2025
Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making
Wang H, Ortega H, Kelly E, Indajang J, Savalia N, Glaeser-Khan S, Feng J, Li Y, Kaye A, Kwan A. Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making. Science Advances 2025, 11: eadr9916. PMID: 40138407, PMCID: PMC11939063, DOI: 10.1126/sciadv.adr9916.Peer-Reviewed Original ResearchConceptsNeuromodulatory signalsCompetitive decision-makingCholinergic transientsNE signalingPremotor cortexAnimal's propensityBehavioral correlatesAcetylcholine signalingMatching pennies gamePattern of NEBehavioral eventsNorepinephrineCortexDecision-makingAcetylcholinePremotorFunctional relevanceOptogeneticsBrain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors
Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors. Translational Psychiatry 2025, 15: 61. PMID: 39979292, PMCID: PMC11842717, DOI: 10.1038/s41398-025-03288-5.Peer-Reviewed Original ResearchConceptsImaging-derived phenotypesBrain imaging-derived phenotypesAlcohol drinkingBrain structuresProcessing of social cuesCorrelates of smoking behaviorRelationship of brain structureSequencing Consortium of AlcoholGlobal genetic correlationsSmoking behaviorSuperior longitudinal fasciculusAssociated with smoking initiationTobacco smokeTobacco smoking behaviorLatent causal variable approachesNicotine useBrain regionsPremotor cortexSocial cuesWhite matter hyperintensitiesLongitudinal fasciculusChemosensory processingCortical thicknessMendelian randomizationPleiotropic mechanisms
2024
Non-dominant, Lesional Frontal Lobe Epilepsy Involving the Prefrontal Cortex
Herlopian A. Non-dominant, Lesional Frontal Lobe Epilepsy Involving the Prefrontal Cortex. 2024, 189-220. DOI: 10.1007/978-3-031-23828-4_10.Peer-Reviewed Original Research
2022
Child Neurology: Functional Reorganization Mediating Supplementary Motor Area Syndrome Recovery in Agenesis of the Corpus Callosum
Obaid S, Qureshi HM, Aljishi A, Shaikh N, Kundishora AJ, Bronen RA, DiLuna M, Damisah E. Child Neurology: Functional Reorganization Mediating Supplementary Motor Area Syndrome Recovery in Agenesis of the Corpus Callosum. Neurology 2022, 99: 161-165. PMID: 35618432, PMCID: PMC9421776, DOI: 10.1212/wnl.0000000000200772.Peer-Reviewed Case Reports and Technical NotesConceptsSMA syndromeFunctional recoveryCorpus callosumSupplementary motor area syndromeCorpus callosal fibersLow-grade gliomasMedial premotor cortexFunctional neuroimaging featuresSurgical resectionClinical presentationHealthy hemisphereTranscallosal fibersAcallosal patientsNeuroimaging featuresPreoperative fMRIParacentral lobuleLeft toePremotor cortexCallosal fibersPatientsSyndromeComplete ACCExact mechanismAgenesisCallosumAcute cannabis-related alterations in an fMRI time estimation task
Patel K, Stevens M, Adhikari S, Book G, Mubeen M, Pearlson G. Acute cannabis-related alterations in an fMRI time estimation task. 2022 DOI: 10.26828/cannabis.2022.02.000.26.Peer-Reviewed Original ResearchMedial temporal cortexPosterior cingulate cortexSomatosensory motor cortexPremotor cortexMotor cortexTemporal cortexMedial prefrontal cortexCingulate cortexFrontal cortexLong-duration stimuliAnterior cingulateInferior frontal cortexVisual cortexBrain activation differencesMultiple comparison correctionPlacebo conditionActivation differencesDuration stimuliPrefrontal cortexVisual areasOccipital junctionDose-related mannerMid-cingulate cortexSignificant activation differencesPopular recreational drug
2021
Frequency-specific network activity predicts bradykinesia severity in Parkinson’s disease
Muthuraman M, Palotai M, Jávor-Duray B, Kelemen A, Koirala N, Halász L, Erőss L, Fekete G, Bognár L, Deuschl G, Tamás G. Frequency-specific network activity predicts bradykinesia severity in Parkinson’s disease. NeuroImage Clinical 2021, 32: 102857. PMID: 34662779, PMCID: PMC8526781, DOI: 10.1016/j.nicl.2021.102857.Peer-Reviewed Original ResearchConceptsSlope of changeContralateral stimulationPremotor cortexParkinson's diseasePrimary motorPresent cross-sectional studyBasal ganglia-thalamoBilateral subthalamic stimulationCross-sectional studyHigh beta frequency bandBeta frequency bandsParkinsonian patientsSubthalamic stimulationContralateral sideScreening periodSubthalamic nucleusBradykinesia severityCortical circuitsGamma frequency bandBradykinesiaDiseaseHigh-gamma frequency bandStimulation levelsStimulationCortexThe adhesio interthalamica as a neuroanatomical marker of structural differences in healthy adult population
Miró-Padilla A, Adrián-Ventura J, Costumero V, Palomar-García M, Villar-Rodríguez E, Marin-Marin L, Aguirre N, Bueichekú E. The adhesio interthalamica as a neuroanatomical marker of structural differences in healthy adult population. Brain Structure And Function 2021, 226: 1871-1878. PMID: 34014400, DOI: 10.1007/s00429-021-02297-6.Peer-Reviewed Original ResearchConceptsAdhesio interthalamicaAssociated with lower GM volumeInferior frontal gyrusAI brainAnterior temporal cortexMRI scanning sessionsWhole-brain gray matterLower GM volumeGray matterGroup comparison analysisMidline brain structuresHealthy human adultsFrontal gyrusNeuroanatomical profileNeuroanatomical markersGM volumeTemporal cortexPremotor cortexBrain processesBrain structuresRight thalamusVolumetric differencesScanning sessionNeuroscience researchAnatomical profile
2019
Corticospinal Tract Injury Estimated From Acute Stroke Imaging Predicts Upper Extremity Motor Recovery After Stroke
Lin D, Cloutier A, Erler K, Cassidy J, Snider S, Ranford J, Parlman K, Giatsidis F, Burke J, Schwamm L, Finklestein S, Hochberg L, Cramer S. Corticospinal Tract Injury Estimated From Acute Stroke Imaging Predicts Upper Extremity Motor Recovery After Stroke. Stroke 2019, 50: 3569-3577. PMID: 31648631, PMCID: PMC6878199, DOI: 10.1161/strokeaha.119.025898.Peer-Reviewed Original ResearchConceptsUpper extremity motor recoveryAcute stroke hospitalizationCST injuryMotor recoveryCorticospinal tractStroke hospitalizationsPremotor cortexPrimary motorUpper extremity Fugl-MeyerAcute Stroke ImagingAcute stroke workupUpper extremity weaknessUpper extremity recoveryCorticospinal tract injuryExtent of injuryStroke standardsExtremity weaknessStroke workupTract injuryIschemic strokeFugl-MeyerInitial impairmentPredictive valueInjuryStroke imaging
2018
Cerebello-cortical network fingerprints differ between essential, Parkinson’s and mimicked tremors
Muthuraman M, Raethjen J, Koirala N, Anwar A, Mideksa K, Elble R, Groppa S, Deuschl G. Cerebello-cortical network fingerprints differ between essential, Parkinson’s and mimicked tremors. Brain 2018, 141: 1770-1781. PMID: 29701820, DOI: 10.1093/brain/awy098.Peer-Reviewed Original ResearchConceptsEssential tremorSensorimotor cortexCerebral cortexHealthy controlsPremotor cortexParkinson's diseaseVoluntary rhythmic movementsPrimary sensorimotor cortexSex-matched groupPrimary sensorimotor regionsEEG-EMG coherenceMotor performance measuresParkinson's tremorEMG oscillationsCortical efferentsSensorimotor regionsCerebellar involvementTremor severityFunctional MRICortexCerebellumDiseaseAdditional studiesTremorMulti-channel EMG
2016
Modulation of Functional Connectivity in Auditory-Motor Networks in Musicians Compared with Nonmusicians.
Palomar-García M, Zatorre R, Ventura-Campos N, Bueichekú E, Ávila C. Modulation of Functional Connectivity in Auditory-Motor Networks in Musicians Compared with Nonmusicians. Cerebral Cortex 2016, 27: 2768-2778. PMID: 27166170, DOI: 10.1093/cercor/bhw120.Peer-Reviewed Original ResearchConceptsMusical trainingFunction of musical trainingRs-FCAuditory-motor networkFunctional connectivityMusiciansRight auditory cortexNonmusiciansRight ventral premotor cortexAuditory-motorModulation of functional connectivityStronger rs-FCReduced rs-FCVentral premotor cortexAnatomically distinct brain areasAuditory cortexInvestigate functional connectivityFunctional brain featuresMotor systemAuditory areasBrain areasPremotor cortexYears of practiceBrain featuresCognitive biasesIpsilesional anodal tDCS enhances the functional benefits of rehabilitation in patients after stroke
Allman C, Amadi U, Winkler A, Wilkins L, Filippini N, Kischka U, Stagg C, Johansen-Berg H. Ipsilesional anodal tDCS enhances the functional benefits of rehabilitation in patients after stroke. Science Translational Medicine 2016, 8: 330re1. PMID: 27089207, PMCID: PMC5388180, DOI: 10.1126/scitranslmed.aad5651.Peer-Reviewed Original ResearchConceptsAnodal transcranial direct current stimulationTranscranial direct current stimulationAction Research Arm TestWolf Motor Function TestMagnetic resonance imagingMotor trainingPremotor cortexIpsilesional motorSham treatmentFunctional magnetic resonance imagingUpper extremity Fugl-Meyer scoreDaily motor trainingLong-term clinical outcomesAnodal tDCS groupFirst unilateral strokeDirect current stimulationIntervention-related increasesFugl-Meyer scoreSham treatment groupMotor Function TestMotor training programPrimary motor cortexStructural magnetic resonance imagingGray matter volumeMotor learning
2015
Brain structural correlates of sensory phenomena in patients with obsessive–compulsive disorder
Subirà M, Sato J, Alonso P, do Rosário M, Segalàs C, Batistuzzo M, Real E, Lopes A, Cerrillo E, Diniz J, Pujol J, Assis R, Menchón J, Shavitt R, Busatto G, Cardoner N, Miguel E, Hoexter M, Soriano-Mas C. Brain structural correlates of sensory phenomena in patients with obsessive–compulsive disorder. Journal Of Psychiatry And Neuroscience 2015, 40: 232-240. PMID: 25652753, PMCID: PMC4478056, DOI: 10.1503/jpn.140118.Peer-Reviewed Original ResearchConceptsGray matter volume increasesObsessive-compulsive disorderSensorimotor cortexHealthy controlsSensory phenomenaGray matter volume differencesLeft sensorimotor cortexStructural correlatesBrain structural correlatesVoxel-based morphometryMagnetic resonance examinationMost patientsSuch patientsTic onsetCortex abnormalitiesTic disordersPremotor cortexPatientsResonance examinationVolume increaseSpecialized unitsCortexParticipant recruitmentDisorders StudyDifferent centers
2013
Oxytocin enhances brain function in children with autism
Gordon I, Vander Wyk B, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA, Zagoory-Sharon O, Leckman JF, Feldman R, Pelphrey KA. Oxytocin enhances brain function in children with autism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 20953-20958. PMID: 24297883, PMCID: PMC3876263, DOI: 10.1073/pnas.1312857110.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSuperior temporal sulcusTemporal sulcusOrbitofrontal cortexLeft superior temporal sulcusMiddle frontal gyrusMedial prefrontal cortexRight orbitofrontal cortexSocial attunementSocial judgmentsMeaningful stimuliFrontal gyrusSpectrum disorderBrain activityPrefrontal cortexRight amygdalaSocial functioningFunctional MRIPremotor cortexHedonic evaluationBrain functionJudgmentsCortexChildrenOxytocin
2007
Functional neural networks underlying response inhibition in adolescents and adults
Stevens MC, Kiehl KA, Pearlson GD, Calhoun VD. Functional neural networks underlying response inhibition in adolescents and adults. Behavioural Brain Research 2007, 181: 12-22. PMID: 17467816, PMCID: PMC2266817, DOI: 10.1016/j.bbr.2007.03.023.Peer-Reviewed Original ResearchConceptsResponse inhibition circuitsBehavioral performance changesBrain hemodynamic activityResponse inhibitionFronto-striatal regionsThalamic modulationThalamic connectivityAge-related differencesPremotor cortexHealthy adolescentsGo/No-Go taskNeural circuitsHemodynamic activityEffective connectivity analysisInhibition circuitAdultsFunctional neural networksResponse suppressionAdolescentsConnectivity analysisFirst descriptionInhibitionNetwork engagementSeparate conflict-specific cognitive control mechanisms in the human brain
Egner T, Delano M, Hirsch J. Separate conflict-specific cognitive control mechanisms in the human brain. NeuroImage 2007, 35: 940-948. PMID: 17276088, DOI: 10.1016/j.neuroimage.2006.11.061.Peer-Reviewed Original ResearchConceptsIrrelevant stimulus featuresCognitive controlStimulus featuresModulation of activityColor-naming Stroop taskCognitive control mechanismsCognitive control systemOptimal task performanceHuman brainLevel-dependent responsesContext-sensitive mannerStroop taskResolution of stimuliStimulus representationsTask performanceParietal cortexMotor programmingPremotor cortexInformation processingControl resourcesConflict resolutionSource of conflictResolution strategiesStimuliCentral resource
2005
Responsivity to food stimuli in obese and lean binge eaters using functional MRI
Geliebter A, Ladell T, Logan M, Schweider T, Sharafi M, Hirsch J. Responsivity to food stimuli in obese and lean binge eaters using functional MRI. Appetite 2005, 46: 31-35. PMID: 16364498, DOI: 10.1016/j.appet.2005.09.002.Peer-Reviewed Original ResearchConceptsObese binge eatersBinge eatersAuditory stimuliFood stimuliNon-food stimuliRandom effects group analysisVentral premotor cortexRight premotor areaNon-binge eatersBinge foodsRight-handed womanFMRI scannerConcurrent motorFunctional neuroimagingFunctional MRIPremotor cortexPremotor areasBrain areasStimuliMotor behaviorEatersType foodsIndividual subjectsGroup analysisBinge
2002
Detection of functional connectivity using temporal correlations in MR images
Hampson M, Peterson BS, Skudlarski P, Gatenby JC, Gore JC. Detection of functional connectivity using temporal correlations in MR images. Human Brain Mapping 2002, 15: 247-262. PMID: 11835612, PMCID: PMC6872035, DOI: 10.1002/hbm.10022.Peer-Reviewed Original Research
1999
A large-scale distributed network for covert spatial attention
Gitelman D, Nobre A, Parrish T, LaBar K, Kim Y, Meyer J, Mesulam M. A large-scale distributed network for covert spatial attention. Brain 1999, 122: 1093-1106. PMID: 10356062, DOI: 10.1093/brain/122.6.1093.Peer-Reviewed Original ResearchConceptsSpatial attention taskSpatial attentionAttention taskParietal cortexInhibition of eye movementsTemporo-occipital activationTemporo-occipital cortexLateral premotor cortexRight parietal cortexPosterior parietal cortexTemporo-occipital areasCovert spatial attentionCognitive controlAnterior insulaWorking memoryCingulate cortexRight hemisphereAttention shiftsSubcortical activityPremotor cortexFunctional MRIAttentional focusExperimental tasksCerebral activityBasal ganglia
1997
Suppression of Task-Related Saccades by Electrical Stimulation in the Primate's Frontal Eye Field
Burman D, Bruce C. Suppression of Task-Related Saccades by Electrical Stimulation in the Primate's Frontal Eye Field. Journal Of Neurophysiology 1997, 77: 2252-2267. PMID: 9163356, DOI: 10.1152/jn.1997.77.5.2252.Peer-Reviewed Original ResearchConceptsFrontal eye fieldPrimate frontal eye fieldSaccadic eye movementsElectrical stimulationEye fieldFEF sitesFoveal receptive fieldsSuppression of saccadesLow-intensity stimulationEye movementsCentral fixation targetMemory-guided saccadesAppropriate saccadeCortex anteriorFEF projectionsContraversive saccadesAnterior bankIntracortical microstimulationStimulation trialsPremotor cortexEvidence of suppressionReflexive saccadesMacaque monkeysSubcortical regionsFrontal lobe damageFunctional localization of the system for visuospatial attention using positron emission tomography.
Nobre A, Sebestyen G, Gitelman D, Mesulam M, Frackowiak R, Frith C. Functional localization of the system for visuospatial attention using positron emission tomography. Brain 1997, 120: 515-533. PMID: 9126062, DOI: 10.1093/brain/120.3.515.Peer-Reviewed Original ResearchConceptsShifts of attentionVisuospatial attentionAttention taskNeural systemsRight anterior cingulate gyrusCovert shifts of attentionPatterns of neural activityRight posterior parietal cortexAnterior cingulate gyrusLateral premotor cortexPosterior parietal cortexIndividual-subject levelRegional functional specializationIntraparietal sulcusCingulate gyrusParietal cortexTarget stimuliAttention conditionCovert shiftsPremotor cortexPeripheral cuesCortical regionsSpatial attentionNeural activityBehavioral studies
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply