2022
Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks
Salvan P, Fonseca M, Winkler A, Beauchamp A, Lerch J, Johansen-Berg H. Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks. Nature Neuroscience 2022, 26: 53-63. PMID: 36522497, PMCID: PMC9829536, DOI: 10.1038/s41593-022-01213-3.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSerotonin neuronsSerotonin receptorsSerotonin regulationDorsal raphe serotonin neuronsReceptor networkResting-state functional magnetic resonance imagingOptogenetic functional magnetic resonance imagingRaphe serotonin neuronsSpecific serotonin receptorsBrain-wide activityFunctional magnetic resonance imagingSerotonin receptor typesDifferent serotonin receptorsBrain-wide distributionSerotonin effectsReceptor typesResonance imagingFunctional connectivityReceptorsNeuronsSingle-cell levelCompelling evidenceFunctional signaturesMultiple aspectsEmergency Department Use by Children and Youth with Mental Health Conditions: A Health Equity Agenda
Hoge MA, Vanderploeg J, Paris M, Lang JM, Olezeski C. Emergency Department Use by Children and Youth with Mental Health Conditions: A Health Equity Agenda. Community Mental Health Journal 2022, 58: 1225-1239. PMID: 35038073, PMCID: PMC8762987, DOI: 10.1007/s10597-022-00937-7.Peer-Reviewed Original ResearchConceptsMental health conditionsEmergency departmentHealth conditionsEmergency department useReferral of childrenBehavioral health professionalsED visitsED useDepartment useHealth equity agendaEvidence-based assessmentHealth professionalsForm of careHealth inequitiesHealth equityMental healthHealthcare qualityWhite childrenSuch childrenChildrenReferralAfrican AmericansFact sheetsCompelling evidenceLatinx children
2020
Preventing the Spread of COVID-19 in Immigration Detention Centers Requires the Release of Detainees.
Lopez WD, Kline N, LeBrón AMW, Novak NL, De Trinidad Young ME, Gonsalves G, Mishori R, Safi BA, Kysel IM. Preventing the Spread of COVID-19 in Immigration Detention Centers Requires the Release of Detainees. American Journal Of Public Health 2020, 111: 110-115. PMID: 33211577, PMCID: PMC7750591, DOI: 10.2105/ajph.2020.305968.Peer-Reviewed Original Research
2018
Revisiting the Consequences of Adolescent Cannabinoid Exposure Through the Lens of the Endocannabinoid System
Ganesh S, Vidya K, Rashid A, Singh J, D’Souza D. Revisiting the Consequences of Adolescent Cannabinoid Exposure Through the Lens of the Endocannabinoid System. Current Addiction Reports 2018, 5: 418-427. DOI: 10.1007/s40429-018-0233-8.Peer-Reviewed Original ResearchAdolescent cannabinoid exposureCannabinoid exposureEndocannabinoid systemHuman studiesAdolescent cannabis exposurePersistent consequencesPatterns of cannabisPotential molecular mechanismsExogenous cannabinoidsCannabis exposureSynaptic potentiationAnimal modelsAdolescent exposureConflicting resultsNeurodevelopmentExposureCannabinoidsMolecular mechanismsPlausible linkRecent studiesPersistent effectsCompelling evidenceCognitive consequencesFurther researchEpigenetic mechanisms
2017
Chapter 15 Mouse Models of Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies
Mao S, Li Y, Liu B, Chi T. Chapter 15 Mouse Models of Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies. 2017, 231-243. DOI: 10.1016/b978-0-12-805388-1.00015-8.Peer-Reviewed Original ResearchEpigenetic inheritanceChromatin modificationsHeritable chromatin modificationsHeritable epigenetic statesSimple reporter geneEpigenetic stateExperimental strategiesEpigenetic mechanismsMolecular basisReporter geneMouse modelInheritanceInheritance modelEnvironmental factorsCompelling evidenceMechanistic studiesEmbryogenesisExtensive contributionsGenesTraitsMechanismMechanistic problemsModificationInducerOffspring
2016
Epoxyeicosatrienoic acids and glucose homeostasis in mice and men
Luther JM, Brown NJ. Epoxyeicosatrienoic acids and glucose homeostasis in mice and men. Prostaglandins And Other Lipid Mediators 2016, 125: 2-7. PMID: 27448715, PMCID: PMC5035218, DOI: 10.1016/j.prostaglandins.2016.07.010.Peer-Reviewed Original ResearchConceptsEpoxyeicosatrienoic acidsInsulin sensitivityRodent modelsSoluble epoxide hydrolaseGlucose homeostasisEpoxide hydrolaseActive dihydroxyeicosatrienoic acidsPancreatic islet cell functionEffects of EETsType 2 diabetesType 1 diabetesIslet cell functionP450 epoxygenasesDihydroxyeicosatrienoic acidsPeripheral tissuesIslet cellsPharmacological inhibitionArachidonic acidDiabetesCell functionGenetic polymorphismsFavorable effectTissue expressionStable analogueCompelling evidence
2015
The Effects of Sitting on a Mechanical Lift Sling on Interface Seat Pressure
Crane B, Wininger M, Strydom E, Hulse J. The Effects of Sitting on a Mechanical Lift Sling on Interface Seat Pressure. Topics In Geriatric Rehabilitation 2015, 31: 67-73. DOI: 10.1097/tgr.0000000000000048.Peer-Reviewed Original ResearchCommunity-dwelling older adultsCurrent clinical recommendationsAdult wheelchair usersSubjects observational studyClinical recommendationsObservational studyOlder adultsSlingLonger durationSignificant differencesFurther investigationPressure parametersSeat-interface pressureMechanical liftCompelling evidenceInterface pressureSeat pressureWheelchair usersFuture Directions and New Targets in Endometrial Cancer
Black J, Roque D, Gold L, Santin A. Future Directions and New Targets in Endometrial Cancer. Current Clinical Oncology 2015, 259-271. DOI: 10.1007/7631_2015_1.Peer-Reviewed Original ResearchEndometrial cancerNext-generation sequencingPathway aberrationsMolecular aberrationsUnique molecular characteristicsCancerNew targetsSomatic mutationsTherapyHeterogeneous somatic mutationsMolecular characteristicsCompelling evidenceGeneration sequencingRecent advancesProper classificationAberrationsTumorsDisease
2013
17Beta-Estradiol Promotes Aggressive Laryngeal Cancer Through Membrane-Associated Estrogen Receptor-Alpha 36
Schwartz N, Chaudhri RA, Hadadi A, Schwartz Z, Boyan BD. 17Beta-Estradiol Promotes Aggressive Laryngeal Cancer Through Membrane-Associated Estrogen Receptor-Alpha 36. Discover Oncology 2013, 5: 22-32. PMID: 24081562, PMCID: PMC3947116, DOI: 10.1007/s12672-013-0161-y.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsApoptosisCarcinogenesisCarcinomaCell ProliferationCell SurvivalDrug Resistance, NeoplasmEstradiolEstrogen Receptor alphaFemaleHeLa CellsHumansLaryngeal NeoplasmsLymphatic MetastasisMaleMembrane ProteinsMiddle AgedMolecular Targeted TherapyNeoplasm StagingNeovascularization, PathologicPhospholipase DProtein IsoformsProtein Kinase CVascular Endothelial Growth Factor AConceptsLaryngeal cancerMembrane associated estrogen receptorsLymph node metastasisRole of E2Estrogen receptor alphaLaryngeal carcinoma cell lineSecondary sex organsChemotherapy-induced apoptosisAntiestrogen therapyNode metastasisCarcinoma cell linesLaryngeal tumorsEstrogen receptorReceptor alphaERα36Metastatic factorsSimilar associationCompelling evidenceCytoplasmic receptorsCancerTumor samplesAntiapoptotic effectNovel drugsClinical analysisE2 responsiveness
2011
Natural Innate and Adaptive Immunity to Cancer
Vesely MD, Kershaw MH, Schreiber RD, Smyth MJ. Natural Innate and Adaptive Immunity to Cancer. Annual Review Of Immunology 2011, 29: 235-271. PMID: 21219185, DOI: 10.1146/annurev-immunol-031210-101324.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsImmune systemAdaptive immune cell typesImmune cell typesTumor-promoting actionsHuman clinical dataNascent tumor cellsCancer immunosurveillanceClinical dataAdaptive immunityMouse modelTumor progressionCancerTumor cellsTumor suppressor mechanismImmunityEffector moleculesFurther studiesCell typesCompelling evidenceImportant defenseImmunotherapyImmunosurveillanceInnateProgression
2008
Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease.
Picciotto MR, Zoli M. Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Frontiers In Bioscience-Landmark 2008, 13: 492-504. PMID: 17981563, DOI: 10.2741/2695.Peer-Reviewed Original ResearchConceptsAbility of nicotineNeurodegenerative disordersRole of nAChRsHuman neurodegenerationNeuroprotective agentsParkinson's diseaseDevelopmental stagesCellular effectsNicotine-mediated neuroprotectionRegimen of administrationDrug discoveryNicotine neuroprotectionNeuronal survivalNeuronal deathEpidemiological studiesNicotinic compoundsAlzheimer's diseaseRecent studiesNeuroprotectionDiseaseNicotineCompelling evidenceNAChRsVivoFull understanding
2001
Structure and function of GABAC receptors: a comparison of native versus recombinant receptors
Zhang D, Pan Z, Awobuluyi M, Lipton S. Structure and function of GABAC receptors: a comparison of native versus recombinant receptors. Trends In Pharmacological Sciences 2001, 22: 121-132. PMID: 11239575, DOI: 10.1016/s0165-6147(00)01625-4.Peer-Reviewed Original ResearchConceptsRecombinant receptorsGABA receptorsIonotropic GABA receptorsRetinal signal processingInhibitory receptorsGABAC receptorsPharmacological profileBrain regionsSpecific drugsReceptorsNative receptorMajor molecular componentsUnique functional rolesFunctional roleMolecular determinantsSlow activationCompelling evidenceSubunit compositionMolecular basisRetina
1998
Differential localization of colonic H+-K+-ATPase isoforms in surface and crypt cells
Rajendran V, Singh S, Geibel J, Binder H. Differential localization of colonic H+-K+-ATPase isoforms in surface and crypt cells. American Journal Of Physiology 1998, 274: g424-g429. PMID: 9486199, DOI: 10.1152/ajpgi.1998.274.2.g424.Peer-Reviewed Original ResearchConceptsCrypt cellsColonic cryptsRat distal colonSurface cellsSurface epithelial cellsATPase isoformsOuabain-insensitive componentApical membraneDistal colonAcid loadDependent intracellularEpithelial cellsATPase activityCryptsDifferential localizationOuabainATPase alpha subunitCellsAlpha subunitCompelling evidenceIsoformsColonActivityRecoveryLife Stressors as Risk Factors in Depression
Mazure C. Life Stressors as Risk Factors in Depression. Clinical Psychology Science And Practice 1998, 5: 291-313. DOI: 10.1111/j.1468-2850.1998.tb00151.x.Peer-Reviewed Original ResearchMajor depressionSubsequent major depressionIndividual vulnerabilityStressful life eventsRisk factorsAdverse life experiencesTreatment outcomesStress-depression relationshipMultivariate modelChronic stressorsDepressionLife stressLife stressorsMajor targetOutcomesLife eventsCompelling evidenceEffects of stressorsStressorsEvaluation of stressors
1997
Relationship between the Ocular Dominance and Orientation Maps in Visual Cortex of Monocularly Deprived Cats
Crair M, Ruthazer E, Gillespie D, Stryker M. Relationship between the Ocular Dominance and Orientation Maps in Visual Cortex of Monocularly Deprived Cats. Neuron 1997, 19: 307-318. PMID: 9292721, DOI: 10.1016/s0896-6273(00)80941-1.Peer-Reviewed Original ResearchConceptsCortical plasticityVisual cortexSame stimulus orientationSingle-unit recordingsStimulus orientationDeprived eyeIntrinsic optical signalsMonocular deprivationOcular dominanceOcular dominance mapsSelective lossOrientation tuningClosed eyesCritical periodCortexEyesNeuronsFunctional mapsBrief periodCompelling evidenceKittensThe role of serotonin in the pathophysiology and treatment of schizophrenia
Abi-Dargham A, Laruelle M, Aghajanian GK, Charney D, Krystal J. The role of serotonin in the pathophysiology and treatment of schizophrenia. Journal Of Neuropsychiatry 1997, 9: 1-17. PMID: 9017523, DOI: 10.1176/jnp.9.1.1.Peer-Reviewed Original ResearchConceptsRole of serotoninBeneficial effectsSubcortical dopamine activityCerebrospinal fluid studiesCortex of patientsTreatment of schizophreniaBrain tissue analysisSerotonergic hypofunctionDopaminergic antagonistsPharmacological challengeDopamine activityNegative symptomsFluid studiesSchizophreniaPathophysiologySerotoninIllnessTissue analysisTreatmentMore researchAntagonismCompelling evidenceHypofunctionPatientsAntagonist
1995
A critical period for long-term potentiation at thalamocortical synapses
Crair M, Malenka R. A critical period for long-term potentiation at thalamocortical synapses. Nature 1995, 375: 325-328. PMID: 7753197, DOI: 10.1038/375325a0.Peer-Reviewed Original ResearchConceptsLong-term potentiationThalamocortical synapsesNMDA receptor-mediated synaptic currentsN-methyl-D-aspartate receptor-dependent long-term potentiationReceptor-mediated synaptic currentsCritical periodRat somatosensory cortexActivity-dependent processesSomatosensory cortexThalamic axonsCortical circuitryNormal connectivitySynaptic currentsTopographical projectionSynaptic connectionsWhisker barrelsLoss of susceptibilitySensory perturbationsLTPPotentiationCortexSynapsesNormal developmentCompelling evidenceLikely mechanismChloride-dependent Na-H Exchange A NOVEL MECHANISM OF SODIUM TRANSPORT IN COLONIC CRYPTS*
Rajendran V, Geibel J, Binder H. Chloride-dependent Na-H Exchange A NOVEL MECHANISM OF SODIUM TRANSPORT IN COLONIC CRYPTS*. Journal Of Biological Chemistry 1995, 270: 11051-11054. PMID: 7744735, DOI: 10.1074/jbc.270.19.11051.Peer-Reviewed Original ResearchConceptsNa-H exchangeColonic crypt cellsCrypt cellsAcid loadRat distal colonApical membrane vesiclesNovel transport processRate of intracellularDistal colonMM amilorideSodium transportApical membraneGradient stimulationColonic cryptsAmiloride inhibitionSodium movementNovel mechanismOutward gradientCompelling evidenceCellsSodiumUptakePrior studiesColonRecovery
1994
Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon
Rajendran V, Binder H. Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon. The Journal Of Membrane Biology 1994, 141: 51-58. PMID: 7966245, DOI: 10.1007/bf00232873.Peer-Reviewed Original ResearchConceptsRat distal colonFatty acid stimulationDistal colonShort-chain fatty acidsNa-H exchangeActive chloride absorptionHalf maximal inhibitory concentrationAcid stimulationApical membrane vesiclesChain fatty acidsChloride absorptionFatty acid exchangeCl- gradientInhibitory concentrationOutward Cl gradientButyrate concentrationExtravesicular ClColonCellular modelMembrane vesiclesFatty acidsStimulationFunctional NaDisulfonic acidCompelling evidence
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