2025
Incorporating Patient and Provider Voices into the Veterans Pain Care Organizational Improvement Comparative Effectiveness Study: Informing Future Implementation
Hagedorn H, Purcell N, DeRonne B, Salameh H, Becker W, Seal K, Krebs E. Incorporating Patient and Provider Voices into the Veterans Pain Care Organizational Improvement Comparative Effectiveness Study: Informing Future Implementation. Journal Of General Internal Medicine 2025, 1-13. PMID: 40481383, DOI: 10.1007/s11606-025-09639-8.Peer-Reviewed Original ResearchInterdisciplinary pain teamVeterans Health AdministrationClinical championsProcess evaluationLeadership supportReducing opioid useConclusionThis process evaluationQualitative process evaluationPrimary care settingOpioid useComparative effectiveness studiesRE-AIMPatient involvementConstructs of implementationPain teamCare settingsPatient perspectiveCategorize themesIdentified themesImprove painClinical teamProvider voicesHealth AdministrationIncorporating patientEffectiveness trialPrimary Care Physician Use of Elastic Scattering Spectroscopy on Skin Lesions Suggestive of Skin Cancer
Merry S, Croghan I, Dukes K, McCormick B, Considine G, Duvall M, Thompson C, Leffell D. Primary Care Physician Use of Elastic Scattering Spectroscopy on Skin Lesions Suggestive of Skin Cancer. Journal Of Primary Care & Community Health 2025, 16: 21501319251344423. PMID: 40470593, PMCID: PMC12144386, DOI: 10.1177/21501319251344423.Peer-Reviewed Original ResearchConceptsPrimary care physiciansElastic scattering spectroscopySkin lesionsSkin cancerPredictive valueSquamous cell cancerNegative predictive valuePositive predictive valueMulticenter pivotal studyAdjunctive diagnostic deviceCell cancerPrimary care physicians' useBiopsy specimensAdult patientsPivotal studiesKeratinocyte carcinomaDiagnostic performanceSubgroup analysisPrimary care settingHistopathological analysisCancerLesionsPatientsClinical interestAge groupsUnderstanding the characteristics and comorbidities of primary care patients with risky opioid use: Baseline data from the multi-site “Subthreshold Opioid Use Disorder Prevention” (STOP) Trial
Rostam-Abadi Y, Liebschutz J, Subramaniam G, Stone R, Appleton N, Mazel S, Alexander K, Brill S, Case A, Gelberg L, Gordon A, Hong H, Incze M, Kawasaki S, Kim T, Kline M, Lovejoy T, McCormack J, Zhang S, McNeely J. Understanding the characteristics and comorbidities of primary care patients with risky opioid use: Baseline data from the multi-site “Subthreshold Opioid Use Disorder Prevention” (STOP) Trial. Journal Of General Internal Medicine 2025, 1-10. PMID: 40457116, DOI: 10.1007/s11606-025-09613-4.Peer-Reviewed Original ResearchOpioid use disorderMental health symptomsHigh-risk useOpioid useHealth symptomsConsequences of opioid useSymptoms of opioid use disorderBaseline characteristics of participantsCollaborative care interventionRates of polysubstance usePrimary care patientsPrimary care sitesOpioid use disorder preventionPrimary care settingSelf-reported demographic characteristicsModerate-severe painSevere opioid use disorderCharacteristics of participantsModerate-severe anxietyPrimary careCare interventionsCare sitesCare settingsOpioid medicationsNon-HispanicA Digital Depression Treatment Program for Adults Treated in Primary Care
Dahne J, Wahlquist A, Carpenter M, Graboyes E, Lejuez C, Kustanowitz J, Natale N, Levins O, Player M, Diaz V. A Digital Depression Treatment Program for Adults Treated in Primary Care. JAMA Internal Medicine 2025, 185: 692-701. PMID: 40227715, PMCID: PMC11997856, DOI: 10.1001/jamainternmed.2025.0494.Peer-Reviewed Original ResearchElectronic health recordsBeck Depression Inventory-IIPrimary care settingBehavioral activation interventionDepressive symptomsClinically significant improvementUsual careActivity interventionsCare settingsElectronic health record featuresElectronic health record integrationPatient Health Questionnaire-9Depression remissionModerate symptoms of depressionPrimary care providersPrimary care clinicsDepression treatment programTreating depressive symptomsSymptoms of depressionPrimary careSignificant improvementCare clinicsIntervention engagementCare providersScalable interventionsCandidate Interventions for Integrating Hypertension and Cardiovascular-Kidney-Metabolic Care in Primary Health Settings: HEARTS 2.0 Phase 1
Rosende A, Romero C, DiPette D, Brettler J, Van der Stuyft P, Satheesh G, Perel P, Chapman N, Moran A, Schutte A, Sharman J, Irazola V, Huffman M, Campbell N, Salam A, Lanas F, Coca A, Garcia-Zamora S, Ferreiro A, Lopez-Jaramillo P, Rico-Fontalvo J, Ridley E, Picone D, Flood D, Piñeiro D, Ojeda C, Rodriguez G, Wellmann I, Orias M, Rivera M, Reyes M, Onuma O, Ramroop S, Khan T, Gonzalez Y, Barroso W, Plavnik F, Zuniga E, Grassani A, Tajer C, Zaidel E, Marin M, Cyr-Philbert S, Amorin I, Aguilera M, Bortolotto L, Avezum A, Ribeiro A, Tobe S, Aumala T, Angell S, Lavados P, Martins S, Echeverri A, Jaffe M, Prabhakaran D, Parati G, Zhang X, Rodgers A, Yusuf S, Whelton P, Ordunez P. Candidate Interventions for Integrating Hypertension and Cardiovascular-Kidney-Metabolic Care in Primary Health Settings: HEARTS 2.0 Phase 1. Global Heart 2025, 20: 45. PMID: 40454106, PMCID: PMC12124280, DOI: 10.5334/gh.1428.Peer-Reviewed Original ResearchConceptsClinical pathwayNon-physician health workersTeam-based careImprove care deliveryReduce care fragmentationPrimary care settingPrimary health settingsCare of hypertensionGlobal Hearts InitiativeCommunity-based screeningEvidence-based interventionsManagement of risk factorsHigher CVD riskLower blood pressure thresholdHigh CVD risk patientsCardiovascular diseaseChronic kidney diseasePhase 1Blood pressure thresholdsHealth equityCare fragmentationHearts InitiativePrimary careCare deliveryHealth settingsImpact of the Kidney Score Platform on Communication About and Patients’ Engagement With Chronic Kidney Disease Health: Pre–Post Intervention Study
Tuot D, Crowley S, Katz L, Leung J, Alcantara-Cadillo D, Ruser C, Talbot-Montgomery E, Vassalotti J. Impact of the Kidney Score Platform on Communication About and Patients’ Engagement With Chronic Kidney Disease Health: Pre–Post Intervention Study. JMIR Formative Research 2025, 9: e56855. PMID: 40300154, PMCID: PMC12054969, DOI: 10.2196/56855.Peer-Reviewed Original ResearchConceptsPre-post intervention studyPatient Activation MeasureKidney healthPractice toolkitIntervention studiesIncrease patient activationDiabetes statusPrimary care cliniciansPrimary care settingPercentage of veteransChronic kidney diseaseUS adult populationClinical practice guidelinesChronic kidney disease managementChronic kidney disease education programClinician engagementPatient engagementCare cliniciansCare settingsPaired t-testPatient knowledgeTailored educationKnowledge scoresPatient activationPatient interactionsInsights into the morbidity profiles of epidemiologically excluded COVID-19 patients in primary care settings during the third wave of the pandemic in the Anuradhapura District, Sri Lanka
Abeyrathna P, Agampodi S, Samaranayake S, Pushpakumara P. Insights into the morbidity profiles of epidemiologically excluded COVID-19 patients in primary care settings during the third wave of the pandemic in the Anuradhapura District, Sri Lanka. BMC Primary Care 2025, 26: 95. PMID: 40181290, PMCID: PMC11967136, DOI: 10.1186/s12875-025-02792-3.Peer-Reviewed Original ResearchConceptsPrivate primary care facilitiesPrimary care settingMorbidity profilePrimary careCare settingsInternational Classification of Primary CareAnuradhapura districtDelivery of healthcare servicesHealthcare-seeking patternsPrimary care servicesPrimary care facilitiesCOVID-19 patientsPrimary care encountersNature of illnessBackgroundThe COVID-19 pandemicInstitution-based studyCOVID-19 pandemicCare encountersCare servicesPrivate sectorHealthcare seekersAnuradhapura district of Sri LankaComprehensive careHealthcare servicesCare facilitiesTreatment of Substance Use Disorders With a Mobile Phone App Within Rural Collaborative Care Management (Senyo Health): Protocol for a Mixed Methods Randomized Controlled Trial
Oesterle T, Bormann N, Paul M, Breitinger S, Lai B, Smith J, Stoppel C, Arndt S, Williams M. Treatment of Substance Use Disorders With a Mobile Phone App Within Rural Collaborative Care Management (Senyo Health): Protocol for a Mixed Methods Randomized Controlled Trial. JMIR Research Protocols 2025, 14: e65693. PMID: 40138685, PMCID: PMC11982759, DOI: 10.2196/65693.Peer-Reviewed Original ResearchConceptsINTERNATIONAL REGISTERED REPORT IDENTIFIERPrimary care settingCollaborative care managementPrimary careSubstance use disordersRandomized controlled trialsCare settingsCare managementRural primary care clinicsMethods Randomized controlled trialsPrimary care clinicsPrimary care providersControlled trialsSpecialty addictions treatmentReferral to treatmentImplementation research methodsMental health treatmentWaitlist-controlled trialWaitlist control groupEvidenced-based strategiesUse disorderMobile appsCare clinicsBrief interventionCare providersCross‐Cultural Validation of the Binge Eating Disorder Screener‐7 (BEDS‐7) Across 42 Countries
Gewirtz‐Meydan A, Spivak‐Lavi Z, Kraus S, Nagy L, Koós M, Demetrovics Z, Potenza M, Ballester‐Arnal R, Batthyány D, Bergeron S, Billieux J, Briken P, Burkauskas J, Cárdenas‐López G, Carvalho J, Castro‐Calvo J, Chen L, Ciocca G, Corazza O, Csako R, Fernandez D, Fernandez E, Fujiwara H, Fuss J, Gabrhelík R, Gjoneska B, Gola M, Grubbs J, Hashim H, Islam S, Ismail M, Jiménez‐Martínez M, Jurin T, Kalina O, Klein V, Költő A, Lee C, Lee S, Lewczuk K, Lin C, Lochner C, López‐Alvarado S, Lukavská K, Mayta‐Tristán P, Miller D, Orosová O, Orosz G, Team S, Chang H, Park K, Ponce F, Quintana G, Garzola G, Ramos‐Diaz J, Rigaud K, Rousseau A, De Tubino Scanavino M, Schulmeyer M, Sharan P, Shibata M, Shoib, Sigre‐Leirós V, Sniewski L, Spasovski O, Steibliene V, Stein D, Strizek J, Ünsal B, Vaillancourt‐Morel M, Van Hout M, Bőthe B. Cross‐Cultural Validation of the Binge Eating Disorder Screener‐7 (BEDS‐7) Across 42 Countries. International Journal Of Eating Disorders 2025, 58: 926-938. PMID: 40040591, PMCID: PMC12067514, DOI: 10.1002/eat.24365.Peer-Reviewed Original ResearchBinge-eating disorderTests of measurement invarianceDiverse community sampleBinge-eating disorder symptomsCross-sectional online studyMeasures of sexualityConfirmatory factor analysisCross-cultural validityPrimary care settingSexual orientationBED symptomsSexual orientation groupsCommunity sampleFactorial invarianceItem interceptsResidual invarianceBEDS-7Measurement invarianceSubstance useDiverse cultural contextsAdequate reliabilityCriterion validityModerate criterion validityMental healthOnline studyCreating Inclusive and Affirming Primary Care Environments for LGBTQIA+ Patients
Korbey S, Iennaco J, Nelson L. Creating Inclusive and Affirming Primary Care Environments for LGBTQIA+ Patients. The Journal For Nurse Practitioners 2025, 21: 105306. DOI: 10.1016/j.nurpra.2024.105306.Peer-Reviewed Original ResearchPrimary care environmentLGBTQIA+ patientsCare environmentCultural competence of providersCompetence of providersPrimary care settingQuality improvement projectEvidence-based modelDisclosure of sexual orientationSignificant health consequencesCare settingsHealth careImprovement projectCultural competenceHealth consequencesMedical CenterHeterosexual communitySexual orientationLGBTQIA+ communityPatientsCareProvidersHealthCommunityDisparitiesTelemedicine Use and Hypertension Control in an Urban Community Health Center Cohort
Molina F, Westvold S, Soulos P, Brockman A, Alcaraz E, Oldfield B. Telemedicine Use and Hypertension Control in an Urban Community Health Center Cohort. Journal Of General Internal Medicine 2025, 40: 1519-1526. PMID: 39920430, PMCID: PMC12052640, DOI: 10.1007/s11606-025-09393-x.Peer-Reviewed Original ResearchBlood pressure <Safety-net primary care settingBlood pressure controlMultisite community health centerHypertension controlMain MeasuresThe primary outcomeBP controlAssociated with blood pressure controlChronic disease managementSocial deprivation indexAssociated with lower oddsCommunity health centersPrimary care settingSafety-net populationMeasuresThe primary outcomeBlack patientsMixed-effects logistic regression modelsIn-person visitsPersistent racial disparitiesAssociated with blood pressureSystolic blood pressure <Logistic regression modelsDeprivation indexDiastolic blood pressure <High deprivation
2024
Digital Elder Abuse Intervention for Early Detection of Abuse in Older Adults Living with Dementia
Abujarad F, Edwards C, Neugroschl J, Hwang U, Marottoli R. Digital Elder Abuse Intervention for Early Detection of Abuse in Older Adults Living with Dementia. Alzheimer's & Dementia 2024, 20: e092332. PMCID: PMC11713709, DOI: 10.1002/alz.092332.Peer-Reviewed Original ResearchElder abuseEmergency departmentSelf-reportYale New Haven Health SystemDigital health interventionsGeriatric memory clinicPrimary care settingEarly detection of abuseEvidence-informed interventionsCognitively intact participantsMontreal Cognitive AssessmentSevere cognitive impairmentCognitive abilities of participantsHigh-risk populationIncreased self-reportsPublic health problemCare settingsED settingPLWDHealth interventionsMemory clinicHealth systemOlder AdultsPost-survey questionsSelf-reported abuseStrategies to Deimplement Opioid Prescribing in Primary Care
Quanbeck A, Robinson J, Jacobson N, Li X, Hennessy-Garza R, Landeck J, Cohen A, Madden L, Pulvermacher A, Brown R. Strategies to Deimplement Opioid Prescribing in Primary Care. JAMA Network Open 2024, 7: e2438325. PMID: 39388183, PMCID: PMC11581553, DOI: 10.1001/jamanetworkopen.2024.38325.Peer-Reviewed Original ResearchConceptsCluster randomized clinical trialDeimplementation strategiesMorphine milligram equivalent doseMorphine milligram equivalentsPractice facilitationOpioid prescribingIncreased screeningTreatment agreementsUS health care systemCenters for Disease Control and Prevention guidelinesRandomized clinical trialsUrine drug screensPrimary care clinicsPrimary care settingPrimary outcomeMental health screeningPain-related interferenceHealth care systemHigh-intensity groupEnjoyment of lifeChronic pain managementPrimary careCare clinicsCare settingsHealth screeningFirst interim results from FINE-REAL: a prospective, non-interventional, phase 4 study providing insights into the use and safety of finerenone in a routine clinical setting
Nicholas S, Correa-Rotter R, Desai N, Guo L, Navaneethan S, Pantalone K, Wanner C, Hamacher S, Fatoba S, Horvat-Broecker A, Garreta-Rufas A, Gay A, Merz M, Wheeler D. First interim results from FINE-REAL: a prospective, non-interventional, phase 4 study providing insights into the use and safety of finerenone in a routine clinical setting. Journal Of Nephrology 2024, 37: 2223-2232. PMID: 39340711, PMCID: PMC11649709, DOI: 10.1007/s40620-024-02070-y.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseMedian follow-upNon-interventional study of patientsNon-steroidal mineralocorticoid receptor antagonistPrimary care settingMonths median follow-upTreatment-emergent adverse eventsSodium-glucose cotransporter 2 inhibitorsInterim analysisAngiotensin-converting enzyme inhibitors/angiotensin receptor blockersCKD risk categoryAssociated with type 2 diabetesMineralocorticoid receptor antagonistsClinical practiceInhibitors/angiotensin receptor blockersPhase 4 studyNon-interventional studyStudy of patientsCare settingsRoutine careType 2 diabetesFinerenone treatmentTreatment discontinuationReceptor antagonistReceptor blockersCamp-style lifestyle modification program (CAMP) for diabetes prevention among rural women with prior GDM: study protocol for a three-arm cluster hybrid type 2 randomized controlled trial
Chen Y, Zhong Q, Lv W, Long Q, Wang M, Chen J, Willey J, Whittemore R, Guo J. Camp-style lifestyle modification program (CAMP) for diabetes prevention among rural women with prior GDM: study protocol for a three-arm cluster hybrid type 2 randomized controlled trial. BMC Public Health 2024, 24: 2570. PMID: 39304869, PMCID: PMC11414119, DOI: 10.1186/s12889-024-20080-0.Peer-Reviewed Original ResearchConceptsIntensive lifestyle modificationLifestyle modification programLifestyle interventionGestational diabetes mellitusImplementation outcomesHealth consultationModification programCluster randomized clinical trialBackgroundIntensive lifestyle interventionsImprove postpartum careRandomized clinical trialsHealth promotion programsUsual care groupRisk of type 2 diabetes mellitusPrimary care settingIn-person sessionsEffective delivery modelsRisk of T2DMGestational diabetes mellitus historyGeneralized estimating equationsChinese Clinical Trial RegistryPostpartum careTechnology-based supportUsual careClinical Trials RegistryDesign and implementation of a Type-2 hybrid, prospective randomized trial of opioid agonist therapies integration into primary care clinics in Ukraine
Machavariani E, Dumchev K, Pykalo I, Filippovych M, Ivasiy R, Esserman D, Madden L, Bromberg D, Haddad M, Morozova O, Ahmad B, Gómez D, Farnum S, Dvoriak S, Altice F. Design and implementation of a Type-2 hybrid, prospective randomized trial of opioid agonist therapies integration into primary care clinics in Ukraine. Contemporary Clinical Trials 2024, 146: 107690. PMID: 39265780, PMCID: PMC11531372, DOI: 10.1016/j.cct.2024.107690.Peer-Reviewed Original ResearchPrimary care centersQuality health indicatorsNon-communicable diseasesSpecialty treatment centersOpioid agonist therapyImplementation of integrated carePay-for-performance incentivesPrimary care clinicsPrimary care settingSelf-reported prevalencePay-for-performancePrevalence of medical comorbiditiesParticipants self-reportedEffective evidence-based treatmentsHealth of PWIDEvidence-based treatmentsIntegrated careCare clinicsImplementation outcomesImplementation trialCare settingsElectronic chart reviewHigh-burden countriesSpecialty servicesHIV prevalenceLearning implementation of a guideline based decision support system to improve hypertension treatment in primary care in China: pragmatic cluster randomised controlled trial
Song J, Wang X, Wang B, Ge Y, Bi L, Jing F, Jin H, Li T, Gu B, Wang L, Hao J, Zhao Y, Liu J, Zhang H, Li X, Li J, Ma W, Wang J, Normand S, Herrin J, Armitage J, Krumholz H, Zheng X. Learning implementation of a guideline based decision support system to improve hypertension treatment in primary care in China: pragmatic cluster randomised controlled trial. The BMJ 2024, 386: e079143. PMID: 39043397, PMCID: PMC11265211, DOI: 10.1136/bmj-2023-079143.Peer-Reviewed Original ResearchConceptsClinical decision support systemsPrimary care practicesElectronic health recordsIntervention groupSystolic blood pressurePrimary careCare practicesBlood pressure <Health recordsPragmatic cluster randomised controlled trialCluster randomised controlled trialImproving hypertension treatmentPrimary care settingBlood pressure control ratesBlood pressureProportion of visitsProportion of participantsRandomised controlled trialsSystolic blood pressure <Control groupInjurious fallsRelated visitsCare settingsDiastolic blood pressure <Follow-upUsing eGFR and Albumin Creatinine Ratio as an Initial Screening Tool in Trinidadian Primary Care to Identify High-risk Population for CKD: A Cross-Sectional Study
Mahadevappa K, Nayak S, Maharaj R, Bhaktha G. Using eGFR and Albumin Creatinine Ratio as an Initial Screening Tool in Trinidadian Primary Care to Identify High-risk Population for CKD: A Cross-Sectional Study. Indian Journal Of Nephrology 2024, 34: 332-337. PMID: 39156845, PMCID: PMC11328054, DOI: 10.25259/ijn_451_23.Peer-Reviewed Original ResearchEastern Regional Health AuthorityCross-sectional studyChronic kidney diseaseCross-sectional study of adultsChronic disease clinicsPrimary care settingPrimary care levelPrimary care physiciansAlbumin-creatinine ratioRegional Health AuthorityRisk of chronic kidney diseaseStudy of adultsPublic health burdenHigh-risk populationPrimary careCare levelNCD patientsCare settingsCare physiciansCreatinine ratioEpidemiology CollaborationProportion of riskType 2 diabetes mellitusHealth authoritiesChronic Kidney Disease Epidemiology CollaborationMeasuring Access to Mental Health Services Among Primary Care Patients
Hargraves J, Cosenza C, Cleary P. Measuring Access to Mental Health Services Among Primary Care Patients. Medical Care 2024, 62: 559-566. PMID: 38842445, PMCID: PMC11226347, DOI: 10.1097/mlr.0000000000002029.Peer-Reviewed Original ResearchConceptsConsumer Assessment of Healthcare Providers and SystemsMental health servicesPrivately insured respondentsMental health medicinesHealth servicesHealth medicineHealth careAssessment of Healthcare Providers and SystemsHealthcare Providers and SystemsRisk of mental health disordersMental health prescriptionsPatient experience surveysPrimary care servicesPrimary care patientsMental health carePrimary care settingBehavioral health careMental health medicationsMental health disordersInternal consistency reliabilityStratified probability sampleMeasure accessAdequate internal consistency reliabilityCare settingsCare servicesIntegrating methadone into primary care settings in Ukraine: effects on provider stigma and knowledge
Bromberg D, Machavariani E, Madden L, Dumchev K, LaMonaca K, Earnshaw V, Pykalo I, Filippovych M, Haddad M, Dvoriak S, Altice F. Integrating methadone into primary care settings in Ukraine: effects on provider stigma and knowledge. Journal Of The International AIDS Society 2024, 27: e26202. PMID: 38379179, PMCID: PMC10879646, DOI: 10.1002/jia2.26202.Peer-Reviewed Original ResearchConceptsPrimary care clinicsStigma reduction interventionsOpioid agonist therapyClinicians' attitudesStigma constructsHIV preventionReduction interventionsEvidence-based HIV preventionCluster randomized controlled trialEvidence-based carePrimary care settingIntegrated care sitesDirect providersRandomized controlled trialsProvider stigmaCare clinicsCare sitesHIV careCare settingsHealth outcomesClinical staffSubstance use disordersLinear mixed-effects modelsTreatment continuumImprove attitudes
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