2025
Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study
Chow T, Meng Q, Xiao J, O'Sharkey K, Liew Z, Ritz B. Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study. Autism Research 2025 PMID: 40542519, DOI: 10.1002/aur.70074.Peer-Reviewed Original ResearchOdds ratioOlder grandparentsBirth cohort studyMother-child pairsHispanic grandmothersASD riskCohort studyInfluence of ageInverse associationWhite raceInvestigate associationsGrandparent ageYounger ageLogistic regressionOlder ageAutism spectrum disorderSpectrum disorderRace/ethnicityAgeOddsRiskMaternal grandparentsGrandparentsDisordersGrandmothersHousing status, mental health, and help-seeking among American Indian and Alaska Native Veterans in the Midwest
Umucu E, Lee B, Chang C, Tsai J. Housing status, mental health, and help-seeking among American Indian and Alaska Native Veterans in the Midwest. Frontiers In Public Health 2025, 13: 1613224. DOI: 10.3389/fpubh.2025.1613224.Peer-Reviewed Original ResearchHousing statusService needsVeterans Integrated Service NetworkMental healthBreslow-Day testAlaska Native veteransHelp-seeking behaviorBreslow-DayMental health conditionsService catchment areaHelp-seekingHousingAlaska NativesAIAN veteransMantel-Haenszel odds ratioIntegrated services networksService networkHealth conditionsOdds ratioVeteransConfidence intervalsStudy cohortHomelessnessServicesMidwestAssociation between hyperkalemia and outcomes in hospitalized patients with acute kidney injury
Wang W, Yang H, Wilson F, Gallagher M, Feng Y. Association between hyperkalemia and outcomes in hospitalized patients with acute kidney injury. Intensive And Critical Care Nursing 2025, 90: 104118. PMID: 40554252, DOI: 10.1016/j.iccn.2025.104118.Peer-Reviewed Original ResearchAcute kidney injuryNadir of riskPrimary outcomeSerum potassiumKidney injuryAKI progressionAssociated with AKI progressionOdds ratioHospitalized patientsAcute kidney injury durationAcute kidney injury patientsAssociation of hyperkalemiaMeasured serum potassiumOutcomes of hospitalized patientsSerum potassium levelsRestricted cubic spline regressionDays of randomizationAcute kidney injury progressionConfidence intervalsCubic spline regressionDose-response relationshipDischarged to homeOutcomes of interestsComposite outcomeHyperkalemiaTranexamic Acid in Body Contouring Surgery: A Systematic Review and Meta-Analysis
Fijany A, Holan C, Troia T, Montorfano L, Mubang R, Givechian K, Karagoz H, Martinez-Jorge J, Perdikis G, Connor L, Slater E. Tranexamic Acid in Body Contouring Surgery: A Systematic Review and Meta-Analysis. Aesthetic Surgery Journal 2025, sjaf112. PMID: 40509914, DOI: 10.1093/asj/sjaf112.Peer-Reviewed Original ResearchBody contouring proceduresWound healing complicationsTranexamic acidTXA administrationContouring proceduresTopical TXA administrationHealing complicationsMeta-analysisImpact of tranexamic acidOdds ratioTranexamic acid cohortRisk of hematomaWound healing issuesDecreased risk of infectionBody contouring surgeryConfidence intervalsRandom-effects modelRisk of infectionBreast reconstructionAntifibrinolytic drugsSeroma formationContouring surgerySubgroup analysisHealing issuesDecreased riskA case-control study of early-life residential exposure to tetrachloroethylene and risks of childhood cancer and birth defects
Rhee J, Michalski A, Kuliszewski M, Musco J, Adler C, Xie S, Friesen M, Insaf T, Purdue M. A case-control study of early-life residential exposure to tetrachloroethylene and risks of childhood cancer and birth defects. Environment International 2025, 201: 109600. PMID: 40516285, DOI: 10.1016/j.envint.2025.109600.Peer-Reviewed Original ResearchConceptsRisk of childhood cancerCase-control studyChildhood cancerNew York CityNew York State Cancer RegistryBureau of Vital StatisticsOdds ratioCases of childhood cancerState Cancer RegistryNon-whiteConfidence intervalsUnconditional logistic regressionComputed odds ratiosBirth Defects RegistryBirth defectsCancer RegistryExposure-response effectTetrachloroethylene exposureBirth certificatesVital statisticsResidential exposureInvestigate associationsCollege-educatedLogistic regressionStrong associationsRisk factors for perioperative nerve injury associated with total knee arthroplasty: Analysis of a national administrative database
Jayaram R, Kim L, Day W, Doshi R, Rubin L, Grauer J. Risk factors for perioperative nerve injury associated with total knee arthroplasty: Analysis of a national administrative database. PLOS ONE 2025, 20: e0324527. PMID: 40455711, PMCID: PMC12129142, DOI: 10.1371/journal.pone.0324527.Peer-Reviewed Original ResearchConceptsBody mass indexIndependent risk factorNerve injuryElixhauser Comorbidity IndexRisk factorsMultivariate analysisAssociated with nerve injuryInvestigate independent risk factorsOdds ratioRevision surgeryIncidence of nerve injuryRisk of nerve injuryPostoperative nerve injuryUnderweight body mass indexType of surgeryDay of surgeryAdministrative databasesNational administrative databaseTKA proceduresPatient ageRisk stratificationMass indexAdverse outcomesDecreased riskFemale sexFactors associated with decreased treatment intensity in patients with metastatic colon cancer: A real world analysis.
Forman R, Wang R, Yasin F, Kwaramba T, Lacy J, Ma X, Dinan M. Factors associated with decreased treatment intensity in patients with metastatic colon cancer: A real world analysis. Journal Of Clinical Oncology 2025, 43: 11168-11168. DOI: 10.1200/jco.2025.43.16_suppl.11168.Peer-Reviewed Original ResearchMetastatic colon cancerNon-intensive therapyNational Comprehensive Cancer NetworkPoor performance statusIntensive therapyFlatiron Health electronic health record-derived deidentified databaseColon cancerIntensive first-line therapyUndertreatment of older patientsNational Comprehensive Cancer Network guidelinesOdds ratioAssociated with treatment choiceFirst-line therapyAssociated with female sexComprehensive Cancer NetworkRetrospective cohort studyYear of diagnosisShorter overall survivalNon-frail patientsOlder ageNon-frailMultivariate logistic regressionEstimate odds ratiosAssociated with receiptTreatment intensityIdentifying multi-level social determinants for disparities in survival and patient-reported outcomes in national head and neck cancer trials.
Bai J, Borges M, Nguyen-Tan F, Rosenthal D, Caudell J, Gillison M, Mell L, Bruner D, Yeager K, Eldridge R, Thorstad W, Xu M, Medek S, Echevarria M, Awan M, Shin D, Pugh S, Yom S. Identifying multi-level social determinants for disparities in survival and patient-reported outcomes in national head and neck cancer trials. Journal Of Clinical Oncology 2025, 43: 11066-11066. DOI: 10.1200/jco.2025.43.16_suppl.11066.Peer-Reviewed Original ResearchSocial determinants of healthArea-level social determinants of healthQoL declineTravel burdenDesigning community-based interventionsHead and neck cancerOdds ratioHazard ratioNeighborhood socioeconomic deprivationDeterminants of healthCommunity-based interventionsConfidence intervalsLogistic regression assessed associationsImprove cancer outcomesPatient's zip codeCox proportional hazards regressionPatient-reported outcomesMultivariable Cox proportional hazards regressionProportional hazards regressionSocioeconomic deprivationSocial determinantsHead and neck cancer trialsNon-HispanicCancer outcomesZip codesPerinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer
Deziel N, Wang R, Warren J, Dinauer C, Ogilvie J, Clark C, Zhong C, Wiemels J, Morimoto L, Metayer C, Ma X. Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer. Environmental Health Perspectives 2025, 133: 057026. PMID: 40209106, PMCID: PMC12121722, DOI: 10.1289/ehp14849.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAir PollutantsCaliforniaCarcinoma, PapillaryCase-Control StudiesChildChild, PreschoolEnvironmental ExposureFemaleHumansInfantInfant, NewbornLightingMaleParticulate MatterPregnancyPrenatal Exposure Delayed EffectsRisk FactorsThyroid Cancer, PapillaryThyroid NeoplasmsYoung AdultConceptsThyroid cancer riskOutdoor artificial lightAmbient fine particulate matterCancer riskOdds ratioAge groupsConfidence intervalsExposure to ambient fine particulate matterIndividual-level exposuresAssociated with thyroid cancerPediatric thyroid cancer incidenceControls frequency-matchedPapillary thyroid cancer riskThyroid cancer incidenceFine particulate matterCalifornia birth cohortOutdoor air pollutionAerodynamic diameter <Case-control studyHypothesized risk factorsStatistically significant associationCancer incidenceThyroid cancerExposure tertilesFrequency-matchedExamining socioeconomic differences in sepsis risk and mediation by modifiable factors: a Mendelian randomization study
Stensrud V, Rogne T, Flatby H, Mohus R, Gustad L, Nilsen T. Examining socioeconomic differences in sepsis risk and mediation by modifiable factors: a Mendelian randomization study. BMC Infectious Diseases 2025, 25: 739. PMID: 40410669, PMCID: PMC12103053, DOI: 10.1186/s12879-025-11130-y.Peer-Reviewed Original ResearchConceptsSummary-level dataSocioeconomic differencesGenome-wide association studiesGenetic instrumentsEducational attainmentMendelian randomizationMR analysisStandard deviation increaseBias due to population stratificationOdds ratioPreventive factorsMR-Egger regressionExamined socioeconomic differencesMultivariable MR analysisEffect of smoking initiationAssociation studiesMendelian randomization studiesEffects of educational attainmentDeviation increaseYears of educationBody mass indexBackgroundEducational attainmentDynastic effectsMedian OREgger regressionPreterm and early-term delivery after heat waves in eight US states: A case-crossover study using the High-resolution Urban Meteorology for Impacts Dataset (HUMID).
Fitch A, Huang M, Strickland M, Newman A, Kalb C, Warren J, Zheng X, Chang H, Darrow L. Preterm and early-term delivery after heat waves in eight US states: A case-crossover study using the High-resolution Urban Meteorology for Impacts Dataset (HUMID). Environmental Health Perspectives 2025 PMID: 40392097, DOI: 10.1289/ehp15953.Peer-Reviewed Original ResearchEarly-term birthEarly-termAssociated with earlier birthEarly-term deliveryPreterm birth ORSingleton pretermPreterm birthPretermPooled ORHeat wavesPooled resultsOdds ratioInverse-variance weightingUrban meteorologyEarly birthBirthImpact datasetsMean temperatureElevated oddsThreshold categoriesVital recordsCase-crossover studyORAcute relationshipsSurface temperature data0740 Loop Gain Predicts Residual Sleep Apnea Events Among People Using Positive Airway Pressure
Eschbach E, Kushida C, Peker Y, Xu Z, Deng A, Azarbarzin A, Wellman A, Yaggi H, Sands S, Zinchuk A. 0740 Loop Gain Predicts Residual Sleep Apnea Events Among People Using Positive Airway Pressure. Sleep 2025, 48: a321-a321. DOI: 10.1093/sleep/zsaf090.0740.Peer-Reviewed Original ResearchPositive airway pressureObstructive sleep apneaPositive airway pressure therapyBody mass indexSleep apneaBaseline AHIPAP therapyAirway pressurePharyngeal collapseIncreased riskOdds ratioPositive airway pressure devicesAssociated with increased riskCoronary artery diseaseSleep apnea eventsEpisodic airway obstructionBaseline polysomnogramRandomized controlled trialsBaseline polysomnographyHigh LGAdjunctive therapyAirway obstructionUpper airwayMass indexApneaImpacts of sample weighting on transferability of risk prediction models across EHR-Linked biobanks with different recruitment strategies
Salvatore M, Mondul A, Friese C, Hanauer D, Xu H, Pearce C, Mukherjee B. Impacts of sample weighting on transferability of risk prediction models across EHR-Linked biobanks with different recruitment strategies. Journal Of Biomedical Informatics 2025, 167: 104853. PMID: 40398830, DOI: 10.1016/j.jbi.2025.104853.Peer-Reviewed Original ResearchConceptsPS weightingRisk prediction modelOdds ratioArea under the receiver operating curveEHR-linked biobanksMichigan Genomics InitiativePhenotype risk scoreYears prior to diagnosisRisk score distributionCancer risk stratificationHigh-risk populationImprove risk predictionEHR dataPoststratification weightsRecruitment strategiesRisk stratificationCharlson Comorbidity IndexAlcohol consumptionRisk scoreBiobankRisk factorsRisk predictionUnderrepresented groupsComorbidity indexReceiver operating curvePrescription Pain Medication Misuse with and Without Heroin Use Among Adolescents: relationships with Routine Healthcare, Family Support, Academic Performance, Violence, and Other Risky Behaviors
Jalilian-Khave L, Stefanovics E, Zhai Z, Potenza M. Prescription Pain Medication Misuse with and Without Heroin Use Among Adolescents: relationships with Routine Healthcare, Family Support, Academic Performance, Violence, and Other Risky Behaviors. Substance Use & Misuse 2025, 60: 1400-1410. PMID: 40383936, PMCID: PMC12187537, DOI: 10.1080/10826084.2025.2499945.Peer-Reviewed Original ResearchConceptsPrescription pain medication misusePain medication misuseFamily supportHealthcare participantsRisky behaviorsHeroin useMedication misuseOpioid misuseYouth Risk Behavior Survey dataPrescription pain medicationBehavior Survey dataRoutine healthcareHealthcare utilizationPublic health crisisChi-square analysisHigher oddsSurvey dataOdds ratioPain medicationHigh school respondentsAdjusted modelsAcademic performanceNegative healthOddsHealth crisisThe Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis
Ein Alshaeba S, Marhoffer E, Holleck J, Theisen-Toupal J, Grimshaw A, Gunderson C. The Effect of Early Warning Systems for Sepsis on Mortality: A Systematic Review and Meta-analysis. Journal Of General Internal Medicine 2025, 1-6. PMID: 40360868, DOI: 10.1007/s11606-025-09569-5.Peer-Reviewed Original ResearchStrength of evidenceLength of stayScreening groupRandomized controlled studyCochrane risk of bias toolRisk of bias toolRandom-effects meta-analysisLow due to riskMeta-analysisEffectiveness of screeningEffectiveness of early warning systemsRisk of biasEffects meta-analysisMethodsA systematic literature searchPooled odds ratioControlled studiesScreened adult patientsSystematic literature searchSurviving Sepsis CampaignRecommendations AssessmentCochrane riskBias toolWeb of Science Core CollectionOdds ratioOvid MEDLINEIdentifying subgroups of adverse childhood experiences (ACEs) in adult general hospital attendees: associations with mental and physical health measures
Saunders R, Nolte T, Osborn T, Delamain H, Riedl D, Fonagy P, Lampe A. Identifying subgroups of adverse childhood experiences (ACEs) in adult general hospital attendees: associations with mental and physical health measures. Journal Of Psychiatric Research 2025, 187: 291-298. PMID: 40408977, DOI: 10.1016/j.jpsychires.2025.05.024.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesACE clustersHealth outcomesHealth conditionsAssessment of adverse childhood experiencesCombinations of adverse childhood experiencesIncreased ACE exposurePhysical health measuresChildhood experiencesPhysical health conditionsMental health conditionsPhysical health outcomesAdult health outcomesHigh adverse childhood experiencesAustrian university hospitalLogistic regression modelsACE exposureMental healthHealth measuresSubgroups of individualsOdds ratioLatent class analysisPrevention strategiesOutpatient departmentHospital attendeesHuman Immunodeficiency Virus Infection and Long COVID: A RECOVER Program, Electronic Health Record–Based Cohort Study
Hawkins K, Dandachi D, Verzani Z, Brannock M, Lewis C, Abedian S, Jaferian S, Wuller S, Truong J, Witvliet M, Dymond G, Mehta H, Patel P, Hill E, Weiner M, Carton T, Kaushal R, Feuerriegel E, Tran H, Marks K, Oliveira C, Gardner E, Ofotokun I, Gulick R, Erlandson K. Human Immunodeficiency Virus Infection and Long COVID: A RECOVER Program, Electronic Health Record–Based Cohort Study. Clinical Infectious Diseases 2025, ciaf242. PMID: 40354184, DOI: 10.1093/cid/ciaf242.Peer-Reviewed Original ResearchDefinition of Long COVIDICD-10Baseline chronic conditionsLong COVIDElectronic health record databaseIncreased riskHealth record databaseICD-10 codesICD-10 definitionRisk of long COVIDClinical Research NetworkChronic conditionsAcute SARS-CoV-2 infectionHIV statusAnalytic sampleOdds ratioCohort definitionsCohort CollaborationComputable phenotypePhenotype definitionRecord databaseSARS-CoV-2 infectionLogistic regressionResearch NetworkMulticenter studyBreastfeeding attributable fraction of triple negative breast cancer in the US
Chehayeb R, Odzer N, Albany R, Ferrucci L, Sarpong D, Perez-Escamilla R, Lewis J, Phipps A, Meisner A, Pusztai L. Breastfeeding attributable fraction of triple negative breast cancer in the US. Npj Breast Cancer 2025, 11: 40. PMID: 40328734, PMCID: PMC12055980, DOI: 10.1038/s41523-025-00755-6.Peer-Reviewed Original ResearchPopulation-attributable fractionTriple negative breast cancerWhite womenBlack womenNon-Hispanic white womenNegative breast cancerRisk factorsBreast cancerPooled odds ratioAttributable fractionLevin's formulaRacial disparitiesBreastfeeding durationOdds ratioBreastfeedingYounger ageWomenDisparitiesPubMed searchRiskAgeCancerMonthsPubMedBirthA sibling study of the prenatal and perinatal risks for cerebral palsy
Zhuo H, Rogne T, Liew Z. A sibling study of the prenatal and perinatal risks for cerebral palsy. Pediatric Research 2025, 1-8. PMID: 40316681, DOI: 10.1038/s41390-025-04055-4.Peer-Reviewed Original ResearchSibling comparison designCerebral palsyLow Apgar scoreMaternal pregnancy complicationsSibling designPerinatal factorsAssociated with CPApgar scoreComparison designPregnancy complicationsOdds ratioPreterm birthAttenuated to nullConfidence intervalsPre-pregnancy overweightLifestyle-related factorsCP riskSibling comparison studiesSibling-comparison designGestational ageMaternal cigarette smokingSingleton birthsCP etiologyInterpretation of findingsPre-pregnancyIncidence of Concurrent Cerebral Desaturation and Electroencephalographic Burst Suppression in Cardiac Surgery Patients
Ramachandran R, Behera A, Hussain Z, Peck J, Ananthakrishanan A, Mathur P, Banner-Goodspeed V, Muehlschlegel J, Pittet J, Bardia A, Schonberger R, Marcantonio E, Kveraga K, Subramaniam B. Incidence of Concurrent Cerebral Desaturation and Electroencephalographic Burst Suppression in Cardiac Surgery Patients. Anesthesia & Analgesia 2025, 140: 1086-1092. PMID: 39446661, PMCID: PMC11996613, DOI: 10.1213/ane.0000000000007209.Peer-Reviewed Original ResearchCerebral desaturationAortic cross-clampingCardiac surgeryPost-CPBBurst suppressionCross-clampingRemoval of aortic cross-clampCerebral oximetryAssociated with postoperative deliriumPhase of cardiac surgeryCardiac surgery patientsElectroencephalographic burst suppressionConfidence intervalsIntraoperative burst suppressionPostoperative cognitive functionPre-CPBPrecardiopulmonary bypassSurgery patientsEntire surgeryEEG monitoringPostoperative deliriumTargeted interventionsOdds ratioSurgerySurgical phase
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