2025
Does intimate partner violence mediate the association between adverse childhood experiences and internalizing symptomatology in women? A mediation meta-analysis
Martini J, Deneault A, Zhu J, Racine N, Fearon P, Madigan S, Jenkins J. Does intimate partner violence mediate the association between adverse childhood experiences and internalizing symptomatology in women? A mediation meta-analysis. Journal Of Affective Disorders 2025, 119742. PMID: 40550278, DOI: 10.1016/j.jad.2025.119742.Peer-Reviewed Original ResearchAdverse childhood experiencesInternalizing symptomatologyIntimate partner violenceTest moderationAssociated with internalizing symptomatologyChildhood experiencesAdverse childhood experience itemsPartner violenceMeta-analyticallySymptomatologyStructural equation modeling approachMethodological factorsIndirect pathwaysEffect sizePath modelFemale participantsStructural equationModeratelyPsychopathologySociodemographic factorsViolenceAssociationMASEMItemsAge of female participantsFor Whom Is Sexual Abuse Related to Compulsive Sexual Behaviors? Timing of Abuse and Sociodemographic Characteristics as Potential Moderators Across 42 Countries
Vaillancourt-Morel M, Bergeron S, Gewirtz-Meydan A, Zippan N, Nagy L, Koós M, Kraus S, Demetrovics Z, Potenza M, Bőthe B. For Whom Is Sexual Abuse Related to Compulsive Sexual Behaviors? Timing of Abuse and Sociodemographic Characteristics as Potential Moderators Across 42 Countries. Archives Of Sexual Behavior 2025, 1-20. PMID: 40481341, DOI: 10.1007/s10508-025-03162-x.Peer-Reviewed Original ResearchCompulsive sexual behaviorSexual abuseSexual orientationCategory of sexual abuseTime of abuseOnline self-report measuresSexual behaviorComplex pattern of findingsUnwanted sexual experiencesCountry of residenceSelf-report measuresPansexual participantsPattern of findingsAbusive relationsSex surveysCisgender menSmall effect sizesSexual experienceRelationship statusPotential moderatorsCross-cultural studiesAbuse categoriesAbuseYounger participantsEffect sizeFunctional connectome correlates of laterality preferences: Insights into Hand, Foot, and Eye Dominance Across the Lifespan.
Tejavibulya L, Horien C, Fredericks C, Ficek B, Westwater M, Scheinost D. Functional connectome correlates of laterality preferences: Insights into Hand, Foot, and Eye Dominance Across the Lifespan. ENeuro 2025, eneuro.0580-24.2025. PMID: 40473471, DOI: 10.1523/eneuro.0580-24.2025.Peer-Reviewed Original ResearchLateral preferenceFunctional connectomeWhole-brain functional connectomePosterior temporal areasBrain functional connectivityWhole-brain connectomePrefrontal lobeNormative variationCerebellar regionsFunctional connectivityDevelopmental shiftTemporal lobeBrain connectivityWhole-brainLeft-handednessFoot preferenceRight-handednessTemporal areaIncreased connectivityResting-state functional connectomesEffect sizeSignificant associationConnectivity patternsBrain hemispheresHandednessProximal Hamstring Repairs Demonstrate Similar Load to Failure as Intact Hamstring Tendons: A Systematic Review and Meta-Analysis of Biomechanical Investigations
MacLeod J, Lee M, Fallon A, Gillinov S, Park N, Girardi K, Vorbau J, Moran J, Fritz J, Nasser A, Surucu S, Jimenez A. Proximal Hamstring Repairs Demonstrate Similar Load to Failure as Intact Hamstring Tendons: A Systematic Review and Meta-Analysis of Biomechanical Investigations. Arthroscopy Sports Medicine And Rehabilitation 2025, 101204. DOI: 10.1016/j.asmr.2025.101204.Peer-Reviewed Original ResearchProximal hamstring repairSystematic reviewQuality assessment toolPreferred Reporting ItemsHamstring tendonsCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsProximal hamstring tearsProximal hamstringsLoad to failureCochrane Central RegisterHamstring tearsReporting ItemsMeta-analysesAssessment toolControlled trialsEffect sizeBiomechanical investigationsMeta-analysisHamstringStatistically significant differenceOpen repairMaximum load to failureCadaveric studyImproving Access to Perinatal Mental Health Care in Miami: An Initial Study [ID 1413]
Desai R, Kumar M, Dalwalla M, Torres C, Paidas M, Gallucci F. Improving Access to Perinatal Mental Health Care in Miami: An Initial Study [ID 1413]. Obstetrics And Gynecology 2025, 145: 9s-9s. DOI: 10.1097/aog.0000000000005916.028.Peer-Reviewed Original ResearchPerinatal mental health careMental health careMental health providersPerinatal psychiatristsHealth careMental health professionalsReferral processHealth providersHealth professionalsHigher health care costsEffect sizePregnancy-related deathsLength of timeMental health conditionsMental health needsPoor birth outcomesHealth care costsEvaluate effect sizesHealth needsMaternal morbidityMaternity careBirth outcomesInpatient servicesAverage length of timeCare costsBeyond Increasing Sample Sizes: Optimizing Effect Sizes in Neuroimaging Research on Individual Differences
DeYoung C, Hilger K, Hanson J, Abend R, Allen T, Beaty R, Blain S, Chavez R, Engel S, Feilong M, Fornito A, Genç E, Goghari V, Grazioplene R, Homan P, Joyner K, Kaczkurkin A, Latzman R, Martin E, Nikolaidis A, Pickering A, Safron A, Sassenberg T, Servaas M, Smillie L, Spreng R, Viding E, Wacker J. Beyond Increasing Sample Sizes: Optimizing Effect Sizes in Neuroimaging Research on Individual Differences. Journal Of Cognitive Neuroscience 2025, 37: 1023-1034. PMID: 39792657, DOI: 10.1162/jocn_a_02297.Peer-Reviewed Original ResearchIndividual differencesNeuroimaging researchEffect sizeStable individual differencesBetween-person effectsNeuroimaging tasksNeuroimaging studiesFocal hypothesisIncreased effect sizePsychological measuresBehavioral constructsSample sizeTheoretical matchingMultivariate approachUnivariate approachNeurobiologyCognitionNeuroimagingEmotionsIndividualsNeuroscienceBrainDifferencesTaskParticipantsLaboratory-Assessed Mistrust in Borderline Personality Disorder: A Meta-Analytic Review
Kurt Y, Walker M, Luyten P, Fonagy P. Laboratory-Assessed Mistrust in Borderline Personality Disorder: A Meta-Analytic Review. Personality Disorders Theory Research And Treatment 2025 PMID: 40402642, DOI: 10.1037/per0000739.Peer-Reviewed Original ResearchBorderline personality disorderMeta-analytic reviewPersonality disorderSmall-to-moderate effect sizesEffect sizeStatistically significant moderatorPsychometrically sound toolBPD symptomsSignificant moderatorMeta-analytic modelMeta-analysisBPDSound toolJoanna Briggs Institute Critical Appraisal ChecklistInternational Prospective Register of Systematic ReviewsSystematic reviewProspective Register of Systematic ReviewsInterpersonal trustCritical Appraisal ChecklistEffective interventionsInternational Prospective RegisterRisk of biasControl groupDisordersBorderlineClinical Evidence of Mesenchymal Stromal Cells for Cerebral Palsy: Scoping Review with Meta-Analysis of Efficacy in Gross Motor Outcomes
Paton M, Griffin A, Blatch-Williams R, Webb A, Verter F, Couto P, Bersenev A, Dale R, Popat H, Novak I, Finch-Edmondson M. Clinical Evidence of Mesenchymal Stromal Cells for Cerebral Palsy: Scoping Review with Meta-Analysis of Efficacy in Gross Motor Outcomes. Cells 2025, 14: 700. PMID: 40422203, PMCID: PMC12110704, DOI: 10.3390/cells14100700.Peer-Reviewed Original ResearchConceptsGross Motor Function MeasureCerebral palsyIPD meta-analysisTreatment of cerebral palsyMeta-analysisMotor Function MeasureGross motor outcomesData meta-analysisScoping reviewWell-designed trialsStudy heterogeneityMeta-analysesEffect sizeMotor outcomeFunction measurementsParticipation variablesSubgroup analysisMeta-analysis of efficacyRegistered trialsPalsyOutcomesVariable reportingReports of efficacyTrialsPublished reportsChildhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry
Jesuthasan J, Watson C, Hafeez D, Lynch-Kelly K, Danese A, Pollak T. Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry. Brain Behavior And Immunity 2025, 128: 643-653. PMID: 40320015, DOI: 10.1016/j.bbi.2025.04.036.Peer-Reviewed Original ResearchRisk of biasChildhood adversityDisease in adulthoodMeta-analysisSystematic reviewSevere mental illnessHigh risk of biasRisk factorsExposure to childhood adversityAssociated with childhood adversityAutoimmune diseasesFunnel plot inspectionRates of childhood adversityHistory of childhood adversityPeer-reviewed studiesEnvironmental risk factorsMental illnessAutoimmune disordersEgger's testElectronic databasesAetiology of autoimmune disordersPublication biasPrevention of autoimmune diseasesEffect sizeDysregulated immune responseAdolescent Dating Violence and Suicide Planning Among Girls in US High Schools: An Intracategorical Intersectional Analysis by Race and Ethnicity.
Sharpless L, Alvarez K, Kershaw T, Willie T. Adolescent Dating Violence and Suicide Planning Among Girls in US High Schools: An Intracategorical Intersectional Analysis by Race and Ethnicity. American Journal Of Public Health 2025, e1-e9. PMID: 40311098, DOI: 10.2105/ajph.2025.308043.Peer-Reviewed Original ResearchYouth Risk Behavior SurveyUS high schoolsSuicide planOdds of suicide planWeighted logistic regressionNationally representative studyRisk Behavior SurveyPrevention programsSuicide preventionWhite girlsLogistic regressionRepresentative studyAssess moderationEffect sizeLatina girlsBehavior SurveyGirlsAdVPreventionOddsRace/ethnicityHigh schoolHealthy relationshipsSuicidePrevention of sexual violenceTargeting problem-solving with a cognitive remediation intervention for suicide prevention in veterans: A pilot study
Goldstein K, Medalia A, Nicholas E, Pietrzak R, Ahmed T, Haznedar M, Sweeney R, Wrobleski J, Dichiara A, Challman K, McClure M, Hazlett E. Targeting problem-solving with a cognitive remediation intervention for suicide prevention in veterans: A pilot study. Military Psychology 2025, ahead-of-print: 1-10. PMID: 40262555, DOI: 10.1080/08995605.2025.2494868.Peer-Reviewed Original ResearchSuicidal behaviorCognitive remediationDepressive disorderHistory of suicidal behaviorCognitive remediation interventionsSuicide risk reductionPost-treatmentAdaptive functioning outcomesAssociated with greater reductionsProblem-solvingSuicidal ideation/behaviorCognitive deficitsTherapy fidelityBrief formatRemedial interventionsVeteran outpatientsSuicide preventionEffect sizeGreater improvementFollow-up time pointsGreater reductionsControl conditionVeteransPilot dataDepressionTranslational genomics of osteoarthritis in 1,962,069 individuals
Hatzikotoulas K, Southam L, Stefansdottir L, Boer C, McDonald M, Pett J, Park Y, Tuerlings M, Mulders R, Barysenka A, Arruda A, Tragante V, Rocco A, Bittner N, Chen S, Horn S, Srinivasasainagendra V, To K, Katsoula G, Kreitmaier P, Tenghe A, Gilly A, Arbeeva L, Chen L, de Pins A, Dochtermann D, Henkel C, Höijer J, Ito S, Lind P, Lukusa-Sawalena B, Minn A, Mola-Caminal M, Narita A, Nguyen C, Reimann E, Silberstein M, Skogholt A, Tiwari H, Yau M, Yue M, Zhao W, Zhou J, Alexiadis G, Banasik K, Brunak S, Campbell A, Cheung J, Dowsett J, Faquih T, Faul J, Fei L, Fenstad A, Funayama T, Gabrielsen M, Gocho C, Gromov K, Hansen T, Hudjashov G, Ingvarsson T, Johnson J, Jonsson H, Kakehi S, Karjalainen J, Kasbohm E, Lemmelä S, Lin K, Liu X, Loef M, Mangino M, McCartney D, Millwood I, Richman J, Roberts M, Ryan K, Samartzis D, Shivakumar M, Skou S, Sugimoto S, Suzuki K, Takuwa H, Teder-Laving M, Thomas L, Tomizuka K, Turman C, Weiss S, Wu T, Zengini E, Zhang Y, Ferreira M, Babis G, Baras A, Barker T, Carey D, Cheah K, Chen Z, Cheung J, Daly M, de Mutsert R, Eaton C, Erikstrup C, Furnes O, Golightly Y, Gudbjartsson D, Hailer N, Hayward C, Hochberg M, Homuth G, Huckins L, Hveem K, Ikegawa S, Ishijima M, Isomura M, Jones M, Kang J, Kardia S, Kloppenburg M, Kraft P, Kumahashi N, Kuwata S, Lee M, Lee P, Lerner R, Li L, Lietman S, Lotta L, Lupton M, Mägi R, Martin N, McAlindon T, Medland S, Michaëlsson K, Mitchell B, Mook-Kanamori D, Morris A, Nabika T, Nagami F, Nelson A, Ostrowski S, Palotie A, Pedersen O, Rosendaal F, Sakurai-Yageta M, Schmidt C, Sham P, Singh J, Smelser D, Smith J, Song Y, Sørensen E, Tamiya G, Tamura Y, Terao C, Thorleifsson G, Troelsen A, Tsezou A, Uchio Y, Uitterlinden A, Ullum H, Valdes A, van Heel D, Walters R, Weir D, Wilkinson J, Winsvold B, Yamamoto M, Zwart J, Stefansson K, Meulenbelt I, Teichmann S, van Meurs J, Styrkarsdottir U, Zeggini E. Translational genomics of osteoarthritis in 1,962,069 individuals. Nature 2025, 641: 1217-1224. PMID: 40205036, PMCID: PMC12119359, DOI: 10.1038/s41586-025-08771-z.Peer-Reviewed Original ResearchConceptsEffector genesGenome-wide association study meta-analysesTargets of approved drugsVariant associationsTranslational genomicsEpigenomic profilingStudy meta-analysesCircadian clockBiological processesLines of evidenceConditions associated with disabilityRepurposing opportunitiesSignal enrichmentGenesEffectorPathwayIndependent associationsMeta-analysesEffect sizeAccelerated translationEpigenomeTranscriptomeProteomicsDisease-modifying treatmentsOsteoarthritisModifiable risk factors for stroke, dementia and late-life depression: a systematic review and DALY-weighted risk factors for a composite outcome
Senff J, Tack R, Mallick A, Gutierrez-Martinez L, Duskin J, Kimball T, Tan B, Chemali Z, Newhouse A, Kourkoulis C, Rivier C, Falcone G, Sheth K, Lazar R, Ibrahim S, Pikula A, Tanzi R, Fricchione G, Brouwers H, Rinkel G, Yechoor N, Rosand J, Anderson C, Singh S. Modifiable risk factors for stroke, dementia and late-life depression: a systematic review and DALY-weighted risk factors for a composite outcome. Journal Of Neurology Neurosurgery & Psychiatry 2025, 96: 515-527. PMID: 40180437, DOI: 10.1136/jnnp-2024-334925.Peer-Reviewed Original ResearchConceptsModifiable risk factorsLate-life depressionDisability-adjusted life yearsMeta-analysesRisk factorsComposite outcomeRelevant meta-analysesBody mass indexPhysical activityIdentified risk factorsComposite outcome of strokeHearing lossIncidence of strokeDepressive symptomsPrevention strategiesLife yearsOutcome of strokeSystematic reviewInclusion criteriaMass indexDementiaFasting plasma glucoseEffect sizeSystematic literature reviewSocial engagementInterpersonal problems as a predictor of treatment outcome in adult depression: An individual participant data meta-analysis
Gómez Penedo J, Meglio M, Flückiger C, Wienicke F, Breunese J, Menchetti M, Rucci P, Johansson R, Town J, Abbass A, Lilliengren P, Bagby R, Quilty L, Lemmens L, van Bronswijk S, Barkham M, Stiles W, Hardy G, Fonagy P, Luyten P, Constantinou M, Barber J, McCarthy K, Solomonov N, Joyce A, Cuijpers P, Driessen E. Interpersonal problems as a predictor of treatment outcome in adult depression: An individual participant data meta-analysis. Clinical Psychology Review 2025, 118: 102570. PMID: 40158500, DOI: 10.1016/j.cpr.2025.102570.Peer-Reviewed Original ResearchConceptsInterpersonal problemsInterpersonal distressAdult depressionParticipant data meta-analysisTreatment outcomesPredictors of treatment outcomeDepression treatment outcomesData meta-analysisDepressive symptom levelsIPD-MAMeta-analytic strategiesEffect of treatment typePost-treatmentTherapist effectsCommunion dimensionIndividual participant data meta-analysisSymptom levelsStudy-level meta-analysesPrimary study analysisMeta-analysisTreatment typeDepressionFollow-upEffect sizeModerating effectThe association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach
Mestre-Bach G, Paiva U, San Martín Iniguez L, Beranuy M, Martín-Vivar M, Mallorquí-Bagué N, Normand E, Chicote M, Potenza M, Arrondo G. The association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach. Psychological Medicine 2025, 55: e77. PMID: 40071718, PMCID: PMC12080635, DOI: 10.1017/s0033291725000376.Peer-Reviewed Original ResearchConceptsInternet-use disordersSystematic reviewMeta-analysisInternet-useInternet use disorderRandom-effects modelWeb of ScienceDegree of lonelinessUCLA Loneliness ScaleStatistical poolingQuantify associationsOdds ratioCohen's dDisorder symptomsGreater lonelinessMeta-regressionPooled differenceEffect sizePre-registeredUCLA-LonelinessLonelinessEffects of ageCategorical approachSymptomsGroup of individualsLow Stability and Specificity of Polygenic Risk Scores for Major Psychiatric Disorders Limit their Clinical Utility
Mollon J, Schultz L, Knowles E, Jacquemont S, Glahn D, Almasy L. Low Stability and Specificity of Polygenic Risk Scores for Major Psychiatric Disorders Limit their Clinical Utility. Biological Psychiatry 2025 PMID: 40113122, DOI: 10.1016/j.biopsych.2025.03.006.Peer-Reviewed Original ResearchAlcohol use disorderPolygenic risk scoresSchizophrenia polygenic risk scoresPercentage of individualsHigh riskDepressive disorderLack of clinical utilityUse disorderValidity of polygenic risk scoresSchizophreniaClinical utilityMDDRisk scoreEffect sizeSNP effect sizesWhite British individualsDisordersHigh-risk individualsUK BiobankType 2 diabetesBritish individualsPRS-CSIndividualsT2DPsychiatryMendelian non-syndromic and syndromic hearing loss genes contribute to presbycusis
Cornejo-Sanchez D, Bharadwaj T, Dong R, Wang G, Schrauwen I, DeWan A, Leal S. Mendelian non-syndromic and syndromic hearing loss genes contribute to presbycusis. European Journal Of Human Genetics 2025, 33: 758-767. PMID: 40055553, PMCID: PMC12185688, DOI: 10.1038/s41431-025-01789-x.Peer-Reviewed Original ResearchRare-variantsHearing loss genesAssociated with HLNon-syndromicAssociation analysisHL geneHearing phenotypeUK BiobankMinor allele frequencyOlder adultsSensorineural disorderARHLEffect sizeWhite EuropeansAssociated with genesAge-relatedIn silico analysisAnalysis of variantsExome dataAssociationGenes i.Allele frequenciesHLGenesPresbycusisThe case-only design is a powerful approach to detect interactions but should be used with caution
Dong R, Wang G, DeWan A, Leal S. The case-only design is a powerful approach to detect interactions but should be used with caution. BMC Genomics 2025, 26: 222. PMID: 40050722, PMCID: PMC11884093, DOI: 10.1186/s12864-025-11318-1.Peer-Reviewed Original ResearchConceptsCase-only designRare disease assumptionType I error rateIncreased type I error ratesDisease prevalenceInvestigated type I errorComplex traitsInteraction termsInteraction effect sizesDetect interactionsCase-control designControlled type I error ratesSample sizeHigher disease prevalenceEffect sizeLow disease prevalenceType I errorPrevalenceExposure frequencyGenesType I andDesign studyEnvironmental factorsTraitsEnvironment interactionConnectome-based predictive modeling of early and chronic psychosis symptoms
Foster M, Ye J, Powers A, Dvornek N, Scheinost D. Connectome-based predictive modeling of early and chronic psychosis symptoms. Neuropsychopharmacology 2025, 50: 877-885. PMID: 40016363, PMCID: PMC12032145, DOI: 10.1038/s41386-025-02064-9.Peer-Reviewed Original ResearchConnectome-based predictive modelingPositive and Negative Syndrome ScalePsychosis symptomsSymptom networksSymptom severityBrain networksNeural correlates of CPResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingNegative Syndrome ScaleIdentified group differencesPredicted effect sizeCorrelates of CPGeneral psychopathologyNegative symptomsPositive symptomsSyndrome ScaleFrontoparietal networkNeural correlatesVirtual lesion analysisGroup differencesConnectivity changesEffect sizeLesion analysisLongitudinal studyBrain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18
Catalogna M, Somerville Y, Saporta N, Nathansohn-Levi B, Shelly S, Edry L, Zagoory-Sharon O, Feldman R, Amedi A. Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18. Scientific Reports 2025, 15: 6863. PMID: 40011544, PMCID: PMC11865443, DOI: 10.1038/s41598-025-91457-3.Peer-Reviewed Original ResearchConceptsBrain connectivityCognitive declineResting-state functional connectivityEffect sizeCognitive behavioral therapyLate-life depressionSelf-reported depressionMedium effect sizeDigital interventionsInterventions targeting mental healthMood regulationBehavioral therapyDepressive symptomsDecreased connectivityPost-intervention changesFunctional connectivityTwo-week interventionCognitive functionSpatial cognitionDepression scoresBrain healthBehavioral outcomesBrain functionPsychological techniquesPsychological health
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