2025
Nicotine e-cigarettes for smoking cessation: a clinical pharmacology perspective
Ameral V, Sofuoglu M, Kelly M. Nicotine e-cigarettes for smoking cessation: a clinical pharmacology perspective. Expert Review Of Clinical Pharmacology 2025, 18: 189-196. PMID: 40047379, PMCID: PMC11961306, DOI: 10.1080/17512433.2025.2472837.Peer-Reviewed Original ResearchSmoking cessationE-cigarettesEvidence-based clinical guidelinesEfficacy of e-cigarettesBenefits of e-cigarettesSmoking cessation treatmentHarm reduction optionsHarm reduction principlesNicotine replacement therapyNicotine e-cigarettesQuality of lifeIncreased life expectancyNicotine useCessation treatmentClinical guidelinesNicotineSmokingLife expectancyCigarette smokingClinical pharmacology perspectivePharmacological perspectiveClinical practiceHigh riskLong-term effectsReplacement therapyBrain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors
Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors. Translational Psychiatry 2025, 15: 61. PMID: 39979292, PMCID: PMC11842717, DOI: 10.1038/s41398-025-03288-5.Peer-Reviewed Original ResearchConceptsImaging-derived phenotypesBrain imaging-derived phenotypesAlcohol drinkingBrain structuresProcessing of social cuesCorrelates of smoking behaviorRelationship of brain structureSequencing Consortium of AlcoholGlobal genetic correlationsSmoking behaviorSuperior longitudinal fasciculusAssociated with smoking initiationTobacco smokeTobacco smoking behaviorLatent causal variable approachesNicotine useBrain regionsPremotor cortexSocial cuesWhite matter hyperintensitiesLongitudinal fasciculusChemosensory processingCortical thicknessMendelian randomizationPleiotropic mechanisms
2024
Preclinical Evidence of the Effects of Sweet Flavors: Sweetness Increases Nicotine Intake and Seeking
Bagdas D, Addy N. Preclinical Evidence of the Effects of Sweet Flavors: Sweetness Increases Nicotine Intake and Seeking. Nicotine & Tobacco Research 2024, 27: 666-675. PMID: 39413033, PMCID: PMC11931221, DOI: 10.1093/ntr/ntae241.Peer-Reviewed Original ResearchNicotine use behaviorsNicotine reinforcementNicotine intakeSelf-administrationNicotine useFlavor exposureUse behaviorsIntravenous nicotine self-administrationPattern of nicotine intakeSessions of self-administrationNicotine self-administrationIncreased nicotine intakeNicotine-related behaviorsSaccharin-flavored solutionInfluence of early exposureSeeking behaviorNo significant sex differencesSignificant sex differencesImpact of early exposureSaccharin exposureEarly exposureFlavored solutionNicotine addictionSex differencesNicotineUse of cannabis among youth who vape nicotine
Davis D, Bold K, Wu R, Morean M, Kong G, Krishnan-Sarin S. Use of cannabis among youth who vape nicotine. Addictive Behaviors 2024, 160: 108173. PMID: 39326231, DOI: 10.1016/j.addbeh.2024.108173.Peer-Reviewed Original ResearchCannabis useNicotine vapingSmoking cannabisRoute of administrationAssociation of cannabis useNicotine co-useCannabis use frequencyInvestigated cannabis useUse of cannabisVaping nicotineNicotine useCannabis smokingCannabisCessation studyCo-useYouth e-cigarette useE-cigarette useCannabis productsNicotineCessation effortsTargeted treatmentPublic health concernModerate desireYouthE-cigarettesThe influence of ovarian hormones on the putative mechanisms that promote female nicotine use
Giner P, Ortegon S, Bagdas D, O'Dell L. The influence of ovarian hormones on the putative mechanisms that promote female nicotine use. Current Opinion In Neurobiology 2024, 88: 102900. PMID: 39153250, PMCID: PMC11560049, DOI: 10.1016/j.conb.2024.102900.Peer-Reviewed Original ResearchNicotine useWithdrawal severityOvarian hormonesImpact of ovarian hormonesNicotine withdrawal severityHormonal interventionsInfluence of ovarian hormonesNovel treatment avenuesHormone-based contraceptivesWithdrawal symptomsPleasurable effectsQuit dateCessation treatmentMenstrual cyclePost-menopausalHormonal fluctuationsTreatment efficacyTreatment avenuesNicotineCessation interventionsCessation strategiesCessation approachesWithdrawalHormoneWomenW35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders
Baldassarri S, Asch R, Hillmer A, Pietrzak R, DellaGioia N, Esterlis I, Davis M. W35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders. Drug And Alcohol Dependence 2024, 260: 110653. DOI: 10.1016/j.drugalcdep.2023.110653.Peer-Reviewed Original ResearchBehavioral Precursors of Nicotine Product Use Trajectories Among Youth
Buta E, Gueorguieva R, Simon P, Garrison K. Behavioral Precursors of Nicotine Product Use Trajectories Among Youth. American Journal Of Preventive Medicine 2024, 67: 360-369. PMID: 38782105, DOI: 10.1016/j.amepre.2024.05.009.Peer-Reviewed Original ResearchNicotine useNicotine productsHarm perceptionsPopulation Assessment of Tobacco and Health StudyBehavioral precursorsPublic health priorityNon-user classPriority intervention targetsPredictors of trajectoriesNonuser classesHealth StudyHealth priorityNicotineHigher oddsCentral network nodesYouth agesNon-usersOddsIntervention targetsPopulation AssessmentYouthPositive expectationsAssociations between gendered racism, racial identity, and nicotine use among Asian American men
Le T, Iwamoto D, Ching T. Associations between gendered racism, racial identity, and nicotine use among Asian American men. Journal Of Clinical Psychology 2024, 80: 1582-1595. PMID: 38509784, DOI: 10.1002/jclp.23681.Peer-Reviewed Original ResearchConceptsNicotine useAsian American menGendered racismRacial identity statusesAssociated with greater conformityAmerican menUnited States of AmericaIdentity statusIntervention targetsIntersectional frameworkNicotineRacial identityRacist beliefsRacismStates of AmericaUnited StatesPrimary analysisCross-sectional surveyEmasculationEndorsementMenApplication of glutamate weighted CEST in brain imaging of nicotine dependent participants in vivo at 7T
Jacobs P, Jee J, Fang L, Devlin E, Iannelli C, Thakuri D, Loughead J, Epperson C, Wilson N, Roalf D, Reddy R, Nanga R. Application of glutamate weighted CEST in brain imaging of nicotine dependent participants in vivo at 7T. PLOS ONE 2024, 19: e0297310. PMID: 38363747, PMCID: PMC10871471, DOI: 10.1371/journal.pone.0297310.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexNon-smokersCingulate gyrusAnterior cingulate cortexContext of addictionTreating nicotine addictionApplication of glutamatePopulation of smokersWilcoxon rank sum testGluCEST imagingTraumatic brain injuryT1-weighted imagesInvestigated glutamateSignificant healthcare issueCingulate cortexGray matter regionsRank sum testNicotine useNicotine addictionNicotine dependenceBrain regionsChemical exchange saturation transferNegative age dependenceHealthy participantsUltra-high field MRIShift From Smoking Cigarettes to Vaping Nicotine in Young Adults
Sanford B, Brownstein N, Baker N, Palmer A, Smith T, Rojewski A, Toll B. Shift From Smoking Cigarettes to Vaping Nicotine in Young Adults. JAMA Internal Medicine 2024, 184: 106-108. PMID: 37955869, PMCID: PMC10644245, DOI: 10.1001/jamainternmed.2023.5239.Peer-Reviewed Original Research
2023
Positive psychological interventions on alcohol use and consequences: Pilot randomized trial in a young adult cannabis-using sample
Trinh C, Girard R, Schick M, Spillane N. Positive psychological interventions on alcohol use and consequences: Pilot randomized trial in a young adult cannabis-using sample. Journal Of Substance Use And Addiction Treatment 2023, 158: 209241. PMID: 38056630, DOI: 10.1016/j.josat.2023.209241.Peer-Reviewed Original ResearchConceptsPositive psychology interventionsAlcohol-related consequencesQuantity of alcohol useFrequency of alcohol usePsychological interventionsCannabis useAlcohol useYoung adultsReducing alcohol-related consequencesNegative alcohol-related consequencesCannabis-related consequencesReducing cannabis useAlcohol use quantitySubstance use disordersAlcohol use frequencySavoring interventionConcurrent alcoholNicotine usePilot randomized trialCannabisEffect sizeBaseline alcoholHarm reduction approachesSavoringPilot studyPandemic-Related Changes in the Prevalence of Early Adolescent Alcohol and Drug Use, 2020–2021: Data From a Multisite Cohort Study
Pelham W, Tapert S, Zúñiga M, Thompson W, Wade N, Gonzalez M, Patel H, Baker F, Dowling G, Van Rinsveld A, Baskin-Sommers A, Kiss O, Brown S. Pandemic-Related Changes in the Prevalence of Early Adolescent Alcohol and Drug Use, 2020–2021: Data From a Multisite Cohort Study. Journal Of Adolescent Health 2023, 73: 338-346. PMID: 37191599, PMCID: PMC10186567, DOI: 10.1016/j.jadohealth.2023.02.040.Peer-Reviewed Original ResearchConceptsPandemic-related increasesPrescription drug misuseSubstance useDrug misuseAlcohol useProspective nationwide cohortInhalant useCoronavirus disease 2019 (COVID-19) pandemicMultisite cohort studyPast-month prevalenceDisease 2019 pandemicCognitive Development StudyPandemic-related changesNationwide cohortAdolescent Brain Cognitive Development (ABCD) studyCohort studyEarly adolescent substance usePrepandemic levelsNicotine useDrug useAdolescent substance usePast-month alcoholEarly adolescent alcoholPrevalenceAge 11.5Protecting Children and Adolescents From Tobacco and Nicotine.
Jenssen B, Walley S, Boykan R, Little Caldwell A, Camenga D, Groner J, Marbin J, Mih B, Rabinow L, Blake G, Smith K, Baumberger J, Gonzalez L, Agarwal R, Quigley J, Zoucha K, Walker-Harding L, Kurien C, Ba’Gah R, Jarrett R. Protecting Children and Adolescents From Tobacco and Nicotine. 2023, 151 PMID: 37066668, DOI: 10.1542/peds.2023-061806.Peer-Reviewed Original ResearchConceptsPreventable causeSecondhand exposurePrenatal exposureAAP recommendationsTobacco useTobacco smokeClinical reportsTobacco epidemicNicotine useThirdhand exposureE-cigarettesEvidence baseSubstantial tollAdolescent HealthChildrenExposureChildhoodAdolescenceHealthReportPregnancyTobaccoDiseaseNicotineProtecting Children and Adolescents From Tobacco and Nicotine.
Jenssen B, Walley S, Boykan R, Little Caldwell A, Camenga D, Groner J, Marbin J, Mih B, Rabinow L, Blake G, Smith K, Baumberger J, Gonzalez L, Agarwal R, Quigley J, Zoucha K, Kurien C, Ba’Gah R, Jarrett R. Protecting Children and Adolescents From Tobacco and Nicotine. 2023, 151 PMID: 37066685, DOI: 10.1542/peds.2023-061804.Peer-Reviewed Original ResearchConceptsE-cigarettesEffective public health approachPublic health approachTobacco product useCigarette smokingPreventable causeTobacco useAerosol exposureTobacco smokeTobacco epidemicNicotine useHealth approachTobacco productsProduct useDevice useAdolescentsChildrenUnited StatesSmokingTobaccoSignificant stridesDiseaseNicotineHookah
2022
Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats
Bagdas D, Harris L, Addy N. Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats. Neuroscience Letters 2022, 793: 137008. PMID: 36476758, PMCID: PMC9948648, DOI: 10.1016/j.neulet.2022.137008.Peer-Reviewed Original ResearchConceptsTaste responsesNicotine concentrationsNicotine exposureNicotine withdrawalNicotine effectsAdolescent ratsChronic exposureOral nicotine exposureTaste reactivityAversive tasteChronic nicotine exposureDevelopment of toleranceLow nicotine concentrationsE-cigarette useE-cigarette flavoringsHigher nicotine concentrationsNicotine abstinenceNicotine useNaïve animalsChronic effectsNicotineRatsAversive responsesDifferent nicotine concentrationsWithdrawalNicotine Pharmacology, Abuse, and Addiction
Miller M, Picciotto M. Nicotine Pharmacology, Abuse, and Addiction. 2022, 4083-4101. DOI: 10.1007/978-3-030-88832-9_157.ChaptersTobacco useDrugs of abuseNeuropsychiatric disordersGreat public health relevanceGreat public health concernMesolimbic dopamine systemPre-clinical studiesPublic health concernPublic health relevanceNicotinic acetylcholine receptorsIonotropic neurotransmitter receptorsPrimary psychoactive componentSubstantial health risksNicotine exposureNicotine actsSustained tobacco useNicotine pharmacologyRewarding effectsNicotine addictionDopamine systemNervous systemNeurotransmitter receptorsNicotine useAcetylcholine receptorsAddictive propertiesThe association between hormonal contraceptive use and smoking, negative affect, and cessation attempts in college females
Stewart S, Peltier M, Roys M, Copeland A. The association between hormonal contraceptive use and smoking, negative affect, and cessation attempts in college females. Drug And Alcohol Dependence Reports 2022, 3: 100063. PMID: 36845992, PMCID: PMC9948877, DOI: 10.1016/j.dadr.2022.100063.Peer-Reviewed Original ResearchHormonal contraceptivesHC useCurrent smokingCessation attemptsCombination hormonal contraceptivesHormonal contraceptive useEndogenous female hormonesSmoking status interactionFemale hormonesContraceptive useQuit attemptsLower anxiety levelsNicotine useTreatment targetsPast cessation attemptsSmokingCurrent HC useProgestinsExogenous hormonesAdditional studiesWomenStatus interactionAnxiety levelsSignificant differencesSignificant main effectAnimal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence
Bagdas D, Kebede N, Zepei AM, Harris L, Minanov K, Picciotto MR, Addy NA. Animal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence. Current Neuropharmacology 2022, 20: 2175-2201. PMID: 35611777, PMCID: PMC9886843, DOI: 10.2174/1570159x20666220524120231.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2021
Potential causal effect of posttraumatic stress disorder on alcohol use disorder and alcohol consumption in individuals of European descent: A Mendelian Randomization Study
Bountress KE, Wendt F, Bustamante D, Agrawal A, Webb B, Gillespie N, Edenberg H, Sheerin C, Johnson E, Group T, Polimanti R, Amstadter A. Potential causal effect of posttraumatic stress disorder on alcohol use disorder and alcohol consumption in individuals of European descent: A Mendelian Randomization Study. Alcohol Clinical And Experimental Research 2021, 45: 1616-1623. PMID: 34120358, PMCID: PMC8429238, DOI: 10.1111/acer.14649.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAlcohol use disorderStress disorderTrauma-related symptomsSelf-medication modelUse disordersAlcohol consumptionLarge-scale genome-wide association study (GWAS) dataCausal effectNicotine usePotential causal effectsPTSD coLatent analysisEtiologic influencesAlcohol phenotypesHealth behaviorsPrevention effortsCorrelated riskDisordersPsychiatric Genomics ConsortiumMendelian randomization studyFindingsIndividualsClinical studiesMillion Veteran ProgramPotentiation of (α4)2(β2)3, but not (α4)3(β2)2, nicotinic acetylcholine receptors reduces nicotine self-administration and withdrawal symptoms
Hamouda AK, Bautista MR, Akinola LS, Alkhlaif Y, Jackson A, Carper M, Toma WB, Garai S, Chen YC, Thakur GA, Fowler CD, Damaj MI. Potentiation of (α4)2(β2)3, but not (α4)3(β2)2, nicotinic acetylcholine receptors reduces nicotine self-administration and withdrawal symptoms. Neuropharmacology 2021, 190: 108568. PMID: 33878302, PMCID: PMC8169606, DOI: 10.1016/j.neuropharm.2021.108568.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsWithdrawal symptomsHypothermic effectMale miceAntinociceptive effectΑ4β2 nAChRsNicotine withdrawal-induced hyperalgesiaNAChR isoformsNicotine's antinociceptive effectsWithdrawal-induced hyperalgesiaNicotine withdrawal symptomsNicotine addiction treatmentAnxiety-like behaviorNicotinic acetylcholine receptorsDose-dependent mannerNociceptive responsesNicotine withdrawalNicotine intakeSomatic signsNicotine abstinencePharmacological effectsNicotine useAcetylcholine receptorsAffective symptomsPathophysiological processes
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