2025
Biomarker-Specific Survival and Medication Cost for Patients With Non–Small Cell Lung Cancer
Tan J, Yang S, Dinan M, Chiang A, Gross C, Wang S. Biomarker-Specific Survival and Medication Cost for Patients With Non–Small Cell Lung Cancer. JAMA Network Open 2025, 8: e2514519. PMID: 40493365, PMCID: PMC12152704, DOI: 10.1001/jamanetworkopen.2025.14519.Peer-Reviewed Original ResearchConceptsAdvanced non-small cell lung cancerNon-small cell lung cancerEGFR variationPD-L1ALK rearrangementCell lung cancerDriver alterationsMedical costsLung cancerCohort studyProgrammed cell death 1 ligand 1Cell death 1 ligand 1Biomarker statusMedian overall survivalRetrospective cohort studyLower medical costsOverall survivalTargeted therapyNon-smallPatient cohortMonthly medical costsFollow-upStudy cohortBiomarker testingAssociated with higher costsEconomic Burden of Patients With Chronic Idiopathic Constipation in the USA Before and After Prucalopride Initiation
Feuerstadt P, Lu M, Terasawa E, Terreri B, Du S, Pi S, Westermeyer B, Ayyagari R, Lembo A, Moshiree B, Boules M, Cash B. Economic Burden of Patients With Chronic Idiopathic Constipation in the USA Before and After Prucalopride Initiation. Gastro Hep Advances 2025, 4: 100664. PMID: 40491438, PMCID: PMC12148438, DOI: 10.1016/j.gastha.2025.100664.Peer-Reviewed Original ResearchChronic idiopathic constipationHealth care resource utilizationHealth care costsCare costsIdiopathic constipationEvaluate health care resource utilizationMedication useStudy periodMedical health care costsMedical costsProportion of patientsIBM MarketScan Commercial ClaimsEconomic burdenEconomic burden of patientsMarketScan Commercial ClaimsIncreased pharmacy costsAssessed 6 monthsBurden of patientsTreatment initiationPrucaloprideAll-causeOutpatient visitsPrescription fillsPatientsDiagnosis codesIdentifying the Financial Toxicity Experiences of Childhood Cancer Survivors Through Partnership With a Community Organization Serving Rural and Minoritized Families
Benedict C, Bloomer K, Billman E, Smith M, Boynton H, Schapira L, Smith S. Identifying the Financial Toxicity Experiences of Childhood Cancer Survivors Through Partnership With a Community Organization Serving Rural and Minoritized Families. Psycho-Oncology 2025, 34: e70120. PMID: 40097346, DOI: 10.1002/pon.70120.Peer-Reviewed Original ResearchConceptsAYA survivors of childhood cancerSurvivors of childhood cancerChildhood cancerAYA survivorsFinancial toxicityAdolescent/young adultPerspectives of staff membersNon-English language preferenceStaff membersCancer support organizationsThematic analysis approachCommunity-based organizationsRural regionsParental employmentIndirect medical costsNeeds assessment studySemi-structured interviewsMedical visitsVulnerable populationsLanguage preferenceInsurance coverageMedical costsQualitative dataRural areasMinoritized familiesEconomic Outcomes With Precision Diagnostic Testing Versus Usual Testing in Stable Chest Pain: Results From the PRECISE Randomized Trial
Chew D, Mark D, Li Y, Nanna M, Kelsey M, Daniels M, Davidson-Ray L, Baloch K, Rogers C, Patel M, Anstrom K, Curzen N, Vemulapalli S, Douglas P, Investigators O. Economic Outcomes With Precision Diagnostic Testing Versus Usual Testing in Stable Chest Pain: Results From the PRECISE Randomized Trial. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011008. PMID: 39895495, PMCID: PMC11837965, DOI: 10.1161/circoutcomes.123.011008.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina, StableComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCost SavingsCost-Benefit AnalysisFemaleFractional Flow Reserve, MyocardialHospital CostsHumansMaleMiddle AgedPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsChest painObstructive coronary artery diseaseCoronary computed tomographic angiographyStable chest painCoronary artery bypass surgeryLow-risk patientsSecondary end pointsPrimary composite of deathPrecision strategyComputed tomographic angiographyHealth care system perspectiveComposite of deathUS health care system perspectiveArtery bypass surgeryMedical costsMean cost differenceNonfatal myocardial infarctionCoronary artery diseaseIntention-to-treatPercutaneous coronary interventionUsual testsEstimated total medical costTotal medical costsClinical practice guidelinesRisk patientsHeartfelt Progress: The Triumphs Of Non-invasive Remote Patient Monitoring In Mitigating Heart Failure Readmissions
REHAN M, ABDULLAH A, LANCASTER G. Heartfelt Progress: The Triumphs Of Non-invasive Remote Patient Monitoring In Mitigating Heart Failure Readmissions. Journal Of Cardiac Failure 2025, 31: 303. DOI: 10.1016/j.cardfail.2024.10.310.Peer-Reviewed Original ResearchCongestive heart failureCongestive heart failure patientsRemote patient monitoring programReadmission ratesOutpatient monitoringHospital data of patientsImplantable pulmonary artery pressure monitorPulmonary artery pressure monitoringComparison to patientsData of patientsArterial pressure monitoringHeart failure readmissionDecreased 30-day readmissionsHeart failureBaseline parametersCompare outcomesBlood pressureCardioMEMSPatientsPressure monitoringWeeks post-dischargePatient monitoringMedical costsReadmissionVital signs
2024
Cardiovascular Events in Adults with Type 2 Diabetes and ASCVD Initiating Once-Weekly Semaglutide vs DPP-4is in the USA
Inzucchi S, Tan X, Liang Y, Yedigarova L, Xie L, de Havenon A. Cardiovascular Events in Adults with Type 2 Diabetes and ASCVD Initiating Once-Weekly Semaglutide vs DPP-4is in the USA. Diabetes Therapy 2024, 16: 187-203. PMID: 39688779, PMCID: PMC11794941, DOI: 10.1007/s13300-024-01678-4.Peer-Reviewed Original ResearchHealth care resource utilizationAtherosclerotic cardiovascular diseaseDPP-4i usersDPP-4isGLP-1 RAsOnce-weekly semaglutideMedical costsType 2 diabetesDPP-4iDecreased risk of strokeRisk of cardiovascular outcomesCardiovascular eventsOnce-weekly GLP-1 RAsPeptide 1 receptor agonistsTotal medical costsDipeptidyl peptidase 4 inhibitorsOccurrence of cardiovascular eventsHigh-risk patientsRisk of strokeObservational cohort analysisData Mart DatabaseOutpatient visitsDecreased riskSemaglutide treatmentBaseline characteristicsAssociation between heat and hospital admissions in people with disabilities in South Korea: a nationwide, case-crossover study
Park J, Kim A, Kim Y, Choi M, Yoon T, Kang C, Kang H, Oh J, Bell M, Kim H, Lee W. Association between heat and hospital admissions in people with disabilities in South Korea: a nationwide, case-crossover study. The Lancet Planetary Health 2024, 8: e217-e224. PMID: 38580423, DOI: 10.1016/s2542-5196(24)00027-5.Peer-Reviewed Original ResearchConceptsEmergency department admissionsBrain lesion disordersCase-crossover studyPhysical disabilityOdds ratioCase-crossover designSample Cohort databaseConditional logistic regressionAssociated with increased riskExcess medical costsNon-disabled populationSevere physical disabilitiesHearing lossEnvironmental heat exposureCohort databaseHospital admissionMental disordersLogistic regressionMedical costsDisabilityAdmissionAction planHigh heat risksKorean Ministry of EducationNational Research FoundationFinancial toxicity of informal caregivers of colorectal cancer patients: A cross-sectional study
Zhang M, Wang X, Shao M, Li T, Guo S, Yang Y, Yu L, Bin M, Li D, Zhou H, Yao L, Chen C, Wang T. Financial toxicity of informal caregivers of colorectal cancer patients: A cross-sectional study. European Journal Of Oncology Nursing 2024, 69: 102519. PMID: 38402718, DOI: 10.1016/j.ejon.2024.102519.Peer-Reviewed Original ResearchConceptsLevels of financial toxicityFinancial toxicity scoresFinancial toxicitySocial supportPerceived stressColorectal cancer patientsQuality of colorectal cancer careEffects of financial toxicityCancer patientsColorectal cancer careHigh social supportCross-sectional studyInformal caregiversCaregiver ageMultivariate linear regressionCancer careAverage household incomeCaregiversTargeted interventionsMedical insuranceHousehold incomeMultivariate regression analysisMedical costsSurvey designIncreased communication
2023
Once-weekly glucagon-like peptide-1 receptor agonists vs dipeptidyl peptidase-4 inhibitors: cardiovascular effects in people with diabetes and cardiovascular disease
Tan X, Liang Y, Rajpura J, Yedigarova L, Noone J, Xie L, Inzucchi S, de Havenon A. Once-weekly glucagon-like peptide-1 receptor agonists vs dipeptidyl peptidase-4 inhibitors: cardiovascular effects in people with diabetes and cardiovascular disease. Cardiovascular Diabetology 2023, 22: 319. PMID: 37985992, PMCID: PMC10662529, DOI: 10.1186/s12933-023-02051-8.Peer-Reviewed Original ResearchConceptsHealth care resource utilizationAtherosclerotic cardiovascular diseaseGLP-1 RAsCause health care resource utilizationPeptide-1 receptor agonistsDipeptidyl peptidase-4 inhibitorsDPP-4i usersPeptidase-4 inhibitorsMyocardial infarctionMedical costsDPP-4iIschemic strokeReceptor agonistCardiovascular diseaseGlucagon-like peptide-1 receptor agonistsWeekly glucagon-like peptide-1 receptor agonistWeekly GLP-1 RAsCause ER visitsCause hospitalization costsCause medical costsNew adult usersClinical cardiovascular outcomesObservational cohort studyType 2 diabetesCause outpatient visitsHealthcare Resource Utilization and Costs Among Newly Diagnosed and Relapsed/Refractory Acute Myeloid Leukemia (AML) Patients: A Retrospective Cohort Study Using Contemporary US Claims
Huntington S, Chang H, Fu A, Loefgren C, Lu X. Healthcare Resource Utilization and Costs Among Newly Diagnosed and Relapsed/Refractory Acute Myeloid Leukemia (AML) Patients: A Retrospective Cohort Study Using Contemporary US Claims. Blood 2023, 142: 2348. DOI: 10.1182/blood-2023-181909.Peer-Reviewed Original ResearchHematopoietic stem cell transplantationHealthcare resource utilizationAcute myeloid leukemia patientsRetrospective cohort studyIndex dateMyeloid leukemia patientsAML patientsAML diagnosisR patientsDiagnosis codesEconomic burdenPPPM costsCohort studyContinuous enrollmentND patientsLeukemia patientsMedical costsLarge US administrative claims databaseRefractory acute myeloid leukemia patientsHigher healthcare resource utilizationUS administrative claims databaseMore outpatient encountersNon-HSCT patientsNon-transplant recipientsOlder AML patientsHeart failure with reduced ejection fraction: clinical and economic burden and insights into current and emerging treatments.
Sen S. Heart failure with reduced ejection fraction: clinical and economic burden and insights into current and emerging treatments. The American Journal Of Managed Care 2023, 29: s180-s186. PMID: 37677742, DOI: 10.37765/ajmc.2023.89415.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyReduced ejection fractionHeart failureEjection fractionEconomic burdenManagement of HFrEFPresence of comorbiditiesEmergency department visitsVentricular ejection fractionDisease-modifying therapiesPoor treatment adherenceHealth care systemDepartment visitsMedical therapyPatient factorsComorbid conditionsMedication costsTreatment adherenceOptimal treatmentOutpatient carePreventable hospitalizationsIndividual patientsHigh riskTarget dosesMedical costsExposures to ambient particulate matter are associated with reduced adult earnings potential
Swetschinski L, Fong K, Morello-Frosch R, Marshall J, Bell M. Exposures to ambient particulate matter are associated with reduced adult earnings potential. Environmental Research 2023, 232: 116391. PMID: 37308068, DOI: 10.1016/j.envres.2023.116391.Peer-Reviewed Original Research
2022
The Impact of Temporary Housing Assistance Expenditures on Subcategories of Health Care Cost for U.S. Veterans Facing Housing Instability.
Nelson R, Montgomery A, Suo Y, Cook J, Pettey W, Evans W, Greene T, Gelberg L, Kertesz S, Tsai J, Byrne T. The Impact of Temporary Housing Assistance Expenditures on Subcategories of Health Care Cost for U.S. Veterans Facing Housing Instability. Journal Of Health Care For The Poor And Underserved 2022, 33: 1821-1843. PMID: 36341665, DOI: 10.1353/hpu.2022.0140.Peer-Reviewed Original ResearchConceptsHealth care costsCare costsOutpatient substance use disorder treatmentMental healthSubstance use disorder treatmentRetrospective cohort studyOutpatient mental healthDirect medical costsInpatient mental healthUse disorder treatmentHealth care encountersBehavioral health costsHealth care servicesCohort studyHousing instabilityMultivariable differenceCare encountersMedical costsCare servicesDisorder treatmentU.S. veteransVeterans AffairsVA systemHealth costsSupportive servicesTreatment Sequencing Patterns and Associated Direct Medical Costs of Metastatic Breast Cancer Care in the United States, 2011 to 2021
Chehayeb R, Hood A, Wang X, Miksad R, Mougalian S, Lustberg M, Wang S, Greenup R, Pusztai L, Kunst N. Treatment Sequencing Patterns and Associated Direct Medical Costs of Metastatic Breast Cancer Care in the United States, 2011 to 2021. JAMA Network Open 2022, 5: e2244204. PMID: 36445704, PMCID: PMC9709649, DOI: 10.1001/jamanetworkopen.2022.44204.Peer-Reviewed Original ResearchConceptsMetastatic breast cancerErbB2-positive metastatic breast cancerHR-positive metastatic breast cancerLines of therapyMBC subtypesDrug costsBreast cancerMedical costsHuman epidermal growth factor receptor 2 receptor statusMBC treatmentERBB2-negative metastatic breast cancerAssociated direct medical costsEarly-stage breast cancerHormone receptorsFlatiron Health databaseMetastatic recurrence ratesDifferent drug regimensBreast cancer careData of patientsDirect medical costsNovel adjuvant therapySupportive care drugsOutcomes of interestCost-effectiveness analysisAdjuvant therapySocietal Cost of Opioid Use in Symptomatic Knee Osteoarthritis Patients in the United States
Huizinga JL, Stanley EE, Sullivan JK, Song S, Hunter DJ, Paltiel AD, Neogi T, Edwards RR, Katz JN, Losina E. Societal Cost of Opioid Use in Symptomatic Knee Osteoarthritis Patients in the United States. Arthritis Care & Research 2022, 74: 1349-1358. PMID: 33629485, PMCID: PMC8382774, DOI: 10.1002/acr.24581.Peer-Reviewed Original ResearchConceptsSymptomatic knee osteoarthritisOpioid use disorderOpioid useMcMaster Universities Osteoarthritis Index (WOMAC) pain scoreSymptomatic knee osteoarthritis patientsLong-term pain managementProlonged opioid usePublic health causeStrong opioid useSocietal costsKnee osteoarthritis patientsSocietal economic burdenDirect medical costsMedicare Current Beneficiary SurveyOsteoarthritis Policy ModelCriminal justice costsOUD prevalencePain scoresSD ageOpioid regimensPain managementKnee osteoarthritisOsteoarthritis patientsWestern OntarioMedical costsReal‐world assessment of the relationship between migraine‐related disability and healthcare costs in the United States
Harris L, L’Italien G, Kumar A, Seelam P, LaVallee C, Coric V, Lipton R. Real‐world assessment of the relationship between migraine‐related disability and healthcare costs in the United States. Headache The Journal Of Head And Face Pain 2022, 62: 473-481. PMID: 35343590, PMCID: PMC9313575, DOI: 10.1111/head.14289.Peer-Reviewed Original ResearchConceptsMigraine-related disabilityDirect medical costsMedical costsIVB patientsEpisodic migrainePharmacy costsGrade IMigraine Disability Assessment Scale (MIDAS) questionnaireMigraine Disability Assessment ScoreHealthcare resource utilizationMigraine Disability AssessmentPrimary care settingElectronic health record dataSubstantial economic burdenHigher medical costsHealth record dataPublic health concernCost-effective treatmentRevision 9Cohort studyHealthcare visitsMIDAS scoreMigraine disabilitySpecialty careReal-world assessmentAssociation of factor expression levels with health-related quality of life and direct medical costs for people with haemophilia B
Burke T, Shaikh A, Ali T, Li N, Curtis R, Diego D, Recht M, Sannie T, Skinner M, O’Hara J. Association of factor expression levels with health-related quality of life and direct medical costs for people with haemophilia B. Journal Of Medical Economics 2022, 25: 386-392. PMID: 35253589, DOI: 10.1080/13696998.2022.2049552.Peer-Reviewed Original ResearchConceptsDirect medical costsHemophilia BHealth-related quality of lifeMedical costsHealth-related qualityMedical recordsQuality of lifeGene therapy trialsFactor replacement therapyRetrospective cross-sectional analysisBody mass indexBlood-borne virusesEQ-5D questionnaireFunctional cureEQ-5D scoresConsecutive patientsTherapy trialsReplacement therapyMass indexCross-sectional analysisI-IIPatientsAssociation of increasesOffice visitsCost of care
2021
Implementing a Program to Reduce Restraint and Seclusion Utilization in a Public-Sector Hospital: Clinical Innovations, Preliminary Findings, and Lessons Learned
Dike CC, Lamb-Pagone J, Howe D, Beavers P, Bugella BA, Hillbrand M. Implementing a Program to Reduce Restraint and Seclusion Utilization in a Public-Sector Hospital: Clinical Innovations, Preliminary Findings, and Lessons Learned. Psychological Services 2021, 18: 663-670. PMID: 32940500, DOI: 10.1037/ser0000502.Peer-Reviewed Original ResearchConceptsPsychiatric hospitalState Mental Health Program DirectorsTertiary care settingPublic sector psychiatric hospitalWellness Recovery Action PlanMental health settingsQuality of careTrauma-sensitive carePublic sector hospitalsEvidence-based practicePositive behavioral support plansStaff injuriesCare settingsRestraint useMedical costsRestraint hoursHealth settingsRecovery Action PlanSensory modulationCase reviewSeclusion useHospitalPrevention toolRestraint ordersBaseline periodHow costly is the first prenatal clinic visit? Analysis of out-of-pocket expenditure in rural Sri Lanka - a country with free maternal health care
Gunarathne SP, Wickramasinghe ND, Agampodi TC, Prasanna IR, Agampodi SB. How costly is the first prenatal clinic visit? Analysis of out-of-pocket expenditure in rural Sri Lanka - a country with free maternal health care. BMC Health Services Research 2021, 21: 974. PMID: 34530827, PMCID: PMC8444532, DOI: 10.1186/s12913-021-07005-y.Peer-Reviewed Original ResearchConceptsFirst prenatal clinic visitPrenatal clinic visitMaternal health servicesClinic visitsPregnant womenHealth servicesRural Sri LankaPocket expenditureFree maternal health careDirect medical costsMaternal health careNumber of pregnanciesCross-sectional studyFree maternal healthcareFree maternal servicesMethodsThe study designPrivate health servicesAnuradhapura districtMaternal healthcareMaternal servicesMicronutrient supplementsMedical costsBackgroundThis studyStudy settingStudy designThe Value of Total Knee Replacement in Patients With Knee Osteoarthritis and a Body Mass Index of 40 kg/m2 or Greater : A Cost-Effectiveness Analysis.
Chen AT, Bronsther CI, Stanley EE, Paltiel AD, Sullivan JK, Collins JE, Neogi T, Katz JN, Losina E. The Value of Total Knee Replacement in Patients With Knee Osteoarthritis and a Body Mass Index of 40 kg/m2 or Greater : A Cost-Effectiveness Analysis. Annals Of Internal Medicine 2021, 174: 747-757. PMID: 33750190, PMCID: PMC8288249, DOI: 10.7326/m20-4722.Peer-Reviewed Original ResearchConceptsIncremental cost-effectiveness ratioBody mass indexTotal knee replacementKnee replacementCost-effectiveness analysisTKR recipientsKnee osteoarthritisMass indexEnd-stage knee osteoarthritisLong-term clinical benefitCost-effective strategyPreoperative pain levelNational InstituteOsteoarthritis Policy ModelLifetime medical costsCost-effectiveness ratioBase-case analysisProbabilistic sensitivity analysesMultiple comorbiditiesCost-effectiveness perspectivePain levelsComplication rateClinical benefitCardiovascular diseaseMedical costs
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