2025
Tranexamic Acid in Body Contouring Surgery: A Systematic Review and Meta-Analysis
Fijany A, Holan C, Troia T, Montorfano L, Mubang R, Givechian K, Karagoz H, Martinez-Jorge J, Perdikis G, Connor L, Slater E. Tranexamic Acid in Body Contouring Surgery: A Systematic Review and Meta-Analysis. Aesthetic Surgery Journal 2025, sjaf112. PMID: 40509914, DOI: 10.1093/asj/sjaf112.Peer-Reviewed Original ResearchBody contouring proceduresWound healing complicationsTranexamic acidTXA administrationContouring proceduresTopical TXA administrationHealing complicationsMeta-analysisImpact of tranexamic acidOdds ratioTranexamic acid cohortRisk of hematomaWound healing issuesDecreased risk of infectionBody contouring surgeryConfidence intervalsRandom-effects modelRisk of infectionBreast reconstructionAntifibrinolytic drugsSeroma formationContouring surgerySubgroup analysisHealing issuesDecreased riskLuspatercept in patients with lower-risk myelodysplastic syndromes (MDS): A systematic review and meta-analysis.
Alhajahjeh A, Woite N, Grimshaw A, Rolles B, Stahl M, Kewan T, Podoltsev N, Stempel J, Mendez L, Zeidan A, Bewersdorf J. Luspatercept in patients with lower-risk myelodysplastic syndromes (MDS): A systematic review and meta-analysis. Journal Of Clinical Oncology 2025, 43 DOI: 10.1200/jco.2025.43.16_suppl.e18574.Peer-Reviewed Original ResearchMyelodysplastic syndromeTransfusion dependenceRinged sideroblastsFrontline settingAcute myeloid leukemia transformationLower-risk myelodysplastic syndromesHigh transfusion burdenBone marrow disordersMeta-analysisErythropoiesis-stimulating agentsSerious adverse eventsStudy's primary endpointResistant to treatmentReduce transfusion needsSystematic reviewIndependent reviewers assessed studiesRandom-effects modelBlack quality assessment checklistTransfusion burdenTransfusion independenceQuality assessment checklistLeukemia transformationRisk of biasLR-MDSPrimary endpointUtilization and fertility preservation outcomes in women undergoing embryo cryopreservation before breast cancer treatment: a meta-analysis
Turan V, Oktem O, Bang H, Oktay K. Utilization and fertility preservation outcomes in women undergoing embryo cryopreservation before breast cancer treatment: a meta-analysis. Clinical Breast Cancer 2025 DOI: 10.1016/j.clbc.2025.06.003.Peer-Reviewed Original ResearchBreast cancer treatmentFertility preservation rateLive birth rateClinical pregnancyCancer treatmentFertility preservationEmbryo transferPreservation rateBirth rateFertility preservation outcomesFrozen embryo transferCochrane Library databasesRandom-effects modelSecondary outcome measuresPregnancy outcomesEmbryo cryopreservationBreast cancerPreservation outcomesLibrary databasesPregnancyBreastMeta-analysisOutcome measuresWomenTreatmentImmune checkpoint inhibitor (ICI) efficacy in triple-negative breast cancer (TNBC) patients with liver metastases (LM): A meta-analysis.
Park D, Abid M, Lustberg M, Kalinski P, Gandhi S, Huang C. Immune checkpoint inhibitor (ICI) efficacy in triple-negative breast cancer (TNBC) patients with liver metastases (LM): A meta-analysis. Journal Of Clinical Oncology 2025, 43: e13131-e13131. DOI: 10.1200/jco.2025.43.16_suppl.e13131.Peer-Reviewed Original ResearchProgrammed death-ligand1Triple-negative breast cancerImmune checkpoint inhibitorsProgression free survivalLiver metastasesHazard ratioBreast cancerEfficacy of immune checkpoint inhibitorsTriple-negative breast cancer casesLog-transformed hazard ratioProgression free survival benefitImmune checkpoint inhibitor therapyAssociated with poor prognosisSite of diseaseAggressive breast cancerMeta-analysisArea of translational researchRandom-effects modelCheckpoint inhibitorsRandomized controlled trialsSystematic literature searchFree survivalOverall survivalDistant metastasisImmunocompromised stateSafety of Stimulants Across Patient Populations
Oliva H, Prudente T, Mayerson T, Mignosa M, Oliva I, Potenza M, Jegede O, Angarita G. Safety of Stimulants Across Patient Populations. JAMA Network Open 2025, 8: e259492. PMID: 40343695, PMCID: PMC12065045, DOI: 10.1001/jamanetworkopen.2025.9492.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderRandomized clinical trialsAdverse eventsStimulant medicationData extractionSafety of stimulationRisk ratioIncreased riskMethodological quality assessmentPreferred Reporting ItemsPatient populationClinical conditionsDiverse patient populationsRisk of biasSafety of stimulant medicationsUnclear risk of biasTreatment of attention-deficit/hyperactivity disorderOverall AEsRandom-effects modelWeb of ScienceBinge eating disorderStimulant use disorderComprehensive literature searchMain OutcomesReporting ItemsEfficacy of enhanced recovery programmes for cardiac surgery: a systematic review and meta-analysis
Hoogma D, Meeusen I, Coppens S, Verbrugghe P, van den Eynde J, Engelman D, Grant M, Stoppe C, Rex S. Efficacy of enhanced recovery programmes for cardiac surgery: a systematic review and meta-analysis. British Journal Of Anaesthesia 2025, 135: 31-39. PMID: 40287362, DOI: 10.1016/j.bja.2025.03.019.Peer-Reviewed Original ResearchConceptsHospital length of stayLength of stayCardiac surgeryFast-track cardiac anesthesiaFast-track (FTICU length of stayMeta-analysisAssessed risk of biasRandom-effects modelAdditive valueRisk of biasPerioperative strategiesEfficacy outcomesVentilation timeFT programmesVentilatory timeHospital lengthPostoperative interventionsCardiac anesthesiaComparative efficacySurgeryWeb of ScienceRandomised trialsPRISMA guidelinesEnhanced recoveryRisk of Early Childhood Dental Caries Associated With Prolonged Breastfeeding: A Systematic Review and Meta‐Analysis
Lustosa K, Rodrigues L, Rocha R, Prudente T, Mezaiko E, Silva F, Silva B. Risk of Early Childhood Dental Caries Associated With Prolonged Breastfeeding: A Systematic Review and Meta‐Analysis. International Journal Of Paediatric Dentistry 2025 PMID: 40254914, DOI: 10.1111/ipd.13313.Peer-Reviewed Original ResearchEarly childhood cariesRisk of early childhood cariesProlonged breastfeedingProspective Register of Systematic ReviewsIncreased riskRisk of dental cariesEarly childhood caries prevalenceEarly childhood caries riskSystematic reviewInternational Prospective Register of Systematic ReviewsMeta-analysesRandom-effects modelChildhood cariesRisk of biasDental cariesInternational Prospective RegisterLanguage restrictionsProlonged durationObservational studyBreastfeedingEligibility criteriaMeta-analysisJBI Critical Appraisal ChecklistCritical Appraisal ChecklistMonthsEfficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials
Tanriverdi L, Barrett A, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Efficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials. Vascular Pharmacology 2025, 159: 107494. PMID: 40204023, DOI: 10.1016/j.vph.2025.107494.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmRandomized controlled trialsPooled risk ratioB-blockersAortic dissectionClinical outcomesAortic aneurysmRisk ratioRisk of aortic dissectionMeta-analysis of randomized controlled trialsControlled trialsB-blocker treatmentCompared to placeboBeta-blocking agentsCochrane Risk of Bias 2 toolRisk of Bias 2 toolRobust randomized controlled trialsInverse variance-weighted random-effects modelRisk of bias assessmentRandom-effects modelEvidence of benefitSystematic literature searchAortic eventsEvidence-based recommendationsFollow-upCraniosynostosis among children with X-linked hypophosphatemia: A systematic review and meta-analysis
Fisch S, Tudor A, Benchekroun E, Landsberg W, Feldstein N, Lamb M, Carpenter T, Rundle A, Jacobson J, Neugut A, Freedberg D. Craniosynostosis among children with X-linked hypophosphatemia: A systematic review and meta-analysis. Bone 2025, 196: 117488. PMID: 40220947, DOI: 10.1016/j.bone.2025.117488.Peer-Reviewed Original ResearchX-linked hypophosphatemiaPrevalence of craniosynostosisPooled prevalenceSystematic reviewMeta-analysisRandom-effects modelWeb of SciencePediatric populationSkull abnormalitiesCohort studyImpaired phosphate reabsorptionElevated FGF23 levelsPrevalenceFemale predominanceCase seriesFGF23 levelsPhosphate reabsorptionGene variantsChildrenIncreased vigilanceCraniosynostosisAbnormal bone growthGenetic disordersHypophosphatemiaAbnormalitiesLateralization and Distalization Shoulder Angles May Not Predict Clinical Outcomes in Reverse Total Shoulder Arthroplasty: A Systematic Review and Meta-Analysis
Surucu S, Okutan A, Lee M, MacLeod J, Kodra J, Fong S, Moran J, Donohue K, Graf A, Jimenez A. Lateralization and Distalization Shoulder Angles May Not Predict Clinical Outcomes in Reverse Total Shoulder Arthroplasty: A Systematic Review and Meta-Analysis. JSES International 2025 DOI: 10.1016/j.jseint.2025.04.004.Peer-Reviewed Original ResearchDistalization shoulder anglesLateralization shoulder angleRange of motionReverse total shoulder arthroplastyRandom-effects modelSystematic reviewMeta-analysisShoulder angleInclusion criteriaTotal shoulder arthroplastyPreferred Reporting ItemsClinical outcomesRetrospective cohort designFollow-upShoulder arthroplastyCohort designReporting ItemsStudy qualityCochrane CenterNon-randomized studiesCorrelation coefficientMeta-analysesOutcome scoresControlled trialsQ testVariability in Learner Performance Using the ACGME Harmonized Milestones During the First Year of Postgraduate Training
Santen S, Ryan M, Fancher T, Carcamo T, Hogan S, Turner L, Cheung J, Berg K, Feldman M, Holmboe E, Park Y, Group F. Variability in Learner Performance Using the ACGME Harmonized Milestones During the First Year of Postgraduate Training. Academic Medicine 2025, 100: 852-859. PMID: 40168552, DOI: 10.1097/acm.0000000000006053.Peer-Reviewed Original ResearchConceptsAccreditation Council for Graduate Medical EducationPGY-1 residentsHarmonized milestonesMedical schoolsPGY-1Residency programsCompetency domainsGraduate Medical EducationPostgraduate medical trainingU.S. medical schoolsPostgraduate year 1Random-effects modelFamily medicineEmergency medicineHealth careClinical educationVariance component analysisMedical trainingPostgraduate traineesInternal medicineMedical educationPostgraduate trainingSpecialtyAssessment of learnersYear 1Optical Coherence Tomography Versus Angiography Alone to Guide PCI for Complex Lesions: A Meta-Analysis of Randomized Controlled Trials
Ezenna C, Krishna M, Joseph M, Ibrahim S, Pereira V, Jenil-Franco A, Nanna M, Bangalore S, Goldsweig A. Optical Coherence Tomography Versus Angiography Alone to Guide PCI for Complex Lesions: A Meta-Analysis of Randomized Controlled Trials. Circulation Cardiovascular Interventions 2025, 18: e015141. PMID: 40159113, DOI: 10.1161/circinterventions.125.015141.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAdverse cardiovascular eventsRandomized controlled trialsOptical coherence tomographyMyocardial infarctionControlled trialsCardiac deathCardiovascular eventsComplex lesionsRisk ratioMeta-analysis of randomized controlled trialsOCT-guided percutaneous coronary interventionHigh-resolution intracoronary imagingMajor adverse cardiovascular eventsAssociated with lower major adverse cardiovascular eventsMedian follow-upTarget vessel revascularizationPeriprocedural myocardial infarctionRandom-effects modelClinical outcomesCoherence tomographyFollow-upCochrane DatabaseCoronary interventionStent thrombosisThe association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach
Mestre-Bach G, Paiva U, San Martín Iniguez L, Beranuy M, Martín-Vivar M, Mallorquí-Bagué N, Normand E, Chicote M, Potenza M, Arrondo G. The association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach. Psychological Medicine 2025, 55: e77. PMID: 40071718, PMCID: PMC12080635, DOI: 10.1017/s0033291725000376.Peer-Reviewed Original ResearchConceptsInternet-use disordersSystematic reviewMeta-analysisInternet-useInternet use disorderRandom-effects modelWeb of ScienceDegree of lonelinessUCLA Loneliness ScaleStatistical poolingQuantify associationsOdds ratioCohen's dDisorder symptomsGreater lonelinessMeta-regressionPooled differenceEffect sizePre-registeredUCLA-LonelinessLonelinessEffects of ageCategorical approachSymptomsGroup of individualsCombined atherectomy and intravascular lithotripsy in calcified coronary lesions: a meta-analysis.
Singh S, Garg A, Tantry U, Bliden K, Gurbel P, Kochar A, Nanna M, Damluji A. Combined atherectomy and intravascular lithotripsy in calcified coronary lesions: a meta-analysis. Journal Of Invasive Cardiology 2025 PMID: 39993271, DOI: 10.25270/jic/24.00312.Peer-Reviewed Original ResearchCalcified coronary lesionsProcedural success rateCoronary lesionsIntravascular lithotripsyCoronary perforationRisk of procedural complicationsRisk of adverse CV eventsAcute procedural successSuccess rateAcute coronary syndromeAdverse CV eventsTarget vessel revascularizationSeverely calcified coronary lesionsRandom-effects modelTreatment of severely calcified coronary lesionsPeriprocedural complicationsPooled proportionProcedural complicationsProcedural successCV deathCoronary syndromeCV eventsFollow-upProcedural outcomesCV outcomesImpact of disease severity, age, sex, comorbidity, and vaccination on secondary attack rates of SARS-CoV-2: a global systematic review and meta-analysis
Sumsuzzman D, Ye Y, Wang Z, Pandey A, Langley J, Galvani A, Moghadas S. Impact of disease severity, age, sex, comorbidity, and vaccination on secondary attack rates of SARS-CoV-2: a global systematic review and meta-analysis. BMC Infectious Diseases 2025, 25: 215. PMID: 39948450, PMCID: PMC11827239, DOI: 10.1186/s12879-025-10610-5.Peer-Reviewed Original ResearchConceptsPopulation settingEffective public health strategiesConfidence intervalsImpact of disease severityModified Newcastle-Ottawa ScalePublic health strategiesHigher secondary attack rateRisk of biasNewcastle-Ottawa ScalePandemic responseGlobal systematic reviewRandom-effects modelFreeman-Tukey double arcsine transformationWeb of ScienceNo significant associationDrivers of SARS-CoV-2 transmissionHealth strategiesSecondary attack rateSARS-CoV-2Disease severityEffective pandemic responseTargeted interventionsDouble arcsine transformationOvid MEDLINESystematic reviewEfficacy and toxicity profile of antibody-drug conjugate (ADC) based combination therapy in patients with advanced urothelial carcinoma (aUC): A systematic review of clinical trials.
Jaime-Casas S, Zugman M, Barragan-Carrillo R, Zang P, Ebrahimi H, Mercier B, Castro D, Yip W, Li X, Dizman N, Salgia N, Hsu J, Nguyen C, Chehrazi-Raffle A, Zengin Z, Meza L, Pal S, Tripathi A. Efficacy and toxicity profile of antibody-drug conjugate (ADC) based combination therapy in patients with advanced urothelial carcinoma (aUC): A systematic review of clinical trials. Journal Of Clinical Oncology 2025, 43: 813-813. DOI: 10.1200/jco.2025.43.5_suppl.813.Peer-Reviewed Original ResearchAny-grade adverse eventsAdvanced urothelial carcinomaObjective-response rateAntibody-drug conjugatesCombination regimensClinical trialsCheckpoint inhibitorsSafety/tolerability profileCombination therapyPublished prospective clinical trialsProspective clinical trialPeer-reviewed clinical trialsSystematic review of clinical trialsReview of clinical trialsRandom-effects modelEnfortumab vedotinSacituzumab govitecanUrothelial carcinomaProspective trialsTreatment landscapeMaculopapular rashEfficacy outcomesRetrospective studyToxicity profileCase reportReproductive and Hormonal Factors and Thyroid Cancer Risk: Pooled Analysis of Prospective Cohort Studies in the Asia Cohort Consortium.
Kazmi S, Shin A, Abe S, Islam M, Rahman M, Saito E, Cho S, Katagiri R, Merritt M, Choi J, Shu X, Sawada N, Tamakoshi A, Sakata R, Hozawa A, Kanemura S, Kim J, Sugawara Y, Park S, Cai H, Tsugane S, Kimura T, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Rothman N, Zheng W, Inoue M, Kang D. Reproductive and Hormonal Factors and Thyroid Cancer Risk: Pooled Analysis of Prospective Cohort Studies in the Asia Cohort Consortium. Cancer Prevention Research 2025, 18: 209-221. PMID: 39846314, PMCID: PMC11961320, DOI: 10.1158/1940-6207.capr-24-0330.Peer-Reviewed Original ResearchConceptsThyroid cancer riskIncreased thyroid cancer riskAnalysis of prospective cohort studyAsia Cohort ConsortiumCancer riskProspective cohort studyCohort ConsortiumIncident thyroid cancer casesReproductive factorsAssociated with increased thyroid cancer riskCohort studyCohort-specific hazard ratiosHazard ratioConfidence intervalsPublic health strategiesYounger birth cohortsOlder ageThyroid cancer casesPooled analysisCox proportional hazards modelsBody mass indexRandom-effects modelPooled analysis of prospective cohort studiesProportional hazards modelThyroid cancerA Bayesian Interpretation of CABANA and Other Randomized Controlled Trials for Catheter Ablation in Patients With Atrial Fibrillation
Nogueira A, Felix N, Kalil F, Tramujas L, Godoi A, Miyawaki I, Bellavia A, Moura F, Cardoso R, d'Avila A, Fernandes G. A Bayesian Interpretation of CABANA and Other Randomized Controlled Trials for Catheter Ablation in Patients With Atrial Fibrillation. Journal Of Cardiovascular Electrophysiology 2025, 36: 617-624. PMID: 39834105, DOI: 10.1111/jce.16552.Peer-Reviewed Original ResearchConceptsBayesian analysisTreatment effect distributionAdverse cardiovascular outcomesAll-cause mortalityCardiovascular outcomesRandomized controlled trialsFrequentist estimatorsCatheter ablationMedical therapyAtrial fibrillationBayesian interpretationImpact of catheter ablationControlled trialsAnalysis of randomized controlled trialsProbability distributionAtrial fibrillation patientsReduce adverse cardiovascular outcomesImpact of ablationEffective distributionRandom-effects modelBayes' theoremTrial-level dataProbabilistic understandingSurvival outcomesFibrillation patientsThe comparative efficacy and safety of Tiger II versus judkins catheters in coronary angiogram via the radial artery access: a meta-analysis
Aljabali A, Alawajneh M, Hammad A, Nguyen D, Alkasabrah A, Abuein K, Altibi A. The comparative efficacy and safety of Tiger II versus judkins catheters in coronary angiogram via the radial artery access: a meta-analysis. Acta Cardiologica 2025, 80: 39-43. PMID: 39781598, DOI: 10.1080/00015385.2024.2442799.Peer-Reviewed Original ResearchConceptsStandardised mean differenceFluoroscopy timeContrast volumeProcedure timeJudkins catheterOdds ratioProcedural successCoronary angiogramTiger IIEstimates of odds ratiosRadiation exposureMeta-analysisReduced fluoroscopy timeRadial artery vasospasmRandom-effects modelWeb of ScienceRadial artery accessComplication rateArtery vasospasmSecondary outcomesPrimary outcomeComparative efficacyArterial accessTransfemoral accessCochrane LibraryTranscatheter Aortic Valve Replacement in Hypertrophic Cardiomyopathy: A Systematic Review and Meta‐Analysis
Ahmed A, Kaddoura R, Aggarwal A, Zinyandu T, Webber F, Davila C, Zarich S. Transcatheter Aortic Valve Replacement in Hypertrophic Cardiomyopathy: A Systematic Review and Meta‐Analysis. Catheterization And Cardiovascular Interventions 2025, 105: 754-760. PMID: 39748537, DOI: 10.1002/ccd.31367.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementOutcomes of transcatheter aortic valve replacementAortic valve replacementHypertrophic cardiomyopathyAortic stenosisRenal impairmentValve replacementAortic dissectionVascular complicationsCardiogenic shockOdds ratioTranscatheter aortic valve replacement outcomesSevere aortic stenosisPermanent pacemaker implantationComplete heart blockAssociated with higher ratesObservational cohort studyGold standard managementConfidence intervalsRandom-effects modelSignificantly higher occurrenceSurgical riskPacemaker implantationHeart blockSurgical intervention
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