2025
Emergency Department Implementation of a Multimodal Electronic Health Record–Integrated Clinical Intervention for High-Sensitivity Troponin Testing Increases Diagnostic Efficiency
Sangal R, Iscoe M, Rothenberg C, Possick S, Taylor R, Safdar B, Desai N, Rhodes D, Venkatesh A. Emergency Department Implementation of a Multimodal Electronic Health Record–Integrated Clinical Intervention for High-Sensitivity Troponin Testing Increases Diagnostic Efficiency. Journal Of The American College Of Emergency Physicians Open 2025, 6: 100202. DOI: 10.1016/j.acepjo.2025.100202.Peer-Reviewed Original ResearchEmergency departmentAcute myocardial infarction diagnosisTroponin testingED dischargeMyocardial infarction diagnosisAssociated with lower oddsAccelerated diagnostic protocolPhysician practice variationAcute coronary syndromeInfarction diagnosisChest pain evaluationMultivariate logistic regressionSuspected acute coronary syndromePostintervention periodDownstream testingPhysician practicesPreintervention periodED dispositionLower oddsCoronary syndromeDecreased oddsIncreased oddsPractice variationED patientsHs-cTnTTiming of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study
Dribin T, Sampson H, Zhang Y, Boyd S, Zhang N, Michelson K, Neuman M, Brousseau D, Mistry R, Freedman S, Aronson P, Bergmann K, Boswell B, Chinta S, Chua W, Cohen A, Cohen J, Daggett A, Davis J, Freeman J, Khanna K, Knoles C, Kwan K, Larsen C, Lee J, Lubell T, Metcalf A, Moake M, Nesiama J, Ngo T, Pulcini C, Russo C, Singh N, Srivastava G, Strutt J, Thapar V, Vander Wyst C, Walsh P, Wolnerman Y, Schnadower D, Academy of Pediatrics P, Kanngiesser A, McGarghan F, Dulchavsky A, Costalez J, DesPain A, Armanious M, Haghnazarian E, Brown-Whitehorn T, Weigert R, Dayan P, Meltzer J, Chowdhury N, Benedetti J, Sinziana C, Handorf A, Ruthford M, Devens M, Mecham C, Holland J, Casas T, Brown J, Panda P, Morrow A, Maready M, Nathani Y, Stevens M, Abraham G, Yen K, Cooper-Sood J, Woolf S. Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study. The Lancet Child & Adolescent Health 2025, 9: 484-496. PMID: 40506197, DOI: 10.1016/s2352-4642(25)00139-7.Peer-Reviewed Original ResearchConceptsElectronic medical recordsEmergency departmentRetrospective cohort studyCohort studyMedical recordsDocumentation of symptomsCardiovascular involvementHealth-care facilitiesEpinephrine doseAcute allergic reactionsNational Institutes of HealthCumulative incidenceNational Center for Advancing Translational SciencesInstitutes of HealthChildren aged 6 monthsClinical ModificationHospital wardsIncidence rateICD-10Observation periodPrimary outcomeAllergic reactionsSecondary to medicationsInitiation to discontinuationKaplan-Meier analysisRisk Factors for Serious Bacterial Infections Among Young Infants With Hypothermia: Protocol for a Multicenter, Retrospective Case-Control Study
Ramgopal S, Aronson P, Lorenz D, Rogers A, Cruz A. Risk Factors for Serious Bacterial Infections Among Young Infants With Hypothermia: Protocol for a Multicenter, Retrospective Case-Control Study. JMIR Research Protocols 2025, 14: e66722. PMID: 40536806, DOI: 10.2196/66722.Peer-Reviewed Original ResearchConceptsEpidemiology of SBIHerpes simplex virusCase-control studyEmergency departmentYoung infantsMultivariable prediction modelRetrospective nested case-control studyBacterial infectionsRetrospective case-control studyManagement of young infantsNested case-control studyUrinary tract infectionOptimal cutoff valueSerious bacterial infectionsSoft tissue infectionsOutcome measuresPediatric Emergency Medicine Collaborative Research CommitteeReceiver operating characteristic curvePediatric emergency departmentOperating characteristics curveUS children's hospitalsMixed effects logistic regressionHSV-positiveBlood culturesPredicting SBIChange in Pediatric Psychiatric Emergency Service Clinicians’ Confidence After Training to Improve Care for Autistic Youth At-Risk for Suicide: A Pilot Study
Cervantes P, Seag D, Baroni A, Horwitz S. Change in Pediatric Psychiatric Emergency Service Clinicians’ Confidence After Training to Improve Care for Autistic Youth At-Risk for Suicide: A Pilot Study. Journal Of Developmental And Physical Disabilities 2025, 1-11. DOI: 10.1007/s10882-025-10025-9.Peer-Reviewed Original ResearchSuicide-related careAutistic youthSystems-level barriersAreas of suicide risk assessmentSuicide risk assessment toolsSuicide risk assessmentClinician confidencePsychiatric emergency serviceEmergency departmentPilot studyYouth at-riskSuicidal ideationSuicide riskEndorsement patternsPsychiatric concernsRisk assessment toolRatings of feasibilityLevel of trainingSuicideAttitude itemsTargeted trainingElevated ratesAssessment toolEmergency servicesClinical guidanceUltrasound‐Guided Nerve Block for Pediatric Femur Fractures in the Emergency Department: A Prospective Multi‐Center Study
Binder Z, Ng C, Klekowski N, Lawson S, Riera A, Toney A, Pade K, Saint The T, Shaahinfar A, Chaudoin L, Lauer E, Snelling P, Moake M. Ultrasound‐Guided Nerve Block for Pediatric Femur Fractures in the Emergency Department: A Prospective Multi‐Center Study. Academic Emergency Medicine 2025 PMID: 40524602, DOI: 10.1111/acem.70084.Peer-Reviewed Original ResearchPediatric emergency medicineFascia iliaca compartment nerve blockEmergency departmentPediatric femur fracturesFemur fracturesPain intensityPediatric emergency medicine physiciansSelf-reported pain intensityFaces Pain Scale-RevisedFracture pain managementPain scoresChildren aged 4Pain score reductionEmergency medicinePost-enrollmentAdverse eventsNerve blockPain managementSecondary outcomesOpioid medicationsPrimary outcomeOral morphine equivalentsProcedure useUltrasound-guided nerve blockProspective multi-center studySocial Determinants of Health and Healthcare Utilization in Infants With Bronchopulmonary Dysplasia
Urbach H, Ostfeld‐Johns S, McCollum S, Weiss P, Kandil S, Brumer E. Social Determinants of Health and Healthcare Utilization in Infants With Bronchopulmonary Dysplasia. Pediatric Pulmonology 2025, 60: e71153. PMID: 40504047, DOI: 10.1002/ppul.71153.Peer-Reviewed Original ResearchConceptsSocial determinants of healthChildhood Opportunity IndexArea Deprivation IndexHealthcare utilizationED visitsImpact of social determinants of healthSocial determinants of health variablesInfluence of social determinants of healthEmergency departmentAssociated with fewer ED visitsAssociated with increased ED visitsHigh-deprivation neighborhoodsDeterminants of healthBronchopulmonary dysplasiaAdverse health outcomesMediation analysisDeprivation indexHealthcare useSocial determinantsNo significant associationHealth outcomesFollow-upHospital utilizationNeighborhood disadvantageRacial/ethnic differencesAn Online Survey of Practicing Emergency Medicine Clinicians' Pediatric Educational Needs
Chang C, Eckerle M, Kaur S, Sobolewski B, Donaldson R, Shihabuddin B, Hong E, Auerbach M. An Online Survey of Practicing Emergency Medicine Clinicians' Pediatric Educational Needs. AEM Education And Training 2025, 9: e70059. PMID: 40510558, PMCID: PMC12159684, DOI: 10.1002/aet2.70059.Peer-Reviewed Original ResearchAdvanced practice providersEvidence-based pathwayInformation seeking behaviorAttending physiciansSeeking behaviorRespiratory emergenciesPediatric emergency medicineOnline medical resourcesDissemination of contentPractice providersClinicians' perceptionsEmergency medicinePediatric-specific proceduresPediatric trainingEmergency departmentPriority topicsPediatric educationAbdominal emergenciesNeonatal emergenciesEducational modalitiesInsufficient timeMedical resourcesPracticing cliniciansLearning modalitiesOnline surveyPeer support enhanced behavioural crisis response teams in the emergency department: protocol for a stepped-wedge cluster-randomised controlled trial
Nath B, Desai R, Cook J, Dziura J, Davis-Plourde K, Youins R, Guy K, Pavlo A, Smith E, Smith D, Kangas K, Heckmann R, Hart L, Powsner S, Sevilla M, Evans M, Kumar A, Faustino I, Hu Y, Bellamy C, Wong A. Peer support enhanced behavioural crisis response teams in the emergency department: protocol for a stepped-wedge cluster-randomised controlled trial. BMJ Open 2025, 15: e103775. PMID: 40484432, PMCID: PMC12161358, DOI: 10.1136/bmjopen-2025-103775.Peer-Reviewed Original ResearchConceptsCluster randomised controlled trialEmergency departmentPeer supportDelivery of trauma-informed careStepped-wedge cluster randomised controlled trialExperience of mental illnessPhysical restraintRate of physical restraintBehavioral crisesPeer support workersReduce restraint useSecondary outcomesFollow-up data collectionResponse teamPatient-centred approachPositive patient outcomesTrauma-informed carePeer-reviewed journalsCrisis response teamsUsual careStepped-wedgeIntervention readinessPeer deliveryRestraint useED settingDiagnostic Accuracy of Point-of-Care Ultrasound for Hip Effusion: A Multicenter Diagnostic Study
Jones R, Malia L, Snelling P, Riera A, Mak W, Moote D, Brimacombe M, Chicaiza H. Diagnostic Accuracy of Point-of-Care Ultrasound for Hip Effusion: A Multicenter Diagnostic Study. Annals Of Emergency Medicine 2025 PMID: 40481828, DOI: 10.1016/j.annemergmed.2025.04.033.Peer-Reviewed Original ResearchPediatric emergency physiciansAccuracy of point-of-care ultrasoundPoint-of-care ultrasoundDiagnostic accuracy of point-of-care ultrasoundPediatric emergency departmentRadiology-performed ultrasoundEmergency physiciansHip effusionDiagnostic accuracyAged 2 monthsEmergency departmentMulticenter diagnostic studyTrained individualsPhysiciansPrimary outcomeHip analysisHipClinical presentationHip ultrasoundProspective studyParticipantsMeasurement definitionsAccurate diagnosisEffusionDiagnostic studiesDiagnostic yield of an abbreviated MRI protocol in the evaluation of dizziness in the emergency department, a single institutional experience
Shareef F, Tu L, Neupane A, Siddique Z, Joshi R, Melnick E, Wira C, Mahajan A. Diagnostic yield of an abbreviated MRI protocol in the evaluation of dizziness in the emergency department, a single institutional experience. Emergency Radiology 2025, 1-10. PMID: 40471503, DOI: 10.1007/s10140-025-02349-y.Peer-Reviewed Original ResearchAbbreviated MRI protocolDiagnostic yieldIntracranial pathologyEmergency departmentAcute findingsMRI protocolEvaluation of dizzinessMethodThis retrospective studyDetecting intracranial pathologySignificant intracranial pathologyAxial DWIAxial FLAIRProtocol MRIAbbreviated protocolSupratentorial pathologySWI sequencesMRI findingsRetrospective studyUrgent care settingsAdult patientsCentral etiologyAcute dizzinessInfratentorial siteInstitutional experienceInfarct characteristicsHealth care utilization after operative versus nonoperative appendicitis management using an administrative claims database.
Mathew P, Moore M, Bhattacharya B, Schneider E, Davis K, Schuster K. Health care utilization after operative versus nonoperative appendicitis management using an administrative claims database. Journal Of Trauma And Acute Care Surgery 2025 PMID: 40462277, DOI: 10.1097/ta.0000000000004682.Peer-Reviewed Original ResearchNonoperative managementUncomplicated appendicitisEmergency departmentRecurrent appendicitisAbdominal painCT scanComputed tomographyNonoperative management of uncomplicated appendicitisManagement of uncomplicated appendicitisAbdominal computed tomographyAbdominal CT scanHealth care utilizationNonoperatively managed patientsAdministrative claims databaseExamined health care utilizationNonoperative groupCare utilizationAcute appendicitisElixhauser Comorbidity IndexIn situ appendixNonoperative treatmentBaseline characteristicsAppendicitis managementPatient sexTherapeutic/care managementA Novel Electronic Health Record-Integrated Clinical Pathway for Nephrolithiasis: Development and Management Outcomes.
Lokeshwar S, Choksi A, Smani S, Heacock D, Kanaparthy N, Shaheen D, Dashevsky M, Martin T, Singh D, Motamedinia P, Sangal R. A Novel Electronic Health Record-Integrated Clinical Pathway for Nephrolithiasis: Development and Management Outcomes. Urology Practice 2025, 101097upj0000000000000847. PMID: 40459510, DOI: 10.1097/upj.0000000000000847.Peer-Reviewed Original ResearchEmergency departmentRenal colicClinical pathwayPain controlEvidence-based pain managementED patient careInadequate discharge planningAcute renal colicMedical expulsive therapyUrological follow-upMann-Whitney <i>Retrospective cohort studyEnhanced pain controlDischarge planningHealth systemDischarge practicesKetorolac doseOpioid alternativesPatient careExpulsive therapyLidocaine usePathway useOpioid useStandard carePain managementEmergency Department Visits for Pelvic Organ Prolapse in the United States.
Markowitz M, St Martin B, Lundsberg L, Ringel N. Emergency Department Visits for Pelvic Organ Prolapse in the United States. Urogynecology 2025 PMID: 40454707, DOI: 10.1097/spv.0000000000001703.Peer-Reviewed Original ResearchEmergency department visitsEmergency department useEmergency department presentationsDepartment visitsPelvic organ prolapseDepartment useUtilization Project Nationwide Emergency Department SampleReduce emergency department useOrgan prolapseEmergency departmentHousehold incomeAnnual emergency department visitsNationwide Emergency Department SampleIncidence of emergency department visitsInternational Classification of DiseasesLower household incomeHealth care systemEmergency Department SampleClinical Modification codesCommunity outreach effortsClassification of DiseasesCross-sectional studyDiagnosis of pelvic organ prolapseOutpatient workflowUnited StatesDetection of emergency department patients at risk of dementia through artificial intelligence
Cohen I, Taylor R, Xue H, Faustino I, Festa N, Brandt C, Gao E, Han L, Khasnavis S, Lai J, Mecca A, Sapre A, Young J, Zanchelli M, Hwang U. Detection of emergency department patients at risk of dementia through artificial intelligence. Alzheimer's & Dementia 2025, 21: e70334. PMID: 40457744, PMCID: PMC12130574, DOI: 10.1002/alz.70334.Peer-Reviewed Original ResearchConceptsElectronic health record dataHealth record dataEmergency departmentDetect dementiaDementia detectionYale New Haven HealthRecord dataRisk of dementiaEmergency department patientsBalance detection accuracyDementia algorithmsImprove patient outcomesCare coordinationCare transitionsDementia diagnosisReal-time applicationsClinical decision-makingClinician supportED usePatient safetyProbable dementiaMachine learning algorithmsED workflowED visitsED encountersDecreasing inappropriate MRCP with contrast exams: impact of an EMR-Embedded clinical care pathway
Asch D, Gunabushanam G, Cole K, Holland C, Pahade J. Decreasing inappropriate MRCP with contrast exams: impact of an EMR-Embedded clinical care pathway. Abdominal Radiology 2025, 1-8. PMID: 40439723, DOI: 10.1007/s00261-025-05022-7.Peer-Reviewed Original ResearchPlan-Do-Study-ActClinical care pathwayCare pathwaysClinical appropriatenessPlan-do-study-act cycle 1Clinical guidanceElectronic medical recordsReduce healthcare costsChi-square testHealthcare costsEmergency departmentMedical recordsResultsAt baselinePatient characteristicsAppropriate ordersStudy periodResource useProvidersStatistical significanceBaselineExamAppropriatenessIV contrastIntravenous contrastGadolinium exposureNovel algorithms & blood‐based biomarkers: Dementia detection and care transitions for persons living with dementia in the emergency department
Saxena S, Carpenter C, Floden D, Meldon S, Taylor R, Hwang U. Novel algorithms & blood‐based biomarkers: Dementia detection and care transitions for persons living with dementia in the emergency department. Alzheimer's & Dementia 2025, 21: e70287. PMID: 40390207, PMCID: PMC12089069, DOI: 10.1002/alz.70287.Peer-Reviewed Original ResearchConceptsElectronic health recordsGeriatric emergency departmentCare partnersEmergency departmentImprove careLeveraging electronic health recordsRisk of dementiaHigh emergency departmentRisk stratification algorithmCare transitionsCoordinated careED environmentDeliver careED settingHealth recordsDementia detectionHealthcare systemHigh acuityCareOutpatient settingStratification algorithmDementiaEmergency cliniciansBlood-based biomarkersPLWDAcquired angio-oedema as a mimicker of drug allergy
Liao J, Mathew M, Elmansy L, Hsu F, Belmont A. Acquired angio-oedema as a mimicker of drug allergy. BMJ Case Reports 2025, 18: e265525. PMID: 40389294, DOI: 10.1136/bcr-2025-265525.Peer-Reviewed Original ResearchConceptsAcquired angio-oedemaAngio-oedemaSplenic marginal zone lymphomaBradykinin-mediated diseaseSevere angio-oedemaMarginal zone lymphomaLocal anaesthetic allergyDrug allergy testingDental proceduresAcute therapyCase reportClinical historyDrug allergyAllergy centresAllergy testingClinical pearlsClinical diagnosisEmergency departmentMultiple physiciansDiagnosisAllergyLymphomaTherapyPatientsAetiologyCorrection: Computational phenotypes for patients with opioid-related disorders presenting to the emergency department
Taylor R, Gilson A, Schulz W, Lopez K, Young P, Pandya S, Coppi A, Chartash D, Fiellin D, D'Onofrio G. Correction: Computational phenotypes for patients with opioid-related disorders presenting to the emergency department. PLOS ONE 2025, 20: e0324877. PMID: 40378111, PMCID: PMC12083821, DOI: 10.1371/journal.pone.0324877.Peer-Reviewed Original ResearchOpioid-related disordersEmergency departmentPostoperative complications in patients with sickle cell disease undergoing single-level anterior cervical discectomy and fusion
Maloy G, Doshi R, Day W, Dhodapkar M, Halperin S, Jayaram R, Jain B, Grauer J, Varthi A. Postoperative complications in patients with sickle cell disease undergoing single-level anterior cervical discectomy and fusion. North American Spine Society Journal (NASSJ) 2025, 22: 100617. PMID: 40548100, PMCID: PMC12182323, DOI: 10.1016/j.xnsj.2025.100617.Peer-Reviewed Original ResearchSickle cell disease patientsSickle cell diseaseSingle-level ACDFAnterior cervical discectomyAdverse eventsCervical discectomyPostoperative complicationsPostoperative outcomesElixhauser Comorbidity IndexCell diseaseSingle-level anterior cervical discectomyEmergency departmentUrinary tract infectionMultiple postoperative complicationsOdds of adverse eventsSerious adverse eventsAcute kidney injuryPostoperative adverse eventsDeep vein thrombosisMinor adverse eventsIndividual adverse eventsDegenerative disc diseaseMultivariate logistic regressionStudent's t-testHigh-risk populationPredicting Agitation Events in the Emergency Department Through Artificial Intelligence
Wong A, Sapre A, Wang K, Nath B, Shah D, Kumar A, Faustino I, Desai R, Hu Y, Robinson L, Meng C, Tong G, Bernstein S, Yonkers K, Melnick E, Dziura J, Taylor R. Predicting Agitation Events in the Emergency Department Through Artificial Intelligence. JAMA Network Open 2025, 8: e258927. PMID: 40332935, PMCID: PMC12059975, DOI: 10.1001/jamanetworkopen.2025.8927.Peer-Reviewed Original ResearchConceptsED visitsEmergency departmentAgitation eventsElectronic health record dataArea under the receiver operating characteristic curvePatient-centered careHealth service utilizationPrimary outcomeHealth record dataUrban health systemED visit dataMode of arrivalPrevention of agitationOutcome of agitationDiverse patient populationsRestraint ordersCross-sectional cohortService utilizationVital signsED sitesHealth systemMain OutcomesRestraint eventsRange of predicted probabilitiesVisit data
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