2025
An interpretable deep-learning approach to detect biomarkers in anxious-depressed symptoms from prefrontal fNIRS signals during an autobiographical memory test
Zhang Y, Xu Y, Cheng Y, Zhao Y, Potenza M, Shi H. An interpretable deep-learning approach to detect biomarkers in anxious-depressed symptoms from prefrontal fNIRS signals during an autobiographical memory test. Asian Journal Of Psychiatry 2025, 107: 104451. PMID: 40158273, DOI: 10.1016/j.ajp.2025.104451.Peer-Reviewed Original ResearchAutobiographical Memory TestNon-anxious depressionFunctional near-infrared spectroscopyAnxious depressionMemory testDepressive symptomsAnxious-depressive symptomsNegative emotional valenceSevere mood disordersFrontal pole areasAD symptomsMood disordersEmotional valenceRight hemisphereNeuroimaging dataDiagnosed depressionSymptom groupsCognitive impairmentSymptom predictionHealthy controlsNear-infrared spectroscopyDepressionSymptomsRecall featuresArea under the receiver operating characteristic curveFunctional connectivity changes in the prefrontal-thalamic-cerebellar circuit in adolescents with first-episode Schizophrenia
Song Y, Zhu H, Wu Z, Hu W, Zhang S, Zhou Y, Peng Y, Yang Y, Li W, Shi H, Yang G, Zhang Y, Lv L. Functional connectivity changes in the prefrontal-thalamic-cerebellar circuit in adolescents with first-episode Schizophrenia. European Child & Adolescent Psychiatry 2025, 1-10. PMID: 39928122, DOI: 10.1007/s00787-025-02656-2.Peer-Reviewed Original ResearchPrefrontal-thalamic-cerebellar circuitMedial prefrontal cortexMiddle temporal gyrusPosterior cerebellar lobeFunctional connectivityReduced FCTemporal gyrusResting-state functional magnetic resonance imaging scansFunctional magnetic resonance imaging scansLeft medial prefrontal cortexEarly stages of schizophreniaCerebellar lobeRight middle temporal gyrusHealthy controlsPositive symptom scoresFirst-episode schizophreniaVisuospatial Memory TestStages of schizophreniaFunctional connectivity changesRight posterior cerebellar lobePrefrontal cortexMemory testLeft precuneusFC abnormalitiesBrain regions
2023
CSF tau markers are associated with fine memory discrimination in older adults with amnestic MCI in the EXERT trial
Fenton L, Aslanyan V, Jacobs D, Salmon D, Brewer J, Rissman R, Feldman H, Shadyab A, LaCroix A, Baker L, Pa J. CSF tau markers are associated with fine memory discrimination in older adults with amnestic MCI in the EXERT trial. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.080157.Peer-Reviewed Original ResearchAmnestic mild cognitive impairmentMemory discriminationOlder adultsMemory testLogical memoryHippocampal volumeAuditory Verbal Learning TestLogical memory testVerbal Learning TestBehavioral pattern separationVerbal memory testsMedial temporal lobeLarger hippocampal volumesMemory measuresList learningStory recallLearning TestObject taskMemory assessmentCognitive performanceMild cognitive impairmentPattern separationCognitive AssessmentStructural brain imagesTemporal lobeMulti‐modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain
Bueichekú E, Diez I, Gagliardi G, Kim C, Mimmack K, Sepulcre J, Vannini P. Multi‐modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.080294.Peer-Reviewed Original ResearchMnemonic anosognosiaOccipito-parietal regionsMemory declineBrain phenotypesSelf-referential brain networkObjective memory testsObjective memory declineResting-state fMRIPosterior cerebral cortexMulti-modal neuroimagingNetwork connectivity patternsAlzheimer's diseaseFunctional connectivity networksGraph theory metricsTau burdenNeurocognitive profileBiomarkers of AD pathologyMemory testMemory impairmentBetween-group comparisonsFunctional network connectivity disruptionBrain networksAging brainAnosognosiaBehavioral conditionsPerceptual Generalization of Alcohol-Related Value Characterizes Risky Drinkers
Kang S, Larrabee G, Nair S, Goldfarb E. Perceptual Generalization of Alcohol-Related Value Characterizes Risky Drinkers. Psychological Science 2023, 34: 1146-1162. PMID: 37682597, PMCID: PMC10985388, DOI: 10.1177/09567976231181516.Peer-Reviewed Original ResearchSurprise recognition memory testAlcohol-related associationsRecognition memory testAlcohol-related imagesRisky drinkingPerceptual generalizationMemory testPerceptual similarityRisky drinkersNovel situationsAdaptive behaviorMaladaptive responsesOnline experimentPast experienceRisky patternsOvergeneralizationDrinkersDrinkingParticipantsConditioningIndividualsOutcomesExperienceAlcoholBias
2022
Lower novelty‐related locus coeruleus function is associated with entorhinal tau‐mediated memory decline in older individuals.
Prokopiou P, Engels N, Schneider C, Schultz A, Sepulcre J, Riphagen J, Koops E, Papp K, Fakhri G, Rentz D, Sperling R, Johnson K, Jacobs H. Lower novelty‐related locus coeruleus function is associated with entorhinal tau‐mediated memory decline in older individuals. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.067706.Peer-Reviewed Original ResearchMemory declineLC activityLocus coeruleusEC tauEntorhinal cortexLC phasic activationAssociated with memory declineFace-name pairsMediation effectHarvard Aging Brain StudySteeper memory declineExposure to noveltyAssociated with tau depositionInferior temporal lobeSpatial patterns of tauAging Brain StudyPreclinical Alzheimer's diseaseCortical tau depositionTau depositionFusiform cortexMemory testInsular cortexMixed-effects analysisMediation analysisInferior temporalTemporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex
Sherman B, Graves K, Huberdeau D, Quraishi I, Damisah E, Turk-Browne N. Temporal Dynamics of Competition between Statistical Learning and Episodic Memory in Intracranial Recordings of Human Visual Cortex. Journal Of Neuroscience 2022, 42: 9053-9068. PMID: 36344264, PMCID: PMC9732826, DOI: 10.1523/jneurosci.0708-22.2022.Peer-Reviewed Original ResearchConceptsVisual cortexStatistical learningIntracranial recordingsStatistical learning taskBehavioural Memory TestMultivariate pattern analysisLong-term memoryExpense of memoryEncoding of informationHuman visual cortexStorage of experienceNew experiencesEpisodic memoryMemory researchMemory testFrequency taggingRapid streamGuide behaviorLearning taskNew predictive relationshipNeural predictionHuman intracranial EEGWeak expectationsNeural activityMemory formationMemory training with the method of loci for children and adolescents with ADHD—A feasibility study
Ruchkin V, Wallonius M, Odekvist E, Kim S, Isaksson J. Memory training with the method of loci for children and adolescents with ADHD—A feasibility study. Applied Neuropsychology Child 2022, 13: 137-145. PMID: 36344263, DOI: 10.1080/21622965.2022.2141120.Peer-Reviewed Original ResearchMethod of lociPost-intervention ratingsMemory trainingMemory testADHD symptomsLack of motivationLack of routinesADHDPotential distractionDuration of trainingFuture researchParticipantsDistractionTrainingAdolescentsChildrenDay lifeQualitative dataContent analysisMotivationPeersParentsRatingsBaseline levelsInterventionClinical and behavior characteristics of individuals who used ketamine
Lee TS, Liu YH, Huang YJ, Tang WK, Wang Y, Hu S, Lin CP, Li CR, Hung CC. Clinical and behavior characteristics of individuals who used ketamine. Scientific Reports 2022, 12: 801. PMID: 35039593, PMCID: PMC8764021, DOI: 10.1038/s41598-022-04832-9.Peer-Reviewed Original ResearchConceptsMemory testLower urinary tract symptomsN-back memory testShort-term recallShort-term memoryDrug-using participantsCigarette smokersImpulsivity measuresTerm recallBehavioral dispositionsPolydrug usersKetamine usersGroup of individualsSex-related behaviorsUrinary tract symptomsPolydrug useDrug-related problemsCross-sectional interviewMemoryRisk behaviorsKetamine useTract symptomsClinical characteristicsParticipantsHIV serostatus
2021
Using functional connectivity models to characterize relationships between working and episodic memory
Stark GF, Avery EW, Rosenberg MD, Greene AS, Gao S, Scheinost D, Constable R, Chun MM, Yoo K. Using functional connectivity models to characterize relationships between working and episodic memory. Brain And Behavior 2021, 11: e02105. PMID: 34142458, PMCID: PMC8413720, DOI: 10.1002/brb3.2105.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelsN-back task performanceEpisodic memoryMemory test scoresFunctional connectivityTask performanceN-back memory taskWord scoresTest scoresCritical cognitive abilityPicture-sequencing taskHuman Connectome Project participantsN-back taskFunctional magnetic resonance imaging (fMRI) dataWhole-brain functional connectivityTask functional connectivityFunctional brain connectionsFunctional connectivity modelsFunctional connectionsMemory taskCognitive processesMemory testCognitive abilitiesSequence taskList Sorting
2020
Autobiographical memory as a latent vulnerability mechanism following childhood maltreatment: Association with future depression symptoms and prosocial behavior
Puetz V, Viding E, Hoffmann F, Gerin M, Sharp M, Rankin G, Maguire E, Mechelli A, McCrory E. Autobiographical memory as a latent vulnerability mechanism following childhood maltreatment: Association with future depression symptoms and prosocial behavior. Development And Psychopathology 2020, 33: 1300-1307. PMID: 32573399, DOI: 10.1017/s0954579420000504.Peer-Reviewed Original ResearchConceptsOvergeneral memoryProsocial behaviorChildhood maltreatmentAutobiographical memory recallAutobiographical Memory TestSocio-emotional functioningPsycho-social functioningValenced cue wordsPoor social functioningSample of adolescentsFuture depression symptomsDepressive symptomsChildhood maltreatment historyTrend-level associationCognitive mechanismsCue wordsNeural reactivityAutobiographical memoryMemory testMemory recallVulnerability mechanismsBrain activitySocial functioningElevated depressive symptomsMaltreatment historyRisk‐Taking Patterns of Children, Associated Cognitive Weaknesses, and Prevention of Negative Outcomes
Imal AE, O’Leary S, Wexler BE. Risk‐Taking Patterns of Children, Associated Cognitive Weaknesses, and Prevention of Negative Outcomes. Psychiatric Research And Clinical Practice 2020, 2: 34-40. PMID: 36101890, PMCID: PMC9175884, DOI: 10.1176/appi.prcp.2020.20190020.Peer-Reviewed Original ResearchRisk-taking groupFlanker testWorking Memory TestMemory test scoresEighth-grade childrenTests of inhibitionHealth-compromising behaviorsClusters of childrenCognitive weaknessesMemory testMemory scoresGo/Focused attentionRisk-taking patternsCognitive functionTest measuresNegative outcomesPrimary prevention interventionsTest scoresFull learningReaction timeEarly interventionAvoidantChildrenPrevention interventionsMemory biases in alcohol use disorder: enhanced memory for contexts associated with alcohol prospectively predicts alcohol use outcomes
Goldfarb EV, Fogelman N, Sinha R. Memory biases in alcohol use disorder: enhanced memory for contexts associated with alcohol prospectively predicts alcohol use outcomes. Neuropsychopharmacology 2020, 45: 1297-1305. PMID: 32126569, PMCID: PMC7297955, DOI: 10.1038/s41386-020-0650-y.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAssociative memoryItem memoryMemory biasesUse disordersNovel memory taskAlcohol-related associationsDifferent memory systemsAlcohol useLater alcohol usePhotographs of objectsTreatment-seeking individualsTypes of memoryAlcohol use outcomesPrior drinking experienceReal-world behaviorMemory biasMemory taskNeutral scenesDetailed memoriesMemory testMaladaptive useHeavy alcohol useDrinking contextsDrinking experienceA double‐blind placebo‐controlled clinical trial testing the effect of hyperbaric oxygen therapy on brain and cognitive outcomes of mildly cognitively impaired elderly with type 2 diabetes: Study design
BenAri O, Efrati S, Hadanny A, Sano M, Bendlin B, Lin H, Liu X, Sela I, Almog G, Livny A, Sandler I, Ben‐Haim S, Sagi R, LeRoith D, Beeri M, Ravona‐Springer R. A double‐blind placebo‐controlled clinical trial testing the effect of hyperbaric oxygen therapy on brain and cognitive outcomes of mildly cognitively impaired elderly with type 2 diabetes: Study design. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2020, 6: e12008. PMID: 32296731, PMCID: PMC7153432, DOI: 10.1002/trc2.12008.Peer-Reviewed Original ResearchHyperbaric oxygen therapyCognitive outcomesEffect of hyperbaric oxygen therapyIntent-to-treat sampleEpisodic memory testsCerebral blood flowClinical trialsType 2 diabetesPrimary cognitive outcomeGlobal cognitive changeBrain glucose utilizationTraumatic brain injury patientsCerebral glucose utilizationOxygen therapyDouble-blind placebo-controlled clinical trialMild cognitive impairmentExecutive functionPlacebo-controlled clinical trialMemory testCognitive domainsNeurobiological outcomesCognitive changesCognitive improvementFluorodeoxyglucose positron emission tomographyImprove cognition
2017
Remoteness and Valence of Autobiographical Memory in Depression
Kim D, Yoon K, Joormann J. Remoteness and Valence of Autobiographical Memory in Depression. Cognitive Therapy And Research 2017, 42: 230-235. DOI: 10.1007/s10608-017-9881-6.Peer-Reviewed Original Research
2015
Visual and verbal learning deficits in Veterans with alcohol and substance use disorders
Bell MD, Vissicchio NA, Weinstein AJ. Visual and verbal learning deficits in Veterans with alcohol and substance use disorders. Drug And Alcohol Dependence 2015, 159: 61-65. PMID: 26684868, PMCID: PMC4724542, DOI: 10.1016/j.drugalcdep.2015.11.007.Peer-Reviewed Original ResearchConceptsHopkins Verbal Learning TestBrief Visuospatial Memory TestVerbal learning deficitsVerbal learningVisual learningLearning deficitsNew verbal informationVisuospatial Memory TestVerbal Learning TestMemory testLearning TestVerbal informationSubstance use disordersSUD participantsAUD participantsWeeks of abstinenceDSM-5Alcohol useUse disordersLearningDeficitsDiagnostic groupsParticipantsAUDComprehensive rehabilitation programSpatial memory for asymmetrical dot locations predicts lateralization among patients with presurgical mesial temporal lobe epilepsy
Brown FC, Hirsch LJ, Spencer DD. Spatial memory for asymmetrical dot locations predicts lateralization among patients with presurgical mesial temporal lobe epilepsy. Epilepsy & Behavior 2015, 52: 19-24. PMID: 26398592, DOI: 10.1016/j.yebeh.2015.08.020.Peer-Reviewed Original ResearchConceptsVerbal memory testsRight temporal lobe epilepsyMemory testTemporal lobe epilepsyMesial temporal lobe epilepsyLobe epilepsyLocation memory testRight mesial temporal lobe epilepsyHemisphere languageCVLT-IISpatial memoryDot locationsPositive predictive valueBinary logistic regressionVideo-EEGPatientsPredictive valueEpilepsyLogistic regressionLimited sample sizeVSRTRTLELTLEMemoryLateralization
2013
Influence of anxiety on memory performance in temporal lobe epilepsy
Brown FC, Westerveld M, Langfitt JT, Hamberger M, Hamid H, Shinnar S, Sperling MR, Devinsky O, Barr W, Tracy J, Masur D, Bazil CW, Spencer SS. Influence of anxiety on memory performance in temporal lobe epilepsy. Epilepsy & Behavior 2013, 31: 19-24. PMID: 24291525, PMCID: PMC3946774, DOI: 10.1016/j.yebeh.2013.10.009.Peer-Reviewed Original ResearchConceptsCalifornia Verbal Learning TestRey Complex Figure TestVerbal memory testsHigher anxiety levelsMemory testLower anxiety levelsAnxiety levelsMemory performanceVisual memory performanceVisual memory testsVerbal Learning TestComplex Figure TestVerbal memory scoresInfluence of anxietyTemporal lobe epilepsyRCFT performanceVerbal memoryLearning TestFigures TestMemory difficultiesMemory scoresLobe epilepsyAnxietyTLEMore confidence
2011
Cognitive Dysfunction in Post-Traumatic Obsessive–Compulsive Disorder
Borges M, Braga D, Iêgo S, D'Alcante C, Sidrim I, Machado M, Pinto P, Cordioli A, do Rosário M, Petribú K, Mendlowicz M, Mari J, Miguel E, Fontenelle L. Cognitive Dysfunction in Post-Traumatic Obsessive–Compulsive Disorder. Australian & New Zealand Journal Of Psychiatry 2011, 45: 76-85. PMID: 21174503, DOI: 10.3109/00048674.2010.527822.Peer-Reviewed Original ResearchConceptsSet-shifting abilityObsessive-compulsive disorderPoor set-shifting abilitiesWechsler Memory Scale-Logical MemoryBrief Visual Memory TestWisconsin Card Sorting TestVisual memory testsIowa Gambling TaskCard Sorting TestFollowing neuropsychological testsWechsler Abbreviated ScaleTypes of OCDPosttraumatic stress disorderObsessive-compulsive symptomsMemory testVisuospatial memoryGambling TaskLogical memorySorting TestAbbreviated ScaleNeurocognitive patternsNeuropsychological testsStress disorderVisuospatial recognitionCompulsive disorderNeuroprotective effects of progesterone and allopregnanolone on long-term cognitive outcome after global cerebral ischemia
Moralí G, Montes P, Hernández-Morales L, Monfil T, Espinosa-García C, Cervantes M. Neuroprotective effects of progesterone and allopregnanolone on long-term cognitive outcome after global cerebral ischemia. Restorative Neurology And Neuroscience 2011, 29: 1-15. PMID: 21335664, DOI: 10.3233/rnn-2011-0571.Peer-Reviewed Original ResearchConceptsNeuroprotective effects of progesteroneEffects of progesteroneTreated ratsGlobal cerebral ischemiaLoss of hippocampal pyramidal neuronsPyramidal neuronsLong-term cognitive outcomesCerebral ischemiaAdult male Sprague-Dawley ratsMale Sprague-Dawley ratsLoss of pyramidal neuronsHippocampal pyramidal neuronsSprague-Dawley ratsWorking memoryMemory testTreated with P4Spatial learningCognitive outcomesAllopregnanoloneNeural conditionsIntact ratsHippocampusSham procedureForebrain ischemiaNonischemic controls
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