2025
Systematic review and meta-analysis of efficacy of helmet use and helmet laws to reduce mortality and cervical spine injury in adult motorcycle riders: A practice management guideline from the Eastern Association for the Surgery of Trauma.
Ratnasekera A, Seng S, Gardiner S, Butler C, Goldenberg-Sandau A, Lu N, Abdel Aziz H, Appelbaum R, Mashbari H, Hafiz S, Chowdhury S, Soe-Lin H, Reynolds J, Teichman A, Kartiko S, Kaufman E, Murphy P, Kodadek L, Rattan R. Systematic review and meta-analysis of efficacy of helmet use and helmet laws to reduce mortality and cervical spine injury in adult motorcycle riders: A practice management guideline from the Eastern Association for the Surgery of Trauma. Journal Of Trauma And Acute Care Surgery 2025 PMID: 40462278, DOI: 10.1097/ta.0000000000004607.Peer-Reviewed Original ResearchCervical spine injuryIncidence of cervical spine injuriesSpine injuriesInjury-related mortalityDischarge dispositionSystematic reviewHelmet useMeta-analysisSignificant methodological heterogeneityPICO 1PICO-2Eastern Association for the Surgery of TraumaEvidence-based guidelinesRisk of biasCertainty of evidenceSignificant public health concernImproved discharge dispositionEvidence-based recommendationsRiders wear helmetsHelmet lawsImprove mortalityEvidence-based systematic reviewMotorcycle ridersPublic health concernPractice management guidelinesLuspatercept in patients with lower-risk myelodysplastic syndromes (MDS): A systematic review and meta-analysis.
Alhajahjeh A, Woite N, Grimshaw A, Rolles B, Stahl M, Kewan T, Podoltsev N, Stempel J, Mendez L, Zeidan A, Bewersdorf J. Luspatercept in patients with lower-risk myelodysplastic syndromes (MDS): A systematic review and meta-analysis. Journal Of Clinical Oncology 2025, 43 DOI: 10.1200/jco.2025.43.16_suppl.e18574.Peer-Reviewed Original ResearchMyelodysplastic syndromeTransfusion dependenceRinged sideroblastsFrontline settingAcute myeloid leukemia transformationLower-risk myelodysplastic syndromesHigh transfusion burdenBone marrow disordersMeta-analysisErythropoiesis-stimulating agentsSerious adverse eventsStudy's primary endpointResistant to treatmentReduce transfusion needsSystematic reviewIndependent reviewers assessed studiesRandom-effects modelBlack quality assessment checklistTransfusion burdenTransfusion independenceQuality assessment checklistLeukemia transformationRisk of biasLR-MDSPrimary endpointLaboratory-Assessed Mistrust in Borderline Personality Disorder: A Meta-Analytic Review
Kurt Y, Walker M, Luyten P, Fonagy P. Laboratory-Assessed Mistrust in Borderline Personality Disorder: A Meta-Analytic Review. Personality Disorders Theory Research And Treatment 2025 PMID: 40402642, DOI: 10.1037/per0000739.Peer-Reviewed Original ResearchBorderline personality disorderMeta-analytic reviewPersonality disorderSmall-to-moderate effect sizesEffect sizeStatistically significant moderatorPsychometrically sound toolBPD symptomsSignificant moderatorMeta-analytic modelMeta-analysisBPDSound toolJoanna Briggs Institute Critical Appraisal ChecklistInternational Prospective Register of Systematic ReviewsSystematic reviewProspective Register of Systematic ReviewsInterpersonal trustCritical Appraisal ChecklistEffective interventionsInternational Prospective RegisterRisk of biasControl groupDisordersBorderlineDelandistrogene Moxeparvovec Gene Therapy in Individuals With Duchenne Muscular Dystrophy: Evidence in Focus
Oskoui M, Caller T, Parsons J, Servais L, Butterfield R, Bharadwaj J, Rose S, Tolchin B, Puskala Hamel K, Silsbee H, Dowling J. Delandistrogene Moxeparvovec Gene Therapy in Individuals With Duchenne Muscular Dystrophy: Evidence in Focus. Neurology 2025, 104: e213604. PMID: 40367405, DOI: 10.1212/wnl.0000000000213604.Peer-Reviewed Original ResearchConceptsDuchenne muscular dystrophyFood and Drug AdministrationClinical trialsImmune-related side effectsMuscular dystrophyFood and Drug Administration approvalFunctional motor outcomePhase 3 clinical trialsTreatment groupsNorth Star Ambulatory Assessment scoresUS Food and Drug AdministrationMotor outcomeClinical trial dataRisk of biasClass I studiesGene therapyTreated patientsAmerican Academy of NeurologyLiver toxicityPrimary outcomeLiver injurySide effectsDrug AdministrationSafety outcomesDose exposureThe Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis
Ein Alshaeba S, Marhoffer E, Holleck J, Theisen-Toupal J, Grimshaw A, Gunderson C. The Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis. Journal Of General Internal Medicine 2025, 1-6. PMID: 40360868, DOI: 10.1007/s11606-025-09569-5.Peer-Reviewed Original ResearchStrength of evidenceLength of stayScreening groupRandomized controlled studyCochrane risk of bias toolRisk of bias toolRandom-effects meta-analysisLow due to riskMeta-analysisEffectiveness of screeningEffectiveness of early warning systemsRisk of biasEffects meta-analysisMethodsA systematic literature searchPooled odds ratioControlled studiesScreened adult patientsSystematic literature searchSurviving Sepsis CampaignRecommendations AssessmentCochrane riskBias toolWeb of Science Core CollectionOdds ratioOvid MEDLINEChildhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry
Jesuthasan J, Watson C, Hafeez D, Lynch-Kelly K, Danese A, Pollak T. Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry. Brain Behavior And Immunity 2025, 128: 643-653. PMID: 40320015, DOI: 10.1016/j.bbi.2025.04.036.Peer-Reviewed Original ResearchRisk of biasChildhood adversityDisease in adulthoodMeta-analysisSystematic reviewSevere mental illnessHigh risk of biasRisk factorsExposure to childhood adversityAssociated with childhood adversityAutoimmune diseasesFunnel plot inspectionRates of childhood adversityHistory of childhood adversityPeer-reviewed studiesEnvironmental risk factorsMental illnessAutoimmune disordersEgger's testElectronic databasesAetiology of autoimmune disordersPublication biasPrevention of autoimmune diseasesEffect sizeDysregulated immune responseSafety of Stimulants Across Patient Populations
Oliva H, Prudente T, Mayerson T, Mignosa M, Oliva I, Potenza M, Jegede O, Angarita G. Safety of Stimulants Across Patient Populations. JAMA Network Open 2025, 8: e259492. PMID: 40343695, PMCID: PMC12065045, DOI: 10.1001/jamanetworkopen.2025.9492.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderRandomized clinical trialsAdverse eventsStimulant medicationData extractionSafety of stimulationRisk ratioIncreased riskMethodological quality assessmentPreferred Reporting ItemsPatient populationClinical conditionsDiverse patient populationsRisk of biasSafety of stimulant medicationsUnclear risk of biasTreatment of attention-deficit/hyperactivity disorderOverall AEsRandom-effects modelWeb of ScienceBinge eating disorderStimulant use disorderComprehensive literature searchMain OutcomesReporting ItemsExercise Interventions Conducted Among Individuals with Co-occurring HIV and Unhealthy Substance Use: A Systematic Review
Mistler C, Allen W, Grimshaw A, Idiong C, Harsono D, Irwin M, Ash G, S. Pescatello L, Meyer J, Jennifer Edelman E. Exercise Interventions Conducted Among Individuals with Co-occurring HIV and Unhealthy Substance Use: A Systematic Review. AIDS And Behavior 2025, 1-14. PMID: 40289036, DOI: 10.1007/s10461-025-04735-6.Peer-Reviewed Original ResearchUnhealthy substance useExercise interventionRandomized controlled trialsSubstance useCochrane data collection formsEvidence-based exercise interventionsCo-occurring risk factorsSystematic reviewPositive associations with outcomesHome-based trainingCo-occurring HIVRisk factorsLow risk of biasFull-text reviewData collection formRisk of biasQuasi-experimental designAerobic/resistance trainingTai ChiPhysical inactivityPhysical activityCognitive behavioral therapyImprove HIVHealth outcomesBehavioral counselingEfficacy of enhanced recovery programmes for cardiac surgery: a systematic review and meta-analysis
Hoogma D, Meeusen I, Coppens S, Verbrugghe P, van den Eynde J, Engelman D, Grant M, Stoppe C, Rex S. Efficacy of enhanced recovery programmes for cardiac surgery: a systematic review and meta-analysis. British Journal Of Anaesthesia 2025, 135: 31-39. PMID: 40287362, DOI: 10.1016/j.bja.2025.03.019.Peer-Reviewed Original ResearchConceptsHospital length of stayLength of stayCardiac surgeryFast-track cardiac anesthesiaFast-track (FTICU length of stayMeta-analysisAssessed risk of biasRandom-effects modelAdditive valueRisk of biasPerioperative strategiesEfficacy outcomesVentilation timeFT programmesVentilatory timeHospital lengthPostoperative interventionsCardiac anesthesiaComparative efficacySurgeryWeb of ScienceRandomised trialsPRISMA guidelinesEnhanced recoveryRisk of Early Childhood Dental Caries Associated With Prolonged Breastfeeding: A Systematic Review and Meta‐Analysis
Lustosa K, Rodrigues L, Rocha R, Prudente T, Mezaiko E, Silva F, Silva B. Risk of Early Childhood Dental Caries Associated With Prolonged Breastfeeding: A Systematic Review and Meta‐Analysis. International Journal Of Paediatric Dentistry 2025 PMID: 40254914, DOI: 10.1111/ipd.13313.Peer-Reviewed Original ResearchEarly childhood cariesRisk of early childhood cariesProlonged breastfeedingProspective Register of Systematic ReviewsIncreased riskRisk of dental cariesEarly childhood caries prevalenceEarly childhood caries riskSystematic reviewInternational Prospective Register of Systematic ReviewsMeta-analysesRandom-effects modelChildhood cariesRisk of biasDental cariesInternational Prospective RegisterLanguage restrictionsProlonged durationObservational studyBreastfeedingEligibility criteriaMeta-analysisJBI Critical Appraisal ChecklistCritical Appraisal ChecklistMonthsCommunity-led strategies for communicable disease prevention and management in low- and middle- income countries: A mixed-methods systematic review of health, social, and economic impact
Indravudh P, McGee K, Sibanda E, Corbett E, Fielding K, Terris-Prestholt F. Community-led strategies for communicable disease prevention and management in low- and middle- income countries: A mixed-methods systematic review of health, social, and economic impact. PLOS Global Public Health 2025, 5: e0004304. PMID: 40173193, PMCID: PMC11964228, DOI: 10.1371/journal.pgph.0004304.Peer-Reviewed Original ResearchCommunity-led strategiesImprove health behaviorsCluster randomised trialCommunicable disease preventionCommunicable disease controlRisk of biasHealth behaviorsSystematic review of healthMixed-methods systematic reviewMixed-method systematic literature reviewIncome countriesDisease preventionCochrane risk-of-bias toolHealth system engagementPrimary health careHealth care accessRisk-of-bias toolReview of healthModerate risk of biasExtent of community participationCommunity participationGlobal health priorityMechanisms of impactCare accessNarrative synthesisMethodology for the international working group clinical practice guidelines on X-linked hypophosphatemia in children and adults
Ali D, Khan A, Mirza R, Appelman-Dijkstra N, Brandi M, Carpenter T, Chaussain C, Imel E, de Beur S, Florenzano P, Morrison A, Alrob H, Alexander R, Alsarraf F, Beck-Nielsen S, Biosse-Duplan M, Cohen-Solal M, Crowley R, Dandurand K, Filler G, Fukumoto S, Gagnon C, Goodyer P, Grasemann C, Grimbly C, Hussein S, Javaid M, Khan S, Khan A, Lehman A, Lems W, Lewiecki E, McDonnell C, Morgante E, Portale A, Rhee Y, Siggelkow H, Tosi L, Ward L, Guyatt G. Methodology for the international working group clinical practice guidelines on X-linked hypophosphatemia in children and adults. Journal Of Bone And Mineral Metabolism 2025, 43: 193-202. PMID: 40119067, DOI: 10.1007/s00774-025-01585-z.Peer-Reviewed Original ResearchConceptsCertainty of evidenceGRADE recommendationsImpact of medical interventionsManagement of "X-linked hypophosphatemiaX-linked hypophosphatemiaClinical practice guidelinesPatient-important outcomesRisk of biasNarrative literature reviewClinical practice surveyPatient partnersGuideline methodologistsGuideline panelFindings tablePractice guidelinesSystematic reviewPractice surveyMedical interventionsPregnant womenRecommendation strengthTreatment recommendationsInternational expertsPatient populationComprehensive guidelinesBody of evidenceAcute Pain Management in People With Opioid Use Disorder : A Systematic Review.
Buonora M, Mackey K, Khalid L, Hickey T, Grimshaw A, Moss M, Starrels J, Alford D, Becker W, Weimer M. Acute Pain Management in People With Opioid Use Disorder : A Systematic Review. Annals Of Internal Medicine 2025, 178: 558-570. PMID: 40096692, DOI: 10.7326/annals-24-01917.Peer-Reviewed Original ResearchConceptsOpioid use disorderOUD outcomesAcute pain interventionsAcute pain managementPain interventionsPain outcomesEmergency departmentPain managementObservational studyUse disorderImprove pain-related outcomesPerioperative settingEffectiveness of pain interventionsPain-related outcomesWell-conducted randomized controlled trialsImprove pain outcomesAcute painful episodesStrength of evidence assessmentIntravenous (IVControlled observational studiesNon-U.S. populationsEffectiveness of interventionsRandomized controlled trialsOral clonidineRisk of biasPerirectal spacers in radiotherapy for prostate cancer – a systematic review and meta-analysis
Miszczyk M, Stando R, Francolini G, Zamboglou C, Cadenar A, Suleja A, Fazekas T, Matsukawa A, Tsuboi I, Przydacz M, Leapman M, Rajwa P, Supiot S, Shariat S. Perirectal spacers in radiotherapy for prostate cancer – a systematic review and meta-analysis. Współczesna Onkologia 2025, 29: 36-44. PMID: 40330445, PMCID: PMC12051878, DOI: 10.5114/wo.2025.148388.Peer-Reviewed Original ResearchProstate cancerAdverse eventsRisk of biasNon-randomised trialsClinically localised PCaOdds ratioAcute rectal toxicityLocalised PCaAssociated with decreased incidenceMeta-analysisSevere adverse eventsModerate risk of biasRandomised clinical trialsSystematic reviewROBINS-I toolModern RTRectal toxicityTreatment toxicityConcealment of allocationClinical outcomesPerirectal spaceClinical trialsRadiotherapyROBINS-IModerate riskImproving peer review of systematic reviews and related review types by involving librarians and information specialists as methodological peer reviewers: a randomised controlled trial
Rethlefsen M, Schroter S, Bouter L, Kirkham J, Moher D, Ayala A, Blanco D, Brigham T, Nardini H, Kirtley S, Nyhan K, Townsend W, Zeegers M. Improving peer review of systematic reviews and related review types by involving librarians and information specialists as methodological peer reviewers: a randomised controlled trial. BMJ Evidence-Based Medicine 2025, bmjebm-2024-113527. PMID: 40074237, DOI: 10.1136/bmjebm-2024-113527.Peer-Reviewed Original ResearchRisk of biasQuality of reportingIntervention groupSystematic reviewPeer reviewMonths post-studyRandomised controlled trialsSystematic review searchControl groupReview typesPRISMA itemsInformation specialistsPost-peer reviewImprove peer reviewGroup allocationReview searchPost-studyInclusion criteriaStudy enrollmentSecondary outcomesJournal peer review processControlled trialsPrimary outcomePeer review processAdequate reportingThe experience and role of dissociation in psychosis following developmental trauma: A systematic review
Melegkovits E, Tang R, Pounds O, Ashcroft K, Jung P, Kennerley H, Fonagy P, Bloomfield M. The experience and role of dissociation in psychosis following developmental trauma: A systematic review. Clinical Psychology Review 2025, 117: 102564. PMID: 40058297, DOI: 10.1016/j.cpr.2025.102564.Peer-Reviewed Original ResearchDevelopmental traumaPositive psychotic symptomsAssociated with dissociationElevated dissociationDelusional ideationDissociative symptomsPsychotic featuresPsychotic symptomsPsychotic manifestationsPsychosisEmotional abuseModerate associationPre-registeredDose-response effectClinical considerationsAbuseGeneral populationElevated riskSymptomsSystematic reviewIdeationParanoiaHallucinationsRisk of biasIndividualsCauses of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential
Bulletti F, Sciorio R, Conforti A, De Luca R, Bulletti C, Palagiano A, Berrettini M, Scaravelli G, Pierson R. Causes of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential. Frontiers In Endocrinology 2025, 15: 1429193. PMID: 40028443, PMCID: PMC11867936, DOI: 10.3389/fendo.2024.1429193.Peer-Reviewed Original ResearchConceptsAssisted reproductive technologyPGT-AImplantation rateImplant successEmbryo transferEndometrial receptivityMeta-analysisMeta-analysis of subgroupsTime of endometrial receptivityGestational carrierMonths of unprotected sexual intercourseReduced embryo implantationPreimplantation genetic testingOlder womenImprove implantation ratesEmbryo implantation potentialUnprotected sexual intercourseOdds of implantationSystematic reviewComprehensive literature searchEmbryo euploidyEuploid embryosDiagnostic hysteroscopyRisk of biasIVF-ETOpioid Misuse and Suicide-Related Outcomes Among Adolescents and Young Adults: A Systematic Review
Cance J, Hairgrove S, Saavedra L, Bonar E, Walton M, Patel S, Yule A, King C, Chavez L, Slesnick N, Fernandes C. Opioid Misuse and Suicide-Related Outcomes Among Adolescents and Young Adults: A Systematic Review. Journal Of Adolescent Health 2025, 76: 781-797. PMID: 39945684, PMCID: PMC12034481, DOI: 10.1016/j.jadohealth.2024.10.026.Peer-Reviewed Original ResearchSuicide-related outcomesOpioid misuseSystematic reviewYoung adultsHigh risk of biasRisk of biasBoolean search strategyAdministrative dataConfounding biasInclusion criteriaReporting biasEligible publicationsObservational studyLongitudinal researchHigh riskAdultsOpioidAssociationSearch strategyOutcomesMisuseData studiesPotential mechanismsYouthConfoundingImpact of disease severity, age, sex, comorbidity, and vaccination on secondary attack rates of SARS-CoV-2: a global systematic review and meta-analysis
Sumsuzzman D, Ye Y, Wang Z, Pandey A, Langley J, Galvani A, Moghadas S. Impact of disease severity, age, sex, comorbidity, and vaccination on secondary attack rates of SARS-CoV-2: a global systematic review and meta-analysis. BMC Infectious Diseases 2025, 25: 215. PMID: 39948450, PMCID: PMC11827239, DOI: 10.1186/s12879-025-10610-5.Peer-Reviewed Original ResearchConceptsPopulation settingEffective public health strategiesConfidence intervalsImpact of disease severityModified Newcastle-Ottawa ScalePublic health strategiesHigher secondary attack rateRisk of biasNewcastle-Ottawa ScalePandemic responseGlobal systematic reviewRandom-effects modelFreeman-Tukey double arcsine transformationWeb of ScienceNo significant associationDrivers of SARS-CoV-2 transmissionHealth strategiesSecondary attack rateSARS-CoV-2Disease severityEffective pandemic responseTargeted interventionsDouble arcsine transformationOvid MEDLINESystematic reviewChikungunya Fever and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
Amaral J, Schoen R, Weinblatt M, Cândido E. Chikungunya Fever and Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Tropical Medicine And Infectious Disease 2025, 10: 54. PMID: 39998058, PMCID: PMC11861052, DOI: 10.3390/tropicalmed10020054.Peer-Reviewed Original ResearchChikungunya virus infectionRheumatoid arthritisChikungunya virusChikungunya feverChronic chikungunya arthritisRheumatology follow-upIncidence of RARisk of biasChikungunya arthritisAutoimmune mechanismsImmunological mechanismsFollow-upRA incidenceRA diagnosisDiagnostic criteriaRA developmentInfectionPRISMA guidelinesRe-emerging infectious diseasesLiterature searchDiagnostic biomarkersLong-term health impactsData extractionInfectious diseasesIncidence
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