2025
Sex and hormonal effects on drug cue-reactivity and its regulation in human addiction
Huang Y, Butelman E, Ceceli A, Kronberg G, King S, McClain N, Wong Y, Boros M, Drury K, Sinha R, Alia-Klein N, Goldstein R. Sex and hormonal effects on drug cue-reactivity and its regulation in human addiction. Biological Psychiatry 2025 PMID: 40441339, DOI: 10.1016/j.biopsych.2025.05.016.Peer-Reviewed Original ResearchDrug cue-reactivityCue-reactivityPrefrontal cortexFrontal eye fieldCue-induced drug cravingVentromedial prefrontal cortexCocaine use disorderMedial prefrontal cortexAnterior prefrontal cortexDrug cravingHuman addictsUse disorderFunctional MRIEye fieldLuteal phaseCravingDevelopment of personalized treatmentsLate-follicularFollicular phaseReappraisalVmPFCDlPFCHormonal effectsProtective factorsAddictionCurrent interpretations of the I-PACE model of behavioral addictions
Brand M, Müller A, Wegmann E, Antons S, Brandtner A, Müller S, Stark R, Steins-Loeber S, Potenza M. Current interpretations of the I-PACE model of behavioral addictions. Journal Of Behavioral Addictions 2025, 14: 1-17. PMID: 40063161, PMCID: PMC11974429, DOI: 10.1556/2006.2025.00020.Peer-Reviewed Original ResearchConceptsI-PACE modelI-PACEBehavioral addictionsInteraction of Person-Affect-Cognition-ExecutionBehavioral addiction researchCue-reactivityDesire thinkingCompulsive behaviorsExecutive functionAddictive behaviorsNegative reinforcementAddiction researchPermissive beliefsAddiction theoryAddiction fieldSelf-controlAddictionCravingEmpirical findingsTheory buildingClinical careStimulate researchGratificationBehaviorContext of changes
2024
Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder
Radoman M, McGowan C, Heilner E, Lacadie C, Sinha R. Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder. Addiction Biology 2024, 29: e70010. PMID: 39660770, PMCID: PMC11632857, DOI: 10.1111/adb.70010.Peer-Reviewed Original ResearchConceptsAnterior insular cortexAlcohol use disorderRight anterior insular cortexOrbitofrontal cortexUse disorderAlcohol cue-induced cravingStages of alcohol use disorderDorsal anterior cingulate cortexLeft anterior insular cortexNeural responses to stressAlcohol cue-reactivityCue-elicited cravingOFC responsesRight dorsal caudateCue-induced cravingAnterior cingulate cortexVoxel-based analysisResponse to stressPreoccupation/anticipation stageAlcohol cuesCraving assessmentCue-reactivityAmygdala hyperactivationAlcohol cravingCue exposure
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