2025
Safety of Stimulants Across Patient Populations
Oliva H, Prudente T, Mayerson T, Mignosa M, Oliva I, Potenza M, Jegede O, Angarita G. Safety of Stimulants Across Patient Populations. JAMA Network Open 2025, 8: e259492. PMID: 40343695, PMCID: PMC12065045, DOI: 10.1001/jamanetworkopen.2025.9492.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderRandomized clinical trialsAdverse eventsStimulant medicationData extractionSafety of stimulationRisk ratioIncreased riskMethodological quality assessmentPreferred Reporting ItemsPatient populationClinical conditionsDiverse patient populationsRisk of biasSafety of stimulant medicationsUnclear risk of biasTreatment of attention-deficit/hyperactivity disorderOverall AEsRandom-effects modelWeb of ScienceBinge eating disorderStimulant use disorderComprehensive literature searchMain OutcomesReporting Items
2022
Helpful or Harmful? The Therapeutic Potential of Medications with Varying Degrees of Abuse Liability in the Treatment of Substance Use Disorders
Martins B, Rutland W, De Aquino JP, Kazer BL, Funaro M, Potenza MN, Angarita GA. Helpful or Harmful? The Therapeutic Potential of Medications with Varying Degrees of Abuse Liability in the Treatment of Substance Use Disorders. Current Addiction Reports 2022, 9: 647-659. PMID: 35990796, PMCID: PMC9376579, DOI: 10.1007/s40429-022-00432-9.Peer-Reviewed Original ResearchSubstance use disordersUse disordersCocaine use disorderWithdrawal symptomsAbuse liabilityMultiple substance use disordersOpioid use disorderRegulatory approval statusFurther clinical researchPotential abuse liabilityNegative subjective effectsClinical trial researchPharmacological treatmentStimulant medicationPossible treatmentReviewThis reviewTherapeutic potentialTrial researchClinical researchSubjective effectsKetamineDecrease useDisordersGabapentinoidsApproval status
2020
Effects of sub-chronic methylphenidate on risk-taking and sociability in zebrafish (Danio rerio)
Brenner R, Oliveri A, Sinnott-Armstrong W, Levin E. Effects of sub-chronic methylphenidate on risk-taking and sociability in zebrafish (Danio rerio). Naunyn-Schmiedeberg's Archives Of Pharmacology 2020, 393: 1373-1381. PMID: 32025747, PMCID: PMC7716188, DOI: 10.1007/s00210-020-01835-z.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderSub-chronic dosesTreated with stimulant medicationVisual stimuliDecreased locomotor responseEffects of methylphenidateDeficit hyperactivity disorderRisk-takingImpaired avoidanceLocomotor responseAvoidance paradigmMethylphenidate exposureSocial stimuliStimulant medicationPsychiatric disordersHyperactivity disorderBehavioral functionsMethylphenidateNovel tankNeurobehavioral impairmentsDosing paradigmNeurobehavioral toxicityDecreased activity levelsAdult zebrafishStimuli
2018
The Use of Stimulant Augmentation of Second Generation Antipsychotics in the Management of Negative Symptoms of Schizophrenia: A Case Report
Azizi H, Zeng Y, Kallikkadan J, Kahn A, Olayinka O, Popoola O, Khan T, Rimawi D, Malik A, Williams S, Langdon S, Obegolu C, Nuthalapati D, Alzear R, Kalbouneh H, Mahbub A, Ojimba C, Oyelakin A, Kodjo K, Ferdous Saad A, Jegede O, Jolayemi A. The Use of Stimulant Augmentation of Second Generation Antipsychotics in the Management of Negative Symptoms of Schizophrenia: A Case Report. International Journal Of Innovative Research In Medical Science 2018, 3 DOI: 10.23958/ijirms/vol03-i08/08.Peer-Reviewed Original ResearchNegative symptomsMesocortical pathwayStimulant medicationSymptom subscalesTwo-point reductionClasses of medicationsSecond-generation antipsychoticsPositive symptom subscaleThree-week trialNegative symptom subscaleAntipsychotic therapyNegative syndrome scoreGeneration antipsychoticsCase reportSyndrome scoreDopamine activityMedicationsSymptomsSchizophreniaThree-week periodScoresPotential benefitsSubscales
2014
Gender and Injuries Predict Stimulant Medication Use
Dalsgaard S, Leckman JF, Nielsen HS, Simonsen M. Gender and Injuries Predict Stimulant Medication Use. Journal Of Child And Adolescent Psychopharmacology 2014, 24: 253-259. PMID: 24813570, PMCID: PMC4064734, DOI: 10.1089/cap.2013.0101.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildChild Development Disorders, PervasiveCraniocerebral TraumaFemaleFollow-Up StudiesHumansMaleMental DisordersPractice Patterns, Physicians'Prospective StudiesSeverity of Illness IndexSex FactorsWounds and InjuriesConceptsAttention-deficit/hyperactivity disorderStimulant treatmentNumber of injuriesADHD medicationPsychiatric disordersStimulant medicationAutism spectrum disorderFirst prospective studyGroup of patientsPopulation-based studyYears of ageEarly life predictorsStimulant medication useMedication useGroup of childrenProspective studyPharmacological treatmentHead injuryNational cohortDrug prescriptionsMale genderPsychiatric diagnosisMedicationsNational registersInjury
2011
The Effects of Stimulant Medication on Working Memory Functional Connectivity in Attention-Deficit/Hyperactivity Disorder
Wong CG, Stevens MC. The Effects of Stimulant Medication on Working Memory Functional Connectivity in Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 2011, 71: 458-466. PMID: 22209640, PMCID: PMC4120250, DOI: 10.1016/j.biopsych.2011.11.011.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderFunctional magnetic resonance imagingFunctional connectivityFMRI taskHyperactivity disorderStimulant medicationNetwork engagementMemory fMRI taskFrontoparietal brain networksBrain regionsFrontoparietal brain regionsConnectivity changesMemory reaction timeVentrolateral prefrontal cortexAdditional brain regionsGroup independent component analysisMedication-related changesFunctional connectivity analysisRegional functional connectivityFunctional connectivity changesMemory performanceRepeated-measures t-testBrain activationIndependent component analysisRetrieval phase
2009
An fMRI Study of the Effects of Psychostimulants on Default-Mode Processing During Stroop Task Performance in Youths With ADHD
Peterson BS, Potenza MN, Wang Z, Zhu H, Martin A, Marsh R, Plessen KJ, Yu S. An fMRI Study of the Effects of Psychostimulants on Default-Mode Processing During Stroop Task Performance in Youths With ADHD. American Journal Of Psychiatry 2009, 166: 1286-1294. PMID: 19755575, PMCID: PMC3289412, DOI: 10.1176/appi.ajp.2009.08050724.Peer-Reviewed Original ResearchConceptsVentral anterior cingulate cortexAnterior cingulate cortexEffects of psychostimulantsCingulate cortexComparison subjectsLateral prefrontal cortexPrefrontal cortexStimulant medicationDefault-mode activityFunctional MRI scansPosterior cingulate cortexVentral anterior cingulateDefault mode processingMedicationsMRI scansAnterior cingulateHealthy comparison youthNormal levelsCortexPsychostimulantsGreater activationFMRI studyGreater reductionLateral prefrontalBrain activitySex Differences in Effectiveness of Extended-Release Stimulant Medication among Adolescents with Attention-Deficit/Hyperactivity Disorder
Mikami AY, Cox DJ, Davis MT, Wilson HK, Merkel RL, Burket R. Sex Differences in Effectiveness of Extended-Release Stimulant Medication among Adolescents with Attention-Deficit/Hyperactivity Disorder. Journal Of Clinical Psychology In Medical Settings 2009, 16: 233-242. PMID: 19418208, DOI: 10.1007/s10880-009-9165-8.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderStimulant medicationHyperactivity disorderFemale adolescentsADHD symptom ratingsOsmotic-release methylphenidateNeuropsychological tasksParent reportAmphetamine saltsAdolescent femalesAdolescent populationSymptom ratingsAdolescentsObjective measuresSex differencesDouble-blind crossover studyMedication regimenCrossover studyMedication efficacyImpulsivityInattentionDisordersMedicationsSide effectsMethylphenidate
2008
The Effects of Methylphenidate on Decision Making in Attention-Deficit/Hyperactivity Disorder
DeVito EE, Blackwell AD, Kent L, Ersche KD, Clark L, Salmond CH, Dezsery AM, Sahakian BJ. The Effects of Methylphenidate on Decision Making in Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 2008, 64: 636-639. PMID: 18504036, PMCID: PMC2577132, DOI: 10.1016/j.biopsych.2008.04.017.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderCambridge Gamble TaskADHD groupHyperactivity disorderDecision-making cognitionDecision-making deficitsEffects of methylphenidatePoor decision makingParent-reported symptomsHealthy age-matched control groupNeuropsychological markersEveryday behaviorStimulant medicationDisruptive behaviorPoor decisionsPoor judgmentBetting behaviorLittle empirical dataControl subjectsPlacebo sessionAge-matched control groupTaskDecision makingMethylphenidatePlacebo-controlled trial
2007
Drug and non-drug treatments of children with ADHD and tic disorders
Poncin Y, Sukhodolsky DG, McGuire J, Scahill L. Drug and non-drug treatments of children with ADHD and tic disorders. European Child & Adolescent Psychiatry 2007, 16: 78-88. PMID: 17665286, DOI: 10.1007/s00787-007-1010-8.ChaptersConceptsAttention deficit hyperactivity disorderTreatment of ADHDTreatment of ticsTic disordersTreatment of childrenStimulant medicationWorsening of ticsNon-pharmacological approachesNon-drug treatmentsChronic tic disorderMinority of childrenDeficit hyperactivity disorderMild ticsSignificant morbiditySchool-aged childrenNovel treatmentsMedicationsLiterature searchPreponderance of evidenceAdverse effectsHyperactivity disorderDisordersMore studiesTreatmentChildren
2003
Is attention deficit hyperactivity disorder over‐represented among HIV‐seronegative boys with haemophilia? Preliminary results from our centre
Wodrich D, Recht M, Gradowski M, Wagner L. Is attention deficit hyperactivity disorder over‐represented among HIV‐seronegative boys with haemophilia? Preliminary results from our centre. Haemophilia 2003, 9: 593-597. PMID: 14511300, DOI: 10.1046/j.1365-2516.2003.00790.x.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderInattentive ADHDTeacher Rating ScaleAttention deficit hyperactivity disorder symptomsDiagnosis of attention deficit hyperactivity disorderPresence of ADHD symptomsTreated with stimulant medicationParent-rating scalesDeficit hyperactivity disorderNon-participating patientsADHD symptomsStimulant medicationHyperactivity disorderCare providersHemophilia care providersComprehensive careRating ScaleEligible boysHIV-negativeChart reviewAged 5PCR-based assayBoysHemophiliaOver-represented
2000
Pharmacologic Treatment of Tic Disorders
Scahill L, Chappell P, King R, Leckman J. Pharmacologic Treatment of Tic Disorders. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 99-117. PMID: 10674192, DOI: 10.1016/s1056-4993(18)30137-8.Peer-Reviewed Original ResearchConceptsTic disordersTreatment of ADHDAtypical neurolepticsLong-term side effectsNewer atypical neurolepticsFirst-line treatmentTreatment of ticsBotulinum toxin injectionMore studiesUse of stimulantsNonstimulant medicationsToxin injectionPharmacologic treatmentPsychiatric comorbidityStandard treatmentTraditional neurolepticsTarget symptomsSide effectsStimulant medicationMedicationsNeurolepticsAdverse effectsComorbid ADHDDisordersTreatment planning
1995
Guanfacine Treatment of Comorbid Attention-Deficit Hyperactivity Disorder and Tourette's Syndrome: Preliminary Clinical Experience
CHAPPELL P, RIDDLE M, SCAHILL L, LYNCH K, SCHULTZ R, ARNSTEN A, LECKMAN J, COHEN D. Guanfacine Treatment of Comorbid Attention-Deficit Hyperactivity Disorder and Tourette's Syndrome: Preliminary Clinical Experience. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1140-1146. PMID: 7559307, DOI: 10.1097/00004583-199509000-00010.Peer-Reviewed Original ResearchConceptsYale Global Tic Severity ScaleAttention deficit hyperactivity disorderTourette syndromeContinuous Performance TestHyperactivity disorderOpen-label studyCommon side effectsSeverity of motorComorbid attention deficit hyperactivity disorderSafe alternative therapySignificant decreaseTic Severity ScalePreliminary clinical experienceMajority of subjectsConners' Parent Rating ScaleTransient sedationControlled TrialsAlternative therapiesSedative effectsGuanfacine treatmentPhonic ticsSeverity ScaleSide effectsStimulant medicationTic severity
1985
Inappropriate Uses of Stimulant Medications
Volkmar F, Hoder E, Cohen D. Inappropriate Uses of Stimulant Medications. Clinical Pediatrics 1985, 24: 127-130. PMID: 2578911, DOI: 10.1177/000992288502400301.Peer-Reviewed Original Research
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