2025
Self-Inflicted Head Injury in Behavioral Variant Frontotemporal Dementia with Compulsive Behaviors: A Case Report
Yang Y, Matuskey D, Benjamin C, Fesharaki-Zadeh A. Self-Inflicted Head Injury in Behavioral Variant Frontotemporal Dementia with Compulsive Behaviors: A Case Report. Cognitive And Behavioral Neurology 2025, 38: 66-72. PMID: 40298273, DOI: 10.1097/wnn.0000000000000392.Peer-Reviewed Original ResearchConceptsBehavioral variant frontotemporal dementiaDiagnosis of behavioural variant frontotemporal dementiaFrontotemporal dementiaEpisodic memory lossLoss of empathyCompulsive behaviorsExecutive functionProgressive behavioral deficitsPsychiatric diagnosisPsychiatric disordersBehavioral deficitsRight hippocampusRight hemisphereBehavioral agitationPersonality changesNeuroimaging findingsInstrumental activities of daily livingMemory lossRight lateral ventricleSevere hypometabolismLateral ventricleParenchymal volume lossClinician's abilityInstrumental activitiesVolume lossCurrent interpretations of the I-PACE model of behavioral addictions
Brand M, Müller A, Wegmann E, Antons S, Brandtner A, Müller S, Stark R, Steins-Loeber S, Potenza M. Current interpretations of the I-PACE model of behavioral addictions. Journal Of Behavioral Addictions 2025, 14: 1-17. PMID: 40063161, PMCID: PMC11974429, DOI: 10.1556/2006.2025.00020.Peer-Reviewed Original ResearchConceptsI-PACE modelI-PACEBehavioral addictionsInteraction of Person-Affect-Cognition-ExecutionBehavioral addiction researchCue-reactivityDesire thinkingCompulsive behaviorsExecutive functionAddictive behaviorsNegative reinforcementAddiction researchPermissive beliefsAddiction theoryAddiction fieldSelf-controlAddictionCravingEmpirical findingsTheory buildingClinical careStimulate researchGratificationBehaviorContext of changes
2024
Association of Irritability with Restricted, Repetitive Behaviors and Social Communication Challenges in Autistic Youth
Menezes M, Rutten M, Anderson S, Linde J, Ibrahim K, Sukhodolsky D. Association of Irritability with Restricted, Repetitive Behaviors and Social Communication Challenges in Autistic Youth. Journal Of Autism And Developmental Disorders 2024, 1-8. PMID: 39141271, DOI: 10.1007/s10803-024-06505-0.Peer-Reviewed Original ResearchSocial communication challengesRestricted/repetitive behaviorsAutistic youthSocial communicationRepetitive behaviorsAutism characteristicsAffective Reactivity IndexAssociations of irritabilitySelf-injurious behaviorSocial Responsiveness ScaleHierarchical multiple regressionMental health concernsAssociated with several categoriesCompulsive behaviorsStereotyped behaviorExamined relationsRitualistic behaviorRestrictive behaviorsSame behaviorSocial motivationResponse scaleAutistic childrenInteraction challengesReactivity indexClinical research program
2022
Male DAT Val559 Mice Exhibit Compulsive Behavior under Devalued Reward Conditions Accompanied by Cellular and Pharmacological Changes
Stewart A, Davis G, Areal L, Rabil M, Tran V, Mayer F, Blakely R. Male DAT Val559 Mice Exhibit Compulsive Behavior under Devalued Reward Conditions Accompanied by Cellular and Pharmacological Changes. Cells 2022, 11: 4059. PMID: 36552823, PMCID: PMC9777203, DOI: 10.3390/cells11244059.Peer-Reviewed Original ResearchConceptsDAT Val559 miceAnomalous DA effluxDorsal medial striatumCompulsive behaviorsFormation of goal-directedLever-pressing paradigmDA agonist apomorphineDevaluation of rewardPairwise discrimination taskGoal-directed behaviorDendritic spine densityDAT Val559Habitual rewardAgonist apomorphineDA neurotransmissionDA effluxReward conditionCognitive flexibilityReinforcement scheduleReward motivationStriatal circuitryChecking behaviorMedial striatumPsychiatric disordersDiscrimination taskThe Potential of N-acetyl Cysteine in Behavioral Addictions and Related Compulsive and Impulsive Behaviors and Disorders: a Scoping Review
Greenberg N, Farhadi F, Kazer B, Potenza M, Angarita G. The Potential of N-acetyl Cysteine in Behavioral Addictions and Related Compulsive and Impulsive Behaviors and Disorders: a Scoping Review. Current Addiction Reports 2022, 9: 660-670. PMID: 38362235, PMCID: PMC10868722, DOI: 10.1007/s40429-022-00446-3.Peer-Reviewed Original ResearchN-acetylcysteineSelf-injurious behaviorEffectiveness of NACEfficacy of NACSmall open-label trialsUse of NACCompulsive sexual behaviorOpen-label trialRepetitive self-injurious behaviorSexual behaviorCompulsive behaviorsGambling disorderGlutamate dysregulationBehavioral addictionsCase reportClinical trialsPreclinical studiesGlutamate homeostasisAcetyl cysteineDisordersMore studiesScoping ReviewCompulsive featuresAddictionImpulsive behavior
2021
Assigning the right credit to the wrong action: compulsivity in the general population is associated with augmented outcome-irrelevant value-based learning
Bullmore E, Dolan R, Goodyer I, Fonagy P, Jones P, Moutoussis M, Hauser T, Neufeld S, Romero-Garcia R, Clair M, Vértes P, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Kiddle B, Polek E, Fearon P, Suckling J, van Harmelen A, Kievit R, Chamberlain S. Assigning the right credit to the wrong action: compulsivity in the general population is associated with augmented outcome-irrelevant value-based learning. Translational Psychiatry 2021, 11: 564. PMID: 34741013, PMCID: PMC8571313, DOI: 10.1038/s41398-021-01642-x.Peer-Reviewed Original ResearchConceptsCompulsive behaviorsCompulsive tendenciesValue-based learningSelf-reported compulsivityReinforcement learning tasksSchizotypal tendenciesStimulus locationCompulsivityFuture eventsWrong actionsLearning processFuture researchPositive relationshipSpecific actsCurrent studyTaskLearningIndividualsGeneral populationCausal relationshipHealthy individualsAnxietyTendencyBehaviorBeliefsImpulsivity and compulsivity in binge eating disorder: A systematic review of behavioral studies
Carr MM, Wiedemann AA, Macdonald-Gagnon G, Potenza MN. Impulsivity and compulsivity in binge eating disorder: A systematic review of behavioral studies. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2021, 110: 110318. PMID: 33794320, PMCID: PMC8222068, DOI: 10.1016/j.pnpbp.2021.110318.Peer-Reviewed Original ResearchConceptsRapid-response impulsivityResponse impulsivityChoice impulsivityTask methodologyBehavioral studiesMultiple psychiatric disordersImpulsivityCompulsive behaviorsSpecific facetsCompulsivityGroup differencesFuture researchSample characteristicsPsychiatric disordersUnique sampleIndividualsDisordersMore researchBingeResearchOverweight/obesityBehavior
2020
Coronavirus: A Trigger for OCD and Illness Anxiety Disorder?
Rivera R, Carballea D. Coronavirus: A Trigger for OCD and Illness Anxiety Disorder? Psychological Trauma Theory Research Practice And Policy 2020, 12: s66-s66. PMID: 32496094, DOI: 10.1037/tra0000725.Peer-Reviewed Original ResearchCirculating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons
Berland C, Montalban E, Perrin E, Di Miceli M, Nakamura Y, Martinat M, Sullivan M, Davis XS, Shenasa MA, Martin C, Tolu S, Marti F, Caille S, Castel J, Perez S, Salinas CG, Morel C, Hecksher-Sørensen J, Cador M, Fioramonti X, Tschöp MH, Layé S, Venance L, Faure P, Hnasko TS, Small DM, Gangarossa G, Luquet SH. Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons. Cell Metabolism 2020, 31: 773-790.e11. PMID: 32142669, PMCID: PMC7250662, DOI: 10.1016/j.cmet.2020.02.010.Peer-Reviewed Original ResearchConceptsDopamine receptor subtype 2Lipoprotein lipaseReceptor subtype 2Energy-rich dietDopaminergic transmissionMesocorticolimbic systemDietary triglyceridesSubtype 2Reward deficitsReward circuitMetabolic signaturesWeight gainCompulsive feedingFood cuesTriglyceridesGenetic riskBrain responsesNew mechanistic basisCompulsive behaviorsNeuronsNovel mechanismMechanistic basisDysfunction
2016
Degree connectivity in body dysmorphic disorder and relationships with obsessive and compulsive symptoms
Beucke J, Sepulcre J, Buhlmann U, Kathmann N, Moody T, Feusner J. Degree connectivity in body dysmorphic disorder and relationships with obsessive and compulsive symptoms. European Neuropsychopharmacology 2016, 26: 1657-1666. PMID: 27514293, PMCID: PMC5316290, DOI: 10.1016/j.euroneuro.2016.04.011.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderBody dysmorphic disorderFunctional magnetic resonance imagingOrbitofrontal cortexDysmorphic disorderSymptom severityFunctional connectivityYale-Brown Obsessive-Compulsive ScaleResting-state functional connectivityDegree connectivityFace processing taskObsessive-Compulsive ScaleBrain-behavior associationsDegree of functional connectivityCompulsive symptomsObsessive-compulsiveAmygdalar connectivityCompulsive behaviorsObsessive thoughtsBrain hyperactivitySymptom provocationDistant connectionsBrain areasDiagnostic groupsBasal ganglia
2013
Monoamine Levels Within the Orbitofrontal Cortex and Putamen Interact to Predict Reversal Learning Performance
Groman SM, James AS, Seu E, Crawford MA, Harpster SN, Jentsch JD. Monoamine Levels Within the Orbitofrontal Cortex and Putamen Interact to Predict Reversal Learning Performance. Biological Psychiatry 2013, 73: 756-762. PMID: 23332512, PMCID: PMC3615106, DOI: 10.1016/j.biopsych.2012.12.002.Peer-Reviewed Original ResearchConceptsGoal-directed behaviorOrbitofrontal cortexReward-directed behaviorPsychiatric disordersObsessive-compulsive disorderIndividual differencesAssociative learningInflexible behaviorBehavioral flexibilityBehavioral addictionsCompulsive behaviorsImportant modulatory influenceDiscrimination problemNeuromodulatory systemsPutamen dopamineNeurochemical dysfunctionBehavioral impairmentsNeurochemical levelsNeurochemical systemsDorsal striatumModulatory influenceCurrent studyDopamine levelsCortexNeurochemical differences
2007
9 Trichotillomania
Franklin M, Tolin D, Diefenbach G. 9 Trichotillomania. 2007, 139-159. DOI: 10.1016/b978-008044701-8/50010-3.Peer-Reviewed Original Research
2005
The Role of the Therapist in Behavior Therapy for OCD
Tolin D, Hannan S. The Role of the Therapist in Behavior Therapy for OCD. Series In Anxiety And Related Disorders 2005, 317-332. DOI: 10.1007/0-387-23370-9_16.Peer-Reviewed Original ResearchResponse preventionCognitive-behavioral interventionsFear-eliciting stimuliCognitive behavioral therapyMechanisms of habituationMaladaptive cognitionsExposure exercisesFear responsesBehavior therapyCompulsive behaviorsContamination concernsStrong evidence baseRear-view mirrorOCDObsessive concernEvidence baseCognitionContaminated objectsBehavioralFearStimuliTherapistsHabituationAbstinenceDriving
2001
Case Study: Bibliotherapy and Extinction Treatment of Obsessive-Compulsive Disorder in a 5-Year-Old Boy
TOLIN D. Case Study: Bibliotherapy and Extinction Treatment of Obsessive-Compulsive Disorder in a 5-Year-Old Boy. Journal Of The American Academy Of Child & Adolescent Psychiatry 2001, 40: 1111-1114. PMID: 11556636, DOI: 10.1097/00004583-200109000-00021.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderCognitive-behavioral therapyTreatment of obsessive-compulsive disorderChildhood obsessive-compulsive disorderSevere obsessive-compulsive disorderPatient's OCD symptomsCase studies of childrenFollow-up assessmentOCD symptomsReassurance-seekingCompulsive behaviorsExtinction treatmentStudy of childrenAge-appropriate booksYoung childrenBibliotherapyDisordersEffective treatmentChildrenBoysExtinctionPosttreatmentChildhoodSymptomsLow levels
1999
Oxytocin, vasopressin, and autism: is there a connection?
Insel T, O’Brien D, Leckman J. Oxytocin, vasopressin, and autism: is there a connection? Biological Psychiatry 1999, 45: 145-157. PMID: 9951561, DOI: 10.1016/s0006-3223(98)00142-5.Peer-Reviewed Original ResearchConceptsVasopressin neurotransmissionAvailable preclinical evidencePreclinical evidenceClinical studiesAnimal studiesRodent brainPeptide receptorFeatures of autismOxytocinVasopressinGenetic disordersCompulsive behaviorsNeurotransmissionNormal expressionDevelopmental disordersSocial impairmentReceptorsCommunication deficitsDisordersSpecies-typical social behaviorsNeurobiological approachAutismEvidenceUnique effectsExpression
1997
Ritual, Habit, and Perfectionism: The Prevalence and Development of Compulsive‐like Behavior in Normal Young Children
Evans D, Leckman J, Carter A, Reznick J, Henshaw D, King R, Pauls D. Ritual, Habit, and Perfectionism: The Prevalence and Development of Compulsive‐like Behavior in Normal Young Children. Child Development 1997, 68: 58-68. PMID: 9084125, DOI: 10.1111/j.1467-8624.1997.tb01925.x.Peer-Reviewed Original Research
1994
"Just right" perceptions associated with compulsive behavior in Tourette's syndrome
Leckman JF, Walker DE, Goodman WK, Pauls DL, Cohen DJ. "Just right" perceptions associated with compulsive behavior in Tourette's syndrome. American Journal Of Psychiatry 1994, 151: 675-680. PMID: 8166308, DOI: 10.1176/ajp.151.5.675.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetAgedAwarenessBasal GangliaChildComorbidityCompulsive BehaviorCross-Sectional StudiesFemaleHumansMaleMiddle AgedObsessive BehaviorObsessive-Compulsive DisorderPerceptionPersonality InventoryPsychiatric Status Rating ScalesSensationSeverity of Illness IndexTourette SyndromeConceptsTic disordersObsessive-compulsive disorderTourette syndromeObsessive-compulsive symptomsCompulsive behaviorsCross-sectional studyYale-Brown Obsessive Compulsive ScaleObsessive Compulsive ScaleTic symptomsChronic disordersPhonic ticsChildhood onsetEpidemiological studiesSyndromeAdult subjectsBrain regionsSymptomsCompulsive ScaleDisordersSensorimotor informationSubjectsThree-quartersCompulsive actsPathobiologySeverity
1990
Treatment of an adolescent with obsessive-compulsive disorder by alternating response prevention and cognitive therapy: An empirical analysis
Kearney C, Silverman W. Treatment of an adolescent with obsessive-compulsive disorder by alternating response prevention and cognitive therapy: An empirical analysis. Journal Of Behavior Therapy And Experimental Psychiatry 1990, 21: 39-47. PMID: 2373767, DOI: 10.1016/0005-7916(90)90047-o.Peer-Reviewed Original ResearchConceptsCognitive therapyObsessive-compulsive disorderResponse preventionCompulsive behaviorsSelf-reported anxietyObsessive-compulsive behaviorSevere obsessive-compulsive disorderParental ratingsClient ratingsAnxietyBaseline measuresPersonal discomfortRatingsDepressionDisordersAdolescentsBehaviorParentsSessionsBoysFrequency levelsMeasuresSignificant influence
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