2025
Pregnenolone reduces provoked craving and cocaine use in men and women with cocaine use disorder: A pilot trial
Sakmar E, Wemm S, Fogelman N, Hermes G, Sinha R, Milivojevic V. Pregnenolone reduces provoked craving and cocaine use in men and women with cocaine use disorder: A pilot trial. Drug And Alcohol Dependence 2025, 274: 112765. PMID: 40570771, DOI: 10.1016/j.drugalcdep.2025.112765.Peer-Reviewed Original ResearchCocaine use disorderCocaine useNeuroactive steroidsUse disorderTreatment of cocaine use disorderCocaine use outcomePregnenolone levelsTreatment-seeking individualsDays of cocaineChronic cocaine useExposure to stressPreg groupCocaine cuesCocaine cravingCraving responsesNeutral cuesInduce cravingCravingWeek 2CocaineChronic treatmentPilot findingsCocaine amountPrecursor pregnenoloneLinear mixed effects models649-P: Sex Differences in Predictors of Food Craving, Eating Behavior, and Weight Changes Assessed Longitudinally over a 24-Month Period
DAUGINIKAS E, HORVATH-DIANO C, HEILNER E, SAKMAR E, SINHA R, HARVANEK Z. 649-P: Sex Differences in Predictors of Food Craving, Eating Behavior, and Weight Changes Assessed Longitudinally over a 24-Month Period. Diabetes 2025, 74 DOI: 10.2337/db25-649-p.Peer-Reviewed Original ResearchEmotion regulationEating behaviorsSex differencesOvereating behaviorFood cravingsResilience factorsDutch Eating Behavior QuestionnaireEmotion Regulation ScaleFood Craving InventoryProblems Experienced questionnaireEating Behavior QuestionnairePerceived Stress ScaleImpact eating behaviorRegulation ScaleCoping OrientationCravingWeight gainBehavior QuestionnaireObesity riskStress ScaleTarget stressEmotionsEatingLinear mixed-effects modelsReduce obesity riskCognitive bias modification for individuals with opioid use disorder and chronic pain did not predict changes in clinical outcomes.
Wolkowicz N, Pittman B, Schrader S, Wesolowicz D, Sofuoglu M, Heapy A, MacLean R. Cognitive bias modification for individuals with opioid use disorder and chronic pain did not predict changes in clinical outcomes. Journal Of Studies On Alcohol And Drugs 2025 PMID: 40536409, DOI: 10.15288/jsad.25-00057.Peer-Reviewed Original ResearchCognitive bias modificationAttentional biasOpioid cravingBias modificationCBM effectsSubstance use disordersPain severityChronic painClinical outcomesAddiction severityOpioid use disorderUse disorderNaturalistic settingsNeutral-cueOpioid withdrawalPain cuesCravingDiverse sampleSalient outcomesSubstance typePreliminary effectivenessPrimary clinical outcomePain catastrophizingModerate painPain intensityExamining the moderating role of intolerance of uncertainty on pain tolerance and craving in patients with chronic pain and alcohol use disorder
Radoman M, Heilner E, McGowan C, Neree-Thompson B, Sakmar E, Sinha R. Examining the moderating role of intolerance of uncertainty on pain tolerance and craving in patients with chronic pain and alcohol use disorder. Alcohol 2025, 127: 55-61. PMID: 40513686, DOI: 10.1016/j.alcohol.2025.06.001.Peer-Reviewed Original ResearchIntolerance of uncertaintyAlcohol use disorderAlcohol use disorder groupAlcohol cravingCraving responsesUse disorderSelf-report measures of IUAlcohol-seeking behaviorMeasures of IUPain toleranceSelf-report measuresPain-related stressChronic painFifty-five adultsCognitive traitsCravingPotential treatment targetCoping behaviorsSubjective painExperimental sessionsLower pain toleranceModerating rolePsychological factorsTreatment targetControl conditionSex and hormonal effects on drug cue-reactivity and its regulation in human addiction
Huang Y, Butelman E, Ceceli A, Kronberg G, King S, McClain N, Wong Y, Boros M, Drury K, Sinha R, Alia-Klein N, Goldstein R. Sex and hormonal effects on drug cue-reactivity and its regulation in human addiction. Biological Psychiatry 2025 PMID: 40441339, DOI: 10.1016/j.biopsych.2025.05.016.Peer-Reviewed Original ResearchDrug cue-reactivityCue-reactivityPrefrontal cortexFrontal eye fieldCue-induced drug cravingVentromedial prefrontal cortexCocaine use disorderMedial prefrontal cortexAnterior prefrontal cortexDrug cravingHuman addictsUse disorderFunctional MRIEye fieldLuteal phaseCravingDevelopment of personalized treatmentsLate-follicularFollicular phaseReappraisalVmPFCDlPFCHormonal effectsProtective factorsAddictionThe Potential Use of Cannabidiol in the Treatment of Opioid Use Disorder: A Systematic Review
Shafie M, Ing K, Rostam‐Abadi Y, Weleff J, Griffin M, Ranganathan M, Aghaei A, Pratt N, Funaro M, Nia A. The Potential Use of Cannabidiol in the Treatment of Opioid Use Disorder: A Systematic Review. Addiction Biology 2025, 30: e70047. PMID: 40415392, PMCID: PMC12104536, DOI: 10.1111/adb.70047.Peer-Reviewed Original ResearchConceptsOpioid use disorderOUD outcomesUse disorderConditioned place preference paradigmPlace preference paradigmReducing withdrawal symptomsPotential of cannabidiolSubstance use disordersEfficacy of cannabidiolTreatment of opioid use disorderPreclinical studiesClinical studiesOpioid use disorder treatmentPreference paradigmAnxiety symptomsWithdrawal symptomsPsychiatric disordersEffective treatment approachTreatment optionsHuman studiesCannabidiolAnimal studiesSystematic reviewShort-term follow-upCravingThe curvilinear relationship between perceived stress and spicy food craving in Young females: A non-linear mediation effect of positive emotional experience of spicy food consumption
Qiu H, Rui Y, Zhang Y, Hu M, Zheng S, Xu N, Jing J, Han P, Chen H, Gao X. The curvilinear relationship between perceived stress and spicy food craving in Young females: A non-linear mediation effect of positive emotional experience of spicy food consumption. Food Quality And Preference 2025, 126: 105412. DOI: 10.1016/j.foodqual.2024.105412.Peer-Reviewed Original ResearchFood cravingsLevels of perceived stressPositive emotional experiencesPerceived stressEmotional experienceSpicy food consumptionFood Cravings QuestionnairesMediated pathwayIndividual emotional responsesPerceived Stress ScaleCraving QuestionnaireIncreased cravingYoung female participantsCravingEmotional responsesEating behaviorsStress ScaleExperience QuestionnaireStress management strategiesSpicy foodsFemale participantsPsychological benefitsEffective stress management strategiesFood consumptionStress managementCurrent interpretations of the I-PACE model of behavioral addictions
Brand M, Müller A, Wegmann E, Antons S, Brandtner A, Müller S, Stark R, Steins-Loeber S, Potenza M. Current interpretations of the I-PACE model of behavioral addictions. Journal Of Behavioral Addictions 2025, 14: 1-17. PMID: 40063161, PMCID: PMC11974429, DOI: 10.1556/2006.2025.00020.Peer-Reviewed Original ResearchConceptsI-PACE modelI-PACEBehavioral addictionsInteraction of Person-Affect-Cognition-ExecutionBehavioral addiction researchCue-reactivityDesire thinkingCompulsive behaviorsExecutive functionAddictive behaviorsNegative reinforcementAddiction researchPermissive beliefsAddiction theoryAddiction fieldSelf-controlAddictionCravingEmpirical findingsTheory buildingClinical careStimulate researchGratificationBehaviorContext of changesW139 Guanfacine Reduces Drug Craving, Stress and Increases the Number of Abstinence Days in Women With Polysubstance Use Disorder (PSUD): A Pilot 2-Site Clinical Study
Wemm S, Fogelman N, Sullivan L, Vacey E, Bera S, Hermes G, Swain J, Fox H, Sinha R. W139 Guanfacine Reduces Drug Craving, Stress and Increases the Number of Abstinence Days in Women With Polysubstance Use Disorder (PSUD): A Pilot 2-Site Clinical Study. Drug And Alcohol Dependence 2025, 267: 112081. DOI: 10.1016/j.drugalcdep.2024.112081.Peer-Reviewed Original ResearchW33 Real-World Cue Reactivity and Subjective Stress Independently Predict Cannabis Craving in Individuals With CUD
Conway R, Pearlman M, Sinha R, Wemm S, Conway R. W33 Real-World Cue Reactivity and Subjective Stress Independently Predict Cannabis Craving in Individuals With CUD. Drug And Alcohol Dependence 2025, 267: 111975. DOI: 10.1016/j.drugalcdep.2024.111975.Peer-Reviewed Original ResearchPreliminary effects of oral ANS-6637, an ALDH2 inhibitor, on cue-induced craving, safety and alcohol consumption among adults with alcohol use disorder: a proof-of-concept, randomized, human laboratory trial
O’Malley S, Miranda R, Book S, Chun T, Liss T, Malcolm R, Muvvala S, Padovano H, Schacht J, Blackburn B, Diamond I, Ransom J, Ryan M, Falk D, Litten R. Preliminary effects of oral ANS-6637, an ALDH2 inhibitor, on cue-induced craving, safety and alcohol consumption among adults with alcohol use disorder: a proof-of-concept, randomized, human laboratory trial. Alcohol And Alcoholism 2025, 60: agaf001. PMID: 39829301, PMCID: PMC11744046, DOI: 10.1093/alcalc/agaf001.Peer-Reviewed Original ResearchAlcohol use disorderAldehyde dehydrogenase 2 inhibitorUse disorderTreat alcohol use disorderCue reactivity sessionsCue-elicited cravingCue-induced cravingHuman laboratory studiesTreatment-seeking adultsAlcohol use disorder pharmacotherapiesAldehyde dehydrogenase 2Multisite clinical trialDose to placeboWeeks of medicationEffect size estimatesReactivation sessionDrinking outcomesGroup differencesCravingMeasured 1 weekEffect sizeCohen's dDouble-blindPreliminary effectivenessAlcohol consumptionPregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder
Gao H, Sinha R, Wemm S, Milivojevic V. Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder. Alcohol Clinical And Experimental Research 2025, 49: 619-628. PMID: 39779217, PMCID: PMC11928267, DOI: 10.1111/acer.15529.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment-seeking individualsAlcohol cuesAlcohol cravingResponse to stressPregnenolone groupUse disorderResponse to alcohol cuesGroup x condition interactionHigher alcohol cravingLinear mixed-effects modelsHeart rate variabilityHeart rate variability indicesAutonomic nervous system dysregulationChronic alcohol consumptionRandomized to placeboAutonomic nervous system responsesNervous system dysregulationCravingAlcohol's impactCondition interactionAssociated with autonomic nervous system dysregulationNervous system responsesAutonomic responsesEnhanced autonomic function
2024
The potential of non-psychedelic 5-HT2A agents in the treatment of substance use disorders: a narrative review of the clinical literature
Pulido-Saavedra A, Borelli A, Kitaneh R, Alrafayia M, Jalilian-Khave L, Funaro M, Potenza M, Angarita G. The potential of non-psychedelic 5-HT2A agents in the treatment of substance use disorders: a narrative review of the clinical literature. Expert Opinion On Pharmacotherapy 2024, 26: 133-146. PMID: 39708346, PMCID: PMC11786980, DOI: 10.1080/14656566.2024.2446623.Peer-Reviewed Original ResearchConceptsTreatment of substance use disordersSubstance use disordersTreating substance use disordersPsychedelic agentsNarrative reviewReceptor agonistsClinical literatureReceptor antagonistNovel interventionsClinical evidenceFDA approvalPublic health issueDisordersReceptorsAgonistsTreatmentCravingPositive resultsPsychedelicsAbstinenceReviewed literatureAgentsHealth issuesAntagonistPrimary affinityAlcohol use and cannabis craving in daily life: Sex differences and associations among young adults
Davis C, Ramer N, Squeglia L, Gex K, McRae‐Clark A, McKee S, Roberts W, Gray K, Baker N, Tomko R. Alcohol use and cannabis craving in daily life: Sex differences and associations among young adults. Alcohol Clinical And Experimental Research 2024, 48: 2331-2340. PMID: 39579151, PMCID: PMC11629456, DOI: 10.1111/acer.15461.Peer-Reviewed Original ResearchCannabis cravingAlcohol useMomentary levelWeeks of ecological momentary assessmentYoung adultsEcological momentary assessmentCo-used substancesFemale participantsPatterns of substance useMale participantsLevels of alcohol consumptionConditioned cuesMomentary assessmentAlcohol quantityCravingNaturalistic conditionsCannabisSubstance useSex differencesCo-useAlcohol consumptionNegative associationAlcoholParticipantsFrequent pairsPrediction of craving across studies: A commentary on conceptual and methodological considerations when using data-driven methods
Antons S, Yip S, Lacadie C, Dadashkarimi J, Scheinost D, Brand M, Potenza M. Prediction of craving across studies: A commentary on conceptual and methodological considerations when using data-driven methods. Journal Of Behavioral Addictions 2024, 13: 695-701. PMID: 39356557, PMCID: PMC11457034, DOI: 10.1556/2006.2024.00050.Peer-Reviewed Original ResearchConceptsAddictive behaviorsDisorders due to addictive behaviorsConnectome-based predictive modelingPrediction of cravingInvestigate neural mechanismsSubstance use disordersNeural mechanismsCravingSubstance useMethodological considerationsDisordersMethodological featuresBehaviorConceptualizationCommentaryStudyFindingsSubstancesDevelopment and preliminary validation of a modified Food Craving Inventory for Pregnancy (FCI-P) in U.S. military active-duty Service women
Thompson K, White M, Schrag R, Lavender J, Bauman V, Mains A, Rioux S, Spinner H, Thorstad I, Klein D, Haigney M, Tanofsky-Kraff M. Development and preliminary validation of a modified Food Craving Inventory for Pregnancy (FCI-P) in U.S. military active-duty Service women. Appetite 2024, 203: 107677. PMID: 39288884, DOI: 10.1016/j.appet.2024.107677.Peer-Reviewed Original ResearchFood Craving InventoryFour-factor structureBinge-eating disorderSeries of confirmatory factor analysesGood-to-excellent internal consistencyMeasures of cravingEating-related measuresDisinhibited eating behaviorsPoor model fitConfirmatory factor analysisModel fitPregnant womenFood cravingsConvergent validityPsychometric propertiesCross-loadingsMultiple subscalesCravingEating behaviorsInternal consistencySample of pregnant womenFactor analysisBehavior scoresEating behavior scoresDisordersNetwork state dynamics underpin basal craving in a transdiagnostic population
Ye J, Garrison K, Lacadie C, Potenza M, Sinha R, Goldfarb E, Scheinost D. Network state dynamics underpin basal craving in a transdiagnostic population. Molecular Psychiatry 2024, 30: 619-628. PMID: 39183336, DOI: 10.1038/s41380-024-02708-0.Peer-Reviewed Original ResearchConnectome-based predictive modelingBrain responsesRegulation of affective statesSample of healthy controlsTransdiagnostic populationTransdiagnostic sampleHigher cravingMotivational stateCravingFMRI methodsAffective statesScan runsExperimental stimuliNetwork engagementBrain dynamicsClinical implicationsHealthy controlsBrainIndividual variationState dynamicsCharacterize individualsReplication datasetPsychopathologyFMRIEngagementFrom alcohol and other drug treatment mediator to mechanism to implementation: A systematic review and the cases of self‐efficacy, social support, and craving
Maisto S, Moskal D, Firkey M, Bergman B, Borsari B, Hallgren K, Houck J, Hurlocker M, Kiluk B, Kuerbis A, Reid A, Magill M. From alcohol and other drug treatment mediator to mechanism to implementation: A systematic review and the cases of self‐efficacy, social support, and craving. Alcohol Clinical And Experimental Research 2024, 48: 1677-1692. PMID: 39182214, DOI: 10.1111/acer.15411.Peer-Reviewed Original ResearchMechanisms of behavior changeSelf-efficacySocial supportAdult samplesEmpirical supportAOD treatmentCase of self-efficacyCravingSystematic review of empirical studiesReview of empirical studiesBehavioral changesDrug useTreatment mechanismsKazdinClinical practiceSystematic reviewNockSystematic review of reviewsResearch evidenceTreatment effectsMeta-analysesAlcoholReview of reviewsPreferred Reporting ItemsMediatorsDexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study
Petrakis I, Nolen T, Vandergrift N, Hirsch S, Krystal J, De Vivo M, Sabados J, Pisani E, Newcomb J, Kosten T. Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study. American Journal On Addictions 2024, 34: 7-14. PMID: 39152094, DOI: 10.1111/ajad.13637.Peer-Reviewed Original ResearchPathophysiology of posttraumatic stress disorderAlcohol use disorderSubjective effects of alcoholEffects of alcoholUse disorderComorbid alcohol use disorderAlcohol cue reactivityPosttraumatic stress disorderCrossover laboratory studyCue reactivityAlcohol cravingNoradrenergic dysregulationStress disorderBlood pressureSubjective effectsEthanol administrationClinically significant adverse effectsPharmacotherapeutic approachesTest daysReceptor agonistsPotential treatmentDouble-blind fashionCravingDrinking alcoholDisordersStress and substance use disorders: risk, relapse, and treatment outcomes
Sinha R. Stress and substance use disorders: risk, relapse, and treatment outcomes. Journal Of Clinical Investigation 2024, 134: e172883. PMID: 39145454, PMCID: PMC11324296, DOI: 10.1172/jci172883.Peer-Reviewed Original ResearchConceptsSubstance use disordersDrug-related environmentPathophysiology of addictionAdaptive stress responseSUD treatment outcomesAssociated with substance misuseTreatment outcomesStress-related alterationsDrug motivationIncreased cravingNeurobiological disruptionsMaladaptive copingRepeated stressorsTreatment implicationsSubstance misuseStress pathophysiologyStress responseDrug intakeDrug withdrawalRelapse riskDrug misuseIntervention developmentDisordersCravingRelapse
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply