2025
Psychological Interventions for Reducing Distress in Patients with Cardiac Arrhythmias
Särnholm J, Gaffey A, Turchio M, Biviano A, Burg M. Psychological Interventions for Reducing Distress in Patients with Cardiac Arrhythmias. Current Cardiology Reports 2025, 27: 102. PMID: 40560300, PMCID: PMC12198271, DOI: 10.1007/s11886-025-02253-4.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPsychological healthPsychological interventionsAssociated with anxietyBehavioral therapyAvoidance behaviorReduce distressArrhythmia careReduce anxietyPoor quality of lifeAnxietyDepressionQuality of lifeCare CollaborativeCare systemImprove QoLInterventionCareSummaryFurther researchHealthPoor qualityDistressQoLAvoidanceFearLinking attention bias to youth social anxiety and depression: Insights from computational modeling of the affective Posner task
Edgar E, Castagna P, Delpech R, Crowley M. Linking attention bias to youth social anxiety and depression: Insights from computational modeling of the affective Posner task. Journal Of Affective Disorders 2025, 388: 119764. PMID: 40562109, DOI: 10.1016/j.jad.2025.119764.Peer-Reviewed Original ResearchDepressive symptom severityParent-reported social anxietyAttentional biasSocial anxietySymptom severityPubertal statusFunction of pubertal statusThreat-related stimuliDrift diffusion model parametersSymptoms of psychopathologyYouth social anxietyLatent cognitive processesSymptoms of anxietyDrift diffusion parametersHigher pubertal statusPosner taskDepressive symptomatologyPredicting anxietyDepressive symptomsCognitive processesEvidence accumulationDrift rateAnxietyDepressionBehavioral dataDivergent synaptic dynamics originate parallel pathways for computation and behavior in an olfactory circuit
Kim H, Santana G, Sancer G, Emonet T, Jeanne J. Divergent synaptic dynamics originate parallel pathways for computation and behavior in an olfactory circuit. Current Biology 2025 PMID: 40541186, DOI: 10.1016/j.cub.2025.05.051.Peer-Reviewed Original ResearchLateral horn neuronsPostsynaptic neuronsProjection neuronsDrosophila olfactory systemCalcium buffer EGTASpike thresholdOlfactory circuitsSensory processingOlfactory systemOdor attractivenessInformation streamsCentral circuitsCellular mechanismsSynaptic dynamicsSpecialized computersNeuronsSubtractive adaptationDepressionSynapsesComputerEfficient wayProcessing pathwayGain controlPresynaptic specializationsBehaviorA network analysis of posttraumatic stress, depression, and alcohol use in U.S. veterans: Exploring differences by childhood maltreatment exposure
Vannini M, Xu B, Blais R, Pietrzak R. A network analysis of posttraumatic stress, depression, and alcohol use in U.S. veterans: Exploring differences by childhood maltreatment exposure. Journal Of Affective Disorders 2025, 389: 119662. PMID: 40505987, DOI: 10.1016/j.jad.2025.119662.Peer-Reviewed Original ResearchChildhood maltreatment experiencesPosttraumatic stressChildhood maltreatmentAlcohol useU.S. veteransAdult psychopathologyMaltreatment experiencesCo-occurring posttraumatic stressTrauma-exposed U.S. veteransImpact of childhood maltreatmentChildhood maltreatment exposureU.S. military veteransU.S. military service membersAlcohol use itemsMilitary service membersTransdiagnostic linkTransdiagnostic approachTransdiagnostic mechanismDepression itemsMaltreatment exposureTraumatized veteransMilitary veteransDepressionMaltreatmentService membersDepressive Personality Vulnerability and Adaptation to Breast Cancer: A Matter of Self‐Criticism?
Shahar G, Aslan C, Rüdiger Z, Elmar B, Globus O, Beutel M. Depressive Personality Vulnerability and Adaptation to Breast Cancer: A Matter of Self‐Criticism? Stress And Health 2025, 41: e70054. PMID: 40448936, DOI: 10.1002/smi.70054.Peer-Reviewed Original ResearchConceptsSelf-criticismPersonal vulnerabilitySupportive-expressive psychodynamic psychotherapyDepressive personality vulnerabilitySymptoms of depressionPsychodynamic psychotherapyPersonality dimensionsComorbid depressionAdaptive outcomesRandomized clinical trialsDepressionRank-orderConfounding roleGeneralized linear modelSymptomatic loadPersonal resilienceBreast cancerIllness managementDiagnosis of breast cancerSymptomsBreast symptomsPsychotherapyAnxietyNo effectVulnerabilityInvestigating the familiality of trichotillomania and excoriation disorder
Chen D, Farhat L, Lebowitz E, Silverman W, Bloch M, Fernandez T, Olfson E. Investigating the familiality of trichotillomania and excoriation disorder. Psychiatry Research 2025, 350: 116560. PMID: 40449230, PMCID: PMC12179820, DOI: 10.1016/j.psychres.2025.116560.Peer-Reviewed Original ResearchConceptsFamily history of mental health disordersFirst-degreeHistory of mental health disordersSelf-reported family historyExcoriation disorderFamily history of individualsMental health historyMental health disordersFamily history of anxietyHistory of anxietyCross-sectional survey responsesFirst-degree relativesHealth historyHealth disordersFamily historySurvey responsesAged 4Etiological underpinningsTrichotillomaniaAnxietyDepressionIndividualsHistory of individualsDisordersEnvironmental factorsPolygenic risks for depression and neural responses to reward and punishment in young adults
Chen Y, Li H, Luo X, Li G, Ide J, Li C. Polygenic risks for depression and neural responses to reward and punishment in young adults. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40412620, DOI: 10.1016/j.bpsc.2025.05.008.Peer-Reviewed Original ResearchPolygenic risk scoresPunishment processingNeural responsesAchenbach Adult Self-ReportInfluence of genetic riskCortical activityAdult Self-ReportYoung adultsGenetic riskRisk of depressionGambling TaskAberrant rewardDrinking severityHuman Connectome ProjectDepression severityPublished routinesBrain responsesPolygenic riskDepression scoresSelf-reportDepressionConnectome ProjectRewardBrain imagingPunishmentCorrection to: Clinician-reported childbirth outcomes, patient-reported childbirth trauma, and risk for postpartum depression
Waller R, Kornfield S, White L, Chaiyachati B, Barzilay R, Njoroge W, Parish-Morris J, Duncan A, Himes M, Rodriguez Y, Seidlitz J, Riis V, Burris H, Gur R, Elovitz M. Correction to: Clinician-reported childbirth outcomes, patient-reported childbirth trauma, and risk for postpartum depression. Archives Of Women's Mental Health 2025, 1-1. PMID: 40387906, DOI: 10.1007/s00737-025-01595-w.Peer-Reviewed Original ResearchPsychological Distress and Cognitive Function in Women: Exploring Potential Mediation by Use of Opiates, Sleep Aids, or Minor Tranquilizers
Sampson L, Lawn R, Murchland A, Liu J, Marquez C, Scoglio A, Jha S, Sumner J, Roberts A, Kang J, Chibnik L, Koenen K, Kubzansky L. Psychological Distress and Cognitive Function in Women: Exploring Potential Mediation by Use of Opiates, Sleep Aids, or Minor Tranquilizers. Journal Of Women's Health 2025 PMID: 40336460, DOI: 10.1089/jwh.2024.0991.Peer-Reviewed Original ResearchPosttraumatic stress disorderCognitive functionMedication useMinor tranquilizersMeasures of posttraumatic stress disorderNurses' Health Study IIAssociated with lower cognitive functionCogstate Brief BatterySleep aidsEvidence of mediationLower cognitive functionLearning/working memoryBrief batteryStress disorderPsychomotor speed/attentionAssociated with useDistress scoresHigh distressMediation analysisPsychological distressLinear regression modelsPotential mediatorsSelf-reportAssessed associationsDepressionTrajectories of Major Depression and Generalized Anxiety Symptoms Among People With Disabilities During the COVID-19 Pandemic
Lowe S, Fan J, Michel C, Manning R, Adler J, Bogart K, Nario-Redmond M, Ostrove J, Wang K. Trajectories of Major Depression and Generalized Anxiety Symptoms Among People With Disabilities During the COVID-19 Pandemic. American Journal Of Orthopsychiatry 2025 PMID: 40338598, DOI: 10.1037/ort0000855.Peer-Reviewed Original ResearchGeneralized anxiety disorderGeneralized anxiety disorder symptomsSymptom trajectoriesSocial isolationDisability stigmaGeneralized anxiety symptomsPredictors of trajectory membershipLatent class growth analysisPandemic-related stressorsAnxiety disordersMajor depressionAnxiety symptomsOdds of membershipTraumatic eventsPersistent MDHigher social isolationTrajectory membershipLongitudinal studyDisability characteristicsDisabilityDepressionSymptomsGeneral populationGrowth analysisPredictors196. Lamotrigine is Not Associated With Differential Clinical Outcomes in a Real-World Sample of Patients With Unipolar Depression Receiving Ketamine/Esketamine
Santucci M, Pittman B, Katz R, Nikayin S, Wilkinson S. 196. Lamotrigine is Not Associated With Differential Clinical Outcomes in a Real-World Sample of Patients With Unipolar Depression Receiving Ketamine/Esketamine. Biological Psychiatry 2025, 97: s176. DOI: 10.1016/j.biopsych.2025.02.433.Peer-Reviewed Original Research144. Negative Life Events, Neural Circuitry, and Familial Risk for Depression Among Healthy Adolescents Interact to Predict the Onset of Psychopathology One Year Later
Holt-Gosselin B, Vives G, Keding T, Castrillon M, Joormann J, Gee D. 144. Negative Life Events, Neural Circuitry, and Familial Risk for Depression Among Healthy Adolescents Interact to Predict the Onset of Psychopathology One Year Later. Biological Psychiatry 2025, 97: s154. DOI: 10.1016/j.biopsych.2025.02.381.Peer-Reviewed Original Research"It was Empowering": Care Pathways a Novel Culturally Informed Inspiration Card Game for Community-Engaged Co-Design with Black American Women and Clinicians
O'Leary T, Batti V, Dhindsa S, Krishnan V, Wilcox L, Woods-Giscombe C, Bellamy C, McCall T. "It was Empowering": Care Pathways a Novel Culturally Informed Inspiration Card Game for Community-Engaged Co-Design with Black American Women and Clinicians. 2025, 1-8. DOI: 10.1145/3706599.3720056.Peer-Reviewed Original ResearchMental health applicationsMental health conditionsMental health professionalsDigital mental health applicationsCare pathwaysHealth professionalsBlack American womenHealth applicationsEvidence-based mental health careHealth conditionsAmerican womenMental health careHistory of anxietyCo-design workshopsCo-designHealth careTreatment disparitiesCommunity-engagedBlack womenCareProfessionalsWomenCognitive therapyAnxietyDepressionTargeting problem-solving with a cognitive remediation intervention for suicide prevention in veterans: A pilot study
Goldstein K, Medalia A, Nicholas E, Pietrzak R, Ahmed T, Haznedar M, Sweeney R, Wrobleski J, Dichiara A, Challman K, McClure M, Hazlett E. Targeting problem-solving with a cognitive remediation intervention for suicide prevention in veterans: A pilot study. Military Psychology 2025, ahead-of-print: 1-10. PMID: 40262555, DOI: 10.1080/08995605.2025.2494868.Peer-Reviewed Original ResearchSuicidal behaviorCognitive remediationDepressive disorderHistory of suicidal behaviorCognitive remediation interventionsSuicide risk reductionPost-treatmentAdaptive functioning outcomesAssociated with greater reductionsProblem-solvingSuicidal ideation/behaviorCognitive deficitsTherapy fidelityBrief formatRemedial interventionsVeteran outpatientsSuicide preventionEffect sizeGreater improvementFollow-up time pointsGreater reductionsControl conditionVeteransPilot dataDepressionExamining the Impact of Social Connectedness on Depression and Suicide Ideation Among Black Youth Experiencing Discrimination: A Path Analysis
Smith B, Boyd D, Quinn C. Examining the Impact of Social Connectedness on Depression and Suicide Ideation Among Black Youth Experiencing Discrimination: A Path Analysis. Journal Of Racial And Ethnic Health Disparities 2025, 1-11. PMID: 40237954, DOI: 10.1007/s40615-025-02414-9.Peer-Reviewed Original ResearchEffects of everyday discriminationSuicidal ideationDepressive symptomsEveryday discriminationSocial connectednessStress buffering modelPath analysisExperiences of racial discriminationBehavioral health outcomesSample self-identifiedIdeationAdverse behavioral health outcomesBlack youthPsychosocial stressBehavioral health practicesDepressionSuicideBuffer modelIndirect effectsRacial discriminationSupport theoryExperienced discriminationSymptomsSocial support theoryImpact of social connectednessKetamine Versus Electroconvulsive Therapy for the Treatment of Depression: A Guide for Clinicians
Elliott S, B Katz R, B Ostroff R, Ansari M, Holmes S, Sanacora G. Ketamine Versus Electroconvulsive Therapy for the Treatment of Depression: A Guide for Clinicians. FOCUS The Journal Of Lifelong Learning In Psychiatry 2025, 23: 195-205. PMID: 40235610, PMCID: PMC11995899, DOI: 10.1176/appi.focus.20240040.Peer-Reviewed Original ResearchTreatment-resistant depressionElectroconvulsive therapyCases of treatment-resistant depressionTreatment of depressionEfficacy of ketamineDepressive disorderSevere casesDepressionPatient selection criteriaPatient-specific factorsOptimal treatment choicePatient-specific considerationsKetamineStudy outcome measuresTreatment deliveryBenefit profileMeta-analysesTreatment choiceNoninferiority trialPublic health challengeEffective treatmentOutcome measuresGold standardUnique risksTherapyMusic mindfulness acutely modulates autonomic activity and improves psychological state in anxiety and depression
Ramirez C, Alayine G, Akafia C, Adichie K, Watts D, Galdamez Y, Harding L, Allsop A. Music mindfulness acutely modulates autonomic activity and improves psychological state in anxiety and depression. Frontiers In Neuroscience 2025, 19: 1554156. PMID: 40264912, PMCID: PMC12013341, DOI: 10.3389/fnins.2025.1554156.Peer-Reviewed Original ResearchMusical mindSymptoms of anxietyMindfulness sessionsMusic listeningMusicImproved psychological stateHeart rate variabilityModerate symptoms of anxietyPsychological stateStates of consciousnessParticipants’ psychological statesMindfulnessSelf-reported sexDepressive symptomsLive sessionsStress managementMeasures of heart rate variabilitySocial connectionsIncreased HRVReduce stressEEG power spectral densityPsychological effectsAnxietyDepressionParticipantsThe inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression
Jiang R, Geha P, Rosenblatt M, Wang Y, Fu Z, Foster M, Dai W, Calhoun V, Sui J, Spann M, Scheinost D. The inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression. Science Advances 2025, 11: eadt1083. PMID: 40173244, PMCID: PMC11964001, DOI: 10.1126/sciadv.adt1083.Peer-Reviewed Original ResearchConceptsDepression riskChronic pain conditionsPain conditionsPrevalence of comorbid depressionPain scoresUK Biobank participantsPain-free individualsComposite pain scoresHigh-risk individualsPain screeningMendelian randomizationBiobank participantsPain sitesDepression incidenceComorbid depressionIncreased riskBody sitesDepressionC-reactive proteinPainCausal inferenceFollow-upScoresRiskInflammatory markersExperiential avoidance in depression, anxiety, obsessive–compulsive related, and posttraumatic stress disorders: A comprehensive systematic review and meta-analysis
Shahar G. Experiential avoidance in depression, anxiety, obsessive–compulsive related, and posttraumatic stress disorders: A comprehensive systematic review and meta-analysis. Psychoanalytic Psychology 2025, 42: 123-127. DOI: 10.1037/pap0000533.Peer-Reviewed Original ResearchDelineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis
Bronstein M, Kummerfeld E, Bearden C, Cornblatt B, Walker E, Woods S, Mathalon D, Perkins D, Cadenhead K, Addington J, Cannon T, Vinogradov S. Delineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis. Journal Of Psychopathology And Clinical Science 2025, 134: 239-250. PMID: 39913476, DOI: 10.1037/abn0000969.Peer-Reviewed Original ResearchConceptsClinical high riskNorth American Prodrome Longitudinal StudyClinical high-risk samplesAttenuated psychosis symptomsPathways to suicideSuicide risk reductionPsychosis symptomsCausal pathwaysDepressed moodPsychosisIntervention effortsSelf-deprecationSuicideLongitudinal studyMeasurement time pointsStudy timepointsHigh riskSymptomsInterventionHopelessnessMoodTime pointsDepressionIndividualsDirect causes
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