2025
Psychometric properties of the Reward Deficiency Syndrome Questionnaire among a non-clinical sample and its relationship with the characteristics of potentially addictive behaviors
Kotyuk E, Demetrovics Z, Urbán R, Czakó A, Blum K, Griffiths M, Potenza M, Efrati Y. Psychometric properties of the Reward Deficiency Syndrome Questionnaire among a non-clinical sample and its relationship with the characteristics of potentially addictive behaviors. Addictive Behaviors Reports 2025, 21: 100598. PMID: 40248688, PMCID: PMC12005299, DOI: 10.1016/j.abrep.2025.100598.Peer-Reviewed Original ResearchReward Deficiency SyndromeCompulsive buying-shopping disorderInternet gaming disorderAddictive behaviorsBehavioral addictionsGambling disorderDevelopment of addictive behaviorsBuying-shopping disorderNon-clinical samplePotential behavioral addictionsProblematic substance useAssociated with anxietyIsraeli young adultsPsychometrically sound instrumentNatural rewardsCompulsive personalityFactor structureGaming disorderProblematic behaviorsSubstance useSocial media usePersonal characteristicsPsychological featuresSound instrumentHebrew versionIn Silico Pharmacogenomic Assessment of Glucagon-like Peptide-1 (GLP1) Agonists and the Genetic Addiction Risk Score (GARS) Related Pathways: Implications for Suicidal Ideation and Substance Use Disorder
Sharafshah A, Lewandrowski K, Gold M, Fuehrlein B, Ashford J, Thanos P, Wang G, Hanna C, Cadet J, Gardner E, Khalsa J, Braverman E, Baron D, Elman I, Dennen C, Bowirrat A, Pinhasov A, Modestino E, Carney P, Cortese R, Fiorelli R, Schmidt S, Pollack A, Badgaiyan R, Blum K. In Silico Pharmacogenomic Assessment of Glucagon-like Peptide-1 (GLP1) Agonists and the Genetic Addiction Risk Score (GARS) Related Pathways: Implications for Suicidal Ideation and Substance Use Disorder. Current Neuropharmacology 2025, 23: 974-995. PMID: 39865816, PMCID: PMC12174944, DOI: 10.2174/011570159x349579241231080602.Peer-Reviewed Original ResearchGenetic Addiction Risk ScoreSubstance use disordersReward Deficiency SyndromeAlcohol use disorderSuicidal ideationDepressive phenotypeGlucagon-like peptide-1Use disorderAnti-addictive compoundsGLP1R agonistsAntiaddictive effectsDopamine signalingDopaminergic signalingGlucagon-like peptide-1 agonistsRisk scoreDopamine regulationDopamine homeostasisGlucagon-like peptide-1 receptorEmpirical clinical studiesPeptide-1 receptorIdeationDeficiency syndromeDisordersLong-term inductionTherapeutic advantage
2024
Genes and Genetic Testing in Addiction Medicine
Blum K, Madigan M, Fuehrlein B, Thanos P, Lewandrowski K, Sharafshah A, Elman I, Baron D, Bowirrat A, Pinhasov A, Braverman E, Zeine F, Jafari N, Gold M. Genes and Genetic Testing in Addiction Medicine. 2024, 303-318. DOI: 10.1016/b978-0-323-95702-1.00227-x.Peer-Reviewed Original ResearchReward Deficiency SyndromeDopamine releaseDopamine D2 receptor geneBrain reward mechanismsBrain reward circuitryD2 receptor geneBrain Reward CascadeEffects of naloxoneOpioid receptor antagonistReward circuitryMesolimbic systemImpulsive behaviorAlcohol dependenceNeurotransmitter systemsDopaminergic dysfunctionNeurotransmitter interactionsSevere alcoholismDeficiency syndromeReward mechanismsNon-drugGenetic testingChronic deficitsAddiction medicineRewardBlum's group
2022
The Reward Deficiency Syndrome and Links with Addictive and Related Behaviors
Kótyuk E, Potenza M, Blum K, Demetrovics Z. The Reward Deficiency Syndrome and Links with Addictive and Related Behaviors. 2022, 59-74. DOI: 10.1007/978-3-030-92392-1_3.Peer-Reviewed Original Research
2021
The Reward Deficiency Syndrome and Links with Addictive and Related Behaviors
Kótyuk E, Potenza M, Blum K, Demetrovics Z. The Reward Deficiency Syndrome and Links with Addictive and Related Behaviors. 2021, 1-16. DOI: 10.1007/978-3-030-67928-6_3-1.Chapters
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