2025
The Impact of Enhanced Behavioral Health Services on Total Healthcare Costs Among US Employers: A Site-Level Analysis of 19 Cohort Studies
Hawrilenko M, Smolka C, Ward E, Kavelaars R, Brown M, Chekroud A. The Impact of Enhanced Behavioral Health Services on Total Healthcare Costs Among US Employers: A Site-Level Analysis of 19 Cohort Studies. Journal Of Health Economics And Outcomes Research 2025, 12: 246-251. PMID: 40546793, PMCID: PMC12182909, DOI: 10.36469/001c.138634.Peer-Reviewed Original ResearchBehavioral health benefitsComprehensive mental health programMedical spendingMental health programsMental health careBehavioral health servicesHealthcare decision-makingReturn-on-investment estimatesRetrospective matched cohort designMeta-analysisHealth benefitsDifference-in-differences analysisUS employersMatched cohort designMedical claims dataEmployer-sponsored health plansMedication management sessionsHealth programsHealth servicesHealth careHealth plansCohort designInverse varianceDifference-in-differences modelReturn on investmenthe Impact of Enhanced Behavioral Health Services on Total Healthcare Costs Among US Employers: A Site-Level Analysis of 19 Cohort Studies
Hawrilenko M, Smolka C, Ward E, Kavelaars R, Brown M, Chekroud A. he Impact of Enhanced Behavioral Health Services on Total Healthcare Costs Among US Employers: A Site-Level Analysis of 19 Cohort Studies. Journal Of Health Economics And Outcomes Research 2025, 246-251. DOI: 10.36469/jheor.2025.138634.Peer-Reviewed Original ResearchBehavioral health benefitsComprehensive mental health programMedical spendingMental health programsMental health careBehavioral health servicesHealthcare decision-makingReturn-on-investment estimatesRetrospective matched cohort designMeta-analysisHealth benefitsDifference-in-differences analysisUS employersMatched cohort designMedical claims dataEmployer-sponsored health plansMedication management sessionsHealth programsHealth servicesHealth careHealth plansInverse varianceCohort designDifference-in-differences modelReturn on investmentCorrection: Prevalence of chronic kidney disease among young people living with HIV in Sub Saharan Africa: A systematic review and meta-analysis
Nasuuna E, Nanyeenya N, Kibirige D, Izudi J, Chikwari C, Kalyesubula R, Castelnuovo B, Tomlinson L, Weiss H. Correction: Prevalence of chronic kidney disease among young people living with HIV in Sub Saharan Africa: A systematic review and meta-analysis. PLOS ONE 2025, 20: e0326624. PMID: 40526591, PMCID: PMC12173373, DOI: 10.1371/journal.pone.0326624.Peer-Reviewed Original ResearchSystematic Review and Meta‐Analysis of Dual‐Layered Stents Versus Single‐Layered Stents for Carotid Artery Stenosis
Mari T, Moeed A, Siddiqui A, Abbasi A, Arif Z, Jannat A, Akman Z, Rossi R, Unnar H, Bhatti H, Batool R, Khan M, Ali M, Batool F, Minahil, Iqbal J, Mena‐Hurtado C, Nanna M. Systematic Review and Meta‐Analysis of Dual‐Layered Stents Versus Single‐Layered Stents for Carotid Artery Stenosis. Catheterization And Cardiovascular Interventions 2025 PMID: 40518749, DOI: 10.1002/ccd.31684.Peer-Reviewed Original ResearchCarotid artery stentingCarotid artery stenosisSingle-layer stentsDual-layer stentsAll-cause mortalityPost-procedural strokeArtery stenosisRandomized controlled trialsStent occlusionHigher risk of peri-procedural strokePostprocedural strokeMeta-analysisRisk of peri-procedural strokeRisk ratioHigh riskCarotid artery stenting proceduresStroke riskPeri-procedural strokeRandom-effects meta-analysisPredictors of strokeTreat carotid artery stenosisLipid-rich carotid plaquesTreatment optionsArtery stentingPrimary outcomeCognitive-behavioral interventions for co-occurring substance use and mental health disorders
Magill M, Helminen E, Lynch-Gadaleta B, Allen K, Kiluk B, Ray L. Cognitive-behavioral interventions for co-occurring substance use and mental health disorders. Drug And Alcohol Dependence 2025, 274: 112756. PMID: 40543363, DOI: 10.1016/j.drugalcdep.2025.112756.Peer-Reviewed Original ResearchMental health disordersUsual careCo-occurring mental health conditionsHealth disordersCo-occurring substance useCognitive-behavioral interventionsPattern of effectsCompared to usual careMental health conditionsSubstance useSample of studyMental healthPsychosocial outcomesDrug useDisordersHealth conditionsDiagnostic criteriaOutcome typesStudy samplePublished outcome dataCareControl comparatorMeta-analysisLiterature searchOutcome dataTranexamic Acid in Body Contouring Surgery: A Systematic Review and Meta-Analysis
Fijany A, Holan C, Troia T, Montorfano L, Mubang R, Givechian K, Karagoz H, Martinez-Jorge J, Perdikis G, Connor L, Slater E. Tranexamic Acid in Body Contouring Surgery: A Systematic Review and Meta-Analysis. Aesthetic Surgery Journal 2025, sjaf112. PMID: 40509914, DOI: 10.1093/asj/sjaf112.Peer-Reviewed Original ResearchBody contouring proceduresWound healing complicationsTranexamic acidTXA administrationContouring proceduresTopical TXA administrationHealing complicationsMeta-analysisImpact of tranexamic acidOdds ratioTranexamic acid cohortRisk of hematomaWound healing issuesDecreased risk of infectionBody contouring surgeryConfidence intervalsRandom-effects modelRisk of infectionBreast reconstructionAntifibrinolytic drugsSeroma formationContouring surgerySubgroup analysisHealing issuesDecreased riskOutpatient or Inpatient Setting for Cervical Ripening Before Induction of Labour: An Individual Participant Data Meta‐Analysis
Patabendige M, Chan F, Wise M, Thompson J, Beckmann M, Saad A, Saade G, Subramaniam A, Tita A, Policiano C, Clode N, Henry A, Haavisto H, Rinne K, Chen V, Sheehan P, Kohari K, Hosier H, Pierce‐Williams R, Berghella V, Rolnik D, Mol B, Li W. Outpatient or Inpatient Setting for Cervical Ripening Before Induction of Labour: An Individual Participant Data Meta‐Analysis. BJOG An International Journal Of Obstetrics & Gynaecology 2025 PMID: 40497299, DOI: 10.1111/1471-0528.18253.Peer-Reviewed Original ResearchCervical ripeningIPD meta-analysisInduction of laborRandomised controlled trialsData meta-analysisBalloon catheterComposite perinatal outcomeVaginal birthVaginal dinoprostoneCINAHL PlusVaginal prostaglandinsMaternal safetyEpidural analgesiaPerinatal deathWomen's experiencesOutpatient groupPerinatal outcomesPregnant individualsControlled trialsSingleton gestationsInpatient groupCochrane LibraryLanguage restrictionsNo trialsMeta-analysisThe Effect of Prophylactic Use of Antifibrinolytics During Pediatric Non‐Cardiac Surgeries on Bleeding and Transfusions: A Systematic Review and Meta‐Analysis
Hickey K, Smith M, Karam O, Demetres M, Faraoni D, Duron V, Wu Y, Nellis M. The Effect of Prophylactic Use of Antifibrinolytics During Pediatric Non‐Cardiac Surgeries on Bleeding and Transfusions: A Systematic Review and Meta‐Analysis. Pediatric Anesthesia 2025 PMID: 40476647, DOI: 10.1111/pan.15137.Peer-Reviewed Original ResearchEstimated blood lossNon-cardiac surgeryBlood lossP-value <Tranexamic acidScoliosis surgeryAminocaproic acidBlood transfusionCraniofacial surgeryProphylactic administration of tranexamic acidMeta-analysisEfficacy of tranexamic acidAdministration of tranexamic acidIntraoperative blood transfusionIntraoperative blood lossAdministration of antifibrinolyticsIntraoperative tranexamic acidSystematic reviewP-valueReduce transfusionsDosing regimensProphylactic administrationCraniosynostosis surgeryPediatric surgeryPrimary outcomeSystematic review and meta-analysis of efficacy of helmet use and helmet laws to reduce mortality and cervical spine injury in adult motorcycle riders: A practice management guideline from the Eastern Association for the Surgery of Trauma.
Ratnasekera A, Seng S, Gardiner S, Butler C, Goldenberg-Sandau A, Lu N, Abdel Aziz H, Appelbaum R, Mashbari H, Hafiz S, Chowdhury S, Soe-Lin H, Reynolds J, Teichman A, Kartiko S, Kaufman E, Murphy P, Kodadek L, Rattan R. Systematic review and meta-analysis of efficacy of helmet use and helmet laws to reduce mortality and cervical spine injury in adult motorcycle riders: A practice management guideline from the Eastern Association for the Surgery of Trauma. Journal Of Trauma And Acute Care Surgery 2025 PMID: 40462278, DOI: 10.1097/ta.0000000000004607.Peer-Reviewed Original ResearchCervical spine injuryIncidence of cervical spine injuriesSpine injuriesInjury-related mortalityDischarge dispositionSystematic reviewHelmet useMeta-analysisSignificant methodological heterogeneityPICO 1PICO-2Eastern Association for the Surgery of TraumaEvidence-based guidelinesRisk of biasCertainty of evidenceSignificant public health concernImproved discharge dispositionEvidence-based recommendationsRiders wear helmetsHelmet lawsImprove mortalityEvidence-based systematic reviewMotorcycle ridersPublic health concernPractice management guidelinesJoint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States.
Chu L, Wang R, Gross C, Wei J, Lu Y, Krumholz H, Ma X, Chen K. Joint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States. Circulation 2025 PMID: 40458867, DOI: 10.1161/circulationaha.124.073614.Peer-Reviewed Original ResearchIncident acute myocardial infarctionAcute myocardial infarctionIncreased oddsRisk of acute myocardial infarctionHigher risk of acute myocardial infarctionProbability of acute myocardial infarctionOccurrence of acute myocardial infarctionRandom-effects meta-analysisCase-crossover studyMultivariate random-effects meta-analysisExposure to ozoneRegion-specific estimatesMyocardial infarctionStatistical interaction termsAmbient ozone pollutionPrevention strategiesUnited StatesJoint exposureMeta-analysisAdult ageYoung adultsHigh riskAdultsOddsInteraction termsLuspatercept in patients with lower-risk myelodysplastic syndromes (MDS): A systematic review and meta-analysis.
Alhajahjeh A, Woite N, Grimshaw A, Rolles B, Stahl M, Kewan T, Podoltsev N, Stempel J, Mendez L, Zeidan A, Bewersdorf J. Luspatercept in patients with lower-risk myelodysplastic syndromes (MDS): A systematic review and meta-analysis. Journal Of Clinical Oncology 2025, 43 DOI: 10.1200/jco.2025.43.16_suppl.e18574.Peer-Reviewed Original ResearchMyelodysplastic syndromeTransfusion dependenceRinged sideroblastsFrontline settingAcute myeloid leukemia transformationLower-risk myelodysplastic syndromesHigh transfusion burdenBone marrow disordersMeta-analysisErythropoiesis-stimulating agentsSerious adverse eventsStudy's primary endpointResistant to treatmentReduce transfusion needsSystematic reviewIndependent reviewers assessed studiesRandom-effects modelBlack quality assessment checklistTransfusion burdenTransfusion independenceQuality assessment checklistLeukemia transformationRisk of biasLR-MDSPrimary endpointGenome-wide meta-analysis identifies nine loci to be associated with higher risk of hepatocellular carcinoma development.
Ghouse J, Gellert-Kristensen H, O’Rourke C, Seidelin A, Thorleifsson G, Sveinbjörnsson G, Tragante V, Konkwo C, Brancale J, Vilarinho S, Eyrich T, Ahlberg G, Bundgaard J, Rand S, Lundegaard P, Sørensen E, Mikkelsen C, Træholt J, Erikstrup C, Dinh K, Bruun M, Jensen B, Bay J, Brunak S, Banasik K, Ullum H, Consortium E, Laisk T, Mägi R, Nadauld L, Knowlton K, Knight S, Gluud L, Vistisen K, Björnsson E, Ulfarsson M, Sulem P, Holm H, Pedersen O, Ostrowski S, Gudbjartsson D, Rafnar T, Stefansson K, Lassen U, Pommergaard H, Hillingsø J, Andersen J, Bundgaard H, Stender S. Genome-wide meta-analysis identifies nine loci to be associated with higher risk of hepatocellular carcinoma development. JHEP Reports 2025, 101485. DOI: 10.1016/j.jhepr.2025.101485.Peer-Reviewed Original ResearchGenome-wide association studiesAssociated with higher riskGenome-wide statistical significanceIncident hepatocellular carcinomaMendelian randomization analysisGenome-wide meta-analysisIdentified variantsPer-allele effectsMeta-analysisMendelian randomizationGenetic risk lociPrevalent obesityRandomization analysisAlcohol intakeMeta-analysesRisk lociAssociation studiesRisk factorsGenetic variantsGenetic underpinningsRisk of hepatocellular carcinomaLociGenetic effectsCohortConcordant effectsExploring Ethnic Disparities in Hypospadias Incidence: A Meta-Analysis of Epidemiological Studies
Santoso B, Situmorang G, Wahyudi I, Rodjani A, Saraiva L, Al-Shafai K, Abbas T, Raharja P. Exploring Ethnic Disparities in Hypospadias Incidence: A Meta-Analysis of Epidemiological Studies. Journal Of Pediatric Urology 2025 DOI: 10.1016/j.jpurol.2025.06.015.Peer-Reviewed Original ResearchEthnic disparitiesMeta-analysis of epidemiological studiesMeta-analysisHypospadias incidenceImprove healthcare outcomesDiverse populationsIncidence of hypospadiasCross-sectional studyCongenital anomaly prevalenceCase-control studyHealthcare outcomesReduce disparitiesJBI toolsPerinatal determinantsNon-white groupsCitation tracingStudy selectionData extractionSystematic reviewBias riskManual searchEpidemiological studiesRisk factorsDisparitiesEthnic variationsProximal Hamstring Repairs Demonstrate Similar Load to Failure as Intact Hamstring Tendons: A Systematic Review and Meta-Analysis of Biomechanical Investigations
MacLeod J, Lee M, Fallon A, Gillinov S, Park N, Girardi K, Vorbau J, Moran J, Fritz J, Nasser A, Surucu S, Jimenez A. Proximal Hamstring Repairs Demonstrate Similar Load to Failure as Intact Hamstring Tendons: A Systematic Review and Meta-Analysis of Biomechanical Investigations. Arthroscopy Sports Medicine And Rehabilitation 2025, 101204. DOI: 10.1016/j.asmr.2025.101204.Peer-Reviewed Original ResearchProximal hamstring repairSystematic reviewQuality assessment toolPreferred Reporting ItemsHamstring tendonsCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsProximal hamstring tearsProximal hamstringsLoad to failureCochrane Central RegisterHamstring tearsReporting ItemsMeta-analysesAssessment toolControlled trialsEffect sizeBiomechanical investigationsMeta-analysisHamstringStatistically significant differenceOpen repairMaximum load to failureCadaveric studyUtility and Outcomes of Ovarian Tissue Cryopreservation and Transplantation for Gynecologic Cancers: A Systematic Review and Meta-analysis
Erden M, Gayete-Lafuente S, Vural N, Oktay K. Utility and Outcomes of Ovarian Tissue Cryopreservation and Transplantation for Gynecologic Cancers: A Systematic Review and Meta-analysis. Obstetrical & Gynecological Survey 2025, 80: 350-351. DOI: 10.1097/ogx.0000000000001414.Peer-Reviewed Original ResearchUtilization and fertility preservation outcomes in women undergoing embryo cryopreservation before breast cancer treatment: a meta-analysis
Turan V, Oktem O, Bang H, Oktay K. Utilization and fertility preservation outcomes in women undergoing embryo cryopreservation before breast cancer treatment: a meta-analysis. Clinical Breast Cancer 2025 DOI: 10.1016/j.clbc.2025.06.003.Peer-Reviewed Original ResearchBreast cancer treatmentFertility preservation rateLive birth rateClinical pregnancyCancer treatmentFertility preservationEmbryo transferPreservation rateBirth rateFertility preservation outcomesFrozen embryo transferCochrane Library databasesRandom-effects modelSecondary outcome measuresPregnancy outcomesEmbryo cryopreservationBreast cancerPreservation outcomesLibrary databasesPregnancyBreastMeta-analysisOutcome measuresWomenTreatmentErratum to ‘High- vs low-dose oxytocin regimens for labor augmentation: a systematic review and meta-analysis’. American Journal of Obstetrics & Gynecology MFM/ Volume 7 Issue 2 (February 2025)/ 101604
Logue T, Zullo F, van Biema F, Son M, London L, Paranandi S, Sciscione A, Rizzo G, Di Mascio D, Chauhan S. Erratum to ‘High- vs low-dose oxytocin regimens for labor augmentation: a systematic review and meta-analysis’. American Journal of Obstetrics & Gynecology MFM/ Volume 7 Issue 2 (February 2025)/ 101604. American Journal Of Obstetrics & Gynecology MFM 2025, 7: 101685. PMID: 40450436, DOI: 10.1016/j.ajogmf.2025.101685.Peer-Reviewed Original ResearchImmune checkpoint inhibitor (ICI) efficacy in triple-negative breast cancer (TNBC) patients with liver metastases (LM): A meta-analysis.
Park D, Abid M, Lustberg M, Kalinski P, Gandhi S, Huang C. Immune checkpoint inhibitor (ICI) efficacy in triple-negative breast cancer (TNBC) patients with liver metastases (LM): A meta-analysis. Journal Of Clinical Oncology 2025, 43: e13131-e13131. DOI: 10.1200/jco.2025.43.16_suppl.e13131.Peer-Reviewed Original ResearchProgrammed death-ligand1Triple-negative breast cancerImmune checkpoint inhibitorsProgression free survivalLiver metastasesHazard ratioBreast cancerEfficacy of immune checkpoint inhibitorsTriple-negative breast cancer casesLog-transformed hazard ratioProgression free survival benefitImmune checkpoint inhibitor therapyAssociated with poor prognosisSite of diseaseAggressive breast cancerMeta-analysisArea of translational researchRandom-effects modelCheckpoint inhibitorsRandomized controlled trialsSystematic literature searchFree survivalOverall survivalDistant metastasisImmunocompromised stateThe efficacy of lithium in the treatment of suicidal ideation, behavior and suicide: An updated systematic review and meta-analysis of randomized controlled trials
Wang J, Le G, Wong S, Teopiz K, Kwan A, Rosenblat J, Rhee T, Ho R, Lo H, Goldberg J, Vinberg M, Grande I, Mansur R, Meyer J, McIntyre R. The efficacy of lithium in the treatment of suicidal ideation, behavior and suicide: An updated systematic review and meta-analysis of randomized controlled trials. Journal Of Affective Disorders 2025, 387: 119487. PMID: 40441661, DOI: 10.1016/j.jad.2025.119487.Peer-Reviewed Original ResearchConceptsSuicidal ideationBipolar disorderSuicide attemptsCompleted suicideTreatment of suicidal ideationTreating acute maniaRate of completed suicideAnti-suicidal effectsEfficacy of lithiumAcute maniaDiagnostic heterogeneityBD-I.Randomized controlled trialsTreatment fidelitySuicide measuresLithium effectsSuicideIdeationLithium levelsMethodological limitationsAssociated with nonsignificant reductionsMeta-analysis of randomized controlled trialsControlled trialsFirst-line treatmentMeta-analysisLaboratory-Assessed Mistrust in Borderline Personality Disorder: A Meta-Analytic Review
Kurt Y, Walker M, Luyten P, Fonagy P. Laboratory-Assessed Mistrust in Borderline Personality Disorder: A Meta-Analytic Review. Personality Disorders Theory Research And Treatment 2025 PMID: 40402642, DOI: 10.1037/per0000739.Peer-Reviewed Original ResearchBorderline personality disorderMeta-analytic reviewPersonality disorderSmall-to-moderate effect sizesEffect sizeStatistically significant moderatorPsychometrically sound toolBPD symptomsSignificant moderatorMeta-analytic modelMeta-analysisBPDSound toolJoanna Briggs Institute Critical Appraisal ChecklistInternational Prospective Register of Systematic ReviewsSystematic reviewProspective Register of Systematic ReviewsInterpersonal trustCritical Appraisal ChecklistEffective interventionsInternational Prospective RegisterRisk of biasControl groupDisordersBorderline
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