2025
The modulating role of interactional contexts in executive functioning of bilinguals: a scoping review
Semenova E, Norkina M, Logvinenko T, Ryseva K, Chinn L, Crabb K, Grigorenko E. The modulating role of interactional contexts in executive functioning of bilinguals: a scoping review. Bilingualism Language And Cognition 2025, 1-35. DOI: 10.1017/s1366728925100084.Peer-Reviewed Original ResearchAdaptive control hypothesisExecutive functionInteraction contextBilingual advantage hypothesisEveryday language useEF tasksEF domainsBilingualsFunction of bilingualismControl hypothesisLanguage-use patternsSample characteristicsExperimental manipulationLanguage useModulating roleClearer predictionsLanguage-useHypothesisDefinitive conclusionsAssociationResearch designTaskContextOperationalizationResearchMultivariate associations between structural brain changes and cognitive impairment in partially or fully remitted persons with bipolar disorder
Schandorff J, Madsen A, Damgaard V, Little B, Sankar A, Macoveanu J, Frokjaer V, Kessing L, Jørgensen M, Knudsen G, Gallagher P, Miskowiak K. Multivariate associations between structural brain changes and cognitive impairment in partially or fully remitted persons with bipolar disorder. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2025, 140: 111425. PMID: 40505718, DOI: 10.1016/j.pnpbp.2025.111425.Peer-Reviewed Original ResearchBipolar disorderGray matter volumeCognitive impairmentMatter volumeBrain structuresReduced gray matter volumeExtensive cognitive test batteryLower gray matter volumeStructural magnetic resonance imagingBrain structural alterationsCognitive test batteryPosterior cingulate regionsStructural brain changesLeft caudate nucleusCanonical correlation analysisRemitted personsVerbal learningWorking memoryExecutive functionPsychomotor speedCingulate regionsCognitive domainsRight hippocampusCognitively impaired personsBrain changesGreater neuroimmune system deficit in women than men with alcohol use disorder
Zakiniaeiz Y, Hillmer A, Shi H, Pittman B, Nabulsi N, Huang Y, Bonomi R, Matuskey D, Angarita G, McKee S, Cosgrove K. Greater neuroimmune system deficit in women than men with alcohol use disorder. Biological Psychiatry 2025 PMID: 40412787, DOI: 10.1016/j.biopsych.2025.05.012.Peer-Reviewed Original ResearchTranslocator protein availabilityAlcohol-induced neurodegenerationExecutive function tasksConsequences of alcohol useAlcohol use disorderBrain imaging scansTranslocator protein levelsSex-matched controlsExecutive functionLower hippocampalTSPO availabilityFrontal cortexTranslocator proteinUse disorderNeurocognitive functionBrain regionsSex differencesAlcohol useBrain-resident immune cellsNeuroimmune mechanismsFunctional tasksSystem deficitsAUDImaging scansNeuroimmune cells211. The Mediating Role of Executive Functioning in the Association between Early Life Adversity and Psychological Functioning in Individuals With and Without a History of Sexual Abuse
Nadarajan R, Gotlib I, O'Donnell K, Noll J, Pokhvisneva I, Meaney M. 211. The Mediating Role of Executive Functioning in the Association between Early Life Adversity and Psychological Functioning in Individuals With and Without a History of Sexual Abuse. Biological Psychiatry 2025, 97: s182. DOI: 10.1016/j.biopsych.2025.02.448.Peer-Reviewed Original ResearchSelf-Inflicted Head Injury in Behavioral Variant Frontotemporal Dementia with Compulsive Behaviors: A Case Report
Yang Y, Matuskey D, Benjamin C, Fesharaki-Zadeh A. Self-Inflicted Head Injury in Behavioral Variant Frontotemporal Dementia with Compulsive Behaviors: A Case Report. Cognitive And Behavioral Neurology 2025, 38: 66-72. PMID: 40298273, DOI: 10.1097/wnn.0000000000000392.Peer-Reviewed Original ResearchConceptsBehavioral variant frontotemporal dementiaDiagnosis of behavioural variant frontotemporal dementiaFrontotemporal dementiaEpisodic memory lossLoss of empathyCompulsive behaviorsExecutive functionProgressive behavioral deficitsPsychiatric diagnosisPsychiatric disordersBehavioral deficitsRight hippocampusRight hemisphereBehavioral agitationPersonality changesNeuroimaging findingsInstrumental activities of daily livingMemory lossRight lateral ventricleSevere hypometabolismLateral ventricleParenchymal volume lossClinician's abilityInstrumental activitiesVolume lossAlcohol use disorder and body mass index show genetic pleiotropy and shared neural associations
Malone S, Davis C, Piserchia Z, Setzer M, Toikumo S, Zhou H, Winterlind E, Gelernter J, Justice A, Leggio L, Rentsch C, Kranzler H, Gray J. Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations. Nature Human Behaviour 2025, 9: 1056-1066. PMID: 40164914, DOI: 10.1038/s41562-025-02148-y.Peer-Reviewed Original ResearchConceptsAlcohol use disorderUse disorderBrain regionsGenotype-Tissue ExpressionSingle-nucleotide polymorphismsPolygenic overlapAssociated with alcohol use disorderCaudate nucleus volumeBody mass indexMultiple brain regionsConjunctional false discovery rateNeurobiological overlapExecutive functionNeurobiological mechanismsNeural associationsBrain phenotypesNucleus volumeFalse discovery rate methodFalse discovery rateGenetic architectureVariant effectsMass indexGenetic pleiotropyDiscovery rateTissue enrichmentSubstance Misuse, Executive Function, and Young Adult Intimate Partner Violence: Direct and Indirect Pathways.
Martin E, Ramos K, Modanesi E, Mayes L, Stover C. Substance Misuse, Executive Function, and Young Adult Intimate Partner Violence: Direct and Indirect Pathways. Journal Of Interpersonal Violence 2025, 8862605251326641. PMID: 40123291, DOI: 10.1177/08862605251326641.Peer-Reviewed Original ResearchIntimate partner violence riskIntimate partner violenceEarly adolescent substance usePrenatal drug exposureAdolescent substance useExecutive functionSubstance useMaternal educationAdult intimate partner violencePredicting intimate partner violencePrevent intimate partner violenceHigh-risk subjectsYoung adult relationshipsContribution of childhood maltreatmentDevelopmental trajectories of individualsAdolescents' executive functionLow maternal educationWell-being consequencesEnhance executive functionLongitudinal birth cohortYoung adultsDrug exposureIPV riskPartner violenceSex-specific effectsI Got Rhythm and Executive Function, Memory, and More: The Automated Test of Embodied Cognition (ATEC)
Bell M, Gonzalez Y, Weinstein A, Ciosek D, Wang Y, Yoon G. I Got Rhythm and Executive Function, Memory, and More: The Automated Test of Embodied Cognition (ATEC). Brain Sciences 2025, 15: 299. PMID: 40149820, PMCID: PMC11940590, DOI: 10.3390/brainsci15030299.Peer-Reviewed Original ResearchPre-morbid IQStory memoryExecutive functionVisual memoryNeurocognitive measuresStandard measures of executive functioningMeasures of executive functionCognitive declineVerbal list learningAdministered standardized measuresCommunity control participantsRisk of cognitive declineYears of educationEF factorIQ estimatesList learningCognitive reserveEF measuresMeasure cognitionAt-risk participantsControl participantsVisual sequencesConcurrent validityCommunity controlsFactor analysisCurrent interpretations of the I-PACE model of behavioral addictions
Brand M, Müller A, Wegmann E, Antons S, Brandtner A, Müller S, Stark R, Steins-Loeber S, Potenza M. Current interpretations of the I-PACE model of behavioral addictions. Journal Of Behavioral Addictions 2025, 14: 1-17. PMID: 40063161, PMCID: PMC11974429, DOI: 10.1556/2006.2025.00020.Peer-Reviewed Original ResearchConceptsI-PACE modelI-PACEBehavioral addictionsInteraction of Person-Affect-Cognition-ExecutionBehavioral addiction researchCue-reactivityDesire thinkingCompulsive behaviorsExecutive functionAddictive behaviorsNegative reinforcementAddiction researchPermissive beliefsAddiction theoryAddiction fieldSelf-controlAddictionCravingEmpirical findingsTheory buildingClinical careStimulate researchGratificationBehaviorContext of changesEmbodied Cognition and Alcohol Use Disorder: Frequency of Impairments and Relationship to Neurocognitive Assessments
Bell M, Weinstein A, Ciosek D, Reilly S, Wang Y, Yoon G. Embodied Cognition and Alcohol Use Disorder: Frequency of Impairments and Relationship to Neurocognitive Assessments. Brain Sciences 2025, 15: 228. PMID: 40149750, PMCID: PMC11940586, DOI: 10.3390/brainsci15030228.Peer-Reviewed Original ResearchAlcohol use disorderEmbodied cognitionTotal scoreExecutive functionUse disorderNeurocognitive assessmentCognitive declineMeasure executive functionFrequency of impairmentPotential protective factorsPremorbid IQEF impairmentsMemory domainDelayed recallOverall impairmentEF domainsCognitive processesNeurocognitive testsConcurrent validityFrequent impairmentCognitionSelf-regulationCognitive scienceImpairmentProtective factors2.13 The circuit mechanisms of working memory: Key roles of the dorsolateral prefrontal cortex
Arnsten A, Martinez-Trujillo J. 2.13 The circuit mechanisms of working memory: Key roles of the dorsolateral prefrontal cortex. 2025, 206-234. DOI: 10.1016/b978-0-443-15754-7.00038-9.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexWorking memoryMechanisms of working memorySpatial working memoryPosterior association cortexExecutive functionMediodorsal thalamusSketch padMental representationsAssociation cortexSubcortical connectionsCholinergic neurotransmissionCircuit mechanismsRecurrent excitatory circuitsNMDA receptorsAbstract thoughtPersistent firingPrimate researchCortexDlPFCExcitatory circuitsMemorySensory stimulationAlzheimer's disease
2024
Neural hyperscanning in caregiver-child dyads: A paradigm for studying the long-term effects of facilitated vs. disrupted attention on working memory and executive functioning in young children
Rosen M, Li A, Mikkelsen C, Aslin R. Neural hyperscanning in caregiver-child dyads: A paradigm for studying the long-term effects of facilitated vs. disrupted attention on working memory and executive functioning in young children. Developmental Review 2024, 75: 101170. PMID: 39802123, PMCID: PMC11720965, DOI: 10.1016/j.dr.2024.101170.Peer-Reviewed Original ResearchDevelopment of working memoryExecutive functionParent-child interactionsChildren's attentionMaturing executive functionsEye-tracking paradigmExecutive function abilitiesComplex cognitive functionsDevelopment of attentionParent-child dyadsYoung childrenChild cognitive outcomesPatterns of interactionCaregiver-child dyadsWorking memoryDisrupt attentionEngaging infantsNeural basisCognitive functionHyperscanning techniqueBrain synchronyChild behaviorCognitive outcomesNaturalistic experimentTracking paradigmEnhanced neurobiological biomarker differentiation for attention-deficit/hyperactivity disorder through a risk-informed design
Duarte I, Hoffmann M, Salum G, Leffa D, Belangero S, Santoro M, Ota V, Ito L, Pan P, Farhat L, Murray A, Miguel E, Kieling C, Rohde L, Caye A. Enhanced neurobiological biomarker differentiation for attention-deficit/hyperactivity disorder through a risk-informed design. European Child & Adolescent Psychiatry 2024, 1-11. PMID: 39625683, DOI: 10.1007/s00787-024-02622-4.Peer-Reviewed Original ResearchNeurobiological measuresADHD polygenic scoresBrazilian High-Risk CohortAttention-deficit/hyperactivity disorderPoorer executive functionPolygenic scoresADHD symptomsExecutive functionHigh-risk subgroupsAttention-deficit/hyperactivitySubcortical volumesHigh-risk cohortMental disordersADHD casesEffect sizeADHDMental conditionDifferential riskClinical practiceRisk cohortBiomarkers to clinical practiceLow-risk groupCalculated riskParticipantsAdolescentsCorrelates of Impaired Timing Abilities in Schizophrenia
Croce E, Simonelli G, Ferrara M, Escelsior A, Folesani F, Bovio A, Muscettola A, Toffanin T, De Bellis G, Nanni M, Caruso R, Murri M, Grassi L. Correlates of Impaired Timing Abilities in Schizophrenia. The Journal Of Nervous And Mental Disease 2024, 212: 603-622. PMID: 39808471, DOI: 10.1097/nmd.0000000000001810.Peer-Reviewed Original ResearchSymptom severityTiming abilityDisorganized symptomsNeurobiological correlatesWorking memoryExecutive functionTiming impairmentsNeurobiological dataSchizophreniaCognitive impairmentNeural circuitsImpairmentSymptomsPreferred Reporting ItemsSystematic literature searchClinical heterogeneityCognitionAbilitySeverityReporting ItemsMemoryStudy designSystematic reviewPsycINFOAssociationCorrelation between changes in apathy and cognition in Alzheimer’s disease associated apathy: analysis of the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2)
Sankhe K, Tumati S, Perin J, Rivet L, Vieira D, Rosenberg P, Herrmann N, Shade D, Lerner A, Padala P, Brawman‐Mintzer O, van Dyck C, Porsteinsson A, Craft S, Levey A, Mintzer J, Lanctôt K. Correlation between changes in apathy and cognition in Alzheimer’s disease associated apathy: analysis of the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2). Alzheimer's & Dementia 2024, 20: e091793. PMCID: PMC11710533, DOI: 10.1002/alz.091793.Peer-Reviewed Original ResearchMini-Mental State ExamBoston Naming TestDigit Span ForwardCategory fluencyWorsening apathyNPI-aCognitive testsAlzheimer's diseaseCognitive change scoresAssociated with cognitive impairmentBaseline cognitive test scoresCognitive test scoresMild to moderate ADAssociated with performanceNaming TestVerbal fluencyExecutive functionMethylphenidate treatmentMethylphenidate groupTrail MakingCognitive domainsCognitive changesMethylphenidatePlacebo-controlled trialNPI-apathyThe Cerebellum Plays a Protective Role in Cognitive Aging and Disease: Insights from a Multi‐Cohort Study
Uquillas F, Sefik E, Seidlitz J, Merriman J, Zhang V, Kislin M, Cohen J, Alexander‐Bloch A, Bethlehem R, Sepulcre J, Wang S, Vannini P, Gomez J, Initiative T. The Cerebellum Plays a Protective Role in Cognitive Aging and Disease: Insights from a Multi‐Cohort Study. Alzheimer's & Dementia 2024, 20: e085743. PMCID: PMC11716736, DOI: 10.1002/alz.085743.Peer-Reviewed Original ResearchMontreal Cognitive AssessmentEstimated intracranial volumeBrain reserveCognitive declineMontreal Cognitive Assessment scoreCerebellar volumePattern of cognitive declineUK BiobankAging-related cognitive declineCerebellar tissue volumesPosterior cerebellar cortexAmyloid burdenAPOE genotypeAlzheimer's diseaseCerebellar associationsMild cognitive impairmentExecutive functionCognitive agingAmyloid-beta burdenVentral attentionPosterior cerebellumCrus IAge-related changesDiagnostic groupsProcessing speedImpact of Type 2 Diabetes and Hypertension on Cognition: A Propensity Score‐Matched Analysis in Mexican Americans from San Antonio
Lopez‐Alvarenga J, Almeida M, Cavazos J, Mahaney M, Maestre G, Glahn D, Duggirala R, Blangero J. Impact of Type 2 Diabetes and Hypertension on Cognition: A Propensity Score‐Matched Analysis in Mexican Americans from San Antonio. Alzheimer's & Dementia 2024, 20: e091135. PMCID: PMC11716190, DOI: 10.1002/alz.091135.Peer-Reviewed Original ResearchCalifornia Verbal Learning TestContinuous Performance TestHigh blood pressureCalifornia Verbal Learning Test scoresMexican AmericansVerbal Learning TestInformation-processing speedAffected cognitive domainsPrevalence of chronic conditionsCognitive screening toolHigh blood pressure statusUS Hispanic/Latino populationEpidemiological observational studiesObservational studyExecutive functionLearning TestCognitive measuresDelayed recallEffect of T2DMemory delayShort-term memoryImpact of type 2 diabetesRisk of hypertensionCognitive functionLow processing speedArousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea
Zinchuk A, Kushida C, Walker A, Wellman A, Azarbarzin A, Alex R, Varga A, Sands S, Yaggi H. Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea. European Respiratory Journal 2024, 65: 2401183. PMID: 39572221, DOI: 10.1183/13993003.01183-2024.Peer-Reviewed Original ResearchEffect of continuous positive airway pressureContinuous positive airway pressureObstructive sleep apneaSleep apneaArousal thresholdApnea Positive Pressure Long-term Efficacy StudySham continuous positive airway pressureEffect of CPAP treatmentPositive airway pressureLong-term efficacy studiesAssociated with neurocognitive dysfunctionCPAP treatmentAirway pressureSham-controlled trialApneaRandomized trialsSecondary outcomesNeurocognitive dysfunctionNeurocognitive outcomesTotal timeEfficacy studiesNeurocognitive functionSecondary analysisArTHExecutive functionInhibition of brain glutamate carboxypeptidase II (GCPII) to enhance cognitive function
Wiseman R, Bigos K, Arnsten A, Slusher B. Inhibition of brain glutamate carboxypeptidase II (GCPII) to enhance cognitive function. Advances In Pharmacology 2024, 102: 27-63. PMID: 39929583, PMCID: PMC12120972, DOI: 10.1016/bs.apha.2024.10.018.Peer-Reviewed Original ResearchN-acetylaspartyl glutamateGlutamate carboxypeptidase IICognitive deficitsCognitive functionDorsolateral prefrontal cortex of primatesPrefrontal cortex of primatesHigher order cognitive processesDorsolateral prefrontal cortexMetabotropic glutamate receptor 3Inhibition of glutamate carboxypeptidase IIImprove cognitive deficitsEnhance cognitive functionImprove cognitive performanceEnzyme glutamate carboxypeptidase IIGlutamate receptor 3Executive functionCortex of primatesMGlu3 receptorsCarboxypeptidase IICognitive performanceCognitive processesPersistent neuronal firingClinical populationsNeuronal firingClinical workChildren’s arithmetic strategy use trajectories: Exploring the roles of executive functions and sociodemographic characteristics
Akhavein K, Clark C, Nelson J, Espy K, Finch J. Children’s arithmetic strategy use trajectories: Exploring the roles of executive functions and sociodemographic characteristics. Journal Of Experimental Child Psychology 2024, 249: 106109. PMID: 39471728, DOI: 10.1016/j.jecp.2024.106109.Peer-Reviewed Original ResearchChildren's math achievementExecutive functionPreschoolers' executive functionMath achievementArithmetic problemsChildren's executive functionEarly elementary schoolTargeted early interventionYears of educationSubtraction problemsDocumented gender differencesStrategy useChildren's strategiesCounting strategiesLongitudinal associationsGender differencesEarly interventionYoung childrenPreschoolYears 3 monthsStrategy selectionChildrenElementary schoolMaternal educationRetrieval
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