2025
Specificities of Mental Functioning and Referential Process in Body Dysmorphic Disorder: A Single Case Study Using the Psychodynamic Diagnostic Manual (PDM-2)
Christian C, Bincoletto A, Mariani R, Negri A, Lingiardi V, Tanzilli A. Specificities of Mental Functioning and Referential Process in Body Dysmorphic Disorder: A Single Case Study Using the Psychodynamic Diagnostic Manual (PDM-2). Journal Of Psycholinguistic Research 2025, 54: 46. PMID: 40553242, DOI: 10.1007/s10936-025-10162-4.Peer-Reviewed Original ResearchConceptsBody dysmorphic disorderPsychodynamic Diagnostic ManualDiagnostic manualsDysmorphic disorderSevere body dysmorphic disorderMental functioningSchizoid personality disorderStages of psychotherapySelf-esteem regulationPersonality disorderReferential processLanguage measuresTherapist interventionsPDM-2Emotional experienceRelational intimacyEmotional activationSingle case studyPsychodynamicsAnalysis of languageClinical implicationsTherapeutic actionSymbolic processingTreatment sessionsDisordersPhenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder
Zadka Ł, Eggerstorfer B, Buzalewicz I, Vraka C, Rusak A, Godbersen G, Opalińska A, Unterholzner J, Ulatowska-Jarża A, Philippe C, Haczkiewicz-Leśniak K, Silberbauer L, Murgaš M, Nics L, Hahn A, Hacker M, Gomułkiewicz A, Rujescu D, Podhorska-Okołów M, Lanzenberger R, Gryglewski G. Phenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder. Journal Of Affective Disorders 2025, 389: 119740. PMID: 40550277, DOI: 10.1016/j.jad.2025.119740.Peer-Reviewed Original ResearchSerotonin transporterDepressive disorderPresence of serotonin transporterAntidepressant treatment responseSerotonin transporter levelsMDD patientsNanoparticle tracking analysisMood disordersPsychiatric disordersMDDBinding potentialExtracellular vesiclesTreatment response predictionPositron emission tomographyTreatment responseDisordersHealthy controlsExosome markers CD63Blood-brain barrierEmission tomographyStudy intercellular communicationPrognostic valueConcentration of extracellular vesiclesPatient stratificationExosomal markersAge, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study
Chow T, Meng Q, Xiao J, O'Sharkey K, Liew Z, Ritz B. Age, Race, and Ethnicity of Maternal Grandparents in Autism Spectrum Disorder, a California Multigenerational Study. Autism Research 2025 PMID: 40542519, DOI: 10.1002/aur.70074.Peer-Reviewed Original ResearchOdds ratioOlder grandparentsBirth cohort studyMother-child pairsHispanic grandmothersASD riskCohort studyInfluence of ageInverse associationWhite raceInvestigate associationsGrandparent ageYounger ageLogistic regressionOlder ageAutism spectrum disorderSpectrum disorderRace/ethnicityAgeOddsRiskMaternal grandparentsGrandparentsDisordersGrandmothersThe Endocannabinoid System and Postnatal Neurodevelopment
Sisk L, Meyer H, Martinez-Garcia A, Gee D. The Endocannabinoid System and Postnatal Neurodevelopment. 2025, 83-112. DOI: 10.1007/978-3-031-87990-6_5.Peer-Reviewed Original ResearchStress-related disordersECB systemResilience to stress-related disordersMaturation of neuronal populationsResponse to stressECB signalingECB levelsFunctional connectivityHuman literaturePostnatal neurodevelopmentNeuronal populationsECBDisordersHuman studiesInfluence riskNeurodevelopmentEndocannabinoidAnxietyEndocrine systemRiskSignaling systemPotential riskYouthAdultsBenchmarking empirical severity for the Yale-Brown Obsessive Compulsive Scale-Second Edition
Pinciotti C, Avery J, Zhang C, Muñoz J, Berrones D, Cruz V, Wiese A, Anderberg J, Frederick R, Miño T, Lanzagorta N, Castro J, Ochoa-Panaifo M, Goodman W, Crowley J, Storch E, Cervin M, Adorno V, Agostini V, Aguilar W, Aguirre C, Alvarado-Quiroz V, Ancalade N, L M, Anderberg J, Aponte D, Espinosa A, Arnold P, Carmelo B, Atkinson E, Avanesyan T, Avery J, Ayala J, Aziz H, Aguirre T, Barrera C, Contreras J, Barry K, Belanger A, Benitez L, Berrones D, Best J, Bigdeli T, Bommiasamy H, Borda T, Boyajian L, Muñoz D, Browning L, Burton C, Busto C, Buxbaum J, Rivera R, Callahan J, Gomez C, Ponce L, Canchari E, Torres R, Cervin M, Chang A, Chazelle E, Cheng J, Chire J, Muñoz M, Cicero D, Cifuentes-Espinoza A, Quiroz P, Colombo G, Comer J, Condori-Apaza L, Cortina J, Crosbie J, Crowley J, Cruz V, Cruz I, Cunning A, Perez G, Dailey M, Dang B, Checco K, Dawson A, del Río D, Dev A, Diaz S, Fay L, Figueroa E, Flecha L, Flores-Garcia Á, Franklin M, Frederick R, Fujita R, Furr J, Gaeta A, Gamarra O, Garay-Contreras C, García-Bravo N, García-Jaimes C, Garrison S, Gil-Hernández D, Giusti-Rodriguez P, Gonzalez A, González R, Gonzalez-Barrios P, Goodman W, Gorosito J, Grice D, Guintivano J, Guttfreund D, Halvorsen M, Miles J, Núñez E, Hettema J, Hovey J, Ccarhuas B, Irreño-Sotomonte J, Jagannathan N, Jensen M, Reynolds A, Jiwani R, Johnson J, Joutteaux S, Lujambio J, Kehrer S, Kennedy J, Lanzagorta N, Lázaro-Muñoz G, Longhurst M, Martinez D, Luna E, MacLellan A, Quispe D, Marques A, Marquez M, Martinez M, Martínez G, Mallen M, Martinez-Gonzalez K, de Los Angeles Matos M, Mattheisen M, McCarty R, McGuire J, McKay D, McOmber C, Minaya C, Miño T, Mithani S, Morales-Rivero A, Moya P, Moyano M, Mukunda P, Muñoz M, Muñoz M, Nicolini H, Bracho A, Bracho B, Obando D, Ochoa M, Ochoa-Panaifo M, O'Higgins M, Castaman L, Balmaceda T, Tobar M, Onyeka O, Ortega I, Paredes-Linares V, Pato M, Paz y Miño M, de Leon E, Orellana J, Sossa N, Pereira S, Morales N, Duarte T, Phan A, Placencia M, Ponce L, Poovey K, Prieto M, Qiao T, Quiroz-Padilla M, Quispe-Correa M, Heros A, Ramos R, Ramos I, Ramsey K, Rancourt D, Gomez S, Espinosa R, Richter P, Rodriguez C, Barajas S, Romero M, Ruggero C, Ruiz-Chow A, Sagarnaga M, Montoya G, Salhadar N, Schachar R, Segovia L, Seligman L, Siegel I, Spencer S, Staples C, Stewart S, Storch E, Tapia-Cuevas V, Thompson P, Timpano K, Tonarelli S, la Garza B, Trujillo A, Villar C, Valdés C, Vallejo-Silva A, Mamani K, Vargas-Medrano J, Vásquez-Suyo M, Mellstrieng A, Vergara M, Vidal-Martinez G, Huaman M, Vollaro C, Wiese A, Wilkerson S, Zai G, Zappa L, Cruz V, Zepeda-Burgos R, Zoghbi A, Alves G, Alves G, Barbosa I, Cappi C, Carneiro M, Costa D, Delage F, Dreher C, Ferrão Y, Ferreira G, Fontenelle L, Fragoso D, Lima M, Menezes G, Miguel E, Moreira-de-Oliveira M, Stumpf B, Quarantini L, Quarantini-Alvim Y, Ramos V, Rosario M, Sampaio A, Saraiva L, Shavitt R. Benchmarking empirical severity for the Yale-Brown Obsessive Compulsive Scale-Second Edition. Journal Of Affective Disorders 2025, 119719. PMID: 40541829, DOI: 10.1016/j.jad.2025.119719.Peer-Reviewed Original ResearchYale-Brown Obsessive Compulsive ScaleY-BOCS-IIObsessive-compulsive disorderYale-Brown Obsessive Compulsive Scale - Second EditionSeverity of obsessive-compulsive disorderSample of OCD patientsObsessive Compulsive ScaleResearch settingsOCD presentationsOCD severityCompulsive ScaleObsessive-compulsiveOCD patientsPsychometric propertiesDiverse sampleSeveral benchmarksEmpirical critiqueHoldout sampleSeverityScoresDisordersAge groupsSingle-cell transcriptomic and chromatin dynamics of the human brain in PTSD
Hwang A, Skarica M, Xu S, Coudriet J, Lee C, Lin L, Terwilliger R, Sliby A, Wang J, Nguyen T, Li H, Wu M, Dai Y, Duan Z, Srinivasan S, Zhang X, Lin Y, Cruz D, Deans P, Huber B, Levey D, Glausier J, Lewis D, Gelernter J, Holtzheimer P, Friedman M, Gerstein M, Sestan N, Brennand K, Xu K, Zhao H, Krystal J, Young K, Williamson D, Che A, Zhang J, Girgenti M. Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD. Nature 2025, 1-11. PMID: 40533550, DOI: 10.1038/s41586-025-09083-y.Peer-Reviewed Original ResearchPost-traumatic stress disorderPrefrontal cortexDorsolateral prefrontal cortexHuman prefrontal cortexTraumatic stress responseHuman brainDepressive disorderStress disorderTrauma exposureCell type-specific contextRegulatory mechanismsGABAergic transmissionCell-type clusteringCell type-specific mannerMolecular regulatory mechanismsGlucocorticoid signalingGene expression changesChromatin dynamicsCredible variantsDisordersTranscriptional regulationEpigenetic dataCortexPersistent effectsPolygenic disorderCognitive-behavioral interventions for co-occurring substance use and mental health disorders
Magill M, Helminen E, Lynch-Gadaleta B, Allen K, Kiluk B, Ray L. Cognitive-behavioral interventions for co-occurring substance use and mental health disorders. Drug And Alcohol Dependence 2025, 274: 112756. PMID: 40543363, DOI: 10.1016/j.drugalcdep.2025.112756.Peer-Reviewed Original ResearchMental health disordersUsual careCo-occurring mental health conditionsHealth disordersCo-occurring substance useCognitive-behavioral interventionsPattern of effectsCompared to usual careMental health conditionsSubstance useSample of studyMental healthPsychosocial outcomesDrug useDisordersHealth conditionsDiagnostic criteriaOutcome typesStudy samplePublished outcome dataCareControl comparatorMeta-analysisLiterature searchOutcome dataIs there harm in behavioral weight loss for binge-eating disorder: Controlled comparison to cognitive behavioral therapy
Grilo C, Yurkow S, White M, Lydecker J, Ivezaj V. Is there harm in behavioral weight loss for binge-eating disorder: Controlled comparison to cognitive behavioral therapy. General Hospital Psychiatry 2025, 96: 72-74. PMID: 40543449, DOI: 10.1016/j.genhosppsych.2025.06.005.Peer-Reviewed Original ResearchRandomized Controlled Trial of Weight Management Versus Weight Management With Concurrent Cognitive‐Behavioral Therapy for Binge‐Eating Disorder in US Veterans With High Weight
Masheb R, Buta E, Snow J, Munro L, Lawless M, Abel E, McWain N, Marsh A, Cary A, Grilo C, Raffa S, Ruser C. Randomized Controlled Trial of Weight Management Versus Weight Management With Concurrent Cognitive‐Behavioral Therapy for Binge‐Eating Disorder in US Veterans With High Weight. International Journal Of Eating Disorders 2025 PMID: 40485646, DOI: 10.1002/eat.24476.Peer-Reviewed Original ResearchDSM-5 binge-eating disorderBinge-eating disorderDSM-5Cognitive-behavioral therapyEating-disorder treatmentRemission rateUS military veteransBinge-eating frequencyMilitary veteransCBTVeteran populationShape-relatedVeteransWeight managementPost-treatmentWeight management programUS veteransMixed-effects modelsDisordersRandomized controlled trialsClinical Trials Registry numberPsychopathologyBinge-eatingWeight lossClinical guidanceExploring dopamine as the master regulator of brain circuitry and mental health genome
Blum K, Braverman E, Sharafshah A, Elman I, Lewandrowski K, Bowirrat A, Pinhasov A, Thanos P, Gold M, Dennen C, Modestino E, Badgaiyan R, Baron D, Fuehrlein B, Sipple D, Ashford J, Sunder K, Makale M, Murphy K, Jafari N, Zeine F, Pollack A, Lewandowski P, Khalsa J. Exploring dopamine as the master regulator of brain circuitry and mental health genome. Gene & Protein In Disease 2025, 0: 6557. DOI: 10.36922/gpd.6557.Peer-Reviewed Original ResearchBrain circuitryDopamine transmissionDopaminergic activityPsychiatric disordersDopamineBrain functionCircuitryLong-term influenceNeurobiologyAddictionImmediate effectsIntracellular signaling pathwaysPotential therapeutic targetDisordersNeurotransmitterBrainClinical relevanceTherapeutic targetSignaling pathwaySubstancesRecommendations for Diagnosing and Quantifying treatment outcomes in clinical trials of compulsive sexual behavior disorder
Engel J, Kraus S, McCurdy L, Potenza M. Recommendations for Diagnosing and Quantifying treatment outcomes in clinical trials of compulsive sexual behavior disorder. Addictive Behaviors Reports 2025, 21: 100610. DOI: 10.1016/j.abrep.2025.100610.Peer-Reviewed Original ResearchCompulsive sexual behaviorCompulsive sexual behavior disorderTreatment of compulsive sexual behaviourSexual behavior disorderTreatment outcome studiesMechanisms of changeNeuropsychological measuresMeasures of quality of lifeParaphilic interestsPrefrontal areasClinical interviewQuantify treatment outcomesProblem behaviorsBehavioral disordersBehavioral engagementReward systemTreatment studiesTreatment trialsOutcome studiesSexual behaviorMoral judgmentTreatment outcomesDiagnostic criteriaDisordersTreatment changesBetting on Change: An Analysis of Cognitive Motivational Behavior Therapy Versus Referral to Gamblers Anonymous for Gambling Disorder
Wulfert E, Wemm S, Broussard J. Betting on Change: An Analysis of Cognitive Motivational Behavior Therapy Versus Referral to Gamblers Anonymous for Gambling Disorder. Psychology Of Addictive Behaviors 2025, 39: 375-388. PMID: 40111861, PMCID: PMC12140906, DOI: 10.1037/adb0001063.Peer-Reviewed Original ResearchConceptsGambling disorderGamblers AnonymousSeverity of problem gamblingSecondary moderation analysisBehavioral therapyModeration analysisLess moneyEfficacy literatureGambling problemsAnchor participantsProblem gamblingGamblingPeriod relative to baselineLow readinessDisordersTreatment sessionsSessionsParticipantsAmount of moneyIncrease adherenceIndividualsCognitionReadinessSymptomsTreatmentCommentary on Nitrous Oxide: Weighing the Toxic Neuropsychiatric Effects of Abuse Against Potential Therapeutic Benefits for Psychiatric Disorders
Garakani A. Commentary on Nitrous Oxide: Weighing the Toxic Neuropsychiatric Effects of Abuse Against Potential Therapeutic Benefits for Psychiatric Disorders. Journal Of Psychiatric Practice 2025, 31: 178-179. PMID: 40440676, DOI: 10.1097/pra.0000000000000854.Peer-Reviewed Original ResearchConceptsPsychiatric disordersDrugs of misuseDepressive disorderPsychiatric historyNeuropsychiatric effectsLow vitamin B12 levelsPsychosisAbuseSubacute combined degenerationNitrous oxide abuseVitamin B12 levelsAbuse of nitrous oxideDisordersResearch supportNitrous oxide usePotential therapeutic benefitDental proceduresCombined degenerationB12 levelsMegaloblastic anemiaTreated patientsTreatment optionsOxide abuseRisk of misuseTherapeutic benefitThe genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders
Galimberti M, Overstreet C, Gupta P, Beck S, Dao C, Deak J, Zhou H, Johnson E, Agrawal A, Stein M, Levey D, Gelernter J. The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders. Nature Mental Health 2025, 3: 700-708. DOI: 10.1038/s44220-025-00440-4.Peer-Reviewed Original ResearchGenomic structural equation modelingCannabis use disorderCannabis usePsychiatric disordersUse disorderStructural equation modelingIncreased rates of psychiatric disordersIncreasing prevalence of cannabis useRates of psychiatric disordersPrevalence of cannabis useThree-factor modelEquation modelingDepressive disorderPsychiatric traitsCannabisLocal genetic correlationDisordersGenetic correlationsMendelian randomization analysisTraitsRandomization analysisSchizophreniaADHDColocalization analysisIncreased riskThe Case for Structured Data in Developmental-Behavioral Pediatrics: Project STANDARD (Structured Approach to Neurodevelopmental Care and Clinical Research Data).
Barbaresi W, Bannett Y, Blum N, Chong S, Clark J, Dall M, Epstein J, Fellinger J, Froehlich T, Hofer J, Holzinger D, Huang P, Kang Y, Aishworiya R, Reilly M, Reynolds A, Roberts G, Sideridis G, Swain D, Weitzman C. The Case for Structured Data in Developmental-Behavioral Pediatrics: Project STANDARD (Structured Approach to Neurodevelopmental Care and Clinical Research Data). Journal Of Developmental And Behavioral Pediatrics 2025 PMID: 40439618, DOI: 10.1097/dbp.0000000000001376.Peer-Reviewed Original ResearchAttention-deficit hyperactivity disorderAutism spectrum disorderEvidence-based treatmentsClinical documentationDocumentation of careHyperactivity disorderDevelopmental-behavioral pediatricsBehavior problemsSpectrum disorderLongitudinal clinical research studiesClinical research studiesDevelopmental-BehavioralClinical careQuality improvementMeasured outcomesDisordersIs there harm in behavioral lifestyle weight management for binge-eating disorder in patients with obesity: Findings from a randomized controlled trial
Grilo C, Ivezaj V, Yurkow S, Lydecker J. Is there harm in behavioral lifestyle weight management for binge-eating disorder in patients with obesity: Findings from a randomized controlled trial. Journal Of Psychosomatic Research 2025, 195: 112169. PMID: 40516275, DOI: 10.1016/j.jpsychores.2025.112169.Peer-Reviewed Original ResearchEating-disorder psychopathologyBinge-eating disorderIncreased symptomsSymptoms of binge eatingRandomized controlled trialsBinge-eating frequencyBinge eatingPsychopathologyRandomized to placeboBinge-eatingWeight managementPlaceboHeterogeneity of outcomesDisordersParticipantsPosttreatmentSecondary analysisFrequency of casesSymptomsClinical contextIndividual levelObesityControlled trialsSmall magnitudePatientsInvestigating the familiality of trichotillomania and excoriation disorder
Chen D, Farhat L, Lebowitz E, Silverman W, Bloch M, Fernandez T, Olfson E. Investigating the familiality of trichotillomania and excoriation disorder. Psychiatry Research 2025, 350: 116560. PMID: 40449230, PMCID: PMC12179820, DOI: 10.1016/j.psychres.2025.116560.Peer-Reviewed Original ResearchConceptsFamily history of mental health disordersFirst-degreeHistory of mental health disordersSelf-reported family historyExcoriation disorderFamily history of individualsMental health historyMental health disordersFamily history of anxietyHistory of anxietyCross-sectional survey responsesFirst-degree relativesHealth historyHealth disordersFamily historySurvey responsesAged 4Etiological underpinningsTrichotillomaniaAnxietyDepressionIndividualsHistory of individualsDisordersEnvironmental factorsPossible role of mosaic mutations of neurodevelopmental disorder-related genes in bipolar disorder: Lessons from Kmt2c chimeric heterozygous knockout mice
Nakamura T, Nakajima K, Fujimori-Tonou N, Kasahara T, Tsuboi T, Kato T. Possible role of mosaic mutations of neurodevelopmental disorder-related genes in bipolar disorder: Lessons from Kmt2c chimeric heterozygous knockout mice. Neuroscience Research 2025, 217: 104910. PMID: 40414358, DOI: 10.1016/j.neures.2025.05.005.Peer-Reviewed Original ResearchBipolar disorderSpectrum of bipolar disordersAutism-like phenotypeAutism spectrum disorderAutism-like behaviorsDepression-like episodesKnockout miceMosaic mutationsHeterozygous knockout miceMental disordersSpectrum disorderKleefstra syndromeGenetic architecture of bipolar disorderDisordersSymptomatic spectrumAnxietyExome sequencing analysisGenetic architectureSequence analysisCausative genesMosaic miceGenesSomatic mutationsAutismKMT2CLaboratory-Assessed Mistrust in Borderline Personality Disorder: A Meta-Analytic Review
Kurt Y, Walker M, Luyten P, Fonagy P. Laboratory-Assessed Mistrust in Borderline Personality Disorder: A Meta-Analytic Review. Personality Disorders Theory Research And Treatment 2025 PMID: 40402642, DOI: 10.1037/per0000739.Peer-Reviewed Original ResearchBorderline personality disorderMeta-analytic reviewPersonality disorderSmall-to-moderate effect sizesEffect sizeStatistically significant moderatorPsychometrically sound toolBPD symptomsSignificant moderatorMeta-analytic modelMeta-analysisBPDSound toolJoanna Briggs Institute Critical Appraisal ChecklistInternational Prospective Register of Systematic ReviewsSystematic reviewProspective Register of Systematic ReviewsInterpersonal trustCritical Appraisal ChecklistEffective interventionsInternational Prospective RegisterRisk of biasControl groupDisordersBorderlinePharmacological and behavioral pain treatment strategies for patients with opioid use disorder
Ameral V, Hickey T, Reilly E, Patterson J, Sofuoglu M. Pharmacological and behavioral pain treatment strategies for patients with opioid use disorder. Expert Opinion On Pharmacotherapy 2025, 26: 1041-1054. PMID: 40366730, PMCID: PMC12202159, DOI: 10.1080/14656566.2025.2506688.Peer-Reviewed Original ResearchConceptsOpioid agonist treatmentOpioid use disorderChronic painUse disorderCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsEffective management of painPain treatment strategiesRegister of Controlled TrialsManagement of painCochrane Central RegisterAgonist treatmentPharmacological optionsTreatment strategiesPainOpioidEffective treatmentControlled trialsBehavioral treatmentTreatmentPatientsDisordersMedical careEffective managementEffective medical care
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