N, Funaro M, Nia A. The Potential Use of Cannabidiol in the Treatment of Opioid Use Disorder: A Systematic Review. Addiction Biology 2025, 30: e70047. PMID: 40415392, PMCID: PMC12104536, DOI: 10.1111/adb.70047.Peer-Reviewed Original ResearchConceptsOpioid use disorderOUD outcomesUse disorderConditioned place preference paradigmPlace preference paradigmReducing withdrawal symptomsPotential of cannabidiolSubstance use disordersEfficacy of cannabidiolTreatment of opioid use disorderPreclinical studiesClinical studiesOpioid use disorder treatmentPreference paradigmAnxiety symptomsWithdrawal symptomsPsychiatric disordersEffective treatment approachTreatment optionsHuman studiesCannabidiolAnimal studiesSystematic reviewShort-term follow-upCravingPolygenic risk and childhood adversity as moderators of drug and alcohol withdrawal symptoms
Han A, Davis C, Jinwala Z, SooHoo J, Gelernter J, Feinn R, Kranzler H. Polygenic risk and childhood adversity as moderators of drug and alcohol withdrawal symptoms. Drug And Alcohol Dependence 2025, 273: 112712. PMID: 40449208, DOI: 10.1016/j.drugalcdep.2025.112712.Peer-Reviewed Original ResearchConceptsAdverse childhood eventsSubstance use disordersPolygenic scoresEUR individualsWithdrawal symptomsWithdrawal severityChildhood adversitySubstance useHigher polygenic scoreAssociated with tobaccoDevelopment of substance use disordersSemi-structured diagnostic instrumentMultivariate regression modelReturn to substance useTobacco withdrawal symptomsPolygenic riskManagement of withdrawal symptomsIndividual withdrawal symptomsStop substance useAlcohol withdrawal severitySecondary analysisAlcohol withdrawal symptomsSevere withdrawal symptomsOpioid withdrawal symptomsChildhood eventsA Picture Worth More Than One Thousand Words: A 30-Year Review of Photovoice Representation Disparities in Psychiatric Research
Metaweh M, Ouellette R, Moses J, Frazier S. A Picture Worth More Than One Thousand Words: A 30-Year Review of Photovoice Representation Disparities in Psychiatric Research. American Journal Of Orthopsychiatry 2025 PMID: 40323854, DOI: 10.1037/ort0000851.Peer-Reviewed Original ResearchPsychiatric researchSchizophrenia spectrum disordersSubstance use disordersSevere mental illnessMental health modelObsessive-compulsiveStressor disordersParticipants' social identitySubstance-relatedPsychiatric diagnosisInternalizing disordersSpectrum disorderMental illnessQuarter of studiesDisordersParticipants' representationsDiagnostic criteriaSocial identityHealth modelThousand WordsParticipantsSchizophreniaTherapeutic interventionsSocial justice approachPsychiatricAssociations of Childhood Adversity and Polygenic Scores with Substance Use Initiation and Disorder Severity
SooHoo J, Davis C, Han A, Jinwala Z, Gelernter J, Feinn R, Kranzler H. Associations of Childhood Adversity and Polygenic Scores with Substance Use Initiation and Disorder Severity. Psychological Medicine 2025, 55: e132. PMID: 40314172, PMCID: PMC12094658, DOI: 10.1017/s0033291725001163.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Childhood ExperiencesAlcoholismBlack or African AmericanFemaleGene-Environment InteractionGenetic Predisposition to DiseaseHumansMaleMarijuana AbuseMiddle AgedMultifactorial InheritanceOpioid-Related DisordersSeverity of Illness IndexSubstance-Related DisordersWhiteYoung AdultConceptsSubstance use disorder severitySubstance use disordersAdverse childhood experiencesGene-by-environment interactionsSubstance use initiationPolygenic scoresOpioid use disorderUse disorderEUR individualsAssociated with AUD severityCannabis use disorderAssociated with adverse childhood experiencesSeverity of alcoholismLatent factorsSubstance use disorder riskGene-environment correlationAssociation of childhood adversityAssociation of adverse childhood experiencesAncestry groupsAUD severityDisorder severityChildhood adversityPolygenic riskChildhood experiencesEnvironmental influencesHome‐based family recovery supports: Feasibility, acceptability, and adoption of training home visitors in “Mothering from the Inside Out”
Peacock‐Chambers E, Jurkowski B, Kangas S, DeCoste C, McMahon T, Borelli J, Feinberg E, Byatt N, Zayde A, Lowell A, Friedmann P. Home‐based family recovery supports: Feasibility, acceptability, and adoption of training home visitors in “Mothering from the Inside Out”. Infant Mental Health Journal Infancy And Early Childhood 2025 PMID: 40318079, DOI: 10.1002/imhj.70019.Peer-Reviewed Original ResearchSubstance use disordersEI providersEarly interventionFamily recoveryEvidence-based parenting interventionsDidactic trainingHome visitation settingRetention of providersTrained home visitorsImplementation outcomesTen providersHome visitorsAssess feasibilityVisit settingIn-personParenting interventionsPostpartum periodWeekly consultationQualitative interviewsProvidersImprove retentionAdequate adoptionDidactic learningAdequate fidelityPilot studyHypothesizing glucagon-like peptide 1 (GLP-1), agonists promote hypodopaminergia, resulting in heightened addictive reward-seeking and altered mood: Breaking the bubble and adding salt to a wound
Blum K, Dennen C, Lewandrowski K, Sharafshah A, Pinhasov A, Bowirrat A, Elman I, Cadet J, Braverman E, Thanos P, Makale M, Baron D, Ashford J, Fuehrlein B, Avena N, Gardner E, Badgaiyan R, Gondré—Lewis M, Modestino E, Khalsa J, Murphy K, Sunder K, Foojan Z, Jafari N, Carney P, Cortes R, Edwards D, Roy A, Smith D, Gold M. Hypothesizing glucagon-like peptide 1 (GLP-1), agonists promote hypodopaminergia, resulting in heightened addictive reward-seeking and altered mood: Breaking the bubble and adding salt to a wound. Medical Hypotheses 2025, 198: 111612. DOI: 10.1016/j.mehy.2025.111612.Peer-Reviewed Original ResearchReceptor agonistsGLP-1 receptor agonistsUse disorderGABA neuronsActivation of VTA GABA neuronsActivity of VTA dopamine neuronsIn vivo fiber photometryAttenuated cocaine seekingVTA dopamine neuronsVTA GABA neuronsReward-seeking behaviorAssociated with increased activityDopaminergic reward pathwayAlcohol use disorderSubstance use disordersGLP-1Cocaine seekingFluorescence in situ hybridizationReward-seekingReward pathwayAntiaddictive propertiesDopamine signalingDopaminergic pathwaysDopamine neuronsFiber photometryMultimorbidity of mental health and substance use disorders among housed and homeless U.S. veterans
Tsai J, Szymkowiak D, Beydoun H. Multimorbidity of mental health and substance use disorders among housed and homeless U.S. veterans. Scientific Reports 2025, 15: 15185. PMID: 40307423, PMCID: PMC12043799, DOI: 10.1038/s41598-025-99394-x.Peer-Reviewed Original ResearchConceptsMental health disorder diagnosisHomeless veteransMental health disordersEmergency department careHoused veteransSubstance use disordersSocial determinants of mental healthSUD diagnosisDeterminants of mental healthMental healthU.S. Department of Veterans Affairs (VA) healthcare systemDepartment of Veterans Affairs (VA) healthcare systemVeterans Affairs (VA) healthcare systemU.S. veteransHousing instabilityHousing situationComorbid mental health disordersSocial determinantsAdministrative dataHousingPsychiatric epidemiologyHealthcare systemHealth disordersNational cohortVeteransBeyond User-Centered Design: Designing Digital Health Technologies for Substance Use Prevention and Treatment in Children and Youth
Singh K, Camenga D, Aneni K, Hieftje K. Beyond User-Centered Design: Designing Digital Health Technologies for Substance Use Prevention and Treatment in Children and Youth. 2025, 231-249. DOI: 10.1007/978-3-031-84655-7_10.Peer-Reviewed Original ResearchDigital health interventionsSubstance use preventionHealth interventionsDevelopment of digital interventionsAssociated with numerous adverse health outcomesNumerous adverse health outcomesMental health disordersDigital health technologiesAdverse health outcomesFuture addictionHealth outcomesDigital interventionsSubstance use disordersUser-centered design approachHealth disordersHealth technologiesYouth substance useInterventionIncreased riskSubstance useUse disorderPreventionYouthChildrenUser experience evaluationCollaborating Across the Globe: The Yale-University of Jordan International Interprofessional Addiction Education Program
Muvvala S, Minahan-Rowley R, Al-Khateeb Y, Abu-Dahab R, Khoshnood K, Wazaify M, Tetrault J. Collaborating Across the Globe: The Yale-University of Jordan International Interprofessional Addiction Education Program. Substance Abuse 2025 DOI: 10.1177/29767342251331389.Peer-Reviewed Original ResearchYale School of MedicineSubstance use disordersTraining programJoint training programsHealth care workforceAddiction medicineInternational conference presentationsGlobal public health challengePublic health challengePeer-reviewed articlesCare workforcePublished peer-reviewed articlesInterprofessional educationTreatment gapTreating substance use disordersKern modelSchool of MedicineHealth challengesConference presentationsTraining workshopsTraining opportunitiesEducation programsPublic healthSubstance useTwo-year programEmerging Therapeutics in the Treatment of Substance Use Disorders: A Focus on GLP-1 Receptor Agonists, D3R Antagonists, and CRF Antagonists
Draghmeh K, Fuehrlein B. Emerging Therapeutics in the Treatment of Substance Use Disorders: A Focus on GLP-1 Receptor Agonists, D3R Antagonists, and CRF Antagonists. Journal Of Integrative Neuroscience 2025, 24: 26361. PMID: 40302255, DOI: 10.31083/jin26361.Peer-Reviewed Original ResearchConceptsSubstance use disordersCorticotropin-releasing factorTreatment of substance use disordersCorticotropin-releasing factor antagonistTreating substance use disordersDrug-seeking behaviorDopamine D3 receptorGlucagon-like peptide-1Reduce substance useUse of alcoholAddiction processD3R antagonistsReward modulationRelapse preventionD3 receptorsUse disorderStimulant useSubstance useGlucagon-like peptide-1 receptor agonistsPrevent relapseReceptor agonistsTarget different aspectsSignificant public health challengeAntagonistDisordersDisease Intervention Specialist Field Experience in Re-engaging Out-of-Care People with HIV in Project CoRECT: A Mixed Methods Study
Macharaviani E, Altice F, Shrestha R, Truebig J, Carroll C, Nichols L, Ahmad B, Copenhaver M, Villanueva M. Disease Intervention Specialist Field Experience in Re-engaging Out-of-Care People with HIV in Project CoRECT: A Mixed Methods Study. AIDS And Behavior 2025, 1-10. PMID: 40205311, DOI: 10.1007/s10461-025-04707-w.Peer-Reviewed Original ResearchDisease intervention specialistsRe-engagement effortsPatient-reported barriersControlled trialsHIV care continuumCenters for Disease Control and PreventionExplanatory sequential mixed methods designSequential mixed methods designClinic operating hoursPatient-centered approachMixed methods studyDisease Control and PreventionPublic health interventionsMixed methods designStructured interactive sessionsControl and PreventionCare continuumCare engagementCare assessmentHealth interventionsSubstance use disordersAnti-retroviral treatmentMethods studyHIV statusSecondary analysisA New CAHPS Measure of Patient Experiences With Mental Health and Substance Use Care
Hargraves J, Cosenza C, Mullin D, Cleary P. A New CAHPS Measure of Patient Experiences With Mental Health and Substance Use Care. Health Services Research 2025, e14623. PMID: 40176578, DOI: 10.1111/1475-6773.14623.Peer-Reviewed Original ResearchSubstance use disordersCounseling servicesInter-unit reliabilityMental health careFamily medicine practiceMental healthSubstance use servicesHealth careMedicaid enrolleesMedicine practiceDifficulty getting appointmentsExperiences of peopleOutpatient mental healthPrimary care providersSocial workersMental health conditionsExcellent internal consistencySubstance use careStudy 1Study 2Care providersPatient experiencePsychometric characteristicsResponses to specific questionsPsychiatric medicineAssociation of psychiatric diagnoses and military sexual trauma type with denied posttraumatic stress disorder service connection
Webermann A, Coppola E, Lazar C, Rosen M, Murdoch M, Portnoy G, Black A. Association of psychiatric diagnoses and military sexual trauma type with denied posttraumatic stress disorder service connection. Journal Of Affective Disorders 2025, 381: 69-76. PMID: 40185410, DOI: 10.1016/j.jad.2025.03.171.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderMilitary sexual traumaPTSD service connectionPsychiatric diagnosisPosttraumatic stress disorder diagnostic criteriaDiagnosis of personality disorderPosttraumatic stress disorder symptomsPosttraumatic stress disorder diagnosisAssociation of psychiatric diagnosesSchizophrenia spectrum disordersSubstance use disordersPersonality disorderAnxiety disordersNon-PTSDStress disorderBipolar disorderTrauma typesSexual traumaSpectrum disorderSexual assault claimsDisordersService connectionVeteransDiagnostic criteriaSexual harassment claims
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