2025
Exploring Ethnic Disparities in Hypospadias Incidence: A Meta-Analysis of Epidemiological Studies
Santoso B, Situmorang G, Wahyudi I, Rodjani A, Saraiva L, Al-Shafai K, Abbas T, Raharja P. Exploring Ethnic Disparities in Hypospadias Incidence: A Meta-Analysis of Epidemiological Studies. Journal Of Pediatric Urology 2025 DOI: 10.1016/j.jpurol.2025.06.015.Peer-Reviewed Original ResearchEthnic disparitiesMeta-analysis of epidemiological studiesMeta-analysisHypospadias incidenceImprove healthcare outcomesDiverse populationsIncidence of hypospadiasCross-sectional studyCongenital anomaly prevalenceCase-control studyHealthcare outcomesReduce disparitiesJBI toolsPerinatal determinantsNon-white groupsCitation tracingStudy selectionData extractionSystematic reviewBias riskManual searchEpidemiological studiesRisk factorsDisparitiesEthnic variationsPrognostic and Predictive Insights From Genomic Assays for Breast Cancer in Diverse Populations
Abdou Y, Kantor O, Racz J, Newman L, Pierce L, Winer E. Prognostic and Predictive Insights From Genomic Assays for Breast Cancer in Diverse Populations. JAMA Oncology 2025, 11: 655-663. PMID: 40178824, DOI: 10.1001/jamaoncol.2025.0178.Peer-Reviewed Original ResearchConceptsEthnic disparitiesBreast cancer mortality ratesBreast cancerGenomic assaysCancer mortality ratesBiological characteristics of tumorsPredictive valueDiverse populationsGenomic assay resultsBreast cancer outcomesPersonalized clinical decision-makingBasal-like subtypeAggressive tumor phenotypeBreast cancer recurrenceCharacteristics of tumorsRandomized clinical trialsEthnic groupsSocial determinantsClinical decision-makingMultigene assaysLuminal BCancer outcomesDistribution of risk estimatesSurvival outcomesMolecular subtypesThe evolving immuno-angiogenic paradigm in NSCLC: lessons from ivonescimab
Herbst R, Chen L. The evolving immuno-angiogenic paradigm in NSCLC: lessons from ivonescimab. Nature Reviews Clinical Oncology 2025, 22: 461-462. PMID: 40329050, DOI: 10.1038/s41571-025-01024-y.Peer-Reviewed Original ResearchAdvanced-stage non-small-cell lung cancerNon-small-cell lung cancerProgression-free survivalOverall survival resultsAntitumour immunityReverse immunosuppressionTumor vasculatureVEGF antibodySurvival resultsLung cancerPembrolizumabNSCLCImmunosuppressionTumorPatientsCancerVasculatureDiverse populationsDobbs-driven expansion of perinatal palliative care: a scoping review of the evidence and its limits
Wilpers A, Kobler K, Schafer R, Wilpers M, Zeme M, Batten J, Canty L, Lorch S. Dobbs-driven expansion of perinatal palliative care: a scoping review of the evidence and its limits. Health Affairs Scholar 2025, 3: qxaf081. PMID: 40313884, PMCID: PMC12043006, DOI: 10.1093/haschl/qxaf081.Peer-Reviewed Original ResearchPerinatal palliative carePalliative careLife-limiting fetal conditionPerson-centered careUS-based evidenceVulnerable patient populationBereavement supportPPC programsCompassionate careMaternal healthEligible individualsEmotional supportCare restrictionsAbortion restrictionsHigh satisfactionCareParental validationDiverse populationsPatient populationMedical managementComfort outcomesDecision-makingFetal conditionSupportAcceptance139 Assessing the inclusion of women and minority populations in ClinicalTrials.gov results in studies focused on type 2 diabetes and GLP1 drugs
Reynolds J, Barone C, Calvocoressi L. 139 Assessing the inclusion of women and minority populations in ClinicalTrials.gov results in studies focused on type 2 diabetes and GLP1 drugs. Journal Of Clinical And Translational Science 2025, 9: 41-41. PMCID: PMC12050505, DOI: 10.1017/cts.2024.799.Peer-Reviewed Original ResearchType 2 diabetesBlack/African AmericanClinical Trials Transformation InitiativeAfrican American individualsCount of participantsGLP-1Diversity of participantsHispanic ethnicityStudy characteristicsIntervention studiesMinority populationsDiverse populationsAmerican individualsOddsStatistically significant differenceEthnicityMedical advancesGroup comparisonsParticipantsInclusion of womenInfluence of covariatesBaseline countsClinical researchMean ratiosClinical trialsSexual Assertiveness Across Cultures, Genders, and Sexual Orientations: Validation of the Short Sexual Assertiveness Questionnaire (SAQ-9).
Nagy L, Koós M, Kraus D, Demetrovics Z, Potenza M, Ballester-Arnal R, Batthyány D, Bergeron S, Billieux J, Briken P, Burkauskas J, Cárdenas-López G, Carvalho J, Castro-Calvo J, Chen L, Chen J, Ciocca G, Corazza O, Csako R, Fernandez D, Fujiwara H, Fernandez E, Fuss J, Gabrhelík R, Gewirtz-Meydan A, Gjoneska B, Gola M, Grubbs J, Hashim H, Islam M, Ismail M, Jiménez-Martínez M, Jurin T, Kalina O, Klein V, Költő A, Lee S, Lewczuk K, Lin C, Lochner C, López-Alvarado S, Lukavská K, Mayta-Tristán P, Miller D, Orosová O, Orosz G, Ponce F, Quintana G, Quintero Garzola G, Ramos-Diaz J, Rigaud K, Rousseau A, De Tubino S, Schulmeyer M, Sharan P, Shibata M, Shoib S, Sigre-Leirós V, Sniewski L, Spasovski O, Steibliene V, Stein D, Strizek J, Štulhofer A, Ünsal B, Vaillancourt-Morel M, Claire Van Hout M, Bőthe B. Sexual Assertiveness Across Cultures, Genders, and Sexual Orientations: Validation of the Short Sexual Assertiveness Questionnaire (SAQ-9). Assessment 2025, 10731911241312757. PMID: 40099831, DOI: 10.1177/10731911241312757.Peer-Reviewed Original ResearchSexual assertivenessAssertiveness questionnaireRelationship statusSexual orientationMeasures of SAAdequate psychometric propertiesMeasurement invariance testingSignificant group differencesMeasurement invarianceGroup differencesPsychometric propertiesSexual well-beingPsychometric evaluationInvariance testingShort versionComparing individualsDiverse populationsWell-beingSex surveysCross-culturallySexually-active adultsLevels of SAGenderDeveloping a digital video to support lung cancer screening in diverse populations
Lindsay M, Odole I, Belliveau O, Abujarad F, Gross C, Richman I. Developing a digital video to support lung cancer screening in diverse populations. PEC Innovation 2025, 6: 100388. PMID: 40212805, PMCID: PMC11982046, DOI: 10.1016/j.pecinn.2025.100388.Peer-Reviewed Original ResearchLung cancer screeningKnowledge of lung cancer screeningCancer screeningLevels of educational attainmentEducational attainmentKnowledge scoresDiverse populationsPrimary care clinicsLung cancer mortalityParticipants' knowledge scoresLower educational attainmentOpen-ended feedbackScreening behaviorLow dose computed tomographyPatient engagementCare clinicsCancer mortalityAssess knowledgeParticipant feedbackIncreased knowledgeParticipantsAdultsScreeningAttainmentScoresRepresenting brain-behavior associations by retaining high-motion minoritized youth
Ramduny J, Uddin L, Vanderwal T, Feczko E, Fair D, Kelly C, Baskin-Sommers A. Representing brain-behavior associations by retaining high-motion minoritized youth. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 39921132, DOI: 10.1016/j.bpsc.2025.01.014.Peer-Reviewed Original ResearchBrain-behavior associationsFunctional MRIAdolescent Brain Cognitive Development<sup>SM<Effect sizeHispanic youthInternalizing psychopathologyCognitive performanceParticipant sexFunctional connectivityFMRI dataMinoritized individualsWhite youthHead motionMinoritized youthYouthSources of noisePsychopathologyDiverse populationsRacial/ethnic groupsAssociationPartial Spearman rank correlationsAdolescentsDisproportionate numberP-1430. Use of Patient-Informed Resources Tailored to Diverse Populations Living with HIV to Improve Shared Decision-Making (SDM)
Nall R, Collins-Ogle M, Short W, Springer S, Molloy L, Simone L, Napolitan C, Carter J, Jimenez J, Pillinger K. P-1430. Use of Patient-Informed Resources Tailored to Diverse Populations Living with HIV to Improve Shared Decision-Making (SDM). Open Forum Infectious Diseases 2025, 12: ofae631.1605. PMCID: PMC11778905, DOI: 10.1093/ofid/ofae631.1605.Peer-Reviewed Original ResearchShared decision-making toolsShared decision-makingPopulation of PWHDiverse populationsConcept of shared decision-makingLack of patient interestLow health literacyCare team rolesHIV care teamSpecific health needsLack of professional trainingHealth literacyCare teamHIV careSDM toolConversation guideHealth needsHealth careHIV clinicPatient interestImprove engagementExpert providersAging adultsFormal trainingPatient informationThe PRO‐AGE Tool and Its Association With Post Discharge Outcomes in Older Adults Admitted From the Emergency Department
Cohen I, Curiati P, Morinaga C, Han L, Gandhi T, Araujo K, Avelino‐Silva T, Bianco L, Brandt C, Capelli S, Carpenter C, Cruz D, Dresden S, Fishman I, Gipson K, Gray E, Hastings S, Hung W, Kang R, Lockhart M, Meeker D, Ohuabunwa U, Ottilie‐Kovelman S, Platts‐Mills T, Sandoval J, Sifnugel N, Taylor Z, Tomasino D, Vaughan C, Aliberti M, Hwang U. The PRO‐AGE Tool and Its Association With Post Discharge Outcomes in Older Adults Admitted From the Emergency Department. Journal Of The American Geriatrics Society 2025, 73: 1419-1428. PMID: 39843218, PMCID: PMC12101947, DOI: 10.1111/jgs.19374.Peer-Reviewed Original ResearchActivities of daily livingEmergency departmentFunctional declineActivities of daily living disabilityInstrumental activities of daily livingRisk scorePro-agingPatients admitted to hospitalPost-discharge outcomesUnited StatesInstrumental ADLRisk of deathProportional hazards modelDaily livingAssociated with mortalityCharlson comorbidity scoreOlder adultsDischarge outcomesDecline outcomesDiverse populationsMultiple hospitalsComorbidity scoreHazards modelOlder patientsMulticenter observational studyExpanded Naloxone Distribution by Opioid Overdose Prevention Programs to High-Need Populations and Neighborhoods in New York City
Behrends C, Trinidad A, Nolan M, Dolatshahi J, Kingsepp A, Jordan A, Welch A, Harocopos A, Shaw L, Green T, Marshall B, Schackman B. Expanded Naloxone Distribution by Opioid Overdose Prevention Programs to High-Need Populations and Neighborhoods in New York City. Journal Of Urban Health 2025, 102: 459-464. PMID: 39820975, PMCID: PMC12031681, DOI: 10.1007/s11524-024-00951-y.Peer-Reviewed Original ResearchHigh-need populationsNaloxone distributionNew York CityNaloxone dispensingOpioid overdose prevention programsOverdose prevention programsDrug overdose death ratesReceipt of naloxoneDistribution of naloxoneProgram typeOverdose death ratesRacially diverse populationYork CityLogistic regression analysisOverdose educationRacial/ethnic differencesPrevention programsDispensing dataOENDPopulation ratesNeighborhood levelDiverse populationsUnivariate logistic regression analysisDeath rateProgram goalsA short screen for lifetime sexual victimization experiences: Expanding research on the Sexual Abuse History Questionnaire (SAHQ) across cultures, genders, and sexual identities
Nagy L, Bergeron S, Koós M, Gewirtz-Meydan A, Vaillancourt-Morel M, Kraus S, Potenza M, Demetrovics Z, Dupuis-Fortier F, Ballester-Arnal R, Batthyány D, Billieux J, Briken P, Burkauskas J, Cárdenas-López G, Carvalho J, Castro-Calvo J, Chen L, Strong C, Ciocca G, Corazza O, Csako R, Fernandez D, Fujiwara H, Fernandez E, Fuss J, Gabrhelík R, Gjoneska B, Gola M, Grubbs J, Hashim H, Islam M, Ismail M, Jiménez-Martínez M, Jurin T, Kalina O, Klein V, Költő A, Lee S, Lewczuk K, Lin C, Lochner C, López-Alvarado S, Lukavská K, Mayta-Tristán P, Miller D, Orosová O, Orosz G, Sungkyunkwan University's research team, Ponce F, Quintana G, Garzola G, Ramos-Diaz J, Rigaud K, Rousseau A, Scanavino M, Schulmeyer M, Sharan P, Shibata M, Shoib S, Sigre-Leirós V, Sniewski L, Spasovski O, Steibliene V, Stein D, Strizek J, Štulhofer A, Ünsal B, Van Hout M, Bőthe B. A short screen for lifetime sexual victimization experiences: Expanding research on the Sexual Abuse History Questionnaire (SAHQ) across cultures, genders, and sexual identities. International Journal Of Clinical And Health Psychology 2025, 25: 100535. PMID: 39877887, PMCID: PMC11773023, DOI: 10.1016/j.ijchp.2024.100535.Peer-Reviewed Original ResearchAdolescent/adult sexual assaultChildhood sexual abuseRisk of childhood sexual abuseSexual victimization experiencesSexual minority individualsQueer individualsSexual victimizationSexual identityVictimization experiencesSexual assaultDiverse gendersSex surveysMarginalized groupsSexual abuseVulnerable groupsGenderSociodemographic groupsNon-representative samplesSexualityDiverse populationsQueerAssaultOnline surveyVictimsPolicy
2024
Evaluation of imputation performance of multiple reference panels in a Pakistani population
Xu J, Liu D, Hassan A, Genovese G, Cote A, Fennessy B, Cheng E, Charney A, Knowles J, Ayub M, Peterson R, Bigdeli T, Huckins L. Evaluation of imputation performance of multiple reference panels in a Pakistani population. Human Genetics And Genomics Advances 2024, 6: 100395. PMID: 39696820, PMCID: PMC11759560, DOI: 10.1016/j.xhgg.2024.100395.Peer-Reviewed Original ResearchGenome-wide association studiesReference panelImputation accuracyMultiple reference panelsPakistani individualsGenotype imputationAssociation studiesGenotype dataAncestry compositionEuropean individualsSample sizeTOPMedDiverse populationsPakistani populationImputationGenomeAncestryIndividualsGenotypesPopulationVariantsFuture panelsSupporting diversity in clinical trials: the equitable breakthroughs in medicine site maturity model
Harris T, Nunez-Smith M, Suttiratana S, Fretz S, Leonard S, Linnander E, Curry L. Supporting diversity in clinical trials: the equitable breakthroughs in medicine site maturity model. Trials 2024, 25: 764. PMID: 39543751, PMCID: PMC11566401, DOI: 10.1186/s13063-024-08594-9.Peer-Reviewed Original ResearchConceptsSocial determinants of healthQuantitative self-report dataDeterminants of healthCommunity engagementHealth care providersRepresentation of diverse populationsSelf-reported dataSocial determinantsCare providersContent validityPotential participantsClinical trial capabilitiesClinical trial diversityDiverse populationsInclusion of diverse participantsClinical trialsAssessment of capabilitiesTrial infrastructureDiverse participantsU.S. sitesClinical researchAbstract BackgroundParticipantsDiversity effortsStructural assessmentBiases in COVID-19 vaccine effectiveness studies using cohort design
Agampodi S, Tadesse B, Sahastrabuddhe S, Excler J, Kim J. Biases in COVID-19 vaccine effectiveness studies using cohort design. Frontiers In Medicine 2024, 11: 1474045. PMID: 39540039, PMCID: PMC11557388, DOI: 10.3389/fmed.2024.1474045.Peer-Reviewed Original ResearchCohort designHealth-promoting behaviorsObservational studyPublic health strategiesPublic health policiesMiddle-income countriesPre-existing data sourcesHealthy user biasHealthy vaccinee effectSociodemographic disparitiesHealth strategiesHealth policyOutcome misclassificationSustaining public trustMisclassification biasHealth statusHealthcare systemVaccinee effectSusceptibility biasDiverse populationsCOVID-19Vaccine effectiveness studiesFrailty biasVaccine effectivenessCOVID-19 pandemicGuide to Understanding and Supporting International Medical Graduates in Hematology/Oncology by the ASCO International Medical Graduates Community of Practice
Dizman N, Bakouny Z, Haykal T, Riano I, Desai A, Butt A, Basu A, Zhao D, Saad E, Saliby R, Gosain R, Gosain R, Ardeshir F, Deng L, Matt-Amaral L, Arnaoutakis K, Bekaii-Saab T, Manochakian R, Marshall A, Forde P, Murphy M, Subbiah V, Chavez-MacGregor M, Owonikoko T, Lopes G, Aggarwal C, Lee A, Choueiri T. Guide to Understanding and Supporting International Medical Graduates in Hematology/Oncology by the ASCO International Medical Graduates Community of Practice. JCO Oncology Practice 2024, 21: 292-299. PMID: 39374449, DOI: 10.1200/op-24-00565.Peer-Reviewed Original ResearchInternational medical graduatesOncology workforceMedical graduatesContribution of international medical graduatesDiverse population of patientsOncology professionalsHematology/oncology fellowsUnited StatesFellowship trainingDiverse populationsMedical oncologyGreater awarenessPopulation of patientsWorkforceOncologyPracticing oncologistsSignificant hardshipASCOEarly career positionsUnique challengesCareer positionsHigh-qualityCommunities of practiceAwarenessCommunityW48. PROFILING THE RARE VARIANT GENETIC RISK FOR DEMENTIA WITH WHOLE EXOME SEQUENCING: A STUDY FROM INDIA
Patra C, Ganesh S, Mahadevan J, Gujarati K, Awasthy D, George S, Ganapathy A, Phalke S, Bettadapura R, Viswanath B, Varghese M, Jain S, Prasad P, Purushottam M. W48. PROFILING THE RARE VARIANT GENETIC RISK FOR DEMENTIA WITH WHOLE EXOME SEQUENCING: A STUDY FROM INDIA. European Neuropsychopharmacology 2024, 87: 126. DOI: 10.1016/j.euroneuro.2024.08.257.Peer-Reviewed Original ResearchVariants of Uncertain SignificanceClinical exome sequencingICD-10 diagnosis of dementiaExome sequencingFronto-temporal dementiaFamily historyMAPT geneExonic variantsAlzheimer's diseaseRare genetic risk variantsDiagnosis of dementiaRisk variantsAbnormal tau protein aggregationDiverse populationsPathogenic variantsICD-10 diagnosisRare variantsGenetic risk variantsExome data analysisAPOE e4 alleleTau protein aggregationRare exonic variantsNational Institute of Mental Health and NeurosciencesWhole-exome sequencingGeriatric clinicExecutive function tests: Normative data for Spanish-speaking adults in the United States
Usuga D, Rivera D, Xia B, Carrión C, Valdés G, Moreno O, Rodriguez M, Krch D, Wongserbchart W, Drago C, García P, Rivera P, Olabarrieta-Landa L, Perrin P, Arango-Lasprilla J. Executive function tests: Normative data for Spanish-speaking adults in the United States. NeuroRehabilitation An International Interdisciplinary Journal 2024, 55: 209-221. PMID: 39240593, DOI: 10.3233/nre-240088.Peer-Reviewed Original ResearchConceptsNormative dataSCWT performanceSpanish-speaking adultsSpanish-speaking HispanicsExecutive function testsCognitive test performanceImpact of acculturationSpanish-speaking populationOlder adultsU.S. METHODSEducational attainmentFactors influencing performanceExecutive dysfunctionNeuropsychological assessmentAcculturation levelSCWT scoresU.S. statesDiverse populationsU.S. residentsSociocultural factorsSeeing in Color: Inclusion and Characterization of Hereditary Eye Disease in African Americans
Owete A, Ionin R, Huryn L, Cukras C, Blain D, Agather A, Hufnagel R, Brooks B, Nwanyanwu K, Zein W. Seeing in Color: Inclusion and Characterization of Hereditary Eye Disease in African Americans. Translational Vision Science & Technology 2024, 13: 4. PMID: 39226063, PMCID: PMC11373706, DOI: 10.1167/tvst.13.9.4.Peer-Reviewed Original ResearchConceptsHereditary eye diseasesEye diseaseOphthalmic genetics researchAfrican American patientsAfrican AmericansGenomic researchEra of molecular geneticsRare diseaseWeb of ScienceAmerican patientsInclusion criteriaPatientsLiterature searchInclusion of African AmericansDiverse cohortPredetermined inclusion criteriaDiseasePatient careCounseling sessionsMolecular geneticsAncestral backgroundDiverse populationsMultimodal fusion learning for long QT syndrome pathogenic genotypes in a racially diverse population
Jiang J, Thi Vy H, Charney A, Kovatch P, Reddy V, Jayaraman P, Do R, Khera R, Chugh S, Bhatt D, Vaid A, Lampert J, Nadkarni G. Multimodal fusion learning for long QT syndrome pathogenic genotypes in a racially diverse population. Npj Digital Medicine 2024, 7: 226. PMID: 39181999, PMCID: PMC11344778, DOI: 10.1038/s41746-024-01218-1.Peer-Reviewed Original ResearchLong QT syndromeUnited Kingdom BiobankHigh-risk genotypesElectronic health record dataHealth record dataPathogenic variantsRacially/ethnically diverse cohortCongenital long QT syndromeLQTS-susceptibility genesRacially diverse populationMount Sinai BioMe BiobankPathogenic genetic mutationsQT corrected intervalArea under the receiver operating curveBioMe BiobankPatient prioritizationReceiver operating curveQT syndromeRecord dataDiverse cohortGenetic testingDiverse populationsPathogen genotypesGenetic mutationsPatients
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