2025
Multivariate associations between structural brain changes and cognitive impairment in partially or fully remitted persons with bipolar disorder
Schandorff J, Madsen A, Damgaard V, Little B, Sankar A, Macoveanu J, Frokjaer V, Kessing L, Jørgensen M, Knudsen G, Gallagher P, Miskowiak K. Multivariate associations between structural brain changes and cognitive impairment in partially or fully remitted persons with bipolar disorder. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2025, 140: 111425. PMID: 40505718, DOI: 10.1016/j.pnpbp.2025.111425.Peer-Reviewed Original ResearchBipolar disorderGray matter volumeCognitive impairmentMatter volumeBrain structuresReduced gray matter volumeExtensive cognitive test batteryLower gray matter volumeStructural magnetic resonance imagingBrain structural alterationsCognitive test batteryPosterior cingulate regionsStructural brain changesLeft caudate nucleusCanonical correlation analysisRemitted personsVerbal learningWorking memoryExecutive functionPsychomotor speedCingulate regionsCognitive domainsRight hippocampusCognitively impaired personsBrain changesStructural Brain Changes Associated With Risky Drinking in Late-Life Depression
Steffens D, Wang L, Manning K, Pearlson G. Structural Brain Changes Associated With Risky Drinking in Late-Life Depression. The American Journal Of Geriatric Psychiatry Open Science Education And Practice 2025, 6: 1-14. PMID: 40535612, PMCID: PMC12176382, DOI: 10.1016/j.osep.2025.01.003.Peer-Reviewed Original ResearchStructural brain changesBrain changesAlcohol useAlcohol consumptionCortical thicknessFronto-striatal circuitsInferior parietal sulcusVolumetric brain changesFrontal cortical regionsLate-life depressionDecreased depression severityModerate drinkersDecreased alcohol consumptionOlder adultsRisky drinkersRisky alcohol useImpact of alcohol useCognitive batteryDepression severityDepressive episodeDSM criteriaStudy psychiatristClinical interviewOlder depressivesPosterior cingulateStructural Brain Changes Associated With Cognitive Behavioral Therapy in Cocaine Use Disorder Treatment
McCurdy L, DeVito E, Loya J, Nich C, Kiluk B, Potenza M. Structural Brain Changes Associated With Cognitive Behavioral Therapy in Cocaine Use Disorder Treatment. Drug And Alcohol Dependence 2025, 267: 112224. DOI: 10.1016/j.drugalcdep.2024.112224.Peer-Reviewed Original Research
2024
Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment
McCurdy L, DeVito E, Loya J, Nich C, Zhai Z, Kiluk B, Potenza M. Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment. Drug And Alcohol Dependence Reports 2024, 11: 100246. PMID: 38966567, PMCID: PMC11222934, DOI: 10.1016/j.dadr.2024.100246.Peer-Reviewed Original ResearchCocaine use disorderCognitive behavioral therapyCocaine useBehavioral therapyBrain changesBrain structuresWhole-brain voxel-based morphometry analysisCocaine use disorder treatmentLevel of cocaine useWeeks of outpatient treatmentVoxel-based morphometry analysisDigital cognitive behavioral therapyT1-weighted magnetic resonance imaging scansRight caudate bodyAssociated with cocaine useMethadone-maintained individualsGray matter volumeStructural brain changesFunction of engagementCaudate bodyRight caudateCUD treatmentMatter volumeUse disorderBilateral cerebellum
2023
6 Graph Analysis of Resting State Functional Brain Networks and Associations with Cognitive Outcomes in Survivors on Pediatric Brain Tumor
Semmel E, Calhoun V, Hillary F, Morris R, King T. 6 Graph Analysis of Resting State Functional Brain Networks and Associations with Cognitive Outcomes in Survivors on Pediatric Brain Tumor. Journal Of The International Neuropsychological Society 2023, 29: 316-317. DOI: 10.1017/s135561772300437x.Peer-Reviewed Original ResearchSurvivors of pediatric brain tumorsFunctional brain networksWorking memoryBrain networksCognitive outcomesProcessing speedLong-term neuropsychological deficitsResting state functional magnetic resonance imagingFunctional magnetic resonance imagingMeasures of attentionCore cognitive skillsLong-term cognitive outcomesStructural brain changesSmall-moderate effect sizeFunctional network propertiesSurvivors of brain tumorsBrain tumor survivorsGraph metricsResting state dataGlobal efficiencyNeuropsychological deficitsNeuropsychological testsBrain changesGroup differencesIndependence in adulthood
2020
Structural and functional brain changes in hepatic and neurological Wilson disease
Tinaz S, Arora J, Nalamada K, Vives-Rodriguez A, Sezgin M, Robakis D, Patel A, Constable RT, Schilsky ML. Structural and functional brain changes in hepatic and neurological Wilson disease. Brain Imaging And Behavior 2020, 15: 2269-2282. PMID: 33244627, DOI: 10.1007/s11682-020-00420-5.Peer-Reviewed Original ResearchConceptsSusceptibility-weighted imagingFunctional brain changesBrain changesWD groupWilson's diseaseWhite matter volume lossBilateral superior frontal cortexBilateral anterior corona radiataResting-state functional MRINeurological Wilson's diseaseStructural brain changesCross-sectional studyGender-matched controlsBrain MRI scansAnterior corona radiataSuperior frontal cortexWhite matter integrityFunctional connectivity analysisSignificant striatalThalamic atrophyNeuropsychiatric symptomsHypointense lesionsTreatment strategiesCorpus callosumNeuropsychiatric assessmentCortical Thickness in Alcohol Dependent Patients With Apathy
Yang K, Yang Q, Niu Y, Fan F, Chen S, Luo X, Tan S, Wang Z, Tong J, Yang F, Le TM, Li CR, Tan Y. Cortical Thickness in Alcohol Dependent Patients With Apathy. Frontiers In Psychiatry 2020, 11: 364. PMID: 32431630, PMCID: PMC7214693, DOI: 10.3389/fpsyt.2020.00364.Peer-Reviewed Original ResearchInferior parietal cortexHealthy controlsCortical thicknessSuperior parietal cortexOccipito-temporal cortexParietal cortexOccipital gyrusBilateral superior parietal cortexCritical clinical featuresStructural brain changesEducation-matched healthy controlsSeverity of apathyRight superior occipital gyrusAlcohol-dependent patientsBilateral lingual gyrusLeft middle occipital gyrusSuperior occipital gyrusMiddle occipital gyrusBilateral inferior parietal cortexOccipital-temporal cortexClinical featuresDependent patientsRight intraparietal sulcusMagnetic resonance imaging dataBrain changes
2018
Longitudinal Trajectories of Brain Volume and Cortical Thickness in Treated and Untreated Primary Human Immunodeficiency Virus Infection
Sanford R, Ances BM, Meyerhoff DJ, Price RW, Fuchs D, Zetterberg H, Spudich S, Collins DL. Longitudinal Trajectories of Brain Volume and Cortical Thickness in Treated and Untreated Primary Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 2018, 67: 1697-1704. PMID: 29697762, PMCID: PMC6233681, DOI: 10.1093/cid/ciy362.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyHuman immunodeficiency virusPrimary HIV infectionChronic HIV infectionCortical thicknessHIV infectionCortical thinningUntreated infectionTemporal lobeBrain volumeImpact of HIVPrimary human immunodeficiency virus (HIV) infectionEarly combination antiretroviral therapyUntreated human immunodeficiency virusHuman immunodeficiency virus (HIV) infectionLongitudinal magnetic resonance imagingImmunodeficiency virus infectionCerebrospinal fluid biomarkersStructural brain changesCortical gray matterMagnetic resonance imagingBrain morphometric measuresCART durationAntiretroviral therapySubcortical atrophy
2017
Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence
de Araujo C, Zugman A, Swardfager W, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, de Moura L, Del Aquilla M, Picon F, Amaro E, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence. Journal Of Psychiatric Research 2017, 98: 51-58. PMID: 29288952, DOI: 10.1016/j.jpsychires.2017.12.008.Peer-Reviewed Original ResearchConceptsPsychiatric disordersVal66Met polymorphismCortical thicknessBrain-derived neurotrophic factor (BDNF) Val66Met polymorphismRegional structural brain changesNeurotrophic factor Val66Met polymorphismPrefrontal cortexStructural brain changesLateral temporal cortexEffect of Val66MetBilateral prefrontal cortexVal66Met effectsWindow of vulnerabilityCortical maturationBrain changesOccipital lobeMet carriersAtypical neurodevelopmentMRI scansPsychiatric diagnosisTemporal cortexDiagnosis interactionVal66MetNeuropsychiatric disordersBrain morphologyGenetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group
Brouwer R, Panizzon M, Glahn D, Hibar D, Hua X, Jahanshad N, Abramovic L, de Zubicaray G, Franz C, Hansell N, Hickie I, Koenis M, Martin N, Mather K, McMahon K, Schnack H, Strike L, Swagerman S, Thalamuthu A, Wen W, Gilmore J, Gogtay N, Kahn R, Sachdev P, Wright M, Boomsma D, Kremen W, Thompson P, Pol H. Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. Human Brain Mapping 2017, 38: 4444-4458. PMID: 28580697, PMCID: PMC5572837, DOI: 10.1002/hbm.23672.Peer-Reviewed Original ResearchConceptsSubcortical brain volumesBrain volumeGenetic influencesBrain changesBrain structuresDevelopmental trajectory of brain structureDeviant developmental trajectoriesMultivariate genetic modelsGeneral cognitive functionStructural brain changesBrain structural changesLongitudinal twin cohortCerebellar gray matterInfluence of genetic factorsSubcortical volumesCognitive functionBaseline volumeBrain plasticityHeritability estimatesDevelopmental changesMental healthBrain developmentTwin cohortEnvironmental influencesGray matterInferring pathobiology from structural MRI in schizophrenia and bipolar disorder: Modeling head motion and neuroanatomical specificity
Yao N, Winkler AM, Barrett J, Book GA, Beetham T, Horseman R, Leach O, Hodgson K, Knowles EE, Mathias S, Stevens MC, Assaf M, van Erp TGM, Pearlson GD, Glahn DC. Inferring pathobiology from structural MRI in schizophrenia and bipolar disorder: Modeling head motion and neuroanatomical specificity. Human Brain Mapping 2017, 38: 3757-3770. PMID: 28480992, PMCID: PMC6867056, DOI: 10.1002/hbm.23612.Peer-Reviewed Original ResearchConceptsBipolar disorderStructural brain changesCortical thickness reductionsCortical thickness indexHealthy comparison subjectsHum Brain MappCortical thickness measurementsBrain changesLarge cohortNeuroanatomic abnormalitiesPsychotic illnessRegional specificityComparison subjectsFunctional changesSchizophreniaThickness indexCurrent imaging technologiesDisordersGroup structural differencesIllnessSimilar protocolEarlier reportsBiological factorsGroup effectsSpecificity
2016
Altered functional brain connectivity in children and young people with opsoclonus–myoclonus syndrome
Chekroud A, Anand G, Yong J, Pike M, Bridge H. Altered functional brain connectivity in children and young people with opsoclonus–myoclonus syndrome. Developmental Medicine & Child Neurology 2016, 59: 98-104. PMID: 27658927, DOI: 10.1111/dmcn.13262.Peer-Reviewed Original ResearchConceptsOpsoclonus-myoclonus syndromeMagnetic resonance imagingMotor cortexOccipito-parietal regionsAltered functional brain connectivityWidespread brain involvementResting-state functional MRI dataComparison groupStructural brain changesCross-sectional studyFunctional brain connectivitySeed-based analysisBrain functional connectivityAge-matched comparison participantsBrain involvementMotor sequelaeBasal gangliaBrain changesPatientsResonance imagingBrain regionsFunctional MRI dataFunctional connectivityVisual networkBrain connectivity
2013
Gray matter volume correlates of global positive alcohol expectancy in non‐dependent adult drinkers
Ide JS, Zhang S, Hu S, Matuskey D, Bednarski SR, Erdman E, Farr OM, Li C. Gray matter volume correlates of global positive alcohol expectancy in non‐dependent adult drinkers. Addiction Biology 2013, 19: 895-906. PMID: 23461484, PMCID: PMC3681829, DOI: 10.1111/adb.12046.Peer-Reviewed Original ResearchConceptsGM volumeVoxel-based morphometrySuperior frontal gyrusPrecentral gyrusBilateral superior frontal gyrusBilateral dorsolateral prefrontal cortexStructural brain changesNumerous imaging studiesLeft precentral gyrusGray matter volumeDrinking behaviorRight ventral putamenDorsolateral prefrontal cortexNon-dependent drinkersStructural brain correlatesVentral putamenBrain changesFrontal cortexGray matter correlatesMatter volumeNon-dependent drinkingRecent drinkingImaging studiesInfluence drinking behaviorPrefrontal cortex
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