2025
Representation of Women, Older Adults, and Racial and Ethnic Minoritized Patients in Pivotal Trials for US Food and Drug Administration Novel Oncology Therapeutic Approvals, 2012-2021: Bright Spot Trials and Trends Over Time.
Miller J, Pelletiers W, Gross C, Mello M, Ramachandran R, Schwartz J, Suttiratana S, Varma T, Ross J. Representation of Women, Older Adults, and Racial and Ethnic Minoritized Patients in Pivotal Trials for US Food and Drug Administration Novel Oncology Therapeutic Approvals, 2012-2021: Bright Spot Trials and Trends Over Time. JCO Oncology Practice 2025, op2400563. PMID: 40493876, DOI: 10.1200/op-24-00563.Peer-Reviewed Original ResearchFood and Drug AdministrationOncology therapeuticsLatino patientsBlack patientsTherapeutic approvalsOlder adultsRetrospective cross-sectional studyUS Food and Drug AdministrationTrial characteristicsMinoritized patientsUS patient populationSpot trialsPivotal trialsPatient demographicsPatient populationRepresentative patientsTrial enrollmentUS Census dataDrug AdministrationPatientsStudy of trialsTrialsOncologyWomenClinical trial diversityUse of targeted therapy in patients with advanced non-small cell lung cancer in response to broad genomic profiling.
Wang X, Long J, Rothen J, Huang S, Soulos P, Robinson T, Presley C, Goldberg S, Mamtani R, Ma S, Wang S, Kunst N, Dinan M, Gross C. Use of targeted therapy in patients with advanced non-small cell lung cancer in response to broad genomic profiling. Journal Of Clinical Oncology 2025, 43: 11155-11155. DOI: 10.1200/jco.2025.43.16_suppl.11155.Peer-Reviewed Original ResearchAdvanced non-small cell lung cancerNon-small cell lung cancerCell lung cancerTargeted therapyLung cancerTargetable alterationsGenomic profilingUsefulness of targeted therapyUS cancer clinicsFirst-line treatmentCohort of patientsClinico-genomic databaseNCCN GuidelinesIdentified patientsPatient populationFDA approvalTreatment selectionPatientsCancer clinicClinical guidelinesTherapyCancerLimited dataTT useFDA approval statusRisk of unprovoked seizures after discontinuation of antiseizure medication at discharge following acute symptomatic seizures
Punia V, Byrnes M, Thompson N, Ayub N, Rubinos C, Zafar S, Sivaraju A, investigators F. Risk of unprovoked seizures after discontinuation of antiseizure medication at discharge following acute symptomatic seizures. Epilepsia 2025 PMID: 40387211, DOI: 10.1111/epi.18464.Peer-Reviewed Original ResearchAcute symptomatic seizuresAntiseizure medicationsUnprovoked seizuresRisk of unprovoked seizuresSymptomatic seizuresAssociated with electrographic seizuresMedian follow-upRetrospective cohort studyCox proportional hazards modelsCause-specific Cox proportional hazards modelsProportional hazards modelIncidence of unprovoked seizuresASyS patientsConsecutive adultsSingle-centerElectrographic seizuresNo significant differenceCumulative incidenceFollow-upCohort studyPatient populationFunctional outcomesSeizure riskPatientsHospital dischargeHow I treat challenging transfusion cases in sickle cell disease
Chou S, Hendrickson J. How I treat challenging transfusion cases in sickle cell disease. Blood 2025, 145: 2257-2265. PMID: 38728382, DOI: 10.1182/blood.2023023648.Peer-Reviewed Original ResearchDelayed hemolytic transfusion reactionSickle cell diseaseRed blood cellsTransfusion of red blood cellsRed blood cell alloantibodiesRed blood cell transfusionCell diseaseHemolytic transfusion reactionsManagement of complicationsAlloimmunized patientsRh alloimmunizationCurative therapyTransfusion guidelinesTransfusion recipientsClinical dilemmaFuture transfusionsTransfusionPatient populationTransfusion casesTransfusion reactionsBlood donorsRH variantsBlood cellsAlloimmunizationMedicine providersFrom embedded interprofessional clinics to expanded alcohol-associated liver disease programs.
Winder G, Arab J, Goswami Banerjee A, Bryce K, Fipps D, Hussain F, Im G, Omary L, Patel A, Patel S, Rubman S, Serper M, Shenoy A, Suzuki J, Zimbrean P, Brown K, Abouljoud M, Mellinger J. From embedded interprofessional clinics to expanded alcohol-associated liver disease programs. Liver Transplantation 2025 PMID: 40359009, DOI: 10.1097/lvt.0000000000000638.Peer-Reviewed Original ResearchAlcohol-associated liver diseaseAUD careLong-term patient relationshipsCare delivery strategiesHazardous alcohol usePatient populationInterprofessional clinicPalliative carePrimary careCare elementsCare frameworkIll patient populationPatient relationshipHealthcare systemLiver transplantationHarm reductionDisease programsCareAlcohol useLiver diseaseEnhanced supportChronic liver diseaseEating disorder treatmentCollaborative modelDisorder treatmentAutomated detection of interictal epileptiform discharges with few electroencephalographic channels
Alkofer M, Yang C, Ganglberger W, Beal J, Hegde M, Kang J, Yoo J, Gelfand M, Thio L, Kutluay E, Campbell Z, Schmitt S, Gleichgerrcht E, Waterhouse E, Lopez M, Eisenschenk S, Galanti M, Singh R, Wills K, Meulenbrugge E, Dlugos D, Dean B, Halford J, Goldenholz D, Jing J, Thomas R, Westover M. Automated detection of interictal epileptiform discharges with few electroencephalographic channels. Epilepsia 2025 PMID: 40317534, DOI: 10.1111/epi.18431.Peer-Reviewed Original ResearchArea under the receiver operating characteristic curveInterictal epileptiform dischargesMedian AUCEpileptiform dischargesFocal interictal epileptiform dischargesReceiver operating characteristic curveArea under the receiver operating characteristic curve valuesEpilepsy diagnosisDetection of interictal epileptiform dischargesClinically available productsDetecting interictal epileptiform dischargesClinically relevant metricsPatient populationPatientsCharacteristic curveDeep neural networksDiagnosisEpilepsyClinicNeural networkIED detectionElectroencephalographic channelsEEG setupElectroencephalographic samplesAutomated detectionSafety of Stimulants Across Patient Populations
Oliva H, Prudente T, Mayerson T, Mignosa M, Oliva I, Potenza M, Jegede O, Angarita G. Safety of Stimulants Across Patient Populations. JAMA Network Open 2025, 8: e259492. PMID: 40343695, PMCID: PMC12065045, DOI: 10.1001/jamanetworkopen.2025.9492.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderRandomized clinical trialsAdverse eventsStimulant medicationData extractionSafety of stimulationRisk ratioIncreased riskMethodological quality assessmentPreferred Reporting ItemsPatient populationClinical conditionsDiverse patient populationsRisk of biasSafety of stimulant medicationsUnclear risk of biasTreatment of attention-deficit/hyperactivity disorderOverall AEsRandom-effects modelWeb of ScienceBinge eating disorderStimulant use disorderComprehensive literature searchMain OutcomesReporting ItemsDobbs-driven expansion of perinatal palliative care: a scoping review of the evidence and its limits
Wilpers A, Kobler K, Schafer R, Wilpers M, Zeme M, Batten J, Canty L, Lorch S. Dobbs-driven expansion of perinatal palliative care: a scoping review of the evidence and its limits. Health Affairs Scholar 2025, 3: qxaf081. PMID: 40313884, PMCID: PMC12043006, DOI: 10.1093/haschl/qxaf081.Peer-Reviewed Original ResearchPerinatal palliative carePalliative careLife-limiting fetal conditionPerson-centered careUS-based evidenceVulnerable patient populationBereavement supportPPC programsCompassionate careMaternal healthEligible individualsEmotional supportCare restrictionsAbortion restrictionsHigh satisfactionCareParental validationDiverse populationsPatient populationMedical managementComfort outcomesDecision-makingFetal conditionSupportAcceptanceDirect anterior approach for femoral neck fractures: Why and how?
Vasudevan R, Brzezinski A, Kaszuba S, Ani L, Essis M, Rubin L. Direct anterior approach for femoral neck fractures: Why and how? Journal Of Clinical Orthopaedics And Trauma 2025, 67: 102995. PMID: 40475841, PMCID: PMC12136708, DOI: 10.1016/j.jcot.2025.102995.Peer-Reviewed Original ResearchFemoral neck fracturesClosed reduction internal fixationNeck fracturesManagement of femoral neck fracturesSurgical management of femoral neck fracturesGeriatric femoral neck fracturesMuscle sparing techniqueReduction internal fixationHigh-energy trauma patientsIncidence of adverse outcomesMeta-analysesOrthopedic injuriesEarly functional outcomesTrauma patientsTotal hip arthroplastyAdverse outcomesInternal fixationHip arthroplastyFunctional outcomesElderly patient populationAnatomical reductionPatient populationHipDAA approachDirect anterior approachComparing major comorbidity indices as predictors of all-cause mortality in the Veterans Affairs health care system
Beydoun H, Szymkowiak D, Beydoun M, Nixdorff N, Brunner R, Tsai J. Comparing major comorbidity indices as predictors of all-cause mortality in the Veterans Affairs health care system. Journal Of Clinical Epidemiology 2025, 182: 111778. PMID: 40185292, PMCID: PMC12146076, DOI: 10.1016/j.jclinepi.2025.111778.Peer-Reviewed Original ResearchConceptsFunctional Comorbidity IndexUS Department of Veterans AffairsDepartment of Veterans AffairsFunctional Comorbidity Index scoresElixhauser Comorbidity IndexMeasures of comorbidityVeterans AffairsCharlson Comorbidity IndexHarrell's concordance statisticMortality riskNonhomeless veteransVeterans Affairs health care systemComorbidity indexHomeless individualsHigh-risk patient populationVA healthcare servicesHigh riskClinical measuresHealth care servicesHealth care systemLow riskAll-cause mortalityPatient populationAssociated with homelessnessPredictor of all-cause mortality16 Resource Allocation: Costs and Length of Stay for Non-Burn Patient in Burn Center
Usman M, Savetamal A. 16 Resource Allocation: Costs and Length of Stay for Non-Burn Patient in Burn Center. Journal Of Burn Care & Research 2025, 46: s13-s14. PMCID: PMC11958293, DOI: 10.1093/jbcr/iraf019.016.Peer-Reviewed Original ResearchNon-burn patientsLength of stayDiverse patient populationsBurn patientsPatient populationBurn centerNecrotizing soft tissue infectionStevens-Johnson syndrome/toxic epidermal necrolysisSoft tissue infectionsEnhance patient outcomesHigh-level careElectronic medical recordsBurn care settingNon-burn injuryHigh-quality treatmentSoft tissue injuriesCare settingsSoft tissue pathologyCare efficiencyTissue infectionsStratify patientsHospital stayFournier's gangreneEpidermal necrolysisRetrospective analysisParallel Detection of Multicontrast MRI and Deuterium Metabolic Imaging for Time-efficient Characterization of Neurologic Diseases.
Liu Y, De Feyter H, Corbin Z, Fulbright R, McIntyre S, Nixon T, de Graaf R. Parallel Detection of Multicontrast MRI and Deuterium Metabolic Imaging for Time-efficient Characterization of Neurologic Diseases. Radiology 2025, 315: e241597. PMID: 40197096, DOI: 10.1148/radiol.241597.Peer-Reviewed Original ResearchConceptsDeuterium metabolic imagingMRI protocolMetabolic imagingDecrease patient complianceUnique metabolic informationClinical MRI protocolsIn vivo human brain dataMRI examinationsMetabolism scansPatient compliancePatient populationNoninvasively in vivoDiverse patient populationsMRI-based methodMRIClinical sitesLong scan timesMetabolic informationScan qualityHuman brain dataNeurological diseasesImage contrastScan durationClinical MRIMulticontrast MRIOral Anticoagulation following intracranial haemorrhage in patients with atrial fibrillation
Shoamanesh A, Klijn C, Sheth K, Veltkamp R, Sandset E, Cordonnier C, Salman R. Oral Anticoagulation following intracranial haemorrhage in patients with atrial fibrillation. European Stroke Journal 2025, 10: 35-45. PMID: 40401653, PMCID: PMC12098311, DOI: 10.1177/23969873241296803.Peer-Reviewed Original ResearchConceptsAtrial fibrillationRandomized trialsIntracranial haemorrhagePhase II randomized trialMajor adverse cardiovascular eventsRandomized trials of anticoagulationPrevalence of AFAdverse cardiovascular eventsHigh-risk subgroupsTrials of anticoagulationEffects of anticoagulantsOptimal timingVulnerable patient populationOral anticoagulantsRisk subgroupsStroke prevention strategiesClinical dilemmaCardiovascular eventsPooled analysisAge-related conditionsPatient populationAnticoagulationHeterogeneity of treatment effectsObservational studyPatientsPLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway–Deficient Acute Myeloid Leukemia
Sheth A, Chan K, Liu S, Wan J, Angus S, Rhodes S, Mitchell D, Davis C, Ridinger M, Croucher P, Zeidan A, Wijeratne A, Qian S, Tran N, Potchanant E. PLK1 Inhibition Induces Synthetic Lethality in Fanconi Anemia Pathway–Deficient Acute Myeloid Leukemia. Cancer Research Communications 2025, 5: 648-667. PMID: 40111122, PMCID: PMC12011380, DOI: 10.1158/2767-9764.crc-24-0260.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaSporadic acute myeloid leukemiasMyeloid leukemiaOS of AMLMitotic centromeresPathway mutationsFA pathway-deficient cellsLack of predictive biomarkersPlk1 inhibitionFanconi anemiaSurvival of acute myeloid leukemiaPlk1 inhibitorsIdentification of patientsSynthetic lethal therapeutic strategyMitotic kinase Plk1Tumor suppression networkOverall survivalPredictive biomarkersClinical successPatient populationKinase Plk1Mitotic chromosomesTherapeutic strategiesMitotic collapseSynthetic lethalityImetelstat in myeloid malignancies: current data and future directions
Bidikian A, Bewersdorf J, Kewan T, Podoltsev N, Stahl M, Zeidan A. Imetelstat in myeloid malignancies: current data and future directions. Expert Review Of Anticancer Therapy 2025, 25: 517-528. PMID: 40116730, DOI: 10.1080/14737140.2025.2482721.Peer-Reviewed Original ResearchMyelodysplastic syndromeLR-MDSClinical trialsPotential disease-modifying propertiesLow-risk myelodysplastic syndromesElevated liver enzymesLR-MDS patientsTreat myelodysplastic syndromeSearch of PubMedTransfusion independenceEssential thrombocythemiaInfusion reactionsMyeloid malignanciesDisease-modifying propertiesCombination therapySurvival benefitEffective telomerase inhibitorImetelstatTelomerase reactivationPatient populationLiver enzymesMyelofibrosisCancer cellsMalignancyConference abstractsCorrection: Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population
Edelman E, Rojas-Perez O, Nich C, Corvino J, Frankforter T, Gordon D, Jordan A, Paris, Jr M, Weimer M, Yates B, Williams E, Kiluk B. Correction: Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population. Addiction Science & Clinical Practice 2025, 20: 29. PMID: 40128914, PMCID: PMC11931771, DOI: 10.1186/s13722-025-00558-x.Peer-Reviewed Original ResearchRates of anxiety disorders, mood disorders, and substance use disorders in federally qualified health centers, 2019-2022
Tsai J, Witte L, Schick V. Rates of anxiety disorders, mood disorders, and substance use disorders in federally qualified health centers, 2019-2022. Psychiatry Research 2025, 348: 116457. PMID: 40147089, DOI: 10.1016/j.psychres.2025.116457.Peer-Reviewed Original ResearchSubstance use disordersDrug use disordersMood disordersDiagnosis of mental healthAlcohol-related disordersFederally Qualified Health CentersUse disorderMental healthRates of anxiety disordersCOVID-19 pandemicTrauma-related disordersDiagnosis of anxietyU.S. statesAnxiety disordersHealth centersComprehensive health care servicesHealth care servicesPatient populationQualified Health CentersUniform Data SystemDisordersCOVID-19PatientsMoodNational dataMethodology for the international working group clinical practice guidelines on X-linked hypophosphatemia in children and adults
Ali D, Khan A, Mirza R, Appelman-Dijkstra N, Brandi M, Carpenter T, Chaussain C, Imel E, de Beur S, Florenzano P, Morrison A, Alrob H, Alexander R, Alsarraf F, Beck-Nielsen S, Biosse-Duplan M, Cohen-Solal M, Crowley R, Dandurand K, Filler G, Fukumoto S, Gagnon C, Goodyer P, Grasemann C, Grimbly C, Hussein S, Javaid M, Khan S, Khan A, Lehman A, Lems W, Lewiecki E, McDonnell C, Morgante E, Portale A, Rhee Y, Siggelkow H, Tosi L, Ward L, Guyatt G. Methodology for the international working group clinical practice guidelines on X-linked hypophosphatemia in children and adults. Journal Of Bone And Mineral Metabolism 2025, 43: 193-202. PMID: 40119067, DOI: 10.1007/s00774-025-01585-z.Peer-Reviewed Original ResearchConceptsCertainty of evidenceGRADE recommendationsImpact of medical interventionsManagement of "X-linked hypophosphatemiaX-linked hypophosphatemiaClinical practice guidelinesPatient-important outcomesRisk of biasNarrative literature reviewClinical practice surveyPatient partnersGuideline methodologistsGuideline panelFindings tablePractice guidelinesSystematic reviewPractice surveyMedical interventionsPregnant womenRecommendation strengthTreatment recommendationsInternational expertsPatient populationComprehensive guidelinesBody of evidenceSystematic Review for the Follow-up of Curatively Treated Patients With Lung Cancer
Shargall Y, Vella E, Del Giudice M, Dennie C, Ellis P, Kulkarni S, MacRae R, Ung Y. Systematic Review for the Follow-up of Curatively Treated Patients With Lung Cancer. Clinical Lung Cancer 2025, 26: e327-e341. PMID: 40240202, DOI: 10.1016/j.cllc.2025.03.003.Peer-Reviewed Original ResearchConceptsSmoking cessation interventionsPatient-reported outcome toolsPatient-reported outcomesRandomized controlled trialsCessation interventionsSystematic reviewOntario Health (Cancer Care OntarioNurse-led interventionRisk factorsClinical practice guidelinesQuality of lifeExercise trainingFollow-upManagement of signsCurative-intent treatmentPractice guidelinesControlled trialsTarget populationCochrane LibraryFollow-up strategiesInterventionLung cancerSymptoms of recurrencePatient populationFollow-up of patientsTraumatic vertebral artery occlusion is associated with high rates of recanalization: insights from a systematic review and meta-analysis
Sujijantarat N, Fathima B, Padmanaban V, Kosyakovsky J, Elsamadicy A, Haynes J, Koo A, Shankar G, Regenhardt R, Stapleton C, Rabinov J, Hebert R, Matouk C, Patel A. Traumatic vertebral artery occlusion is associated with high rates of recanalization: insights from a systematic review and meta-analysis. Neurosurgical Review 2025, 48: 306. PMID: 40097874, DOI: 10.1007/s10143-025-03460-x.Peer-Reviewed Original ResearchConceptsSpine interventionsSpinal cord injuryCervical deformityMeta-analysisSystematic reviewCord injuryRandom-effects meta-analysisAssociated with spinal cord injuryManual citation searchingEffects meta-analysisMeta-analysis of literaturePost-interventionFollow-upIncidence of strokeCitation searchingCervical injuryArtery occlusionAssociated with higher ratesNon-embolized patientsFollow-up periodVertebral artery occlusionInterventionInitial admissionClinical practicePatient population
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