2025
Effects of oral nicotine pouches on cigarette smoking behaviour and tobacco harm exposure: a randomised pilot trial in adults
Fucito L, Baldassarri S, Wu R, Gueorguieva R, Morean M, Herbst R, Krishnan-Sarin S, O’Malley S. Effects of oral nicotine pouches on cigarette smoking behaviour and tobacco harm exposure: a randomised pilot trial in adults. Tobacco Control 2025, tc-2024-059094. PMID: 40550628, DOI: 10.1136/tc-2024-059094.Peer-Reviewed Original ResearchSmoking abstinenceOral nicotine pouchesSmoking behaviorNicotine pouchesRandomised pilot trialPoint prevalence smoking abstinenceComplete smoking abstinenceOutpatient research clinicCigarette smoking behaviorPreliminary supportTobacco-specific carcinogenNon-significantNicotineResearch clinicOpen-labelSmoking cessationAbstinenceCigarette substituteUrinary levelsWeek 4Nicotine strengthSmoking cigarettesParticipantsCompare groupsAdultsBrain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors
Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors. Translational Psychiatry 2025, 15: 61. PMID: 39979292, PMCID: PMC11842717, DOI: 10.1038/s41398-025-03288-5.Peer-Reviewed Original ResearchConceptsImaging-derived phenotypesBrain imaging-derived phenotypesAlcohol drinkingBrain structuresProcessing of social cuesCorrelates of smoking behaviorRelationship of brain structureSequencing Consortium of AlcoholGlobal genetic correlationsSmoking behaviorSuperior longitudinal fasciculusAssociated with smoking initiationTobacco smokeTobacco smoking behaviorLatent causal variable approachesNicotine useBrain regionsPremotor cortexSocial cuesWhite matter hyperintensitiesLongitudinal fasciculusChemosensory processingCortical thicknessMendelian randomizationPleiotropic mechanismsEstimating the impact of cigarette smoking on life expectancy from 1950 to 2000
Holford T. Estimating the impact of cigarette smoking on life expectancy from 1950 to 2000. Open Access Government 2025, 46: 43-45. DOI: 10.56367/oag-046-11540.Peer-Reviewed Original ResearchImpact of cigarette smokingLife expectancyCigarette smokingUniversity School of Public HealthSchool of Public HealthSurveillance Modeling NetworkEstimates of initiationCessation probabilitiesSmoker prevalenceSmoking behaviorCancer interventionSmokingPublic healthCISNETDepartment of BiostatisticsLifeU.S.Expectations
2024
Sex differences in dorsal striatal volume and interest in quitting smoking
Huang S, MacLean R, Beltz A, McClernon F, Kozink R, Wilson S. Sex differences in dorsal striatal volume and interest in quitting smoking. Drug And Alcohol Dependence 2024, 267: 112543. PMID: 39764928, PMCID: PMC11771478, DOI: 10.1016/j.drugalcdep.2024.112543.Peer-Reviewed Original ResearchConceptsGray matter volumePutamen gray matter volumesVoxel-based morphometryStriatal grey matter volumeAverage gray matter volumeQuitting interestDorsal striatal volumesStructural magnetic resonance imagingQuit smokingMagnetic resonance imagingSubstance use behaviorsROI-based analysisSelf-reported interestDorsal striatumBrain mechanismsNeuroanatomical mechanismsMatter volumeStriatal volumeBrain regionsSensorimotor cuesVolumetric differencesSex differencesPutamenMultiple regression analysisSmoking behaviorUS Tobacco 21 Policies and Potential Mortality Reductions by State
Tam J, Crippen A, Friedman A, Jeon J, Colston D, Fleischer N, Vander Woude C, Boelter M, Holford T, Levy D, Meza R. US Tobacco 21 Policies and Potential Mortality Reductions by State. JAMA Health Forum 2024, 5: e244445. PMID: 39705045, PMCID: PMC11662258, DOI: 10.1001/jamahealthforum.2024.4445.Peer-Reviewed Original ResearchConceptsPotential mortality reductionT21 policiesMortality reductionPremature deathEstimate smoking-attributable deathsLife yearsT21 lawsSmoking-attributable deathsTobacco-21 policiesPremature mortality reductionQuasi-experimental studyPolicy coverageState-specific dataDistrict of ColumbiaMortality rateTobacco 21Smoking cessationMain OutcomesSmoking initiationBirth cohortTobacco productsSmoking behaviorStatewide implementationCigarette policiesSmokingDevelopment of a Mobile App for Smoking Cessation: a Qualitative Study
Hargono A, Ni Z, Artanti K, Nastiti R, Martini S. Development of a Mobile App for Smoking Cessation: a Qualitative Study. Unnes Journal Of Public Health 2024, 13: 105-116. DOI: 10.15294/ujph.v13i2.5335.Peer-Reviewed Original ResearchFocus group discussionsPrevent smokingSmoking cessationImplementing evidence‐based practiceApp-based interventionsMobile appsSmoking cessation counselingIndonesian healthcare systemIndonesian policy makersSmoking cessation programEvidence-based practicePolicy makersCessation counselingHealth workersPublic health concernReviewing relevant documentsCounseling servicesCessation programsHealth researchQuit smokingSmoker characteristicsHealthcare systemSmoking statusQualitative studySmoking behaviorMulti-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes
Toikumo S, Jennings M, Pham B, Lee H, Mallard T, Bianchi S, Meredith J, Vilar-Ribó L, Xu H, Hatoum A, Johnson E, Pazdernik V, Jinwala Z, Pakala S, Leger B, Niarchou M, Ehinmowo M, Jenkins G, Batzler A, Pendegraft R, Palmer A, Zhou H, Biernacka J, Coombes B, Gelernter J, Xu K, Hancock D, Cox N, Smoller J, Davis L, Justice A, Kranzler H, Kember R, Sanchez-Roige S. Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes. Nature Human Behaviour 2024, 8: 1177-1193. PMID: 38632388, PMCID: PMC11199106, DOI: 10.1038/s41562-024-01851-6.Peer-Reviewed Original ResearchConceptsTobacco use disorderPotential risk genesMulti-ancestry meta-analysisMultiple health outcomesElectronic health recordsSource of phenotypic informationGenome-wide association studiesUse disorderAscertainment cohortHealth outcomesHealth recordsPrevalent substance use disordersRisk genesIndependent risk lociUK BiobankSubstance use disordersSmoking behaviorMedical outcomesFunctional genomics toolsPsychiatric traitsAssociation studiesRisk lociRisk variantsHeart diseaseGenomic toolsNetwork analysis of smoking-related sleep characteristics in Chinese adults
Xie Y, Sun P, Huang H, Wu J, Ba Y, Zhou G, Yu F, Zhang D, Zhang Y, Qie R, Hu Z, Zou K, Zhang Y. Network analysis of smoking-related sleep characteristics in Chinese adults. Annals Of Medicine 2024, 56: 2332424. PMID: 38527416, PMCID: PMC10964831, DOI: 10.1080/07853890.2024.2332424.Peer-Reviewed Original ResearchConceptsLate bedtimeMultiple sleep characteristicsChinese adultsCancer-related risk factorsPotential core domainsSleep characteristicsSleep health promotionLogistic regression modelsShort sleep durationHealth promotionTobacco preventionCurrent smokingSmoking cessationSmoking intensitySmoking behaviorHeavy smokingSleep durationNap timeSmokingPositive associationRisk factorsRegression modelsYoung adultsAdultsAssociationDeployment-related Cigarette Smoking Behaviors and Pulmonary Function Among U.S. Veterans
Maccarone J, Sterns O, Timmons A, Korpak A, Smith N, Nakayama K, Baird C, Ciminera P, Kheradmand F, Fan V, Hart J, Koutrakis P, Jerrett M, Kuschner W, Ioachimescu O, Montgrain P, Proctor S, Redlich C, Wendt C, Blanc P, Garshick E, Wan E. Deployment-related Cigarette Smoking Behaviors and Pulmonary Function Among U.S. Veterans. Military Medicine 2024, 189: 2030-2038. PMID: 38536226, DOI: 10.1093/milmed/usae049.Peer-Reviewed Original ResearchPack-yearsEver-smokersMultivariable linear regression models assessed associationsLinear regression models assessed associationsRegression models assessed associationsVeterans Affairs sitesModels assessed associationsPost-9/11 veteransLand-based deploymentsPack-years smokingEffects of smokingPulmonary functionCigarette smoking behaviorDeployed veteransInverse associationSmoking intensityLevels of ambient particulate matterSmoking behaviorU.S. veteransVeteransSmokingCigarette smokingAmbient particulate matterMultiple deploymentsFEV1%-predictedA randomized controlled trial of potential tobacco policies prohibiting menthol flavor in cigarettes and e-cigarettes: a study protocol
Bold K, Sharma A, Haeny A, Gueorguieva R, Buta E, Baldassarri S, Lempert L, Krishnan-Sarin S, O’Malley S. A randomized controlled trial of potential tobacco policies prohibiting menthol flavor in cigarettes and e-cigarettes: a study protocol. BMC Psychiatry 2024, 24: 201. PMID: 38475757, PMCID: PMC10935798, DOI: 10.1186/s12888-024-05619-0.Peer-Reviewed Original ResearchConceptsSmoking menthol cigarettesE-cigarettesCigarette useReduce tobacco-related health disparitiesTobacco-related health disparitiesMenthol cigarettesRates of menthol cigarette useTobacco use statusMenthol cigarette useRandomized controlled trialsPublic health problemHealth disparitiesTobacco policiesFlavored e-cigarettesSmoke-freeMenthol flavorsMenthol policiesBlack adultsQuit smokingNon-Black participantsSmoking behaviorFollow-up visitHealth problemsSecondary outcomesE-cigarette productsHepatitis C and Cigarette Smoking Behavior: Themes From Focus Groups
Cohen J, Ward K, Gittleman J, Perez E, Pia T, Shuter J, Weinberger A, Sulkowski M. Hepatitis C and Cigarette Smoking Behavior: Themes From Focus Groups. Nicotine & Tobacco Research 2024, 26: 1029-1037. PMID: 38422381, DOI: 10.1093/ntr/ntae032.Peer-Reviewed Original ResearchFocus group dataFocus groupsCigarette useSmoking behaviorSemi-structured interview guideCessation-related behaviorsHCV diagnosisChronic hepatitis C virusCigarette smokingHCV care continuumGroup dataHepatitis C virusCare continuumCigarette smoking behaviorCessation effortsInterview guideQuit smokingQuitting cigarettesCessation treatmentSmoking cigarettesC virusSmokingQualitative dataCigaretteThemes
2023
Effect of a Personalized Tobacco Treatment Intervention on Smoking Abstinence in Individuals Eligible for Lung Cancer Screening
Cartmel B, Fucito L, Bold K, Neveu S, Li F, Rojewski A, Gueorguieva R, O'Malley S, Herbst R, Toll B. Effect of a Personalized Tobacco Treatment Intervention on Smoking Abstinence in Individuals Eligible for Lung Cancer Screening. Journal Of Thoracic Oncology 2023, 19: 643-649. PMID: 37977486, PMCID: PMC10999350, DOI: 10.1016/j.jtho.2023.11.012.Peer-Reviewed Original ResearchStandard of careLung cancer screeningCancer screeningQuit ratesGain-framed messagingPack-year smoking historySmoking cessation ratesSmoking quit ratesNumber of cigarettesTobacco treatment interventionsYears of ageCessation/reductionChi-square testSelf-reported numberSmoking historyStandard careCessation ratesRandomized trialsTobacco treatmentTobacco cessationBiomarker feedbackLung cancerSmoking abstinencePost randomizationSmoking behaviorMULTI-ANCESTRY META-ANALYSIS OF TOBACCO USE DISORDERS PRIORITIZES NOVEL CANDIDATE RISK GENES AND REVEALS ASSOCIATIONS WITH NUMEROUS HEALTH OUTCOMES
Sanchez-Roige S, Toikumo S, Jennings M, Pham B, Lee H, Mallard T, Bianchi S, Meredith J, Smoller J, Davis L, Justice A, Kranzler H, Kember R, Sanchez-Roige S. MULTI-ANCESTRY META-ANALYSIS OF TOBACCO USE DISORDERS PRIORITIZES NOVEL CANDIDATE RISK GENES AND REVEALS ASSOCIATIONS WITH NUMEROUS HEALTH OUTCOMES. European Neuropsychopharmacology 2023, 75: s8-s9. DOI: 10.1016/j.euroneuro.2023.08.024.Peer-Reviewed Original ResearchTobacco use disorderUse disordersPrevalent substance use disordersSubstance use disordersRisk genesNumerous health outcomesHIV infectionHeart diseaseSmoking behaviorMedical outcomesGenome-wide association studiesNicotine consumptionHealth outcomesCandidate risk genesPotential risk genesGenetic factorsIndependent risk lociDisordersRisk variantsNovel candidate risk genesRisk lociOutcomesMajority of variantsFunctional genomics toolsPsychiatric traitsAssociations Between Childhood Trauma and Tobacco Use Outcomes in Adults after Overnight Abstinence
Palmisano A, Schwartz E, Gueorguieva R, Sofuoglu M. Associations Between Childhood Trauma and Tobacco Use Outcomes in Adults after Overnight Abstinence. Nicotine & Tobacco Research 2023, 26: 324-332. PMID: 37565294, PMCID: PMC10882440, DOI: 10.1093/ntr/ntad135.Peer-Reviewed Original ResearchSevere nicotine dependenceNicotine dependenceCotinine levelsChildhood traumaWithdrawal severityOvernight abstinenceSmoking outcomesAbuse groupHigher plasma cotinine levelsTrauma subscalesPlasma cotinine levelsNegative affectSmoking-related outcomesPublic health interventionsStudies of adultsTobacco use outcomesSevere childhood traumaChildhood trauma historyCessation interventionsMinimal groupsSmoking riskBiochemical assessmentSmoking behaviorSmoking urgesPlasma cortisolUnderstanding cigarette smoking among mothers with opioid use disorder
Wanar A, Morrison T, Standish K, Colson E, Drainoni M, Colvin B, Safon C, Crowell L, Friedman H, Schiff D, Parker M. Understanding cigarette smoking among mothers with opioid use disorder. Journal Of Substance Use And Addiction Treatment 2023, 150: 209065. PMID: 37156425, DOI: 10.1016/j.josat.2023.209065.Peer-Reviewed Original ResearchConceptsOpioid use disorderCigarette smokingSmoke exposurePostnatal periodUse disordersCigarette smoke exposureCigarette smoking behaviorMonths of ageNegative health consequencesInfants 2Withdrawal symptomsPostpartum mothersAmerican CollegeSmokingSmoking behaviorMedical providersInfantsNegative health impactsPrenatal periodHealth consequencesThematic saturationCigarettesVaried adviceMothersHealth impactsThe role of sex hormones in targeting stress-induced tobacco craving, stress-reactivity, and smoking with guanfacine among women who smoke
Peltier M, McKee S. The role of sex hormones in targeting stress-induced tobacco craving, stress-reactivity, and smoking with guanfacine among women who smoke. Addiction Neuroscience 2023, 7: 100084. PMID: 37396408, PMCID: PMC10311966, DOI: 10.1016/j.addicn.2023.100084.Peer-Reviewed Original ResearchSex hormonesTobacco cravingMedication effectsMedication trialsSmoking behaviorCortisol responsePlacebo-controlled studySmoking cessation trialAd libitum periodGuanfacine's effectsCessation trialSmoking periodDrug effectsSecondary analysisGuanfacineEstradiolHormoneProgesteroneWomenCravingTrialsSex differencesContext of stressPresent studyPost-stress inductionAssociations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls
Lin B, Vermeulen J, Bolhuis K, Chang X, Schirmbeck F, van Eijk K, investigators G, Alizadeh B, Bartels-Velthuis A, van Amelsvoort T, Bruggeman R, Cahn W, de Haan L, Rutten B, Guloksuz S, Luykx J, van Os J, Simons C, van Winkel R, Guloksuz S, Blankers M, van den Brink W, de Haan L, Luykx J. Associations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls. Psychiatry Research 2023, 323: 115143. PMID: 36948018, DOI: 10.1016/j.psychres.2023.115143.Peer-Reviewed Original ResearchConceptsHealthy controlsSmoking behaviorPsychotic symptomsSchizophrenia symptomsUnaffected siblingsProspective cohort studySix-year followMental health symptomsSymptom dimensionsCohort studyRisk factorsDepressive symptomsPsychotic disordersPatientsPositive symptomsHealth symptomsNegative symptomsSimilar effect sizesSymptomsLinear mixed-effects modelsMixed-effects modelsGenetic riskMean numberPolygenic scoresOverall sampleCigarettes: A toxic lifelong cycle
Gribben V, Chang A. Cigarettes: A toxic lifelong cycle. 2023, 388-399. DOI: 10.1016/b978-0-12-818872-9.00138-2.Peer-Reviewed Original ResearchAdult caregiversGlobal tobacco useStructural competency frameworkHealth effects of cigarettesThirdhand smoke exposurePublic policy levelsReduce cigarette useNegative health effectsHealth providersCigarette smoking behaviorEffects of cigarettesTobacco useTobacco smokeSmoking behaviorDisproportionate riskSmoke exposureCigarette useLife courseCigarette smokingCompetency frameworkSmokingPolicy levelCaregiversCigaretteSpecial risk
2022
Catechol-O-Methyltransferase Effects on Smoking: a Review and Proof of Concept of Sex-Sensitive Effects
DeVito E, Sofuoglu M. Catechol-O-Methyltransferase Effects on Smoking: a Review and Proof of Concept of Sex-Sensitive Effects. Current Behavioral Neuroscience Reports 2022, 9: 113-123. PMID: 36644316, PMCID: PMC9838826, DOI: 10.1007/s40473-022-00251-2.Peer-Reviewed Original ResearchSmoking behaviorPreliminary dataHuman laboratory studiesCigarette smoking behaviorShort-term abstinenceNicotine administrationSmoking cessationTreatment optionsWithdrawal symptomsCessation outcomesPharmacogenetic effectsOvernight abstinenceMet carriersSmoking urgesActivity genotypeReviewThis articleSymptomsCOMT geneSex differencesAbstinenceFunctional variantsSmokingCigarettesAdministrationIndividualsCigarette Smoking in Response to COVID-19: Examining Co-Morbid Medical Conditions and Risk Perceptions
Fucito LM, Bold KW, Cannon S, Serrantino A, Marrero R, O’Malley S. Cigarette Smoking in Response to COVID-19: Examining Co-Morbid Medical Conditions and Risk Perceptions. International Journal Of Environmental Research And Public Health 2022, 19: 8239. PMID: 35886090, PMCID: PMC9317071, DOI: 10.3390/ijerph19148239.Peer-Reviewed Original ResearchConceptsChronic medical conditionsMedical conditionsCigarette smokingCOVID-19 risk perceptionCOVID-19 riskGreater oddsSmoking changesHigher COVID-19 risk perceptionsCo-morbid medical conditionsCOVID-19Tobacco cessation treatmentCoronavirus disease 2019 (COVID-19) pandemicDisease 2019 pandemicPublic health threatCessation treatmentMedical historyWhite raceSmokingSmoking behaviorSample of adultsOngoing COVID-19Younger ageLogistical regressionHealth threatPreventive healthcare
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