2025
Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses
Pathak G, Pietrzak R, Lacobelle A, Overstreet C, Wendt F, Deak J, Friligkou E, Nunez Y, Montalvo-Ortiz J, Levey D, Kranzler H, Gelernter J, Polimanti R. Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses. Molecular Psychiatry 2025, 1-9. PMID: 40247127, DOI: 10.1038/s41380-025-03031-y.Peer-Reviewed Original ResearchSubstance dependence diagnosesLatent class analysisDependence diagnosisLatent classesComorbidity patternsPolygenic scoresPolygenic overlapSD diagnosisPsychosocial traitsEpigenetic mechanismsClass analysisEpigenome-wide significant associationsEpigenome-wide association analysisCo-occurrenceTraitsIndividualsAssociated with CpG sitesAssociationComorbidityTDSD patternSubstancesEpigenome-wide changesIndividuals of European descentSignificant associationGambling disorder and problematic pornography use: Does co-occurrence influence treatment outcome?
Mestre-Bach G, Potenza M, Granero R, Håkansson A, Gómez-Peña M, Perales I, Vicó À, Uríszar J, Fernández-Aranda F, Sánchez I, Jiménez-Murcia S. Gambling disorder and problematic pornography use: Does co-occurrence influence treatment outcome? Journal Of Behavioral Addictions 2025, 14: 465-479. PMID: 40116860, PMCID: PMC11974433, DOI: 10.1556/2006.2025.00023.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapyGambling disorderPornography useEmotion regulationGD severityTreatment outcomesCognitive-behavioral therapy approachCognitive-behavioral therapy sessionsTreatment outcomes of individualsCo-occurrence of GDCo-occurrenceMental health concernsImprove treatment adherenceBehavioral addictionsTreatment dropoutOutcomes of individualsWeekly sessionsTreatment adherencePsychopathologyGamblingSessionsDisordersAssociated with higher likelihoodRelapseImpulseSpecificity, Co-Occurrence, and Growth: Math and Reading Skill Development in Children With Learning Disabilities.
Connors K, Guertin E, Nichol M, Bosson-Heenan J, Gruen J, Frijters J. Specificity, Co-Occurrence, and Growth: Math and Reading Skill Development in Children With Learning Disabilities. Journal Of Learning Disabilities 2025, 222194241312189. PMID: 39924773, DOI: 10.1177/00222194241312189.Peer-Reviewed Original ResearchLearning disabilitiesMath disabilitiesReading disabilityCo-occurring disabilitiesDomain-specificReading skills of childrenGrade 1 childrenCo-occurrenceGroup-level differencesSkills of childrenTrajectories of childrenMath deficitsMath difficultiesGrowth trajectories of childrenMath interventionReading skillsReading trajectoriesSkill growthPatterns of childrenImpairment levelMathDisabilityImpairmentLinear mixed-effects modelsElementary schoolDual Diagnosis
Caldwell E, Obiozor C, Kofos M, Martell J, Agerwala S, Petrakis I. Dual Diagnosis. 2025, 706-712. DOI: 10.1016/b978-0-323-95702-1.00275-x.Peer-Reviewed Original ResearchSubstance use disordersPsychiatric conditionsComorbid psychiatric conditionsAnxiety disordersPsychotic disordersStress disorderMood disordersAttention deficitHyperactivity disorderUse disorderEating disordersMental illnessDisordersCo-occurrenceMoodAnxietyHyperactivityNicotineSubstancesDeficitsIllnessProfessional individualsAlcohol
2024
Social Anxiety Reduces Visual Attention to the Eyes of Emotional Faces in Autistic Youth
Franke C, Griffin J, Naples A, Wolf J, McPartland J. Social Anxiety Reduces Visual Attention to the Eyes of Emotional Faces in Autistic Youth. Journal Of Autism And Developmental Disorders 2024, 1-13. PMID: 39556296, DOI: 10.1007/s10803-024-06636-4.Peer-Reviewed Original ResearchNon-autistic participantsSocial attentionSocial anxietyEye contactAutistic youthEyes of emotional facesSA characteristicsEye trackingReduced eye contactSelf-reported SAReduced visual attentionNon-autistic childrenEmotional facesAutistic participantsPsychiatric characteristicsNon-autistic youthAutistic individualsEmotional expressionVisual attentionEye regionBehavioral featuresSocial interactionAutismParticipantsCo-occurrenceNerve growth factor gene polymorphisms may be associated with heroin dependence in women but do not mediate specific personality traits
Kuo S, Lin C, Tsou C, Yeh Y, Yang B, Chen C, Huang C, Huang S. Nerve growth factor gene polymorphisms may be associated with heroin dependence in women but do not mediate specific personality traits. European Archives Of Psychiatry And Clinical Neuroscience 2024, 275: 487-498. PMID: 39311999, PMCID: PMC11976897, DOI: 10.1007/s00406-024-01906-9.Peer-Reviewed Original ResearchTridimensional Personality QuestionnairePersonality traitsHeroin dependenceHarm avoidanceBarratt Impulsiveness Scale version 11Tridimensional Personality Questionnaire scoresTrait of impulsivityAssociated with heroin dependenceChinese versionBIS-11Reward processingPersonality QuestionnaireAssociated with traitsFemale HD patientsNeurotrophic factors nerve growth factorFemale subgroupPotential confounding effectsHD patientsGenetic contributionPersonsTraitsCo-occurrenceGene polymorphismsVersion 11Confounding effectsStatistical predictors of the co-occurrence between gambling disorder and problematic pornography use
Mestre-Bach G, Potenza M, Granero R, Uríszar J, Fernández-Aranda F, Jiménez-Murcia S. Statistical predictors of the co-occurrence between gambling disorder and problematic pornography use. Journal Of Psychiatric Research 2024, 178: 125-129. PMID: 39137720, DOI: 10.1016/j.jpsychires.2024.07.033.Peer-Reviewed Original ResearchProblematic pornography useCo-occurrence of GDGambling disorderEmotion dysregulationEmotion regulationImpulsivity levelsStructural equation modelingPornography useMaladaptive personality featuresCo-occurrenceHighest impulsivity levelProblematic Pornography Consumption ScaleMaladaptive personalityPsychopathological distressPersonality measuresMental disordersPersonality featuresShort versionPsychopathologyStatistical predictorsEquation modelingDisordersImpulseSociodemographic variablesYounger ageSubunit-specific analysis of cohesin-mutant myeloid malignancies reveals distinct ontogeny and outcomes
Jann J, Hergott C, Winkler M, Liu Y, Braun B, Charles A, Copson K, Barua S, Meggendorfer M, Nadarajah N, Shimony S, Winer E, Wadleigh M, Stone R, DeAngelo D, Garcia J, Haferlach T, Lindsley R, Luskin M, Stahl M, Tothova Z. Subunit-specific analysis of cohesin-mutant myeloid malignancies reveals distinct ontogeny and outcomes. Leukemia 2024, 38: 1992-2002. PMID: 39033241, PMCID: PMC11347381, DOI: 10.1038/s41375-024-02347-y.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaDana-Farber Cancer InstituteMyelodysplastic neoplasmsCohesin complex componentSubunit specificityAssociated with secondary AMLCohesin complexDe novo acute myeloid leukemiaSecondary acute myeloid leukemiaComplex mutationsCohesinGenetic driversGenetic characteristicsSTAG2 mutationsCo-occurrenceSubunit mutationsMutationsMyeloid malignanciesPrognostic significanceAdverse prognosisPrognostic classificationMyeloid leukemiaClinical characteristicsDana-FarberOntogenyFamily Accommodation in Anxious Irritable and Anxious Nonirritable Youth
Budagzad-Jacobson R, Musicaro R, Marin C, Silverman W, Lebowitz E. Family Accommodation in Anxious Irritable and Anxious Nonirritable Youth. Behavior Therapy 2024, 55: 913-921. PMID: 39174269, PMCID: PMC11341947, DOI: 10.1016/j.beth.2024.03.003.Peer-Reviewed Original ResearchFamily accommodationIrritable youthYouth anxietyParent ratingsCo-occurrence of anxietyLevels of irritabilityInfluence of irritabilityClinic-referredAnxiety disordersDiagnostic InterviewChild anxietyYouth ratingsAnxietyAccommodation behaviorAnxiety levelsTreatment targetModerating effectIrritability levelsYouthCo-occurrenceParentsIrritationDisordersFindingsAssociationHealth and psychiatric impairment associated with moral injury, military sexual trauma, and their co-occurrence in U.S. combat veterans
Nichter B, Hill M, Maguen S, Norman S, Fischer I, Pietrzak R. Health and psychiatric impairment associated with moral injury, military sexual trauma, and their co-occurrence in U.S. combat veterans. Journal Of Psychosomatic Research 2024, 179: 111617. PMID: 38394711, DOI: 10.1016/j.jpsychores.2024.111617.Peer-Reviewed Original ResearchMilitary sexual traumaExposure to military sexual traumaU.S. combat veteransCombat veteransMoral injurySexual traumaNational Health and ResilienceSeverity of posttraumatic stressPast-year suicidal ideationPrevalence of military sexual traumaPhysical health comorbiditiesCo-occurrenceChronic medical conditionsGeneralized anxietyPopulation-based studyPosttraumatic stressSuicidal ideationVeterans StudySomatic complaintsPsychosocial functioningInsomnia symptomsMilitary veteransLifetime prevalencePMIEsHealth comorbidities
2023
Depressive symptoms, alcohol use, and alcohol-related consequences: the moderating role of gender among American Indian adolescents
Schick M, Hostetler K, Kirk-Provencher K, Spillane N. Depressive symptoms, alcohol use, and alcohol-related consequences: the moderating role of gender among American Indian adolescents. Journal Of Ethnicity In Substance Abuse 2023, 24: 393-409. PMID: 37222686, PMCID: PMC10667562, DOI: 10.1080/15332640.2023.2216162.Peer-Reviewed Original ResearchAlcohol-related consequencesDepressive symptomsAlcohol use frequencyAlcohol useAI adolescentsAssociated with alcohol-related consequencesInteraction of depressive symptomsCo-occurrence of depressionTreatment of alcohol useReducing alcohol useSelf-report questionnairesLifetime alcohol useAmerican Indian adolescentsAssociated with increased riskGender-sensitive recommendationsIntervention effortsEvaluate gender differencesModerating roleAdolescentsGender differencesIndian adolescentsNear reservationsDepressionSymptomsCo-occurrence
2020
Alcohol misuse to down-regulate positive emotions: A cross-sectional multiple mediator analysis among US military veterans
Weiss N, Forkus S, Raudales A, Schick M, Contractor A. Alcohol misuse to down-regulate positive emotions: A cross-sectional multiple mediator analysis among US military veterans. Addictive Behaviors 2020, 105: 106322. PMID: 32006684, PMCID: PMC7059215, DOI: 10.1016/j.addbeh.2020.106322.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPositive emotional avoidanceCo-occurrence of posttraumatic stress disorderUS military veteransPosttraumatic stress disorder symptomsEmotional avoidancePositive emotional intensityMilitary veteransAlcohol misuseEmotional intensityPositive emotionsPosttraumatic stress disorder symptomatologyDown-regulate positive emotionsMultiple mediation analysisCo-occurrenceFindings advance theoryClinically relevant concernStress disorderEmotional dysfunctionMediation analysisVeteransAvoidanceEmotionsAlcoholMisuse
2019
Posttraumatic stress disorder and substance use: Identifying the underlying role of difficulties regulating positive emotions
Weiss N, Schick M, Contractor A, Dixon-Gordon K. Posttraumatic stress disorder and substance use: Identifying the underlying role of difficulties regulating positive emotions. Addictive Behaviors 2019, 96: 119-126. PMID: 31075729, DOI: 10.1016/j.addbeh.2019.04.029.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorder symptom severityDifficulties regulating positive emotionsPosttraumatic stress disorderSymptom severityPositive emotionsSubstance useEmotion dysregulationAlcohol useStress disorderCo-occurrence of posttraumatic stress disorderPositive zero-order correlationsDrug useTrauma-exposed individualsZero-order correlationsReduce substance useNegative emotionsEmotionsAmazon MTurkCo-occurrenceDisordersAlcoholDysregulationPotential utilitySeverityDifficultiesDepression and risky alcohol use: an examination of the role of difficulties regulating positive emotions in trauma-exposed individuals
Schick M, Weiss N, Contractor A, Dixon-Gordon K, Spillane N. Depression and risky alcohol use: an examination of the role of difficulties regulating positive emotions in trauma-exposed individuals. The American Journal Of Drug And Alcohol Abuse 2019, 45: 323-332. PMID: 30848960, PMCID: PMC6450725, DOI: 10.1080/00952990.2019.1572759.Peer-Reviewed Original ResearchConceptsDepressive symptom severityRisky alcohol useSymptom severityAlcohol useEmotion dysregulationPositive emotionsDifficulties regulating positive emotionsCo-occurrence of depressionTrauma-exposed adultsEmotion regulation skillsRates of comorbidityZero-order correlationsSelf-report questionnairesImpulsive behaviorRegulation skillsAmazon Mechanical TurkNegative emotionsDepressionEmotionsMechanical TurkSubscalesCo-occurrenceDysregulationSeverityDifficulties
2018
Mental Illness and Substance Use Disorders Among Homeless Veterans
Gabrielian S, Gores A, Gelberg L, Tsai J. Mental Illness and Substance Use Disorders Among Homeless Veterans. 2018, 35-60. DOI: 10.1093/oso/9780190695132.003.0003.Peer-Reviewed Original ResearchSubstance use disordersMental illnessHomeless veteransPsychiatric disordersInfluence of psychiatric disordersVeterans with mental illnessFactors associated with homelessnessAbstract Mental illnessMental health problemsHousing outcomesUse disorderVeteran statusVeteransHealth problemsUnited States Armed ForcesDisordersRisk factorsIllnessEpidemiological dataHomelessnessCo-occurrenceStates Armed ForcesQuantitative dataOutcomesArmed forces
2015
The analysis of semantic networks in multiple sclerosis identifies preferential damage of long-range connectivity
Abad E, Sepulcre J, Martinez-Lapiscina E, Zubizarreta I, Garcia-Ojalvo J, Villoslada P. The analysis of semantic networks in multiple sclerosis identifies preferential damage of long-range connectivity. Multiple Sclerosis And Related Disorders 2015, 4: 387-394. PMID: 26346784, DOI: 10.1016/j.msard.2015.07.002.Peer-Reviewed Original Research
2014
Abstract PR04: Cooperation between Ras network mutations in cancer
Stites E, Trampont P, Haney L, Walk S, Ravichandran K. Abstract PR04: Cooperation between Ras network mutations in cancer. Molecular Cancer Research 2014, 12: pr04-pr04. DOI: 10.1158/1557-3125.rasonc14-pr04.Peer-Reviewed Original ResearchRas signaling networkSignaling networksGenomic dataRAS pathway mutationsRas mutantsNetwork mutationGenomic data setsCancer Cell Line EncyclopediaCancer genome sequencingPathway mutationsTumor suppressor gene NF1Wild-type cellsCancer genomic dataGenome sequenceTumor suppressor gene mutationsCancer Genome AtlasGene NF1Cell-based experimentsDisplay synergyMutational pathwaysRAS networkRas oncogeneCo-occurrenceMutationsRas
2002
Eating Disorders and Alcohol Use Disorders
Grilo C, Sinha R, O’Malley S. Eating Disorders and Alcohol Use Disorders. Alcohol Research 2002, 26: 151-160. PMCID: PMC6683826.Peer-Reviewed Original Research
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