2025
Artificial Intelligence–Enabled Prediction of Heart Failure Risk From Single-Lead Electrocardiograms
Dhingra L, Aminorroaya A, Pedroso A, Khunte A, Sangha V, McIntyre D, Chow C, Asselbergs F, Brant L, Barreto S, Ribeiro A, Krumholz H, Oikonomou E, Khera R. Artificial Intelligence–Enabled Prediction of Heart Failure Risk From Single-Lead Electrocardiograms. JAMA Cardiology 2025, 10: 574-584. PMID: 40238120, PMCID: PMC12004248, DOI: 10.1001/jamacardio.2025.0492.Peer-Reviewed Original ResearchYale New Haven Health SystemELSA-BrasilPCP-HFNew-onset HFHarrell's C-statisticProspective population-based cohortUK Biobank (UKBBrazilian Longitudinal StudyELSA-Brasil participantsC-statisticPopulation-based cohortIntegrated discrimination improvementReclassification improvementRisk of deathUKB participantsHealth systemRetrospective cohort studyDiscrimination improvementMain OutcomesLeft ventricular systolic dysfunctionHF riskUKBCohort studySingle-lead ECGIndependent of agePsychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults
Didriksen M, Daníelsdottir H, Bjarnadóttir M, Overstreet C, Choi K, Christoffersen L, Mikkelsen C, Aspelund T, Hauksdóttir A, Thordardottir E, Jakobsdóttir J, Tómasson G, Erikstrup C, Aagaard B, Bruun M, Ullum H, Sørensen E, Fischer I, Pietrzak R, Gelernter J, Campbell-Sills L, Stein M, Werge T, Pedersen O, Valdimarsdóttir U, Ostrowski S, Schork A. Psychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults. Journal Of Mood And Anxiety Disorders 2025, 10: 100112. DOI: 10.1016/j.xjmad.2025.100112.Peer-Reviewed Original ResearchMeasures of psychological resilienceCD-RISC-10Connor-Davidson Resilience ScalePsychometric propertiesCD-RISC-10 scoresPsychological resilienceResilience ScalePopulation-based cohortExploratory factor analysisDepressive disorderDepressive symptomsLongitudinal stabilityInternal consistencyUnidimensional measureConstruct validitySocio-demographic correlatesFactor analysisPhysical healthLower scoresHigher scoresResilient cohortsDanish Blood Donor StudyIcelandic adultsDanish individualsBlood Donor StudyIs university attendance associated with differences in health service use for a mental health problem in emerging adulthood? Evidence from the ALSPAC population-based cohort
Osborn T, Saunders R, Fonagy P. Is university attendance associated with differences in health service use for a mental health problem in emerging adulthood? Evidence from the ALSPAC population-based cohort. Social Psychiatry And Psychiatric Epidemiology 2025, 1-14. PMID: 40389705, DOI: 10.1007/s00127-025-02922-3.Peer-Reviewed Original ResearchHealth service useMental health problemsAssociated with health service useService useHealth problemsAvon Longitudinal Study of ParentsMultiple imputationLongitudinal Study of ParentsAvon Longitudinal StudyMaternal education levelPopulation-based cohortStudy of ParentsRobustness of associationsLogistic regression modelsHealth servicesSTROBE guidelinesConfounder adjustmentAnalytic sampleEducation levelALSPACMental disordersAttend universityEmerging adulthoodStudy protocolHealthExploring the link between grandmaternal air pollution exposure and Grandchild’s ASD risk: A multigenerational population-based study in California
O'Sharkey K, Chow T, Mitra S, Thompson L, Su J, Cockburn M, Liew Z, Ritz B. Exploring the link between grandmaternal air pollution exposure and Grandchild’s ASD risk: A multigenerational population-based study in California. Environment International 2025, 200: 109526. PMID: 40378475, DOI: 10.1016/j.envint.2025.109526.Peer-Reviewed Original ResearchConceptsAir pollutionLand-use regression modelsExposure to air pollutionAP exposureAir pollution exposureMaternal pregnancy exposuresPopulation-based cohortPopulation-based studyMultigenerational exposurePollution exposureLand-useIncreased ASD riskPregnancy exposurePollutionASD riskInfluence ASD riskMaternal pregnancyExposure levelsInfant exposureLogistic regressionMaternal exposureRisk factorsRegression modelsIncreased prevalenceEnvironmental factorsDevelopment and Multinational Validation of an Ensemble Deep Learning Algorithm for Detecting and Predicting Structural Heart Disease Using Noisy Single-lead Electrocardiograms
Aminorroaya A, Dhingra L, Pedroso A, Shankar S, Coppi A, Khunte A, Foppa M, Brant L, Barreto S, Ribeiro A, Krumholz H, Oikonomou E, Khera R. Development and Multinational Validation of an Ensemble Deep Learning Algorithm for Detecting and Predicting Structural Heart Disease Using Noisy Single-lead Electrocardiograms. European Heart Journal - Digital Health 2025, ztaf034. DOI: 10.1093/ehjdh/ztaf034.Peer-Reviewed Original ResearchDetectable structural heart diseaseStructural heart diseaseCommunity-based screeningLeft-sided valvular diseaseHeart diseaseELSA-BrasilYale-New Haven HospitalAI-ECG algorithmDeep learning algorithmsPopulation-based cohortSevere LVHEchocardiographic dataPredictive biomarkersHospital-based sitesNew Haven HospitalRisk stratificationValvular diseaseEnsemble deep learning algorithmUK BiobankCommunity hospitalLead I ECGPolypharmacy and its association with dementia, Parkinson’s disease, and mortality risk in UK adults: a multistate modeling approach
Weiss J, Beydoun M, Georgescu M, Maldonado A, Beydoun H, Noren Hooten N, Tsai J, Song M, Nieva A, Evans M, Zonderman A. Polypharmacy and its association with dementia, Parkinson’s disease, and mortality risk in UK adults: a multistate modeling approach. GeroScience 2025, 47: 4349-4367. PMID: 40080299, PMCID: PMC12181516, DOI: 10.1007/s11357-025-01586-w.Peer-Reviewed Original ResearchConceptsHealth transitionOlder adultsCardiovascular healthLatent class analysisUK Biobank participantsRisks associated with polypharmacyHealth statesAssociated with dementiaPopulation-based cohortAssociated with higher riskYears of follow-upMedication combinationsClass analysisBiobank participantsHealth outcomesPolypharmacy statusPolypharmacy prevalenceSocioeconomic statusUK adultsMortality riskDementiaParkinson's diseasePolypharmacyHealthAdverse outcomes
2024
Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium
Kishida R, Yin X, Abe S, Rahman S, Saito E, Islam R, Lan Q, Blechter B, Rothman N, Sawada N, Tamakoshi A, Shu X, Hozawa A, Kanemura S, Kim J, Sugawara Y, Park S, Kweon S, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Zheng W, Inoue M, Kang D, Seow W. Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium. International Journal Of Cancer 2024, 156: 723-733. PMID: 39361428, PMCID: PMC11661513, DOI: 10.1002/ijc.35191.Peer-Reviewed Original ResearchFamily history of lung cancerAsia Cohort ConsortiumCohort ConsortiumLC incidenceSmoking statusFamily historyHazard ratioRisk of lung cancerIncreased risk of lung adenocarcinomaHistory of lung cancerConfidence intervalsLung cancer incidenceSignificant effect modificationEstimate hazard ratiosIncreased riskPopulation-based cohortCox proportional hazards regression modelsRisk of lung adenocarcinomaProspective cohort studyAssociated with increased riskLung cancerProportional hazards regression modelsEthnic groupsHazards regression modelsCancer incidenceCystic Phenotypes Associated with Monoallelic COL4A3/A4/A5 Pathogenic Variants Identified in a Population-Based Cohort
Sohi G, Elbarougy D, Yang H, Schauer R, McDonnell S, Frank J, Ma J, Dahl N, Hogan M, Torres V, Harris P. Cystic Phenotypes Associated with Monoallelic COL4A3/A4/A5 Pathogenic Variants Identified in a Population-Based Cohort. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.202460cgtrgd. DOI: 10.1681/asn.202460cgtrgd.Peer-Reviewed Original ResearchPopulation-based cohortPathogenic variantsOccupational exposure to benzene and risk of non‐Hodgkin lymphoma in an extended follow‐up of two population‐based prospective cohorts of Chinese men and women
Bassig B, Shu X, Friesen M, Vermeulen R, Purdue M, Ji B, Yang G, Wong J, Appel N, Hu W, Gao Y, Zheng W, Rothman N, Lan Q. Occupational exposure to benzene and risk of non‐Hodgkin lymphoma in an extended follow‐up of two population‐based prospective cohorts of Chinese men and women. International Journal Of Cancer 2024, 155: 2159-2168. PMID: 39221990, DOI: 10.1002/ijc.35095.Peer-Reviewed Original ResearchNon-Hodgkin's lymphomaRisk of non-Hodgkin lymphomaPopulation-based cohortCumulative exposurePopulation-based prospective cohortOccupational benzene exposurePooled analysisFollow-upAssociated with non-Hodgkin lymphomaChronic lymphocytic leukemia subtypesNon-Hodgkin lymphoma riskAssociated with NHL riskPopulation-based cohort of menLifetime cumulative exposureInternational Agency for Research on CancerCox proportional hazards modelsCumulative exposure estimatesCohort of menProportional hazards modelInconclusive associationsNHL riskExposure-response relationshipProspective cohortElevated riskSignificant exposure-responseOccupational Benzene Exposure and Cancer Risk among Chinese Men: A Report from the Shanghai Men's Health Study.
DeMoulin D, Cai H, Vermeulen R, Zheng W, Lipworth L, Shu X. Occupational Benzene Exposure and Cancer Risk among Chinese Men: A Report from the Shanghai Men's Health Study. Cancer Epidemiology Biomarkers & Prevention 2024, 33: 1465-1474. PMID: 39145717, PMCID: PMC11530315, DOI: 10.1158/1055-9965.epi-24-0325.Peer-Reviewed Original ResearchConceptsRisk of leukemiaIncreased risk of leukemiaCancer riskStomach cancerShanghai Men's Health StudyAssociated with increased risk of leukemiaCancer associationAlcohol consumptionOccupational benzene exposureConfidence intervalsMen's Health StudyIncreased riskPopulation-based cohortJob-exposure matrixCumulative benzene exposureAssociated with increased riskMitigate cancer riskYears of follow-upKidney cancerLinear dose-response patternDose-response patternHealth StudyPotential confoundersBenzene exposureRisk associationEffectiveness of the fourth dose of COVID-19 vaccines against severe COVID-19 among adults 40 years or older in Brazil: a population-based cohort study
Neto F, Hitchings M, Amin A, de França G, Lind M, Torres M, Tsuha D, de Oliveira R, Cummings D, Dean N, Andrews J, Ko A, Croda J, Ranzani O. Effectiveness of the fourth dose of COVID-19 vaccines against severe COVID-19 among adults 40 years or older in Brazil: a population-based cohort study. The Lancet Regional Health - Americas 2024, 34: 100755. PMID: 38737773, PMCID: PMC11087726, DOI: 10.1016/j.lana.2024.100755.Peer-Reviewed Original ResearchSevere COVID-19Cohort ACohort B.Cohort BTwo-doseMRNA vaccinesPrimary outcomeBooster dose effectivenessCOVID-19 outcomesPopulation-based cohort studyDose of COVID-19 vaccinePopulation-based cohortPopulation-based cohort of individualsCOVID-19 vaccine dosesSevere COVID-19 outcomesFollow-upCohort studyMRNA-basedVaccine doseCohort of individualsVaccine effectivenessVaccine combinationsDoseLower hazardCohortSex-specific associations of environmental exposures with prevalent diabetes and obesity – Results from the KORA Fit study
Niedermayer F, Wolf K, Zhang S, Dallavalle M, Nikolaou N, Schwettmann L, Selsam P, Hoffmann B, Schneider A, Peters A. Sex-specific associations of environmental exposures with prevalent diabetes and obesity – Results from the KORA Fit study. Environmental Research 2024, 252: 118965. PMID: 38642640, DOI: 10.1016/j.envres.2024.118965.Peer-Reviewed Original ResearchConceptsAssociations of environmental exposuresAssociated with higher body-mass indexBody-mass indexHigh body-mass indexSex-specific associationsPrevalent diabetesEnvironmental exposuresAssociated with lower obesity prevalenceUrban menRural womenAssociated with diabetes prevalenceEvaluated sex-specific associationsLower obesity prevalenceAir pollutionAnalyzed cross-sectional dataGerman population-based cohortPopulation-based cohortSusceptibility to air pollutionSex-stratified analysesLack of greennessEffects of environmental exposuresFitness studiesSusceptibility to environmental exposuresSurrounding greennessCross-sectional dataStatus epilepticus in Auckland, New Zealand: Treatment patterns and determinants of outcome in a prospective population‐based cohort
Fong M, Stephens E, Brockington A, Jayabal J, Scott S, Zhang T, Litchfield R, Beilharz E, Dalziel S, Jones P, Yates K, Thornton V, Bergin P. Status epilepticus in Auckland, New Zealand: Treatment patterns and determinants of outcome in a prospective population‐based cohort. Epilepsia 2024, 65: 1605-1619. PMID: 38634858, DOI: 10.1111/epi.17975.Peer-Reviewed Original ResearchHealth care systemCare systemStatus Epilepticus Severity ScoreProspective population-based cohortMulticenter population-based studyUniversal health careStatus epilepticusPopulation-based cohortPre-hospital settingEthnic groupsTreatment patternsHealth careSE durationContinuous minutesNew ZealandHospital admissionIncidence of SEDuration of SETreatment of status epilepticusHigh Status Epilepticus Severity ScoreHealthOlder patientsTreatment of SEDeterminants of outcomeEthnic discrepanciesThe relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self‐harm and depression: findings from three UK prospective population‐based cohorts
Farooq B, Russell A, Howe L, Herbert A, Smith A, Fisher H, Baldwin J, Arseneault L, Danese A, Mars B. The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self‐harm and depression: findings from three UK prospective population‐based cohorts. Journal Of Child Psychology And Psychiatry 2024, 65: 1369-1387. PMID: 38613494, PMCID: PMC7616850, DOI: 10.1111/jcpp.13986.Peer-Reviewed Original ResearchAdverse childhood experiencesMillennium Cohort StudyExposure to adverse childhood experiencesSelf-harmChildhood experiencesACE typesAvon Longitudinal Study of ParentsProspective population-based cohortRisk of self-harmLongitudinal Study of ParentsCo-occurring depressionImpact of adverse childhood experiencesParental mental health problemsStructured life course modeling approachAdolescent self-harmAvon Longitudinal StudyMental health problemsPopulation-based cohortStudy of ParentsMultinomial logistic regression modelLogistic regression modelsMiddle childhoodImpact of developmental timingLong duration of exposureDepressionAssociation between thymectomy and incidence of renal cell carcinoma (RCC).
Barragan-Carrillo R, Ebrahimi H, Chawla N, Salgia N, Castro D, Chehrazi-Raffle A, Dizman N, Hsu J, Meza L, Zengin Z, LeVee A, Tripathi A, Dorff T, Bergerot C, Bergerot P, Eilber K, Dallas K, Pal S. Association between thymectomy and incidence of renal cell carcinoma (RCC). Journal Of Clinical Oncology 2024, 42: 371-371. DOI: 10.1200/jco.2024.42.4_suppl.371.Peer-Reviewed Original ResearchRenal cell carcinomaIncidence of nephrectomyIncidence of renal cell carcinomaMedian age of patientsFrequency of nephrectomyAge of patientsT cell productionProportion of patientsRate of nephrectomyFisher's exact testGeneral populationAge-matched populationICD-9/10 codesPopulation-based cohortPopulation-based studyImmunogenic cancerPrior thymectomyChi-square testCell carcinomaMedian ageSurgical interventionNephrectomyThymectomyExact testOSHPD database
2023
Rates and reasons for hospital readmission after acute ischemic stroke in a US population-based cohort
Zhou L, Lansberg M, de Havenon A. Rates and reasons for hospital readmission after acute ischemic stroke in a US population-based cohort. PLOS ONE 2023, 18: e0289640. PMID: 37535655, PMCID: PMC10399731, DOI: 10.1371/journal.pone.0289640.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeAcute renal failureHospital readmissionIschemic strokeReadmission ratesRenal failureRisk factorsUS population-based cohortUnplanned hospital readmissionNationwide Readmissions DatabaseRisk of readmissionVascular risk factorsHospital-level characteristicsPopulation-based cohortKaplan-Meyer analysisWorsened patient outcomesState administrative databasesModifiable comorbiditiesRecurrent strokeInitial hospitalizationDisadvantaged patientsLonger initial lengthMedicare insuranceAIS patientsSecondary strokeBreast Cancer Mode of Detection in a Population-Based Cohort
Basappa S, Finney Rutten L, Hruska C, Olson J, Jacobson D, Rhodes D. Breast Cancer Mode of Detection in a Population-Based Cohort. Mayo Clinic Proceedings 2023, 98: 278-289. PMID: 36737116, PMCID: PMC9907001, DOI: 10.1016/j.mayocp.2022.10.010.Peer-Reviewed Original ResearchConceptsPopulation-based cohortBreast cancerAdvanced cancerBreast densityRetrospective medical record reviewDense breastsPositive lymph nodesFirst-time diagnosisRochester Epidemiology ProjectMedical record reviewStage of diseaseLarger tumor sizeWomen age 40High-grade tumorsMultiple logistic regressionYears of ageLymph nodesRecord reviewTumor characteristicsTumor sizeCancer characteristicsCancer modeAge 40Clinical attentionCancer
2022
Incidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study
Liyanarachi KV, Solligård E, Mohus RM, Åsvold BO, Rogne T, Damås JK. Incidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study. PLOS ONE 2022, 17: e0271263. PMID: 35819970, PMCID: PMC9275692, DOI: 10.1371/journal.pone.0271263.Peer-Reviewed Original ResearchConceptsSevere bacterial infectionsPositive blood culturesBacterial infectionsBlood culturesPopulation-based HUNT StudyPositive blood culture rateTrøndelag Health StudyUrinary tract infectionPopulation-based cohortBlood culture rateCommon infectious diseasesInfectious disease burdenRegistry linkageTract infectionsLoss of healthMedian timeHUNT StudyDisease burdenIncidence rateCulture rateGeneral populationHealth StudyHospitalizationImportant causeTotal burdenSexual orientation-related patterns of 12-month course and severity of suicidality in a longitudinal, population-based cohort of young adults in Sweden
Clark KA, Hatzenbuehler ML, Bränström R, Pachankis JE. Sexual orientation-related patterns of 12-month course and severity of suicidality in a longitudinal, population-based cohort of young adults in Sweden. Social Psychiatry And Psychiatric Epidemiology 2022, 57: 1931-1934. PMID: 35829726, PMCID: PMC9378663, DOI: 10.1007/s00127-022-02326-7.Peer-Reviewed Original ResearchDNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors
Wang Y, Zhao W, Ammous F, Song Y, Du J, Shang L, Ratliff S, Moore K, Kelly K, Needham B, Roux A, Liu Y, Butler K, Kardia S, Mukherjee B, Zhou X, Smith J. DNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors. Frontiers In Cardiovascular Medicine 2022, 9: 848768. PMID: 35665255, PMCID: PMC9162507, DOI: 10.3389/fcvm.2022.848768.Peer-Reviewed Original ResearchBody mass indexCardiovascular risk factorsNeighborhood socioeconomic disadvantageMulti-Ethnic Study of AtherosclerosisNeighborhood-level disadvantagePoor cardiovascular healthSocioeconomic statusSocioeconomic disadvantageRisk factorsCardiovascular healthAssociated with poor cardiovascular healthSocial disadvantageAdult socioeconomic statusBody mass index adjustmentAssociations of individual-HDL-CPrincipal components of ancestryGenetic principal componentsMeasures of obesityLow socioeconomic statusPopulation-based cohortMulti-Ethnic StudyStudy of AtherosclerosisHDL-C associationHigh-density lipoprotein cholesterol
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply