2025
Autonomic modulation of the immune response and implications for CNS malignancies
Wachsmuth L, Srinivasan E, Puviindran B, Haskell-Mendoza A, DeSpenza T, Fecci P. Autonomic modulation of the immune response and implications for CNS malignancies. Npj Precision Oncology 2025, 9: 168. PMID: 40483275, PMCID: PMC12145445, DOI: 10.1038/s41698-025-00957-y.Peer-Reviewed Original ResearchCentral nervous systemAntitumor immune responseImmune responseAutonomic nervous systemNervous systemCentral nervous system malignanciesCentral nervous system inflammationModulation of immune responsesCentral nervous system inputImmune cell functionRegulate immune responsesIntracranial malignanciesImmune cellsMalignancyAutonomic modulationNeuro-immunologyCell functionImmune organsSignaling pathwayGlobal physiological processesTripartite interactionResponseInflammationCancerPhysiological processesPrefrontal 5α-reductase 2 mediates male-specific acute stress response
Cadeddu R, Braccagni G, Floris G, Branca C, Corridori E, Salviati S, Sánchez P, Santovito L, Torres J, Ortega E, Pinna G, Moos P, Scheggi S, Bortolato M. Prefrontal 5α-reductase 2 mediates male-specific acute stress response. Science Advances 2025, 11: eadr0563. PMID: 39841836, PMCID: PMC11753402, DOI: 10.1126/sciadv.adr0563.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexStress reactivityAcute stressAcute stress reactivitySexually dimorphic effectsAcute stress responsePrefrontal cortexStress responseNeurosteroid allopregnanoloneReduced stress responseDimorphic effectsBrain synthesisKnockdown ratsKnockout ratsAllopregnanoloneAP synthesisRatsSingle-nucleus transcriptomesCortexNeurosteroidsDown-regulationIncreased levelsMaleStressResponse
2024
Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response
Bhagchandani S, Yang L, Lam J, Maiorino L, Ben-Akiva E, Rodrigues K, Romanov A, Suh H, Aung A, Wu S, Wadhera A, Chakraborty A, Irvine D. Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response. Science Immunology 2024, 9: eadl3755-eadl3755. PMID: 39303017, PMCID: PMC11492009, DOI: 10.1126/sciimmunol.adl3755.Peer-Reviewed Original ResearchConceptsDendritic cellsGerminal centersHumoral immunityAntigen-specific germinal centerGerminal center responseSubunit vaccineFollicular dendritic cellsPrimary immune responseIncreased T<sub>rDose 7 daysPrime immunizationGC responseImmune responseVaccine deliveryCenter responseAdministered vaccinesImmunityVaccineRegimensAdjuvant vaccineDoseCellsHIVResponseBolusInterferon-stimulated neutrophils as a predictor of immunotherapy response
Benguigui M, Cooper T, Kalkar P, Schif-Zuck S, Halaban R, Bacchiocchi A, Kamer I, Deo A, Manobla B, Menachem R, Haj-Shomaly J, Vorontsova A, Raviv Z, Buxbaum C, Christopoulos P, Bar J, Lotem M, Sznol M, Ariel A, Shen-Orr S, Shaked Y. Interferon-stimulated neutrophils as a predictor of immunotherapy response. Cancer Cell 2024, 42: 253-265.e12. PMID: 38181798, PMCID: PMC10864002, DOI: 10.1016/j.ccell.2023.12.005.Peer-Reviewed Original ResearchImmunotherapy responseNon-small cell lung cancerAnti-PD1 responseAnti-PD1 therapyCohort of patientsNon-responsive tumorsCell lung cancerAnti-cancer immunotherapyPre-clinical findingsBlood-borne biomarkersCytotoxic TLung cancerPredictive biomarkersCurrent biomarkersTreatment responseNeutrophilsLY6EBiomarkersActive biomarkersPatientsMiceFurther mechanistic understandingActivationResponseImmunotherapyAmygdala response to emotional faces following acute administration of psilocybin in healthy individuals
Armand S, Larsen K, Madsen M, Ozenne B, Preller K, Knudsen G, Stenbæk D, Fisher P. Amygdala response to emotional faces following acute administration of psilocybin in healthy individuals. Neuroscience Applied 2024, 3: 103934. DOI: 10.1016/j.nsa.2023.103934.Peer-Reviewed Original ResearchPlasma psilocin levelsFunctional magnetic resonance imagingAmygdala reactivityHealthy individualsAmygdala responseMagnetic resonance imagingAcute administrationDrug intensityAcute exposureTherapeutic outcomesResonance imagingSignificant associationBrain regionsPsychedelic psilocybinPsilocybinBaselineFuture studiesSignificant changesExposureFearful facesEmotion processingResponseIndividualsAdministration
2023
Delayed effective connectivity characterizes the epileptogenic zone during stereo-EEG
Feys O, Wens V, Rovai A, Schuind S, Rikir E, Legros B, De Tiège X, Gaspard N. Delayed effective connectivity characterizes the epileptogenic zone during stereo-EEG. Clinical Neurophysiology 2023, 158: 59-68. PMID: 38183887, DOI: 10.1016/j.clinph.2023.12.013.Peer-Reviewed Original ResearchSingle-pulse electrical stimulationEpileptogenic zoneRefractory focal epilepsyEffective connectivityEffective connectivity changesResection limitsEpileptogenic networksFocal epilepsyAbnormal responseCortico-subcorticoCortical levelElectrical stimulationStereo-EEGPatientsDepth electrodesConnectivity changesStereoelectroencephalographyAnalysis of varianceCharacteristic curveOccurrence of spikesCCEPsStimulationHigh-frequency oscillationsAssociationResponseWhy young adults use tobacco-free nicotine E-cigarettes: An analysis of qualitative data
Davis D, Rajesh Kumar L, Morean M, Kong G, Bold K, Krishnan-Sarin S, Camenga D. Why young adults use tobacco-free nicotine E-cigarettes: An analysis of qualitative data. Addictive Behaviors 2023, 150: 107925. PMID: 38056193, PMCID: PMC10842804, DOI: 10.1016/j.addbeh.2023.107925.Peer-Reviewed Original ResearchConceptsTobacco-derived nicotineE-cigarettesE-cigarette useYoung adultsNicotine e-cigarettesHuman experimental studiesU.S. young adultsAversive effectsPrevention communicationHealth benefitsHealth reasonsAdultsIndependent ratersNicotineResults ReasonsQualitative studyQualitative dataOnline Qualtrics surveyQualtrics surveyDifferencesPrimary reasonNecessary next stepResponseBrn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat
Lee H, Weinberg-Wolf H, Lee H, Lee T, Conte J, Godoy-Parejo C, Demb J, Rudenko A, Kim IJ. Brn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat. PLOS Biology 2023, 21: e3002386. PMID: 37983249, PMCID: PMC10695396, DOI: 10.1371/journal.pbio.3002386.Peer-Reviewed Original ResearchConceptsTranscription factor Brn3bLoss of neuronsVisual threatLateral posterior nucleusMutant mice displayDefensive responsesDefensive freezing responsesPosterior nucleusTachykinin 2Mice displayMidbrain circuitVisual circuitsNeural circuitryBrn3bSpecific genetic componentsFreezing responseFear-associated behaviorsSocial isolationTac2Behavioral phenotypesMolecular mechanismsFunctional organizationGenetic componentResponseSimilar mechanismReframing macrophage diversity with network motifs
Pizzurro G, Miller-Jensen K. Reframing macrophage diversity with network motifs. Trends In Immunology 2023, 44: 965-970. PMID: 37949786, PMCID: PMC11057955, DOI: 10.1016/j.it.2023.10.009.Commentaries, Editorials and LettersConceptsNetwork motifsDistinct biological functionsSystems biology conceptsMacrophage stateMacrophage responseBiological functionsMacrophage diversityExtracellular networkMacrophage activationDisease contextsMotifLocal molecular interactionsMolecular interactionsFunctional modulesBiology conceptsDiversityActivationTissueIntracellularResponseDiverging humoral and cellular immune responses due to Omicron—a national study from the Faroe Islands
Petersen M, Pérez-Alós L, Kongsstovu S, Eliasen E, Hansen C, Larsen S, Hansen J, Bayarri-Olmos R, Fjallsbak J, Weihe P, Garred P. Diverging humoral and cellular immune responses due to Omicron—a national study from the Faroe Islands. Microbiology Spectrum 2023, 11: e00865-23. PMID: 37909772, PMCID: PMC10714973, DOI: 10.1128/spectrum.00865-23.Peer-Reviewed Original ResearchConceptsT cell responsesOmicron infectionHumoral responseUnvaccinated individualsImmune responseRobust T cell responsesSARS-CoV-2 Omicron variantPositive T-cell responsesDetectable humoral responseLow humoral responseLower humoral immune responseT cell immunityCellular immune responsesHumoral immune responsePrior vaccinationThird doseHumoral immunityImmune evasionOmicron variantInfectionInfection statusImmunityVaccinationNational studyResponseLeishmania major-derived lipophosphoglycan influences the host’s early immune response by inducing platelet activation and DKK1 production via TLR1/2
Ihedioha O, Sivakoses A, Beverley S, McMahon-Pratt D, Bothwell A. Leishmania major-derived lipophosphoglycan influences the host’s early immune response by inducing platelet activation and DKK1 production via TLR1/2. Frontiers In Immunology 2023, 14: 1257046. PMID: 37885890, PMCID: PMC10598878, DOI: 10.3389/fimmu.2023.1257046.Peer-Reviewed Original ResearchConceptsLeukocyte-platelet aggregatesEarly immune responseImmune responsePlatelet activationHost's early immune responseCell-mediated immune responsesTh2 cell polarizationAdaptive immune responsesPro-inflammatory responsePattern recognition receptorsKey virulence factorsRecognition receptorsInfectious diseasesPathogenic moleculesEndothelial cellsWnt antagonistsInfection siteVirulence factorsTLR1/2PlateletsDickkopf1Cell typesLipophosphoglycanActivationResponseLong-timescale anti-directional rotation in Drosophila optomotor behavior
Mano O, Choi M, Tanaka R, Creamer M, Matos N, Shomar J, Badwan B, Clandinin T, Clark D. Long-timescale anti-directional rotation in Drosophila optomotor behavior. ELife 2023, 12: e86076. PMID: 37751469, PMCID: PMC10522332, DOI: 10.7554/elife.86076.Peer-Reviewed Original ResearchConceptsRetinal slipLobula plateLobula plate tangential cellsVisual stimuliDirection-selective cellsExtensive dissectionTangential cellsCertain stimulus conditionsLocomotor movementsCH cellsStabilization responseMotion visionStimulus conditionsOptomotor responseOptomotor behaviorCellsAnimalsResponseOptomotorStimuliReflexDissectionSelf-reported Impacts of the COVID-19 Pandemic and Economic Inflation on the Well-being of Low-income U.S. Veterans
Tsai J, Hird R, Collier A. Self-reported Impacts of the COVID-19 Pandemic and Economic Inflation on the Well-being of Low-income U.S. Veterans. Journal Of Community Health 2023, 48: 970-974. PMID: 37605100, DOI: 10.1007/s10900-023-01267-9.Peer-Reviewed Original ResearchConceptsSelf-reported impactU.S. veteransLong-term health effectsLow-income veteransMajor public healthCOVID-19 pandemicNegative psychosocial impactSmall proportionLow-income populationsPsychosocial impactCoronavirus diseaseMental healthRapid assessment procedureHealth effectsSocial isolationPublic healthVeteransHealthNational samplePandemicParticipantsFurther researchResponsePopulationProportionAssessment of proxy‐reported responses as predictors of motor and sensory peripheral neuropathy in children with B‐lymphoblastic leukemia
Rodwin R, DelRocco N, Hibbitts E, Devidas M, Whitley M, Mohrmann C, Schore R, Raetz E, Winick N, Hunger S, Loh M, Hockenberry M, Ma X, Angiolillo A, Ness K, Kairalla J, Kadan‐Lottick N. Assessment of proxy‐reported responses as predictors of motor and sensory peripheral neuropathy in children with B‐lymphoblastic leukemia. Pediatric Blood & Cancer 2023, 70: e30634. PMID: 37592363, PMCID: PMC10552080, DOI: 10.1002/pbc.30634.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyPeripheral neuropathyLymphoblastic leukemiaPediatric Outcomes Data Collection InstrumentPT/OTSensory peripheral neuropathyAcute lymphoblastic leukemiaPredictor of motorProxy-report measuresCommon conditionOccupational therapistsNeuropathyChildrenLeukemiaFunction studiesResponseChromophobe renal cell carcinoma
Henske E, Cheng L, Hakimi A, Choueiri T, Braun D. Chromophobe renal cell carcinoma. Cancer Cell 2023, 41: 1383-1388. PMID: 37541245, DOI: 10.1016/j.ccell.2023.07.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChromophobe renal cell carcinomaClear cell RCCRenal cell carcinomaCell carcinomaCell/ILTerms of geneticsCell of originImmune therapyCell RCCTargetable pathwaysMTOR inhibitorsMitochondrial dysfunctionPathway mutationsOxidative stressPotential mechanismsChRCCCarcinomaCurrent dataRCCGenomicsKinaseImmunotherapyResponseDysfunctionGeneticsResponse to substance use during hospitalization: A survey study of current and ideal policies and practices
Huxley‐Reicher Z, Puglisi L, Tetrault J, Weimer M, Stellini M, Bhandary‐Alexander J, Thomas K, Donroe J. Response to substance use during hospitalization: A survey study of current and ideal policies and practices. Journal Of Hospital Medicine 2023, 18: 829-834. PMID: 37475186, DOI: 10.1002/jhm.13162.Peer-Reviewed Original ResearchHospital policiesAddiction medicine fellowshipsPatient-directed dischargeSubstance useCross-sectional studyWorse patient outcomesMajority of hospitalsAcute hospitalizationPatient outcomesUse of substancesPatient-centered policiesHospitalizationUS hospitalsLittle dataGraduate Medical EducationHospitalCliniciansAccreditation CouncilSurvey studyResponseCurrent practiceEmerging Biomarkers of Response to Systemic Therapies in Metastatic Clear Cell Renal Cell Carcinoma
Labaki C, Saliby R, Bakouny Z, Saad E, Semaan K, Eid M, Lalani A, Choueiri T, Braun D. Emerging Biomarkers of Response to Systemic Therapies in Metastatic Clear Cell Renal Cell Carcinoma. Hematology/Oncology Clinics Of North America 2023, 37: 937-942. PMID: 37407357, DOI: 10.1016/j.hoc.2023.05.021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMetastatic clear cell renal cell carcinomaClear cell renal cell carcinomaCell renal cell carcinomaRenal cell carcinomaSystemic therapyCell carcinomaImmunotherapy-based regimensBiomarkers of responseSystemic regimensClinical responseValid biomarkersPromising biomarkerHeterogeneous outcomesTherapyBiomarkersRegimensPatientsCarcinomaMccRCCResponseImpact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination
Messina N, Sperotto M, Puga M, da Silva P, de Oliveira R, Moore C, Pittet L, Jamieson T, Dalcolmo M, dos Santos G, Jardim B, Lacerda M, Curtis N, Croda J. Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination. Frontiers In Immunology 2023, 14: 1172851. PMID: 37465688, PMCID: PMC10352084, DOI: 10.3389/fimmu.2023.1172851.Peer-Reviewed Original ResearchConceptsRecent BCG vaccinationBCG vaccinationAntibody responseVaccine platformAnti-spike IgG responseCOVID-19 vaccinationCOVID-19 vaccineCoronaVac vaccinationPrior vaccinationVaccine responsesIgG responsesSecond doseIgG antibodiesHealthcare workersVaccinationChAdOx1CoronaVacCOVID-19VaccineMultiple factorsResponsePlaceboDoseTrialsAntibodiesResponse to "NLRC5 germline variants and their potential role in eliciting an immune response in patients with cancer treated with immune checkpoint inhibitors" by Xiang-Yu Meng
Aizenbud L, Schoenfeld D, Caulfield J, Mann J, Austin M, Perdigoto A, Herold K, Kluger H. Response to "NLRC5 germline variants and their potential role in eliciting an immune response in patients with cancer treated with immune checkpoint inhibitors" by Xiang-Yu Meng. Journal For ImmunoTherapy Of Cancer 2023, 11: e007397. PMID: 37349129, PMCID: PMC10314693, DOI: 10.1136/jitc-2023-007397.Peer-Reviewed Original ResearchEnhanced IgG immune response to COVID‐19 vaccination in patients with sickle cell disease
Nakahara H, Cheedarla N, Verkerke H, Cheedarla S, Wu S, Hendrickson J, Chang A, McLemore M, Rassi F, Roback J, Neish A, Fasano R, Stowell S. Enhanced IgG immune response to COVID‐19 vaccination in patients with sickle cell disease. British Journal Of Haematology 2023, 202: 937-941. PMID: 37287128, PMCID: PMC10751105, DOI: 10.1111/bjh.18899.Peer-Reviewed Original ResearchConceptsSickle cell diseaseCOVID-19 vaccinationAntibody responseCell diseaseSARS-CoV-2 vaccinationIgG immune responseSimilar antibody responsesOptimal vaccination strategyIgG titresIgG responsesVaccination strategiesImmune responseSCD controlsGeneral populationPatientsVaccinationDiseaseResponseCohortTitres
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