2025
APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, de Havenon A, Hawkes M, Gilmore E, Schwamm L, Sheth K, Gill T, Falcone G. APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban. JAMA Neurology 2025, 82 PMID: 40549373, PMCID: PMC12186128, DOI: 10.1001/jamaneurol.2025.0182.Peer-Reviewed Original ResearchRisk of intracranial hemorrhagePopulation-based studyYears of follow-up dataApo E4Cox proportional hazards modelsAPOE e4 alleleIntracranial hemorrhageRisk prediction scoreCerebral amyloid angiopathyClinical decision-makingProportional hazards modelAtrial fibrillationIncreased risk of ICHMultivariate Cox proportional hazards modelMain OutcomesIncident intracranial hemorrhageEuropean ancestryCohort studyInclusion criteriaHistory of ischemic strokeAmyloid angiopathyE4 variantHazards modelIncreased riskE4 allele695-P: Exploring Cultural and Immigration-Related Factors Associated with Type 2 Diabetes among Hispanic/Latino Adults
DING Q, GRISMER M, WOJECK B, MARRERO D. 695-P: Exploring Cultural and Immigration-Related Factors Associated with Type 2 Diabetes among Hispanic/Latino Adults. Diabetes 2025, 74 DOI: 10.2337/db25-695-p.Peer-Reviewed Original ResearchHispanic/Latino adultsImmigration-related factorsType 2 diabetesFactors associated with type 2 diabetesAdjusted modelsReduce diabetes burdenLimited healthcare accessHealthcare accessSocioeconomic disparitiesDiabetes burdenLifestyle factorsHispanic/Latino populationPreventive healthcarePoverty indexImprove accessHigh poverty levelsSelf-reportEvaluate associationsU.S. HispanicsLanguage barriersNational averagePoverty levelDiabetes/prediabetesIncreased riskOlder agePerceived understanding and psychosocial outcomes: employees’ responses to learning results of workplace genetic testing
Charnysh E, McCain S, Truhlar A, Pal S, Reader J, Sanghavi K, Uhlmann W, Hendy K, Leader A, Blasco D, Prince A, Feero W, Brandt R, Giri V, Lee C, Roberts J. Perceived understanding and psychosocial outcomes: employees’ responses to learning results of workplace genetic testing. Personalized Medicine 2025, ahead-of-print: 1-11. PMID: 40497788, DOI: 10.1080/17410541.2025.2515003.Peer-Reviewed Original ResearchPsychosocial responsesGenetic testingIncreased riskUS healthcare systemAbstractText Label="MATERIALS &Open-ended responsesPositive feelingsPredictors of scoresAssociated with lower levelsPsychosocial supportPsychosocial harmPsychosocial outcomesHealthcare systemAfrican American/BlackMean scoreResults QuestionnairesPerceived understandingNegative emotionsDifficulty interpretingAbstractText Label="AIMTesting understandingUncertainty scoreRegression analysisScoresFeelingsRisk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study.
Morales D, Bu F, Viernes B, DuVall S, Matheny M, Simon K, Falconer T, Richter L, Ostropolets A, Lau W, Man K, Chattopadhyay S, Mathioudakis N, Minty E, Nishimura A, Sun F, Yin C, Seager S, Chai Y, Zhou J, Lu Y, Reyes C, Pistillo A, Duarte-Salles T, Blacketer C, Schuemie M, Ryan P, Krumholz H, Hripcsak G, Khera R, Suchard M. Risk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study. Diabetes Care 2025 PMID: 40465422, DOI: 10.2337/dc25-0154.Peer-Reviewed Original ResearchRisk of thyroid tumorThyroid tumorsGLP-1RADPP-4isHazard ratioThyroid malignancyCohort studyIncreased riskSodium-glucose cotransporter 2 inhibitorsElectronic health record databaseGlucagon-like peptide 1 receptor agonistsEstimate hazard ratiosRandom-effects meta-analysisGLP-1 receptor agonistsPeptide 1 receptor agonistsDipeptidyl peptidase 4 inhibitorsThyroid tumor incidenceUsers of SGLT2isHealth record databaseSecond-line treatmentType 2 diabetes mellitusNew-user cohort studyRetrospective cohort studyUsers of sulfonylureasIntention-to-treatMulticenter performance comparison of the hepatitis C antibody serology assay on the new Atellica integrated chemistry and immunoassay analyzer
El-Khoury J, Bonito A, Fonstad R, Anostario M, Quintanilla M, Birmingham N, Mohammad A. Multicenter performance comparison of the hepatitis C antibody serology assay on the new Atellica integrated chemistry and immunoassay analyzer. Journal Of Clinical Virology Plus 2025, 5: 100215. DOI: 10.1016/j.jcvp.2025.100215.Peer-Reviewed Original ResearchHepatitis C virusHCV seroconversion panelsSeroconversion panelsRisk of transmitting HCVExposure to hepatitis C virusIMS analyzerHepatitis C virus serologic testsSerological testsAnti-HCV serological testAnti-HCV antibodiesSerological assaysCenters for Disease ControlIntegrative chemistryC virusSerum specimensIncreased riskNegative individualsAtellicaClinical performanceImmunoassay analyzerPositive individualsIdentification of individualsMethod comparison studyDisease controlPositive agreementClostridium difficile Induced Coagulopathy: Implications for Microsurgery in the Setting of Limb Salvage
Rohrich R, Li K, Azimi R, Junn A, Ferdousian S, Lin R, Lee W, Currin M, Youn R, Attinger C, Akbari C, Evans K. Clostridium difficile Induced Coagulopathy: Implications for Microsurgery in the Setting of Limb Salvage. Journal Of Plastic Reconstructive & Aesthetic Surgery 2025 DOI: 10.1016/j.bjps.2025.06.010.Peer-Reviewed Original ResearchClostridium difficile infectionCDI groupFlap takebacksNon-CDI groupImpact of Clostridium difficile infectionPartial flap necrosisLower extremitiesRetrospective cohort studyC. diff infectionFlap complicationsMicrosurgical outcomesFlap necrosisThrombotic complicationsDifficile infectionPedicle thrombosisMicrovascular thrombosisFollow-upClinical managementMultivariate regression modelCohort studyIncreased riskC. difficilePlastic surgeonsPatientsLimb salvageThe genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders
Galimberti M, Overstreet C, Gupta P, Beck S, Dao C, Deak J, Zhou H, Johnson E, Agrawal A, Stein M, Levey D, Gelernter J. The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders. Nature Mental Health 2025, 3: 700-708. DOI: 10.1038/s44220-025-00440-4.Peer-Reviewed Original ResearchGenomic structural equation modelingCannabis use disorderCannabis usePsychiatric disordersUse disorderStructural equation modelingIncreased rates of psychiatric disordersIncreasing prevalence of cannabis useRates of psychiatric disordersPrevalence of cannabis useThree-factor modelEquation modelingDepressive disorderPsychiatric traitsCannabisLocal genetic correlationDisordersGenetic correlationsMendelian randomization analysisTraitsRandomization analysisSchizophreniaADHDColocalization analysisIncreased riskSex Differences in Perioperative Complications of Lower Extremity Revascularization for Peripheral Artery Disease
Terrazos-Moreno R, Vu A, Alameddine D, Zhuo H, Mena-Hurtado C, Mojibian H, Guzman R, Ochoa Chaar C. Sex Differences in Perioperative Complications of Lower Extremity Revascularization for Peripheral Artery Disease. Annals Of Vascular Surgery 2025, 121: 113-119. PMID: 40447038, DOI: 10.1016/j.avsg.2025.05.041.Peer-Reviewed Original ResearchLower extremity revascularizationPeripheral arterial diseaseArtery diseaseEndovascular lower extremity revascularizationPerioperative complicationsExtremity revascularizationChronic renal insufficiencyOutcomes of patientsRetrospective chart reviewOutcomes of lower extremity revascularizationCoronary artery diseaseRisk of early thrombosisLower-extremity revascularizationRenal insufficiencyTertiary centerInitial presentationWound infectionIncreased bleedingNo significant differenceSmoking historyProcedure typePAD patientsPatient characteristicsPerioperative periodIncreased riskWeight Loss Is Protective in Preclinical Breast Cancer Models: Interactions with the Anticancer Immune Response.
Sassoon R, Perry R. Weight Loss Is Protective in Preclinical Breast Cancer Models: Interactions with the Anticancer Immune Response. Cancer Prevention Research 2025, of1-of2. PMID: 40421602, DOI: 10.1158/1940-6207.capr-25-0168.Peer-Reviewed Original ResearchICR miceIntermittent calorie restrictionE0771 breast cancer cellsPreclinical breast cancer modelsRate of tumor growthTriple-negative breast cancerAnticancer immune responseBreast cancer modelBreast cancer cellsCancer prevention researchAntitumor immunityHigh-fat dietTumor sizeImmune dysfunctionPreclinical evidenceLean controlsPoor prognosisCancer modelsBreast cancerTumor growthOld miceObesogenic dietAdvanced ageIncreased riskImmune responsePenetrance of neurodevelopmental copy number variants is associated with variations in cortical morphology
Silva A, Sønderby I, Kirov G, Abdellaoui A, Agartz I, Ames D, Armstrong N, Artiges E, Banaschewski T, Bassett A, Bearden C, Blangero J, Boen R, Boomsma D, Bülow R, Butcher N, Calhoun V, Campbell L, Chow E, Ciufolini S, Craig M, Crespo-Farroco B, Cunningham A, Dalvie S, Daly E, Dazzan P, de Geus E, de Zubicaray G, Doherty J, Donohoe G, Drakesmith M, Espeseth T, Frouin V, Garavan H, Glahn D, Goodrich-Hunsaker N, Gowland P, Grabe H, Grigis A, Gudbrandsen M, Gutman B, Haavik J, Håberg A, Hall J, Heinz A, Hohmann S, Hottenga J, Jacquemont S, Jahanshad N, Jonas R, Jones D, Jönsson E, Koops S, Kumar K, Le Hellard S, Lemaitre H, Liu J, Lundervold A, Martinot J, Mather K, McDonald-McGinn D, McMahon K, McRae A, Medland S, Moreau C, Murphy K, Murphy D, Murray R, Nees F, Owen M, Martinot M, Orfanos D, Paus T, Poustka L, Marques T, Roalf D, Sachdev P, Scheffler F, Schmitt J, Schumann G, Steen V, Stein D, Strike L, Teumer A, Thalamuthu A, Thomopoulos S, Tordesillas-Gutiérrez D, Trollor J, Uhlmann A, Vajdi A, van ’t Ent D, van Amelsvoort T, van den Bree M, van der Meer D, Vázquez-Bourgon J, Villalón-Reina J, Völker U, Völzke H, Vorstman J, Westlye L, Williams N, Wittfeld K, Wright M, Thompson P, Andreassen O, Linden D, group E. Penetrance of neurodevelopmental copy number variants is associated with variations in cortical morphology. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40414598, DOI: 10.1016/j.bpsc.2025.05.010.Peer-Reviewed Original ResearchCopy number variantsDevelopmental disordersNeurobiological mechanismsPenetration scoresMechanisms of genetic riskAssociated with variationBrain magnetic resonance imagingCohort of patientsCortical surface areaT1-weighted brain magnetic resonance imagingMagnetic resonance imagingCortical morphometric featuresGenetic dataLingual gyrusClinical phenotypeSubcortical morphologyIncreased riskNeuroimaging dataSchizophreniaBrain abnormalitiesNeurodevelopmental conditionsIntracranial volumeCerebral cortexResonance imagingCortical morphology0740 Loop Gain Predicts Residual Sleep Apnea Events Among People Using Positive Airway Pressure
Eschbach E, Kushida C, Peker Y, Xu Z, Deng A, Azarbarzin A, Wellman A, Yaggi H, Sands S, Zinchuk A. 0740 Loop Gain Predicts Residual Sleep Apnea Events Among People Using Positive Airway Pressure. Sleep 2025, 48: a321-a321. DOI: 10.1093/sleep/zsaf090.0740.Peer-Reviewed Original ResearchPositive airway pressureObstructive sleep apneaPositive airway pressure therapyBody mass indexSleep apneaBaseline AHIPAP therapyAirway pressurePharyngeal collapseIncreased riskOdds ratioPositive airway pressure devicesAssociated with increased riskCoronary artery diseaseSleep apnea eventsEpisodic airway obstructionBaseline polysomnogramRandomized controlled trialsBaseline polysomnographyHigh LGAdjunctive therapyAirway obstructionUpper airwayMass indexApneaHuman Immunodeficiency Virus Infection and Long COVID: A RECOVER Program, Electronic Health Record–Based Cohort Study
Hawkins K, Dandachi D, Verzani Z, Brannock M, Lewis C, Abedian S, Jaferian S, Wuller S, Truong J, Witvliet M, Dymond G, Mehta H, Patel P, Hill E, Weiner M, Carton T, Kaushal R, Feuerriegel E, Tran H, Marks K, Oliveira C, Gardner E, Ofotokun I, Gulick R, Erlandson K. Human Immunodeficiency Virus Infection and Long COVID: A RECOVER Program, Electronic Health Record–Based Cohort Study. Clinical Infectious Diseases 2025, ciaf242. PMID: 40354184, DOI: 10.1093/cid/ciaf242.Peer-Reviewed Original ResearchDefinition of Long COVIDICD-10Baseline chronic conditionsLong COVIDElectronic health record databaseIncreased riskHealth record databaseICD-10 codesICD-10 definitionRisk of long COVIDClinical Research NetworkChronic conditionsAcute SARS-CoV-2 infectionHIV statusAnalytic sampleOdds ratioCohort definitionsCohort CollaborationComputable phenotypePhenotype definitionRecord databaseSARS-CoV-2 infectionLogistic regressionResearch NetworkMulticenter studyHealth and Utilization Burden of Obstructive Sleep Apnea among U.S. Active-Duty Military Personnel
Wickwire E, Capaldi V, Herrin J, Stryckman B, Thomas C, Williams S, Werner J, Funk W, Nassif T, Albrecht J. Health and Utilization Burden of Obstructive Sleep Apnea among U.S. Active-Duty Military Personnel. CHEST Journal 2025 PMID: 40368028, DOI: 10.1016/j.chest.2025.05.007.Peer-Reviewed Original ResearchObstructive sleep apneaBurden of obstructive sleep apneaSleep apneaUtilization burdenNewly diagnosed OSAIncreased riskObstructive sleep apnea diagnosisObstructive sleep apnea treatmentMonths of continuous enrollmentAssociated with increased riskHealthcare resource utilizationActive-duty military personnelInternational Classification of DiseasesMilitary Data RepositoryContinuous enrollmentClassification of DiseasesPsychological health outcomesWhite racePsychiatric comorbiditiesService membersApneaED encountersHealth outcomesInternational ClassificationMedical outcomes[Association between dietary behavior and sarcopenia in older adults aged 65 years and above in longevity areas of China: a latent class analysis].
Zhao Y, Zhang Z, Wang J, Zhou J, Chen H, Qi L, Li Y, Chen Y, Meng X, Zhang Z, Chen C, Shi X, Lyu Y, Shi W. [Association between dietary behavior and sarcopenia in older adults aged 65 years and above in longevity areas of China: a latent class analysis]. Chinese Journal Of Epidemiology 2025, 46: 746-752. PMID: 40494780, DOI: 10.3760/cma.j.cn112338-20241117-00729.Peer-Reviewed Original ResearchConceptsDietary behaviorsOlder adultsCategory scoresLatent class analysisDietary intakeFood intake frequencyRisk of sarcopeniaIncreased riskBalanced dietary patternFood frequency questionnaireIntake of cerealsMultivariate logistic regression modelChronic disease historyNon-sarcopenia groupLogistic regression modelsClass analysisIntake categoriesSARC-CalF.Frequency questionnaireBiomarkers Cohort StudyIntake frequencyDietary patternsSarcopenia groupCohort studyLongevity areasUsing geospatial analysis to describe the association between active tick surveillance data and clinical cases of anaplasmosis in Connecticut
Desiato J, Chan G, Palmeri M, Cantoni J, Cozens D, Linske M, Brackney D, Stafford K, Banach D. Using geospatial analysis to describe the association between active tick surveillance data and clinical cases of anaplasmosis in Connecticut. Journal Of Medical Entomology 2025, tjaf055. PMID: 40341955, DOI: 10.1093/jme/tjaf055.Peer-Reviewed Original ResearchDepartment of Public HealthConnecticut Department of Public HealthCases of anaplasmosisClinical cases of anaplasmosisIncidence ratePublic healthSurveillance dataPublic health interventionsPotential associationI. scapularisHealth interventionsTick surveillance dataConnecticut Agricultural Experiment StationIdentified geographic areasAgricultural Experiment StationEvaluate potential associationsIxodes scapularis ticksBacterium Anaplasma phagocytophilumPrevalence dataActive tick surveillanceClinical casesQuesting I. scapularisSpearman rank correlationIncreased riskAnaplasma phagocytophilumTraumatic Vertebral Artery Injury: Diagnosis, Natural History, and Key Considerations for Management
Teasdale B, Owolo E, Padmanaban V, Elsamadicy A, Amllay A, Shankar G, Krieger P, Regenhardt R, Hebert R, Stapleton C, Rabinov J, Matouk C, Patel A, Sujijantarat N. Traumatic Vertebral Artery Injury: Diagnosis, Natural History, and Key Considerations for Management. Journal Of Clinical Medicine 2025, 14: 3159. PMID: 40364191, PMCID: PMC12072270, DOI: 10.3390/jcm14093159.Peer-Reviewed Original ResearchVertebral artery injuryBlunt cervical spine traumaRisk of vertebral artery injuryNatural historyCervical spine traumaVertebral artery occlusionPotential risk of strokeRisk of strokeComprehensive narrative reviewCo-existing injuriesCervical traumaSpine traumaSpinal cord injuryIntracranial hemorrhageIschemic sequelaeEndovascular managementAntiplatelet therapySurgical interventionRecanalization rateArterial injuryArtery occlusionIncreased riskTherapeutic strategiesDiagnostic approachBony injuriesSerotype specific pneumococcal vaccine effectiveness in children with sickle cell disease: A two-decade analysis
Zhang Z, Yildirim M, Keskinocak P, Dasthagirisaheb Y, Hinderstein S, Tran K, Crockett M, Burns M, Johnson H, Popstefanija M, Madoff L, Pelton S, Yildirim I. Serotype specific pneumococcal vaccine effectiveness in children with sickle cell disease: A two-decade analysis. Vaccine 2025, 56: 127193. PMID: 40318350, DOI: 10.1016/j.vaccine.2025.127193.Peer-Reviewed Original ResearchIncidence rate ratiosInvasive pneumococcal diseaseSickle cell diseaseIncidence ratePost-PCV13 periodCalculated incidence ratesValency vaccinesVaccine effectivenessPneumococcal diseaseHealthy childrenRates of invasive pneumococcal diseasePopulation-basedCell diseaseHealth conditionsRate ratiosNon-PCV13 serotypesPneumococcal vaccine effectivenessVulnerable populationsBootstrapping resamplingIncreased riskHigher IRNon-PCV13Genetic hematological diseasesHematological diseasesVaccine formulationsSafety of Stimulants Across Patient Populations
Oliva H, Prudente T, Mayerson T, Mignosa M, Oliva I, Potenza M, Jegede O, Angarita G. Safety of Stimulants Across Patient Populations. JAMA Network Open 2025, 8: e259492. PMID: 40343695, PMCID: PMC12065045, DOI: 10.1001/jamanetworkopen.2025.9492.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderRandomized clinical trialsAdverse eventsStimulant medicationData extractionSafety of stimulationRisk ratioIncreased riskMethodological quality assessmentPreferred Reporting ItemsPatient populationClinical conditionsDiverse patient populationsRisk of biasSafety of stimulant medicationsUnclear risk of biasTreatment of attention-deficit/hyperactivity disorderOverall AEsRandom-effects modelWeb of ScienceBinge eating disorderStimulant use disorderComprehensive literature searchMain OutcomesReporting ItemsBeyond User-Centered Design: Designing Digital Health Technologies for Substance Use Prevention and Treatment in Children and Youth
Singh K, Camenga D, Aneni K, Hieftje K. Beyond User-Centered Design: Designing Digital Health Technologies for Substance Use Prevention and Treatment in Children and Youth. 2025, 231-249. DOI: 10.1007/978-3-031-84655-7_10.Peer-Reviewed Original ResearchDigital health interventionsSubstance use preventionHealth interventionsDevelopment of digital interventionsAssociated with numerous adverse health outcomesNumerous adverse health outcomesMental health disordersDigital health technologiesAdverse health outcomesFuture addictionHealth outcomesDigital interventionsSubstance use disordersUser-centered design approachHealth disordersHealth technologiesYouth substance useInterventionIncreased riskSubstance useUse disorderPreventionYouthChildrenUser experience evaluationAssociation between endometriosis and type and age of menopause: a pooled analysis of 279 948 women from five cohort studies
Chung H, Hayashi K, Dobson A, Sandin S, Ideno Y, Hardy R, Weiderpass E, Mishra G. Association between endometriosis and type and age of menopause: a pooled analysis of 279 948 women from five cohort studies. Human Reproduction 2025, 40: 1210-1219. PMID: 40304605, PMCID: PMC12127511, DOI: 10.1093/humrep/deaf068.Peer-Reviewed Original ResearchConceptsPremature ovarian insufficiencySpontaneous premature ovarian insufficiencySurgical menopauseNatural menopauseAge of menopauseBilateral oophorectomyOvarian reserveEarly menopauseMenopausal ageCohort studyHazard ratioIncreased riskMenopause typeOdds ratioInternational Agency for Research on CancerImpact ovarian reservePremature surgical menopauseMenopausal hormone therapyStages of endometriosisPremenopausal bilateral oophorectomyManagement of endometriosisMonitoring of womenOvarian preservationPremenopausal hysterectomyFine-Gray subdistribution hazard model
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