2025
Reduced prefrontal response to fearful faces in recent mothers with bipolar disorder and its association with mother-infant interaction and infant development
Bjertrup A, Andreu H, Macoveanu J, Sankar A, Moszkowicz M, Nielsen R, Pagsberg A, Vieta E, Kessing L, Miskowiak K. Reduced prefrontal response to fearful faces in recent mothers with bipolar disorder and its association with mother-infant interaction and infant development. Psychiatry Research 2025, 351: 116610. PMID: 40582275, DOI: 10.1016/j.psychres.2025.116610.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingMother-infant interactionBipolar disorderMother infant interactionsFearful facesNeural responsesInfant interactionsNeural activityInfant developmentEmotion processing regionsHappy facial expressionsWhole-brain analysisSevere mood disordersLeft frontal poleFacial expression recognition taskFacial expression recognition accuracyExpression recognition taskHappy facesPrefrontal responsesBD mothersMood disordersChildren of individualsFrontal poleDyadic reciprocityProcessing regionsPhenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder
Zadka Ł, Eggerstorfer B, Buzalewicz I, Vraka C, Rusak A, Godbersen G, Opalińska A, Unterholzner J, Ulatowska-Jarża A, Philippe C, Haczkiewicz-Leśniak K, Silberbauer L, Murgaš M, Nics L, Hahn A, Hacker M, Gomułkiewicz A, Rujescu D, Podhorska-Okołów M, Lanzenberger R, Gryglewski G. Phenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder. Journal Of Affective Disorders 2025, 389: 119740. PMID: 40550277, DOI: 10.1016/j.jad.2025.119740.Peer-Reviewed Original ResearchSerotonin transporterDepressive disorderPresence of serotonin transporterAntidepressant treatment responseSerotonin transporter levelsMDD patientsNanoparticle tracking analysisMood disordersPsychiatric disordersMDDBinding potentialExtracellular vesiclesTreatment response predictionPositron emission tomographyTreatment responseDisordersHealthy controlsExosome markers CD63Blood-brain barrierEmission tomographyStudy intercellular communicationPrognostic valueConcentration of extracellular vesiclesPatient stratificationExosomal markersNetwork-wide aberrancies in neuronal activity during working memory in a large cohort of patients with mood disorders: associations with cognitive impairment and functional disability
Damgaard V, Schandorff J, Macoveanu J, Sankar A, Zarp J, Fisher P, Jørgensen M, Kessing L, Knudsen G, Frokjaer V, Miskowiak K. Network-wide aberrancies in neuronal activity during working memory in a large cohort of patients with mood disorders: associations with cognitive impairment and functional disability. Molecular Psychiatry 2025, 1-9. PMID: 40527901, DOI: 10.1038/s41380-025-03078-x.Peer-Reviewed Original ResearchCognitive control networkFunctional magnetic resonance imagingMood disordersCognitive performanceHypo-activityCross-sectional functional magnetic resonance imagingWorking memory n-back taskCognitive impairmentHyper-activityRight middle frontal gyrusLeft dorsolateral prefrontal cortexDaily functioningHealthy controlsDorsolateral prefrontal cortexFrontal medial cortexN-back taskMiddle frontal gyrusAssociated with cognitive impairmentAssociated with cognitionComprehensive neurocognitive testingAssessment of daily functionCognitive controlDMN abnormalitiesPrefrontal cortexFrontal gyrusRates of anxiety disorders, mood disorders, and substance use disorders in federally qualified health centers, 2019-2022
Tsai J, Witte L, Schick V. Rates of anxiety disorders, mood disorders, and substance use disorders in federally qualified health centers, 2019-2022. Psychiatry Research 2025, 348: 116457. PMID: 40147089, DOI: 10.1016/j.psychres.2025.116457.Peer-Reviewed Original ResearchSubstance use disordersDrug use disordersMood disordersDiagnosis of mental healthAlcohol-related disordersFederally Qualified Health CentersUse disorderMental healthRates of anxiety disordersCOVID-19 pandemicTrauma-related disordersDiagnosis of anxietyU.S. statesAnxiety disordersHealth centersComprehensive health care servicesHealth care servicesPatient populationQualified Health CentersUniform Data SystemDisordersCOVID-19PatientsMoodNational dataAn interpretable deep-learning approach to detect biomarkers in anxious-depressed symptoms from prefrontal fNIRS signals during an autobiographical memory test
Zhang Y, Xu Y, Cheng Y, Zhao Y, Potenza M, Shi H. An interpretable deep-learning approach to detect biomarkers in anxious-depressed symptoms from prefrontal fNIRS signals during an autobiographical memory test. Asian Journal Of Psychiatry 2025, 107: 104451. PMID: 40158273, DOI: 10.1016/j.ajp.2025.104451.Peer-Reviewed Original ResearchAutobiographical Memory TestNon-anxious depressionFunctional near-infrared spectroscopyAnxious depressionMemory testDepressive symptomsAnxious-depressive symptomsNegative emotional valenceSevere mood disordersFrontal pole areasAD symptomsMood disordersEmotional valenceRight hemisphereNeuroimaging dataDiagnosed depressionSymptom groupsCognitive impairmentSymptom predictionHealthy controlsNear-infrared spectroscopyDepressionSymptomsRecall featuresArea under the receiver operating characteristic curveRelation Between Brain Morphological Features and Psychiatric Hospitalization Risk in Major Depressive and Bipolar Disorders
Miskowiak K, Macoveanu J, Ozenne B, Beaman E, Dam V, Fisher P, Knudsen G, Kessing L, Jørgensen M, Frokjaer V, Sankar A. Relation Between Brain Morphological Features and Psychiatric Hospitalization Risk in Major Depressive and Bipolar Disorders. Acta Psychiatrica Scandinavica 2025, 151: 689-697. PMID: 39980329, PMCID: PMC12045658, DOI: 10.1111/acps.13790.Peer-Reviewed Original ResearchBipolar disorderPsychiatric hospitalHippocampal asymmetryMood disordersMatter volumeCognitive functionRisk of relapseStructural magnetic resonance imaging scansHippocampal gray matter volumeWhole-brain white matter volumeRight hippocampus volumeBrain morphological featuresGray matter volumeBrain structural measuresMarker of cognitive functionExploratory analysisWhite matter volumePrefrontal volumesDepressive disorderMajor depressionPsychiatric rehospitalizationBrain reserveHippocampus volumeMagnetic resonance imaging scansRisk of hospitalizationLate life mood disorders and suicidality
Khasnavis S, Asghar-Ali A. Late life mood disorders and suicidality. 2025, 235-246. DOI: 10.1093/med/9780198874799.003.0017.Peer-Reviewed Original ResearchMood disordersPresentation of mood disordersOlder adultsStudy of mental healthDepressive illnessBipolar disorderTreatment allianceMental healthHealth of older adultsTreatment formulationDisordersMoodCulturally responsive approachSuicideIntersection of cultureAdultsYoung individualsOlder patientsAge groupsIllnessHealthTreatmentAllianceIndividualsAssociations between childhood trauma and adolescent psychiatric disorders in Brazil: a longitudinal, population-based birth cohort study
Bailey M, Fairchild G, Hammerton G, Bauer A, Carpena M, Murray J, Santos I, Barros A, Tovo-Rodrigues L, Danese A, Halligan S, Matijasevich A. Associations between childhood trauma and adolescent psychiatric disorders in Brazil: a longitudinal, population-based birth cohort study. The Lancet Global Health 2025, 13: e309-e318. PMID: 39890231, DOI: 10.1016/s2214-109x(24)00452-2.Peer-Reviewed Original ResearchConceptsLow-income and-middle-income countriesPopulation attributable fractionPelotas Birth CohortAdolescent psychiatric disordersAnxiety disordersPsychiatric disordersTrauma exposureCumulative traumaBirth cohortLongitudinal associationsChildhood traumaMood disordersComputed population attributable fractionsTrauma loadPopulation-based birth cohort studyMental disordersRisk of mental disordersAnd Middle-Income CountriesExposure to childhood traumaPrevalence of trauma exposureAssociated with increased oddsAssociated with mental disordersBirth cohort studyIncreased exposure to traumaBurden of traumaDual Diagnosis
Caldwell E, Obiozor C, Kofos M, Martell J, Agerwala S, Petrakis I. Dual Diagnosis. 2025, 706-712. DOI: 10.1016/b978-0-323-95702-1.00275-x.Peer-Reviewed Original ResearchSubstance use disordersPsychiatric conditionsComorbid psychiatric conditionsAnxiety disordersPsychotic disordersStress disorderMood disordersAttention deficitHyperactivity disorderUse disorderEating disordersMental illnessDisordersCo-occurrenceMoodAnxietyHyperactivityNicotineSubstancesDeficitsIllnessProfessional individualsAlcohol
2024
Structural neural plasticity evoked by rapid-acting antidepressant interventions
Liao C, Dua A, Wojtasiewicz C, Liston C, Kwan A. Structural neural plasticity evoked by rapid-acting antidepressant interventions. Nature Reviews Neuroscience 2024, 26: 101-114. PMID: 39558048, PMCID: PMC11892022, DOI: 10.1038/s41583-024-00876-0.Peer-Reviewed Original ResearchAntidepressant interventionsStructural neural plasticityNeural plasticityPsychoactive drugsRapid-acting antidepressant drugsAction of psychoactive drugsRepetitive transcranial magnetic stimulationExcitatory synaptic functionAntidepressant effectsPrefrontal cortexDepressive disorderNon-invasive neurostimulationAntidepressant drugsMood disordersNeurobiological actionsTranscranial magnetic stimulationElectroconvulsive therapyPsychedelic drugsCortical pyramidal neuronsMechanisms of plasticityLongitudinal effectsGrowth of dendritic spinesPyramidal neuronsStructural plasticitySynaptic functionImplementation of American Society of Hematology (ASH) Neuro-Related Guidelines at a Sickle Cell Center: How Are We Doing?
Afranie-Sakyi J, Karimi M, Bozzo J, Cole J, Van Doren L, Calhoun C. Implementation of American Society of Hematology (ASH) Neuro-Related Guidelines at a Sickle Cell Center: How Are We Doing? Blood 2024, 144: 5009-5009. DOI: 10.1182/blood-2024-201816.Peer-Reviewed Original ResearchYale New Haven Health SystemHistory of strokeCognitive screeningGuideline publicationHealth systemSilent cerebral infarctionCognitive disordersImplementation ratePredictors of screeningSickle cell diseaseRates of screeningMood disordersAmerican Society of HematologyPrevalence of cognitive disordersDetect silent cerebral infarctsDevelopment of interventionsCognitive impairmentManual chart reviewICD-10 diagnosisEmergency room visitsDiagnosis of sickle cell diseaseSickle Cell CenterAmerican Society of Hematology guidelinesOutpatient encountersMRI screeningScreening for Cognitive Impairment and Depression in Sickle Cell Disease: How Are We Doing?
Afranie-Sakyi J, Karimi M, Bozzo J, Cole J, Van Doren L, Calhoun C. Screening for Cognitive Impairment and Depression in Sickle Cell Disease: How Are We Doing? Blood 2024, 144: 2249-2249. DOI: 10.1182/blood-2024-211906.Peer-Reviewed Original ResearchPatient Health QuestionnaireCognitive screeningAmerican Society of HematologyPsychiatric disordersSickle cell diseaseMood screeningMood disordersCognitive disordersDisorder screeningYale New Haven Health SystemPredictors of screeningDisease-modifying therapiesICD-10 diagnosisManual chart reviewImplementation of recommendationsEmergency room visitsDiagnosis of sickle cell diseaseHistory of strokeCell diseaseScreening ratesAnxious symptomsHealthcare teamPromote screeningNeuropsychological testsCognitive domainsW69. ALTERNATIVE SPLICING DYNAMICS IN HUMAN PREFRONTAL CORTEX SUBREGIONS
Nunez D, Martinez-Magana J, Nagamatsu S, Andrade-Brito D, Hernandez-Amaya L, Montalvo-Ortiz J. W69. ALTERNATIVE SPLICING DYNAMICS IN HUMAN PREFRONTAL CORTEX SUBREGIONS. European Neuropsychopharmacology 2024, 87: 138-139. DOI: 10.1016/j.euroneuro.2024.08.278.Peer-Reviewed Original ResearchDorsal anterior cingulate cortexPrefrontal cortex subregionsPrefrontal cortexOrbitofrontal cortexDifferential transcript usagePercent-spliced-inSubgenual prefrontal cortexPrefrontal cortex regionsAnterior cingulate cortexDorsolateral prefrontal cortexDSM-IV criteriaAS eventsTranscript usageSynaptic processesExon skippingDSM-IVSCID-1Cingulate cortexIntron retentionMood disordersPsychiatric disordersSplice siteAlternative splicingCognitive functionNon-psychiatric diagnosesCharacterizing the dynamics, reactivity and controllability of moods in depression with a Kalman filter
Malamud J, Guloksuz S, van Winkel R, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Rutten B, Huys Q. Characterizing the dynamics, reactivity and controllability of moods in depression with a Kalman filter. PLOS Computational Biology 2024, 20: e1012457. PMID: 39312537, PMCID: PMC11449358, DOI: 10.1371/journal.pcbi.1012457.Peer-Reviewed Original ResearchConceptsEcological momentary assessmentEcological momentary assessment dataMood statesMood disordersDepressive stateMood dynamicsFeatures of mood disordersCombination of ecological momentary assessmentsControl of moodSymptoms of depressionInternal emotional statesAlterations to interactionsPsychopathological featuresMomentary assessmentMoodEmotional statesDepressionEnvironmental stimuliAssociation between rumination, suicidal ideation and suicide attempts in persons with depressive and other mood disorders and healthy controls: A systematic review and meta-analysis
Le G, Wong S, Au H, Badulescu S, Gill H, Vasudeva S, Teopiz K, Rhee T, Ho R, Kwan A, Mansur R, Rosenblat J, McIntyre R. Association between rumination, suicidal ideation and suicide attempts in persons with depressive and other mood disorders and healthy controls: A systematic review and meta-analysis. Journal Of Affective Disorders 2024, 368: 513-527. PMID: 39303880, DOI: 10.1016/j.jad.2024.09.118.Peer-Reviewed Original ResearchSuicidal ideationMood disordersPsychiatric disordersLifetime history of suicide attemptsHealthy controlsHistory of suicide attemptsMeasures of ruminationSuicide attempt historyDiagnosed mood disorderTransdiagnostic associationsAttempt historyDepressive disorderNeurobiological substratesSuicide completersLifetime historyGeneral cognitionSuicide attemptsMeta-analysisIdeationSystematic reviewMoodClinically meaningful associationsSuicideResearch vistasFunctional impairmentPharmacological Interventions and an Emerging Understanding of the Need to Consider Sex Differences in Treatment Planning
Fanta A, Bordofsky A, Sebolt C, Jou R. Pharmacological Interventions and an Emerging Understanding of the Need to Consider Sex Differences in Treatment Planning. 2024, 157-167. DOI: 10.1007/978-3-031-62072-0_10.Peer-Reviewed Original ResearchAutism spectrum disorderPharmacological treatmentComorbid disordersCore symptoms of autism spectrum disorderSymptoms of autism spectrum disorderPharmacological treatment of individualsTreating comorbid disordersFDA-approved medicationsTreatment of individualsEffective pharmacological treatmentAnxiety disordersCore symptomsMood disordersEating disordersASD populationSpectrum disorderSex differencesTreatment of maleDisordersPharmacological interventionsInvestigational clinical trialsNumerous medicationsClinical trialsTreatment planningOCDMultiscale Neuroimaging Features for the Identification of Medication Class and Non-Responders in Mood Disorder Treatment
Baker B, Salman M, Fu Z, Iraji A, Osuch E, Bockholt H, Calhoun V. Multiscale Neuroimaging Features for the Identification of Medication Class and Non-Responders in Mood Disorder Treatment. 2024, 00: 1-5. DOI: 10.1109/isbi56570.2024.10635741.Peer-Reviewed Original ResearchTreatment of mood disordersMood disordersCourse of antidepressantsFunctional network connectivity measuresMedication classesMood disorder treatmentNeuroimaging featuresComplex behavioral symptomsNetwork connectivity measuresMood stabilizersNon-respondersBehavioral symptomsDisorder treatmentNeuroimaging scansResting state functional networksNeural featuresConnectivity measuresFunctional networksMoodDisordersEffective courseAntidepressantsClinical decision supportClinical treatmentSymptomsCharacterizing the distinct imaging phenotypes, clinical behavior, and genetic vulnerability of brain maturational subtypes in mood disorders.
Zheng J, Zong X, Tang L, Guo H, Zhao P, Womer F, Zhang X, Tang Y, Wang F. Characterizing the distinct imaging phenotypes, clinical behavior, and genetic vulnerability of brain maturational subtypes in mood disorders. Psychological Medicine 2024, 54: 2774-2784. PMID: 38804091, DOI: 10.1017/s0033291724000886.Peer-Reviewed Original ResearchGray matter volumeMood disordersGenetic vulnerabilityDepressive disorderHeterogeneity of mood disordersRegional gray matter volumeDrug-free patientsClinical behaviorIncreased genetic vulnerabilityGenetic riskSevere depressive symptomsClinical manifestationsBipolar disorderDrug-naiveFrontal cortexPolygenic risk scoresMatter volumeDepressive symptomsNeurocognitive assessmentCognitive impairmentPrimary motor cortexBehavioral termsDisordersHealthy controlsMotor cortexRepetitive Transcranial Magnetic Stimulation Reversing Abnormal Brain Function in Mood Disorders with Early Life Stress: from preclinical models to clinical applications
Zhao T, Guo H, Yang J, Cai A, Liu J, Zheng J, Xiao Y, Zhao P, Li Y, Luo X, Zhang X, Zhu R, Wang J, Wang F. Repetitive Transcranial Magnetic Stimulation Reversing Abnormal Brain Function in Mood Disorders with Early Life Stress: from preclinical models to clinical applications. Asian Journal Of Psychiatry 2024, 97: 104092. PMID: 38823081, DOI: 10.1016/j.ajp.2024.104092.Peer-Reviewed Original ResearchEarly life stressFunctional magnetic resonance imagingRepetitive transcranial magnetic stimulationMood disorder patientsChronic unpredictable mild stressMood disordersDisorder patientsAbnormal functional activityLife stressCross-species translational studiesImpact of early life stressFunctional magnetic resonance imaging analysisPrimary cortexRisk of mood disordersUnpredictable mild stressTargeting rTMSRTMS interventionAbnormal brain functionIncreased activityDecreased activityDepression-relatedAdolescent ratsCUMS ratsFrontal cortexMild stressBipolar Disorders
Tampi R, Tampi D. Bipolar Disorders. 2024, 139-149. DOI: 10.1007/978-3-031-55711-8_10.Peer-Reviewed Original ResearchOlder age bipolar disorderEarly-onset bipolar disorderCases of bipolar disorderBipolar disorderElectroconvulsive therapyFamily history of mood disordersHistory of mood disorderInpatient psychiatric hospitalizationTreatment of individualsMental health servicesPsychosocial treatmentsMood disordersCompared to age-matched controlsPsychiatric hospitalAge-matched controlsAdjunctive treatmentTreated individualsDisordersMedication classesHealth servicesFamily historyIndividualsNeurological disordersCerebrovascular diseaseRefractory cases
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