2025
The Impact of Cognitive Impairment on Cardiovascular Disease
Jamil Y, Krishnaswami A, Orkaby A, Stimmel M, Brown Iv C, Mecca A, Forman D, Rich M, Nanna M, Damluji A. The Impact of Cognitive Impairment on Cardiovascular Disease. Journal Of The American College Of Cardiology 2025, 85: 2472-2491. PMID: 40562512, DOI: 10.1016/j.jacc.2025.04.057.Peer-Reviewed Original ResearchConceptsImpact of cognitive impairmentCognitive impairmentCardiovascular diseaseHealth care utilizationOlder adult populationEvidence-based management strategiesMedical adverse eventsHealth literacyCare utilizationOlder adultsMitigate cognitive impairmentUnder-prescribedReduced participationU.S. populationTreatment of patientsAdult populationGuideline-directedExcess morbidityCardiac patientsRisk factorsOlder patientsAdverse eventsHealthMechanism of cognitive impairmentInterventional managementA Review of the Evidence Surrounding Popular Cognitive Enhancers
Draghmeh K, Elmarasi M, Fuehrlein B. A Review of the Evidence Surrounding Popular Cognitive Enhancers. Current Psychopharmacologye 2025, 13 DOI: 10.2174/0122115560363501250609121229.Peer-Reviewed Original ResearchNetwork-wide aberrancies in neuronal activity during working memory in a large cohort of patients with mood disorders: associations with cognitive impairment and functional disability
Damgaard V, Schandorff J, Macoveanu J, Sankar A, Zarp J, Fisher P, Jørgensen M, Kessing L, Knudsen G, Frokjaer V, Miskowiak K. Network-wide aberrancies in neuronal activity during working memory in a large cohort of patients with mood disorders: associations with cognitive impairment and functional disability. Molecular Psychiatry 2025, 1-9. PMID: 40527901, DOI: 10.1038/s41380-025-03078-x.Peer-Reviewed Original ResearchCognitive control networkFunctional magnetic resonance imagingMood disordersCognitive performanceHypo-activityCross-sectional functional magnetic resonance imagingWorking memory n-back taskCognitive impairmentHyper-activityRight middle frontal gyrusLeft dorsolateral prefrontal cortexDaily functioningHealthy controlsDorsolateral prefrontal cortexFrontal medial cortexN-back taskMiddle frontal gyrusAssociated with cognitive impairmentAssociated with cognitionComprehensive neurocognitive testingAssessment of daily functionCognitive controlDMN abnormalitiesPrefrontal cortexFrontal gyrusMultivariate associations between structural brain changes and cognitive impairment in partially or fully remitted persons with bipolar disorder
Schandorff J, Madsen A, Damgaard V, Little B, Sankar A, Macoveanu J, Frokjaer V, Kessing L, Jørgensen M, Knudsen G, Gallagher P, Miskowiak K. Multivariate associations between structural brain changes and cognitive impairment in partially or fully remitted persons with bipolar disorder. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2025, 140: 111425. PMID: 40505718, DOI: 10.1016/j.pnpbp.2025.111425.Peer-Reviewed Original ResearchBipolar disorderGray matter volumeCognitive impairmentMatter volumeBrain structuresReduced gray matter volumeExtensive cognitive test batteryLower gray matter volumeStructural magnetic resonance imagingBrain structural alterationsCognitive test batteryPosterior cingulate regionsStructural brain changesLeft caudate nucleusCanonical correlation analysisRemitted personsVerbal learningWorking memoryExecutive functionPsychomotor speedCingulate regionsCognitive domainsRight hippocampusCognitively impaired personsBrain changesPredicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models
O’Neill A, Pax M, Parent J, Sepulcre J, Camprodon J, Noble S, Roffman J, Eryilmaz H. Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models. NPP—Digital Psychiatry And Neuroscience 2025, 3: 11. PMID: 40475845, PMCID: PMC12133584, DOI: 10.1038/s44277-025-00032-1.Peer-Reviewed Original ResearchConnectome-based predictive modelingEarly psychosisCognitive functionGoal of precision psychiatryPredictors of cognitive functionPrediction of cognitive functionPredicting cognitive performancePredicting cognitive functionModels of cognitionConnectome-based modelsPersonalized treatment developmentBrain connectivity patternsImpact functional outcomesHuman Connectome ProjectFluid cognitionPsychotic disordersSomatomotor networkCognitive abilitiesCognitive performancePrecision psychiatryVirtual lesion analysisTreatment developmentPsychosisCognitive outcomesCognitive impairment‘I just feel so unloved’: using grounded theory to explore adult children’s experiences of unresponsiveness from their parents living with dementia
Wood K, Suizzo M, Monin J, Crasta D, Lum H. ‘I just feel so unloved’: using grounded theory to explore adult children’s experiences of unresponsiveness from their parents living with dementia. Aging & Mental Health 2025, ahead-of-print: 1-9. PMID: 40444297, DOI: 10.1080/13607863.2025.2508757.Peer-Reviewed Original ResearchAdult child caregiversCaregiver supportChild caregiversSemi-structured video interviewsCaregiver mental healthCaregivers of parentsPositive coping strategiesAdult children's experiencesDementia prevalenceTwelve caregiversSelf-careSelf-imageMental healthCaregiversCoping strategiesDementiaGrounded theoryEmotional painCognitive impairmentDisorganized attachment patternSelf-worthChild developmentVideo interviewsIntense emotional painTheory studyImpact of Polygenic Interactions With Anticholinergic Burden on Cognition and Brain Structure in Psychosis Spectrum Disorders.
Zhang L, Ivleva E, Parker D, Hill S, Lizano P, Keefe R, Keedy S, McDowell J, Pearlson G, Clementz B, Keshavan M, Gershon E, Tamminga C, Sweeney J, Bishop J. Impact of Polygenic Interactions With Anticholinergic Burden on Cognition and Brain Structure in Psychosis Spectrum Disorders. American Journal Of Psychiatry 2025, appiajp20240709. PMID: 40432343, DOI: 10.1176/appi.ajp.20240709.Peer-Reviewed Original ResearchReduced gray matter volumePsychosis spectrum disordersGray matter volumeBrain structuresPolygenic scoresPsychotic disordersMatter volumeImpact cognitionSpectrum disorderBrief Assessment of CognitionCognitive impairmentGray matter volume reductionBipolar-Schizophrenia NetworkBrain structural outcomesAssessment of CognitionBrain structure phenotypesAnticholinergic burdenPrimary cognitive outcomeGene-by-environment interactionsModerated mediation modelBrief AssessmentBipolar disorderStructural neuroimagingPsychiatric conditionsCognitive abilitiesDevelopment and Validation of Models to Estimate the Incident Risk of Cognitive Impairment and Atherosclerotic Cardiovascular Disease in Older Adults.
Nanna M, Wojdyla D, Peterson E, Navar A, Williamson J, Colantonio L, Wang S, Jamil Y, Bertoni A, Nahid M, Damluji A, Goyal P, Chaudhry S, Gill T, Alexander K. Development and Validation of Models to Estimate the Incident Risk of Cognitive Impairment and Atherosclerotic Cardiovascular Disease in Older Adults. Journal Of The American Heart Association 2025, 14: e038949. PMID: 40401627, DOI: 10.1161/jaha.124.038949.Peer-Reviewed Original ResearchConceptsRisk of cognitive impairmentAtherosclerotic cardiovascular disease eventsAtherosclerotic cardiovascular diseaseRisk prediction modelCognitive impairmentOlder adultsMeasures of healthIncident cognitive impairmentOlder person's riskPooled Cohort EquationsCardiovascular diseaseRisk of deathCohort EquationsFramingham OffspringOlder personsExternal validationFunctional statusPersonal riskIncidence riskValidation cohortYoung adultsInternal validityFraminghamCohortTreatment decisionsSex differences in event-related potentials and their clinical predictive value in first-episode antipsychotic-naïve schizophrenia
Qin Q, Lu C, Li S, Liu N, Li Y, Li T, Dong Y, Wang X, Li S, Li J, Zhang X. Sex differences in event-related potentials and their clinical predictive value in first-episode antipsychotic-naïve schizophrenia. European Archives Of Psychiatry And Clinical Neuroscience 2025, 1-10. PMID: 40397181, DOI: 10.1007/s00406-025-02020-0.Peer-Reviewed Original ResearchPositive and Negative Syndrome ScaleHamilton Depression ScaleHamilton Anxiety ScaleReduced P3 amplitudeHamilton Anxiety Scale scoresEvent-related potentialsSex differencesP3 amplitudeP3a latencyHealthy controlsN1 amplitudeAntipsychotic-naive schizophreniaGeneral psychopathology scoreNegative Syndrome ScaleHamilton Depression Scale scoresAuditory oddball paradigmSyndrome ScaleCompare sex differencesProlonged latencyPsychopathology scoresP3 componentN100 amplitudeAnxiety ScaleOddball paradigmCognitive impairmentElevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer’s disease continuum
Nasiri H, Azargoonjahromi A, Nouri Z, Azimi S, Zand H, Shourideh A, Heydari S, Mahmoudvand B, Barabadi S, Samadpour N, Mohamadhosseini A, Khodadadi A, Shakeri S, Mayeli M, Initiative F. Elevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer’s disease continuum. Neuroscience 2025, 577: 47-53. PMID: 40348165, DOI: 10.1016/j.neuroscience.2025.05.013.Peer-Reviewed Original ResearchConceptsCognitive performanceBrain volumeMediation analysisAlzheimer's Disease Assessment Scale-cognitive subscaleReduced gray matterGray matter volumeStructural brain volumesAssociated with cognitive impairmentAlzheimer's diseaseGray matterMagnetic resonance imagingPoor cognitive outcomesAlzheimer's disease continuumMatter volumeT1-weighted magnetic resonance imagingBrain structuresCognitive outcomesCerebral volumeCognitive impairmentCognitive declineBrain atrophyAD continuumBrainSerum leucine levelsAD pathology[Association between physical activity and cognitive impairment in older adults aged 65 years and above in longevity areas of China].
Xu H, Wu Y, Chen C, Meng X, Chen J, Zhang Z, Zhong Z, Yang J, Fu X, Chen S, Chen Y, Li Z, Ye L, Shi X, Lyu Y. [Association between physical activity and cognitive impairment in older adults aged 65 years and above in longevity areas of China]. Chinese Journal Of Epidemiology 2025, 46: 753-760. PMID: 40494781, DOI: 10.3760/cma.j.cn112338-20250124-00060.Peer-Reviewed Original ResearchConceptsLevels of physical activityPhysical activityOlder adultsCognitive impairmentIntensity levels of physical activityIntensity of physical activityPhysical Activity ScaleChronic disease historyWork-related activitiesMultifactorial logistic regression modelsLogistic regression modelsMini-MentalBiomarkers Cohort StudyChinese versionActivity ScaleActive leisureCohort studyLongevity areasDemographic characteristicsHealthy agingDisease historyHousehold activitiesRegression modelsCognitive functionNegative associationCombining transcranial direct current stimulation with music therapy improves cognitive function in schizophrenia: study protocol for a randomized, double-blind, sham-controlled clinical trial
Wei Y, He S, Luo P, Su H, Chen Y, Qin S, Zhang Z, Liu R, Wei D, Wang J, Wang F, Wang C. Combining transcranial direct current stimulation with music therapy improves cognitive function in schizophrenia: study protocol for a randomized, double-blind, sham-controlled clinical trial. Frontiers In Psychiatry 2025, 16: 1543789. PMID: 40417274, PMCID: PMC12100747, DOI: 10.3389/fpsyt.2025.1543789.Peer-Reviewed Original ResearchMusic therapyQuality of lifeTranscranial direct current stimulationCognitive impairmentCognitive functionMT groupProtocol registration numberSham-controlled clinical trialSecond Affiliated Hospital of Xinxiang Medical UniversityEnhance cognitive functionResearch Ethics CommitteeChinese classical musicPrimary outcome measureDirect current stimulationSham-controlled trialActive transcranial direct current stimulationCombined interventionSham transcranial direct current stimulationOutcome measuresClassical musicSecondary outcomesEfficacy of transcranial direct current stimulationStudy protocolRegistration numberSocial functioning32. Cognitive Impairment in Patients With Early Onset Psychosis and Their Siblings: Age and Sex Differences
Mollon J, Lanzagorta N, Mathias S, Rodrigue A, Knowles E, Deaso E, Saavedra J, Cadavid L, Polat N, Nieto M, Brownstein C, D’Angelo E, Deo A, Gonzalez-Heydrich J, Sarmiento E, Walsh C, Almasy L, Nicolini H, Glahn D. 32. Cognitive Impairment in Patients With Early Onset Psychosis and Their Siblings: Age and Sex Differences. Biological Psychiatry 2025, 97: s87-s88. DOI: 10.1016/j.biopsych.2025.02.222.Peer-Reviewed Original ResearchRegional disparities in cognitive life expectancy: The role of birth and current residence in the United States
Wong J, Zang E. Regional disparities in cognitive life expectancy: The role of birth and current residence in the United States. Health & Place 2025, 94: 103475. PMID: 40311376, DOI: 10.1016/j.healthplace.2025.103475.Peer-Reviewed Original ResearchConceptsCognitive impairment riskCurrent residenceLife expectancyCognitive impairmentMultistate life table approachHealth and Retirement StudyRegional disparitiesHealthy life expectancyImpairment riskImpact of birthLong-term healthLife table approachPercentage of lifeRetirement StudyImpaired life expectancyEstimate yearsBirth regionDementiaPolicy implicationsCombination of birthCognitive declineResidentsHealthDisparitiesBirthCerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum
Sritharan J, Zeng V, Petr J, Mutsaerts H, Hoang D, Bolo N, Ivleva E, Dai W, Gershon E, Keedy S, Parker D, Trotti R, McDowell J, Clementz B, Tamminga C, Pearlson G, Keshavan M, Lizano P. Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum. Frontiers In Psychiatry 2025, 16: 1566184. PMID: 40365009, PMCID: PMC12069394, DOI: 10.3389/fpsyt.2025.1566184.Peer-Reviewed Original ResearchPsychosis spectrum disordersFusiform gyrusSchizoaffective disorderPseudo-continuous arterial spin-labeling scansCerebral blood flowOccipital lobeOverall cognitive performanceArterial spin labeling scansGray matter cerebral blood flowPsychosis spectrumBipolar disorderCognitive measuresCognitive performancePsychosisSpectrum disorderDiagnostic groupsPerfusion differencesVisual processingCognitive impairmentVisual hallucinationsCytoarchitectonic subregionsPerfusion alterationsLabeling scansSchizophreniaHealthy controlsEffects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study
Baker L, Pa J, Katula J, Aslanyan V, Salmon D, Jacobs D, Chmelo E, Hodge H, Morrison R, Matthews G, Brewer J, Jung Y, Rissman R, Taylor C, Léger G, Messer K, Evans A, Okonkwo O, Shadyab A, Zou J, Jin S, Thomas R, Zhang J, La Croix A, Cotman C, Feldman H, Group F. Effects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study. Alzheimer's & Dementia 2025, 21: e14586. PMID: 40271888, PMCID: PMC12019696, DOI: 10.1002/alz.14586.Peer-Reviewed Original ResearchConceptsSedentary older adultsAmnestic mild cognitive impairmentIntensity aerobic trainingMild cognitive impairmentEffects of exerciseRandomized controlled trialsIntervention deliveryAerobic trainingOlder adultsMonths of supervised exerciseCognitive impairmentMultisite randomized controlled trialCognitive trajectoriesLower-intensity exerciseMeasure of global cognitive functionRandomized controlled trials of adultsTests of executive functionIntervention group differencesMeasures of brain healthAssess intervention efficacyGlobal cognitive functionGlobal cognitive compositeMild cognitive impairment groupSupervised exerciseMild memory problemsEffects of exercise versus usual care on older adults with amnestic mild cognitive impairment: EXERT versus ADNI
Shadyab A, Aslanyan V, Jacobs D, Salmon D, Morrison R, Katula J, Jin S, Thomas R, LaCroix A, Pa J, Cotman C, Feldman H, Baker L, Group F. Effects of exercise versus usual care on older adults with amnestic mild cognitive impairment: EXERT versus ADNI. Alzheimer's & Dementia 2025, 21: e70118. PMID: 40271887, PMCID: PMC12019695, DOI: 10.1002/alz.70118.Peer-Reviewed Original ResearchConceptsUsual careRandomized controlled trialsAmnestic mild cognitive impairmentOlder adultsMild cognitive impairmentADNI-1Multisite randomized controlled trialNo interventionSedentary older adultsIntensity aerobic trainingAlzheimer's Disease Neuroimaging Initiative 1Moderate-high intensityEffects of exerciseCognitive declineCognitive impairmentFlexibility exercisesExercise armAerobic trainingAD-signature regionsExertion groupCognitive trajectoriesExertionCarePost hoc analysisExerciseFamily cohesion and conflict in the context of adult children and parents living with early-stage cognitive impairment
Wang Z, Wang K, Monin J. Family cohesion and conflict in the context of adult children and parents living with early-stage cognitive impairment. Aging & Mental Health 2025, ahead-of-print: 1-7. PMID: 40271652, DOI: 10.1080/13607863.2025.2495282.Peer-Reviewed Original ResearchAdult child caregiversEarly-stage cognitive impairmentFamily relationshipsFamily conflictFamily cohesionPhysical healthMental healthAssociated with child mental healthCaregivers of older adultsStructural family theorySupportive family relationshipsImpaired self-reportedAssociated with caregiversChild mental healthRisk of burnoutCognitive impairmentAdult childrenSecondary data analysisAssociated with childrenFamily theoryCaregiving demandsFamily dynamicsTailored interventionsOlder adultsCaregiversElevated serum cortisol associated with early‐detected increase of brain amyloid deposition in Alzheimer's disease imaging biomarkers among menopausal women: The Framingham Heart Study
Salardini A, Himali J, Abdullah M, Chaudhari R, Young V, Zilli E, McGrath E, Gonzales M, Thibault E, Salinas J, Aparicio H, Himali D, Ghosh S, Buckley R, Satizabal C, Johnson K, DeCarli C, Fakhri G, Vasan R, Beiser A, Seshadri S. Elevated serum cortisol associated with early‐detected increase of brain amyloid deposition in Alzheimer's disease imaging biomarkers among menopausal women: The Framingham Heart Study. Alzheimer's & Dementia 2025, 21: e70179. PMID: 40271551, PMCID: PMC12019305, DOI: 10.1002/alz.70179.Peer-Reviewed Original ResearchConceptsPost-menopausal womenFramingham Heart Study participantsIncreased risk of ADFramingham Heart StudyRisk of ADNo significant associationHeart StudyEarly risk factorsStudy participantsMenopausal statusMultivariate regression analysisApolipoprotein E4Significant associationAlzheimer's diseaseIncreased riskRisk factorsCognitive impairmentMenopausal womenBrain amyloid depositionRegression analysisWomenAnalyzed dataPositron emission tomographyIncreased amyloid depositionBurdenDetection and differentiation of undiagnosed dementia in the emergency department: A pilot referral pathway
Gettel C, Galske J, Araujo K, Dresden S, Dussetschleger J, Iannone L, Lai J, Martin P, Mignosa B, Muschong K, Safdar B, Weintraub S, Hwang U. Detection and differentiation of undiagnosed dementia in the emergency department: A pilot referral pathway. Alzheimer's & Dementia 2025, 21: e70189. PMID: 40257011, PMCID: PMC12010273, DOI: 10.1002/alz.70189.Peer-Reviewed Original ResearchConceptsEmergency departmentClinician referralED cliniciansOutpatient referralsCognitive impairmentOutpatient evaluationCognitive evaluationOlder adult patientsUndiagnosed dementiaReferral pathwaysReporting such issuesEmergency careFollow-upReferral ratesCI screeningCognitive screeningOutpatient follow-upTelephone interviewsED patientsReferral statusReferralFollow-up challengesDementiaChart reviewOlder patients
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