2025
Reduced prefrontal response to fearful faces in recent mothers with bipolar disorder and its association with mother-infant interaction and infant development
Bjertrup A, Andreu H, Macoveanu J, Sankar A, Moszkowicz M, Nielsen R, Pagsberg A, Vieta E, Kessing L, Miskowiak K. Reduced prefrontal response to fearful faces in recent mothers with bipolar disorder and its association with mother-infant interaction and infant development. Psychiatry Research 2025, 351: 116610. PMID: 40582275, DOI: 10.1016/j.psychres.2025.116610.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingMother-infant interactionBipolar disorderMother infant interactionsFearful facesNeural responsesInfant interactionsNeural activityInfant developmentEmotion processing regionsHappy facial expressionsWhole-brain analysisSevere mood disordersLeft frontal poleFacial expression recognition taskFacial expression recognition accuracyExpression recognition taskHappy facesPrefrontal responsesBD mothersMood disordersChildren of individualsFrontal poleDyadic reciprocityProcessing regionsAn interpretable deep-learning approach to detect biomarkers in anxious-depressed symptoms from prefrontal fNIRS signals during an autobiographical memory test
Zhang Y, Xu Y, Cheng Y, Zhao Y, Potenza M, Shi H. An interpretable deep-learning approach to detect biomarkers in anxious-depressed symptoms from prefrontal fNIRS signals during an autobiographical memory test. Asian Journal Of Psychiatry 2025, 107: 104451. PMID: 40158273, DOI: 10.1016/j.ajp.2025.104451.Peer-Reviewed Original ResearchAutobiographical Memory TestNon-anxious depressionFunctional near-infrared spectroscopyAnxious depressionMemory testDepressive symptomsAnxious-depressive symptomsNegative emotional valenceSevere mood disordersFrontal pole areasAD symptomsMood disordersEmotional valenceRight hemisphereNeuroimaging dataDiagnosed depressionSymptom groupsCognitive impairmentSymptom predictionHealthy controlsNear-infrared spectroscopyDepressionSymptomsRecall featuresArea under the receiver operating characteristic curve
2018
A review of brain insulin signaling in mood disorders: From biomarker to clinical target
Nguyen T, Chan L, Borreginne K, Kale R, Hu C, Tye S. A review of brain insulin signaling in mood disorders: From biomarker to clinical target. Neuroscience & Biobehavioral Reviews 2018, 92: 7-15. PMID: 29758232, DOI: 10.1016/j.neubiorev.2018.05.014.Peer-Reviewed Original ResearchConceptsMood disordersCentral insulin signalingInsulin signalingSevere mood disordersBrain insulin signalingSynaptic plasticity processesPoor treatment outcomesInsulin signaling pathwayMood regulationMetabolic dysfunctionNeurotrophic processesMoodSevere disease courseBidirectional relationshipCellular metabolismInsulin receptor expressionMetabolic homeostasisSignaling pathwayMetabolic processesPrecision medicine approachMechanistic overlapTreatment outcomesMetabolic functionsDisordersBiomarker-based diagnostics
2016
Impact of psychotic symptoms on cognitive functioning in child and adolescent psychiatric inpatients with severe mood disorders
McCarthy JB, Weiss SR, Segovich KT, Barbot B. Impact of psychotic symptoms on cognitive functioning in child and adolescent psychiatric inpatients with severe mood disorders. Psychiatry Research 2016, 244: 223-228. PMID: 27497293, DOI: 10.1016/j.psychres.2016.07.049.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffective Disorders, PsychoticBipolar DisorderChildCognitionDepressive Disorder, MajorDiagnostic and Statistical Manual of Mental DisordersFemaleHospitals, PsychiatricHumansInpatientsIntelligence TestsMaleMemory, Short-TermMood DisordersNeuropsychological TestsPsychotic DisordersRetrospective StudiesSeverity of Illness IndexConceptsCognitive functioningSevere mood disordersMood disordersPsychotic symptomsAdolescent psychiatric inpatientsNon-affective psychotic disorderPsychotic featuresLower IQMemory deficitsAdolescent inpatientsDSM-IV criteriaCurrent psychotic featuresSpeed scoresFunctioningIQAdolescentsRetrospective chart reviewPsychotic disordersChildrenPsychiatric inpatientsState psychiatric hospitalTerms of treatmentDisordersChart reviewPsychiatric hospital
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