2025
Emergency Department Implementation of a Multimodal Electronic Health Record–Integrated Clinical Intervention for High-Sensitivity Troponin Testing Increases Diagnostic Efficiency
Sangal R, Iscoe M, Rothenberg C, Possick S, Taylor R, Safdar B, Desai N, Rhodes D, Venkatesh A. Emergency Department Implementation of a Multimodal Electronic Health Record–Integrated Clinical Intervention for High-Sensitivity Troponin Testing Increases Diagnostic Efficiency. Journal Of The American College Of Emergency Physicians Open 2025, 6: 100202. DOI: 10.1016/j.acepjo.2025.100202.Peer-Reviewed Original ResearchEmergency departmentAcute myocardial infarction diagnosisTroponin testingED dischargeMyocardial infarction diagnosisAssociated with lower oddsAccelerated diagnostic protocolPhysician practice variationAcute coronary syndromeInfarction diagnosisChest pain evaluationMultivariate logistic regressionSuspected acute coronary syndromePostintervention periodDownstream testingPhysician practicesPreintervention periodED dispositionLower oddsCoronary syndromeDecreased oddsIncreased oddsPractice variationED patientsHs-cTnTDifferences in In-Hospital and Post-Discharge Ischemic Stroke Care According to Prestroke Functional Status.
Wechsler P, Mistry E, Sucharew H, Robinson D, Stanton R, de Los Rios La Rosa F, Mackey J, Ferioli S, Demel S, Coleman E, Jasne A, Slavin S, Walsh K, Star M, Haverbusch M, Alwell K, Woo D, Kleindorfer D, Kissela B. Differences in In-Hospital and Post-Discharge Ischemic Stroke Care According to Prestroke Functional Status. Journal Of The American Heart Association 2025, 14: e040499. PMID: 40417811, DOI: 10.1161/jaha.124.040499.Peer-Reviewed Original ResearchConceptsIschemic stroke carePrestroke disabilityStroke careIn-hospitalGreater Cincinnati/Northern Kentucky populationAssociated with lower oddsPopulation-based dataSecondary stroke prevention treatmentPrestroke functional statusMedical decision-makingCare continuumStroke prevention treatmentRehabilitation therapyLower oddsIschemic stroke patientsFunctional statusStroke reperfusion therapyStroke patientsLogistic regressionCareDisabilityKentucky populationAcute ischemic strokeReperfusion therapyPrestrokeSpinal cord stimulator utilization trends and predictors of unsuccessful trial-to-implant conversion
Day W, Maloy G, Winter A, Chapman K, Seddio A, Doshi R, Ratnasamy P, Varthi A, Fourman M, Grauer J. Spinal cord stimulator utilization trends and predictors of unsuccessful trial-to-implant conversion. North American Spine Society Journal (NASSJ) 2025, 22: 100616. PMID: 40548099, PMCID: PMC12182330, DOI: 10.1016/j.xnsj.2025.100616.Peer-Reviewed Original ResearchSpinal cord stimulationSpinal cord stimulator trialFactors associated with failureUtilization of spinal cord stimulationSpinal cord stimulator implantationPermanent SCS implantationLower oddsMultivariate logistic regressionAssociated with lower oddsLow comorbidity burdenSCS trialSCS implantationCord stimulationNeurological painMale sexPermanent implantationAnnual incidenceComorbidity burdenClaims databaseTobacco useLogistic regressionNeuromodulatory devicesOlder ageImplantationUtilization trendsExamining measurement discrepancies in adolescent screen media activity with insights from the ABCD study
Zhao Y, Han X, Bagot K, Tapert S, Potenza M, Paulus M. Examining measurement discrepancies in adolescent screen media activity with insights from the ABCD study. Npj Mental Health Research 2025, 4: 15. PMID: 40346141, PMCID: PMC12064680, DOI: 10.1038/s44184-025-00131-z.Peer-Reviewed Original ResearchPredictors and prognostic implication of early lactate clearance among patients with cardiogenic shock
Cordovez C, Rali A, Katz J, Gastanadui M, Safiriyu I, Dudzinski D, Senman B, Alviar C, Elliott A, Gage A, Tavazzi G, Miller P. Predictors and prognostic implication of early lactate clearance among patients with cardiogenic shock. European Heart Journal Acute Cardiovascular Care 2025, 14: zuaf044.123. DOI: 10.1093/ehjacc/zuaf044.123.Peer-Reviewed Original ResearchEarly lactate clearancePulmonary artery catheterDay of admissionIn-hospital mortalityCardiogenic shockLactate clearancePrognostic implicationsAssociated with lactate clearanceLogistic regressionDiagnosis of CSAssociated with lower in-hospital mortalityLower in-hospital mortalityAssociated with improved mortalityHospital-level variablesIn-hospital deathMultivariate logistic regressionAssociated with mortalityClinical Data BaseArtery catheterElevated lactateLower oddsImprove mortalityMultivariable adjustmentMultivariate analysisPatients1145 Higher Proceduralist Stroke Thrombectomy Volume is Associated With Reduced Inpatient Mortality
Koo A, Renedo D, Ney J, Amllay A, Kanzler M, Stogniy S, Alawieh A, Sujijantarat N, Antonios J, Al Kasab S, Malhotra A, Hebert R, Matouk C, de Havenon A. 1145 Higher Proceduralist Stroke Thrombectomy Volume is Associated With Reduced Inpatient Mortality. Neurosurgery 2025, 71: 177-178. DOI: 10.1227/neu.0000000000003360_1145.Peer-Reviewed Original ResearchCut-pointsAbsolute risk of deathAssociated with lower oddsState Inpatient DatabasesFlorida State Inpatient DatabaseIn-hospital moralityRates of in-hospital mortalityPrimary study outcomeCare certificationRisk of deathOptimal cut-pointAssociated with reduced inpatient mortalityThrombectomy-capable stroke centersOverall careRetrospective cohort studyAIS patientsIn-hospital deathLow-volume cohortLower oddsIn-hospital mortalityPotential confoundersAbsolute riskVolume cohortsInpatient mortalityCohort studyThe Impact of Medical School Experiences in Global Surgery on Perceptions and Career Plans Among U.S. Medical Students
Kersh L, Serrato P, Anderson C, Raguveer V, Peck C, Ally S, Gondi I, Subhedar S, Rollins A, Hauser B, Jayaram A, Hill S, Wariso B, Rehman S, Alliance G, Clune J. The Impact of Medical School Experiences in Global Surgery on Perceptions and Career Plans Among U.S. Medical Students. Journal Of Surgical Education 2025, 82: 103441. PMID: 39894006, DOI: 10.1016/j.jsurg.2025.103441.Peer-Reviewed Original ResearchConceptsMedical school experienceGlobal surgeryMedical studentsMedical schoolsSurgical mission tripsCross-sectional survey studyAssociated with lower oddsMission tripsAssociated with increased oddsMedical school curriculumGlobal health researchU.S. medical studentsCareer planningSurgery researchGlobal surgery educationResponding medical studentsMultivariate regression modelHealth researchSurgery opportunitiesLower oddsSchool experiencesSurgeryOddsSurgery educationMedical institutionsTransient Ischemic Attack in Women: Real-World Hospitalization Incidence, Outcomes, and Risk of Hemorrhage and Stroke
Chen H, Khunte M, Colasurdo M, Majmundar S, Payabvash S, Chaturvedi S, Malhotra A, Gandhi D. Transient Ischemic Attack in Women: Real-World Hospitalization Incidence, Outcomes, and Risk of Hemorrhage and Stroke. Stroke 2025, 56: 285-293. PMID: 39869710, DOI: 10.1161/strokeaha.124.049278.Peer-Reviewed Original ResearchConceptsRates of vascular risk factorsTransient ischemic attackUS Census Bureau dataAssociated with lower oddsHigher odds of deathIschemic strokeRisk factorsAnnual incidenceTransient neurological symptomsStroke risk factorsOdds of deathLogistic regression modelsVascular risk factorsCensus Bureau dataRate of headacheRetrospective cohort studyLower oddsHigher oddsNeurological symptomsHome dischargeCohort studyIschemic attackHospital incidenceExcess hospitalizationsRisk of hemorrhage
2024
Association of clerical burden and EHR frustration with burnout and career intentions among physician faculty in an urban academic health system
Ripp J, Pietrzak R, de Guillebon E, Peccoralo L. Association of clerical burden and EHR frustration with burnout and career intentions among physician faculty in an urban academic health system. International Journal Of Medical Informatics 2024, 195: 105740. PMID: 39644795, DOI: 10.1016/j.ijmedinf.2024.105740.Peer-Reviewed Original ResearchElectronic health recordsClerical burdenAssociated with greater likelihoodPhysician facultyHealth systemEHR timeUrban academic health systemClerical timeGreater likelihoodOdds of burnoutAssociated with lower oddsAcademic health systemMultivariate logistic regression analysisHealth recordsLogistic regression analysisHospital-based departmentsInstitution-wide surveyLower oddsHealthy workforceHealthcare systemDemographic characteristicsNew York CityBurnoutCareer intentionsPhysiciansIdentifying diagnosed major chronic diseases associated with recent housing instability among aging adults: data from the ‘All of Us’ research program
Beydoun H, Vieytes C, Beydoun M, Lampros A, Tsai J. Identifying diagnosed major chronic diseases associated with recent housing instability among aging adults: data from the ‘All of Us’ research program. Journal Of Public Health 2024, 47: 15-23. PMID: 39586798, PMCID: PMC12034092, DOI: 10.1093/pubmed/fdae300.Peer-Reviewed Original ResearchUs Research ProgramHousing instabilityAging adultsChronic diseasesOdds ratioChronic disease preventionAssociated with lower oddsPsychiatric diagnosisConfidence intervalsElectronic health recordsAssociated with psychiatric diagnosesEstimate odds ratiosCardiovascular diseaseMultivariate logistic regression modelDiverse group of adultsLogistic regression modelsTreatment of chronic diseasesCross-sectional dataHealth recordsHealthcare utilizationLower oddsGroup of adultsYears of ageDiagnosed diabetesCancer diagnosisLatent transition analysis of use frequencies for multiple nicotine and tobacco products among US adults
Mistry R, Bondarenko I, Jeon J, Brouwer A, Jimenez Mendoza E, Levy D, Elliott M, Tam J, Fleischer N, Meza R. Latent transition analysis of use frequencies for multiple nicotine and tobacco products among US adults. Addictive Behaviors 2024, 161: 108217. PMID: 39616861, PMCID: PMC12120682, DOI: 10.1016/j.addbeh.2024.108217.Peer-Reviewed Original ResearchNon-Hispanic blacksDaily cigarettesTobacco productsNon-dailyAssociated with lower oddsAssociated with higher oddsNon-Hispanic whitesFactors associated with transitionLow socioeconomic statusDaily smokeless tobaccoLatent transition analysisMultinomial logistic regressionHealth disparitiesLower educationUS adultsNon-currentSmokeless tobaccoSocioeconomic statusHigher oddsLower oddsLow-incomeLogistic regressionLatent transitionCigaretteTobaccoFactors associated with elective surgical case cancellation at a tertiary hospital in Malawi
Serrato P, Msosa V, Kondwani J, Nkhumbwah M, Mowafi H, Smith J, Mulima G, Sion M. Factors associated with elective surgical case cancellation at a tertiary hospital in Malawi. World Journal Of Surgery 2024, 48: 2990-3000. PMID: 39558490, DOI: 10.1002/wjs.12404.Peer-Reviewed Original ResearchKamuzu Central HospitalFactors associated with lower oddsLower oddsFactors associated with cancellationTertiary hospitalProcess-related factorsAssociated with lower oddsPublic tertiary hospitalCase cancellationsElective surgical case cancellationCancellation of elective surgeriesCross-sectional studyMedian waiting timeReturn for surgerySurgery completion rateMultivariate regression modelHigher cancellation rateSurgical case cancellationCancellation of surgeryCompletion ratesPatient outcomesPatient demographicsOddsElective surgeryRegression modelsBaseline predictors associated with successful weight loss among breast cancer survivors in the Lifestyle, Exercise, and Nutrition (LEAN) study
Hoobler R, Puklin L, Harrigan M, Cartmel B, Li F, Sanft T, Ferrucci L, Irwin M, Playdon M. Baseline predictors associated with successful weight loss among breast cancer survivors in the Lifestyle, Exercise, and Nutrition (LEAN) study. Journal Of Cancer Survivorship 2024, 1-9. PMID: 39528779, DOI: 10.1007/s11764-024-01702-3.Peer-Reviewed Original ResearchBreast cancer survivorsClinically meaningful weight lossCancer survivorsWeight loss interventionCancer SurvivorsBreast cancer survivorsWeight loss successConclusionBreast cancer survivorsPrevention of weight gainAssociated with lower oddsHistory of weight gainHealthy body weightMultivariate logistic regressionCancer treatmentSuccessful weight lossBreast cancer treatmentIntervention armLower oddsResultsBaseline dataDesign of programsWeight lossLogistic regressionC-statisticWeight gainSurvivorsInterventionSickle Pain-Related Impact (SPiRIt): A Prospective Study of Impact of Chronic Pain in Sickle Cell Disease
Jagtiani A, Sinha C, Hawk A, Gillespie S, Mirbeyk M, El Rassi F, Smith W, Krishnamurti L, Sil S, Bakshi N. Sickle Pain-Related Impact (SPiRIt): A Prospective Study of Impact of Chronic Pain in Sickle Cell Disease. Blood 2024, 144: 3899-3899. DOI: 10.1182/blood-2024-210575.Peer-Reviewed Original ResearchHigh-impact chronic painPain-related patient-reported outcomesChronic pain acceptanceSickle cell diseaseChronic painAssociated with lower oddsPain acceptancePain catastrophizingPain intensitySelf-efficacyCell diseaseManaging symptomsImpact of chronic painLower oddsHigher oddsHigher pain impactPain quality scoresDissemination strategiesHigher pain interferenceFactors associated with higher oddsFear of movementMultivariate logistic regression modelSickle cell disease clinicYoung adultsAssociated with higher oddsInequalities in Treatment Utilization Among Older Medicare Beneficiaries with Newly Diagnosed Acute Myeloid Leukemia Who Are Ineligible for Induction Therapy
Zeidan A, Xu Y, Kapustyan T, Miu K, Chen C, Kamalakar R, Lin C, Ma E, Montez M, Wu Z, Yee T, Sun H, Rava A, Kim S, Huntington S. Inequalities in Treatment Utilization Among Older Medicare Beneficiaries with Newly Diagnosed Acute Myeloid Leukemia Who Are Ineligible for Induction Therapy. Blood 2024, 144: 3795-3795. DOI: 10.1182/blood-2024-200213.Peer-Reviewed Original ResearchTime to treatment initiationND-AMLAssociated with lower oddsAcute myeloid leukemiaAML treatmentVEN-HMACharlson Comorbidity IndexTargeted therapyInduction therapyFemale patientsMyeloid leukemiaTreatment initiationShorter time to treatment initiationTherapy uptakeMedicare beneficiariesNewly diagnosed acute myeloid leukemiaLower oddsOdds ratioHematopoietic stem cell transplantationTime-to-treatment initiationDiagnosed acute myeloid leukemiaIn-hospital survival rateLow-dose chemotherapyClinical performance statusStem cell transplantationAssociation of Psychological Safety with Burnout and Intent to Leave Among Physician Faculty in New York City
de Guillebon E, He C, Akhtar S, Pietrzak R, Ripp J, Peccoralo L. Association of Psychological Safety with Burnout and Intent to Leave Among Physician Faculty in New York City. Journal Of General Internal Medicine 2024, 40: 361-367. PMID: 39354250, PMCID: PMC11803037, DOI: 10.1007/s11606-024-09034-9.Peer-Reviewed Original ResearchPhysician facultyAssociated with lower oddsAssociated with lower scoresAmbulatory care departmentPrevalence of PSClinical faculty membersStandard deviation unit increasePsychologically safe environmentMultivariate logistic regression analysisFaculty physiciansLogistic regression analysisHealth systemSeven-itemInstitution-wide surveyLower oddsConclusionsA majorityCare departmentNew York CityBurnoutPhysiciansSafe environmentFemale genderOrganization QuestionnaireLower scoresOccupational characteristicsHigher proceduralist stroke thrombectomy volume is associated with reduced inpatient mortality
Koo A, Renedo D, Ney J, Amllay A, Kanzler M, Stogniy S, Alawieh A, Sujijantarat N, Antonios J, Al Kasab S, Malhotra A, Hebert R, Matouk C, de Havenon A. Higher proceduralist stroke thrombectomy volume is associated with reduced inpatient mortality. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022021. PMID: 39214687, DOI: 10.1136/jnis-2024-022021.Peer-Reviewed Original ResearchIn-hospital deathIn-hospital mortalityAcute ischemic strokeCut-pointsAbsolute risk of deathAssociated with lower oddsState Inpatient DatabasesFlorida State Inpatient DatabaseIn-hospital moralityRates of in-hospital mortalityDiagnosis of acute ischemic strokePrimary study outcomeRisk of deathStroke careOptimal cut-pointAssociated with reduced inpatient mortalityEndovascular thrombectomyRetrospective cohort studyLower oddsPotential confoundersAbsolute riskAcute ischemic stroke patientsInpatient mortalityCohort studyInpatient DatabaseContemporary Prestroke Dual Antiplatelet Use and Symptomatic Intracerebral Hemorrhage Risk After Thrombolysis
Peng T, Schwamm L, Fonarow G, Hassan A, Hill M, Messé S, Coronado F, Falcone G, Sharma R. Contemporary Prestroke Dual Antiplatelet Use and Symptomatic Intracerebral Hemorrhage Risk After Thrombolysis. JAMA Neurology 2024, 81: 722-731. PMID: 38767894, PMCID: PMC11106713, DOI: 10.1001/jamaneurol.2024.1312.Peer-Reviewed Original ResearchRisk of symptomatic intracerebral hemorrhageSymptomatic intracerebral hemorrhageTreated with IV-tPAAcute ischemic strokeIV-tPAAmerican Heart Association and American Stroke AssociationAssociated with lower oddsIschemic strokeDual antiplatelet therapyAssociated with increased riskPropensity score subclassificationAmerican Stroke AssociationIntracerebral hemorrhage riskGWTG-StrokeSymptomatic intracerebral hemorrhage riskGuidelines-StrokeDischarge modified Rankin Scale scoreIn-hospital deathStroke AssociationLower oddsRate of symptomatic intracerebral hemorrhageAntiplatelet therapyCohort studyAssociated with symptomatic intracerebral hemorrhagePrestrokeAnalysis of Clinical Criteria for Discharge Among Patients Hospitalized for COVID-19: Development and Validation of a Risk Prediction Model
Schnipper J, Oreper S, Hubbard C, Kurbegov D, Egloff S, Najafi N, Valdes G, Siddiqui Z, O.’Leary K, Horwitz L, Lee T, Auerbach A. Analysis of Clinical Criteria for Discharge Among Patients Hospitalized for COVID-19: Development and Validation of a Risk Prediction Model. Journal Of General Internal Medicine 2024, 39: 2649-2661. PMID: 38937368, PMCID: PMC11534938, DOI: 10.1007/s11606-024-08856-x.Peer-Reviewed Original ResearchTime of dischargeInternal validation setPost-discharge readmissionRisk factorsDays of dischargeRetrospective observational cohort studyIndependent risk factorReceiver operating characteristic curveObservational cohort studyReversible risk factorsAssociated with lower oddsPatients 7Lack of improvementRetrospective studyValidation setFollow-upCohort studyRisk prediction modelReadmission risk scoreAcademic centersPositive testPatientsRisk scoreCOVID-19 respiratory diseaseLower oddsAssociation between dual orexin receptor antagonists (DORAs) and suicidality: reports to the United States Food and Drug Administration Adverse Event Reporting System (FAERS)
McIntyre R, Wong S, Kwan A, Rhee T, Teopiz K, Ho R, Cao B, Mansur R, Rosenblat J, Le G. Association between dual orexin receptor antagonists (DORAs) and suicidality: reports to the United States Food and Drug Administration Adverse Event Reporting System (FAERS). Expert Opinion On Drug Safety 2024, 24: 753-757. PMID: 38804896, DOI: 10.1080/14740338.2024.2361300.Peer-Reviewed Original ResearchDual orexin receptor antagonistsFDA Adverse Event Reporting SystemAdverse Event Reporting SystemEvent Reporting SystemConfidence intervalsFood and Drug Administration Adverse Event Reporting SystemAnd Drug Administration Adverse Event Reporting SystemUnited States Food and Drug Administration Adverse Event Reporting SystemOrexin receptor antagonistsAssociated with lower oddsIncreased RORReceptor antagonistOdds ratioDepressed suicidesSuicidal behaviorPackage insertsSuicidal ideationSuicide riskSuicide attemptsLower oddsNonsignificant associationsDaridorexantDisproportionate reportingTrazodoneSuicide
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