2025
Issues in Clinical Trial Design—Lessons From the FDA’s Rejection of MDMA
Wilkinson S, Sanacora G. Issues in Clinical Trial Design—Lessons From the FDA’s Rejection of MDMA. JAMA Psychiatry 2025, 82: 545-546. PMID: 40238126, DOI: 10.1001/jamapsychiatry.2025.0442.Peer-Reviewed Original ResearchPsychological Distress and Cognitive Function in Women: Exploring Potential Mediation by Use of Opiates, Sleep Aids, or Minor Tranquilizers
Sampson L, Lawn R, Murchland A, Liu J, Marquez C, Scoglio A, Jha S, Sumner J, Roberts A, Kang J, Chibnik L, Koenen K, Kubzansky L. Psychological Distress and Cognitive Function in Women: Exploring Potential Mediation by Use of Opiates, Sleep Aids, or Minor Tranquilizers. Journal Of Women's Health 2025 PMID: 40336460, DOI: 10.1089/jwh.2024.0991.Peer-Reviewed Original ResearchPosttraumatic stress disorderCognitive functionMedication useMinor tranquilizersMeasures of posttraumatic stress disorderNurses' Health Study IIAssociated with lower cognitive functionCogstate Brief BatterySleep aidsEvidence of mediationLower cognitive functionLearning/working memoryBrief batteryStress disorderPsychomotor speed/attentionAssociated with useDistress scoresHigh distressMediation analysisPsychological distressLinear regression modelsPotential mediatorsSelf-reportAssessed associationsDepressionPictorial representation of illness and self measure (PRISM): A putative transdiagnostic tool for evaluating therapeutic effects of psychedelic treatments
Pouyan N, Aday J, Harte S, Kaplan C, Williams D, Glynos N, Herberholz M, Kruger D, Barron J, Mashour G, Clauw D, Preller K, Schrepf A, Boehnke K. Pictorial representation of illness and self measure (PRISM): A putative transdiagnostic tool for evaluating therapeutic effects of psychedelic treatments. Journal Of Psychopharmacology 2025, 39: 489-498. PMID: 40323119, DOI: 10.1177/02698811251330763.Peer-Reviewed Original ResearchConceptsNaturalistic psychedelic usePsychedelic useSymptom changeSymptom improvementAssociated with symptom improvementEffects of psychedelicsPosttraumatic stress disorderIndividual perceptions of selfPerceptions of selfPRISM scoreRepresentations of illnessPsychedelic treatmentStress disorderGlobal ImpressionPsychedelic experiencePictorial representationPictorial Representation of IllnessRetrospective reportsSelf-perceptionReduced identificationChange scoresRetrospectively assessed changesPGIC scoresPatient Global ImpressionConvenience sampleComorbid Chronic Pain and Posttraumatic Stress Disorder Among Veterans: Approaches to Care
Pratt A, Van Tiem J, Lund B, Johnson N, Steffensmeier K, Ball D, Thomas E, Mengeling M, Norman S, Driscoll M, Garvin L, Hart K, Hadlandsmyth K. Comorbid Chronic Pain and Posttraumatic Stress Disorder Among Veterans: Approaches to Care. Military Medicine 2025, usaf118. PMID: 40215123, DOI: 10.1093/milmed/usaf118.Peer-Reviewed Original ResearchComorbid chronic painChronic painMental health service linesVeterans AdministrationQualitative interviewsOptimize care coordinationVA administrative dataService linesClinical settingAdministrative data analysisQualitative interview participantsCare coordinationIdentified barriersCombined careHealth careMental healthInterview participantsAdministrative dataPosttraumatic stress disorderVeteransCareVisitsParticipantsStress disorderPainCombining Ketamine Infusions and Written Exposure Therapy for Chronic PTSD: An Open-Label Trial.
Feder A, Brown O, Rutter S, Cahn L, Overbey J, Seeley S, Yu A, Bonanno P, Fremont R, Delgado A, Jha M, Costi S, Yehuda R, Schiller D, Pietrzak R, Charney D, Sloan D, Murrough J. Combining Ketamine Infusions and Written Exposure Therapy for Chronic PTSD: An Open-Label Trial. The Journal Of Clinical Psychiatry 2025, 86 PMID: 40215385, DOI: 10.4088/jcp.24m15622.Peer-Reviewed Original ResearchConceptsChronic posttraumatic stress disorderPosttraumatic stress disorderKetamine infusionPosttraumatic stress disorder symptom severityClinician-Administered PTSD ScalePosttraumatic stress disorder symptomsDSM-5</i>Written exposure therapyOpen-label clinical trialIntravenous ketamine infusionSevere symptom levelsPTSD ScaleCAPS-5Exposure therapyStress disorderOpen-label trialSymptom levelsSymptom severityTreatment respondersPreliminary efficacyClinical trialsPreliminary findingsCombined treatmentLarge-scale randomized controlled trialsRandomized controlled trialsAssociation of psychiatric diagnoses and military sexual trauma type with denied posttraumatic stress disorder service connection
Webermann A, Coppola E, Lazar C, Rosen M, Murdoch M, Portnoy G, Black A. Association of psychiatric diagnoses and military sexual trauma type with denied posttraumatic stress disorder service connection. Journal Of Affective Disorders 2025, 381: 69-76. PMID: 40185410, DOI: 10.1016/j.jad.2025.03.171.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderMilitary sexual traumaPTSD service connectionPsychiatric diagnosisPosttraumatic stress disorder diagnostic criteriaDiagnosis of personality disorderPosttraumatic stress disorder symptomsPosttraumatic stress disorder diagnosisAssociation of psychiatric diagnosesSchizophrenia spectrum disordersSubstance use disordersPersonality disorderAnxiety disordersNon-PTSDStress disorderBipolar disorderTrauma typesSexual traumaSpectrum disorderSexual assault claimsDisordersService connectionVeteransDiagnostic criteriaSexual harassment claimsExperiential avoidance in depression, anxiety, obsessive–compulsive related, and posttraumatic stress disorders: A comprehensive systematic review and meta-analysis
Shahar G. Experiential avoidance in depression, anxiety, obsessive–compulsive related, and posttraumatic stress disorders: A comprehensive systematic review and meta-analysis. Psychoanalytic Psychology 2025, 42: 123-127. DOI: 10.1037/pap0000533.Peer-Reviewed Original ResearchAssociation of Psychological Resilience With Decelerated Brain Aging in Cognitively Healthy World Trade Center Responders
Seeley S, Fremont R, Schreiber Z, Morris L, Cahn L, Murrough J, Schiller D, Charney D, Pietrzak R, Perez-Rodriguez M, Feder A. Association of Psychological Resilience With Decelerated Brain Aging in Cognitively Healthy World Trade Center Responders. Biological Psychiatry Global Open Science 2025, 5: 100489. PMID: 40487784, PMCID: PMC12143172, DOI: 10.1016/j.bpsgos.2025.100489.Peer-Reviewed Original ResearchPosttraumatic stress disorderWorld Trade Center respondersBrain agingLifetime psychopathologyPsychological resilienceResilient groupPosttraumatic stress disorder groupStructural magnetic resonance imagingLong-term psychopathologyFunctional MRI studiesBrain age gapLower emotional suppressionAbsence of cognitive impairmentT1-weighted MRI dataMagnetic resonance imagingChronological ageHigh resilience groupWorld Trade CenterPTSD groupVerbal learningStress disorderCognitive measuresEmotional suppressionTraumatic stressorsGroup differencesIntegration of Metabolomic and Brain Imaging Data Highlights Pleiotropy Among Posttraumatic Stress Disorder, Glycoprotein Acetyls, and Pallidum Structure
Løkhammer S, Tesfaye M, Cabrera-Mendoza B, Sandås K, Pathak G, Friligkou E, Le Hellard S, Polimanti R. Integration of Metabolomic and Brain Imaging Data Highlights Pleiotropy Among Posttraumatic Stress Disorder, Glycoprotein Acetyls, and Pallidum Structure. Biological Psychiatry Global Open Science 2025, 5: 100482. PMID: 40270839, PMCID: PMC12013147, DOI: 10.1016/j.bpsgos.2025.100482.Peer-Reviewed Original ResearchPosttraumatic stress disorderLocal genetic correlationImaging-derived phenotypesBrain imaging-derived phenotypesStress disorderAssociated with posttraumatic stress disorderDevelopment of posttraumatic stress disorderExposure to severe traumatic eventsGenetic correlationsGenome-wide dataSevere traumatic eventsBrain frontal cortexBrain imaging markersFrontal cortexLeft pallidumMap genesGenetic regionsGlycoprotein acetylsTraumatic eventsMetabolic biomarkersGenetic relationshipsTranscriptome regulationGenetic overlapStress responseMetabolic processesDiagnostic accuracy and psychometric performance of two self‐report measures of posttraumatic stress disorder in older veterans
Cook J, Pietrzak R, Kimerling R, Schnurr P, Bovin M. Diagnostic accuracy and psychometric performance of two self‐report measures of posttraumatic stress disorder in older veterans. Journal Of Traumatic Stress 2025 PMID: 40097911, DOI: 10.1002/jts.23154.Peer-Reviewed Original ResearchPosttraumatic stress disorderPC-PTSD-5DSM-5PCL-5Stress disorderSelf-report measures of posttraumatic stress disorderMeasures of posttraumatic stress disorderOlder veteransPsychometric propertiesPosttraumatic Stress Disorder ChecklistPosttraumatic stress disorder prevalencePrimary Care PTSD ScreenSelf-report measuresSample of veteransOptimal cutoff scoreU.S. Department of Veterans AffairsPTSD screenCutoff scoreDepartment of Veterans AffairsYounger veteransPsychometric performanceTested PSVeteransOlder adultsPrimary care servicesPhysical health correlates of co-occurring chronic pain and PTSD Among U.S. Veterans: Results from a nationally representative study
Reed D, Fischer I, Williams R, Na P, Engel C, Pietrzak R. Physical health correlates of co-occurring chronic pain and PTSD Among U.S. Veterans: Results from a nationally representative study. Psychiatry Research 2025, 348: 116440. PMID: 40088518, DOI: 10.1016/j.psychres.2025.116440.Peer-Reviewed Original ResearchConceptsPhysical health conditionsCo-occurring chronic painPosttraumatic stress disorderHealth conditionsChronic painU.S. veteransNational Health and ResilienceNon-Hispanic whitesMental health concernsPhysical health correlatesPosttraumatic Stress Disorder ChecklistPosttraumatic stress disorder diagnosisU.S. veteran populationNationally representative samplePhysical functionLogistic regression analysisPsychosocial burdenVeterans StudyVeteran populationSelf-reportDSM-5Representative sampleStress disorderVeteransHealth concernConnectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience networkTrauma and related measures one year after the 2023 earthquakes in Türkiye: post-traumatic stress, post-traumatic growth, spiritual well-being, and self-compassion
Kartol A, Üztemur S, Chen C, Lin C, Gökalp A, Potenza M, Pakpour A. Trauma and related measures one year after the 2023 earthquakes in Türkiye: post-traumatic stress, post-traumatic growth, spiritual well-being, and self-compassion. Current Psychology 2025, 44: 5033-5043. DOI: 10.1007/s12144-025-07563-y.Peer-Reviewed Original ResearchPosttraumatic stress disorderPromote post-traumatic growthSelf-compassionPost-traumatic growthReducing posttraumatic stress disorderPosttraumatic stress disorder symptomsSpiritual well-beingLevels of self-compassionPosttraumatic stress disorder scoreWell-beingPost-traumatic stressMental health professionalsAdverse effects of traumaEffects of traumaAdverse psychological effectsStress disorderTraumatic eventsEarthquake-related traumaEarthquake survivorsPsychological effectsTraumatic effectsHealth professionalsIndividualsHealthy wayTraumaObservational and Genetic Analyses of Traumatic Experiences and Endometriosis
Koller D, Løkhammer S, Goroshchuk O, Denner V, Stiltner B, Mitjans M, He J, Taylor H, Lawn R, Koenen K, Polimanti R. Observational and Genetic Analyses of Traumatic Experiences and Endometriosis. JAMA Psychiatry 2025, 82: 386-394. PMID: 39908042, PMCID: PMC11800128, DOI: 10.1001/jamapsychiatry.2024.4694.Peer-Reviewed Original ResearchPolygenic risk scoresLatent class analysisAssociated with increased oddsTraumatic experiencesImpact of childhoodIndividual-level dataCase-control studyStressful eventsGenetic predispositionTrauma-related outcomesUnaffected womenMain OutcomesFinnGen cohortRisk scoreAssociation of endometriosisPosttraumatic stress disorderTrauma eventsMeta-analysisSexual traumaAssociated with endometriosisContact traumaPotential associationStress disorderPsychological traumaPhenotypic associationsPosttraumatic stress disorder and eating disorders: maintaining mechanisms and treatment targets
Mitchell K, Scioli E, Galovski T, Belfer P, Cooper Z. Posttraumatic stress disorder and eating disorders: maintaining mechanisms and treatment targets. 2025, 95-109. DOI: 10.4324/9781003607403-10.Peer-Reviewed Original ResearchPosttraumatic stress disorderStress disorderComorbid posttraumatic stress disorderPosttraumatic stress disorder symptomsExposure to interpersonal traumaCognitive behavioral theoryHistory of eating disordersLow self-worthEvidence-based treatmentsEmotion dysregulationHyperarousal symptomsInterpersonal traumaBinge eatingTrauma exposureED behaviorsLifetime historyEating disordersSelf-criticismSelf-worthEvidence-based therapiesTreatment of EDCoping strategiesBidirectional relationshipTreatment targetDisordersCorrelates of Impaired Sleep Duration Among Adults With Trauma Alone and With Posttraumatic Stress Disorder
Havlik J, Rhee T, Rosenheck R. Correlates of Impaired Sleep Duration Among Adults With Trauma Alone and With Posttraumatic Stress Disorder. Psychological Trauma Theory Research Practice And Policy 2025 PMID: 39836166, DOI: 10.1037/tra0001846.Peer-Reviewed Original ResearchImpaired sleep durationStress disorderSleep durationEffect sizePosttraumatic stress disorderClinically meaningful effect sizesNational Epidemiologic SurveyMeaningful effect sizesPsychiatric multimorbidityPTSDTrauma/PTSDImprove treatment outcomesMedical comorbiditySleep disturbanceImpaired sleepBehavioral variablesTreatment outcomesAllostatic loadNationally representative sampleAdjusted multivariable regressionEpidemiological surveyDisordersBody mass indexRepresentative sampleSleepA genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases
Lukas E, Veeneman R, Smit D, Ahluwalia T, Vermeulen J, Pathak G, Polimanti R, Verweij K, Treur J. A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases. Translational Psychiatry 2025, 15: 1. PMID: 39755697, PMCID: PMC11700205, DOI: 10.1038/s41398-024-03197-z.Peer-Reviewed Original ResearchPosttraumatic stress disorderMendelian randomizationCardiovascular diseaseCausal pathwaysData of genome-wide association studiesGenetic liabilityMultivariable Mendelian randomizationWaist-to-hip ratioPotential mediatorsWaist-to-hipRisk of cardiovascular diseaseGenome-wide association studiesPotential causal pathwaysPrevent cardiovascular diseaseStress disorderIncreased risk of cardiovascular diseaseGenomic structural equationSignificant genetic correlationsPsychosocial factorsEffects of posttraumatic stress disorderAssociation studiesIncreased riskPosttraumatic stress disorder patientsCausal effectsTraumatic eventsChapter 20 Neuroglia in anxiety disorders
Bonomi R, Pietrzak R, Cosgrove K. Chapter 20 Neuroglia in anxiety disorders. Handbook Of Clinical Neurology 2025, 210: 335-346. PMID: 40148054, DOI: 10.1016/b978-0-443-19102-2.00008-9.Peer-Reviewed Original ResearchConceptsAnxiety disordersPathology of anxiety disordersDebilitating anxiety disorderPosttraumatic stress disorderPathophysiology of PTSDTarget of treatmentStress disorderNeurobiological perspectivePTSDAnxietyGlial cellsHypothesized mechanismsDisordersCell typesIllnessNeuronal signalingNovel treatmentPrecision treatmentPathophysiologyPharmacological developmentNeurobiology
2024
MDMA and MDMA-Assisted Therapy
Wolfgang A, Fonzo G, Gray J, Krystal J, Grzenda A, Widge A, Kraguljac N, McDonald W, Rodriguez C, Nemeroff C. MDMA and MDMA-Assisted Therapy. American Journal Of Psychiatry 2024, 182: 79-103. PMID: 39741438, DOI: 10.1176/appi.ajp.20230681.Peer-Reviewed Original ResearchConceptsMDMA-assisted therapyPosttraumatic stress disorderControlled clinical settingRecreational useMDMA administrationNeurobiological mechanismsStress disorderEgo functionsSelf-compassionMDMAEfficacious treatmentPreliminary evidenceHeightened trustTherapeutic settingNonclinical settingsDiagnostic criteriaFood and Drug AdministrationBreakthrough therapiesClinical settingNonmedical settingsConsiderable bodyPsychotherapyPsychedelicsLong-term follow-upDrug AdministrationVoice hearing in young people with posttraumatic stress disorder (PTSD) following multiple trauma exposure
Lofthouse K, Beeson E, Dalgleish T, Danese A, Hodgekins J, Mahoney-Davies G, Smith P, Stallard P, Wilson J, Meiser-Stedman R. Voice hearing in young people with posttraumatic stress disorder (PTSD) following multiple trauma exposure. European Journal Of Psychotraumatology 2024, 15: 2435790. PMID: 39691055, PMCID: PMC11656750, DOI: 10.1080/20008066.2024.2435790.Peer-Reviewed Original ResearchConceptsNegative post-traumatic cognitionsPosttraumatic stress disorderPost-traumatic cognitionsPosttraumatic stress disorder symptom severityHearing groupPrevalence of sexual traumaVoice hearingPanic symptomsSymptom severitySexual traumaSecondary analysisExposure to multiple traumatic eventsCognitive phenotype of childrenHearing voicesExposure to multiple traumasPosttraumatic stress disorder diagnosisTrauma memory qualityMental health difficultiesMethods:</b> ParticipantsMultiple traumatic eventsMultiple trauma exposuresExploratory secondary analysisCognitive-behavioral factorsPhenotype of childrenHealth difficulties
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