2025
Diagnosis and management of cardiogenic shock.
Bellumkonda L. Diagnosis and management of cardiogenic shock. Current Opinion In Critical Care 2025 PMID: 40552838, DOI: 10.1097/mcc.0000000000001288.Peer-Reviewed Original ResearchCardiogenic shockLong-term outcomes of patientsOutcomes of patientsMultidisciplinary team-based approachLong-term outcomesManagement of cardiogenic shockAcute myocardial infarctionOverall prognosisStages of shockInfluence prognosisAggressive managementPoor prognosisRisk stratificationImprove mortalityTreatment strategiesTeam-based approachPhenotypic presentationMyocardial infarctionPrognosisClinical practiceEscalate careDisease processEarly identificationRefining interventionsPatientsPatient-reported outcomes (PROs) in clinical trials and in clinical practice: report from the XXI national conference of the Italian Association of Medical Oncology (AIOM)
Puccini A, Viscardi G, Ciani O, Efficace F, Piattelli A, Beretta G, Petruzzelli D, Popoli P, De Lorenzo F, Longo F, Zibellini M, Gitto L, Brunello A, Maiello E, Servetto A, Pagliuca M, Raimondi A, Marandino L, Cinieri S, Iannelli E, Ripamonti C, Bossi P, Numico G, Latiano T, Pinto C, Quaglini S, Locati L, Gussoni G, Mignone G, Carrera P, Basch E, Di Maio M, Perrone F. Patient-reported outcomes (PROs) in clinical trials and in clinical practice: report from the XXI national conference of the Italian Association of Medical Oncology (AIOM). BMJ Oncology 2025, 4: e000783. PMID: 40546927, PMCID: PMC12182000, DOI: 10.1136/bmjonc-2025-000783.Peer-Reviewed Original ResearchPatient-reported outcomesElectronic PROsFinancial toxicityImplementation of patient-reported outcomesElectronic patient-reported outcomesClinical practiceRoutine oncology careQuality cancer carePatient-centred careDigital health interventionsImpact of patient-reported outcomesTargeted clinician educationPatient well-beingQuality of lifeCancer journeyCancer careOncology careAt-risk patientsItalian AssociationHealth interventionsClinician educationQoL measuresOptimal careConsensus discussionQoL assessmentContraceptive Selection for the Endocrine Patient: What an Endocrinologist Should Know
Zaman A, Lazorwitz A, Wierman M. Contraceptive Selection for the Endocrine Patient: What an Endocrinologist Should Know. Endocrine Reviews 2025, bnaf016. PMID: 40519043, DOI: 10.1210/endrev/bnaf016.Peer-Reviewed Original ResearchContraceptive methodsPregnancy preventionSex steroid replacementHormonal contraceptive methodsHypothalamic-pituitary-gonadal axisBirth control optionsAndrogen suppressionRegular mensesSteroid replacementContraceptive optionsContraceptive usageContraceptive selectionEndocrine patientsEndocrine disordersMetabolic disordersContraceptionEndocrinologistsClinical practiceExogenous hormonesPregnancyPatientsHistory of contraceptionHormoneComprehensive careMedical providersGender Differences in Medicare Practice and Payment of Neuroradiologists.
Malhotra A, Lee C, Khunte M, Futela D, Moily R, Payabvash S, Gandhi D, Wintermark M. Gender Differences in Medicare Practice and Payment of Neuroradiologists. American Journal Of Neuroradiology 2025, 46: 1093-1099. PMID: 40461255, PMCID: PMC12152790, DOI: 10.3174/ajnr.a8633.Peer-Reviewed Original ResearchAddressing international research challenges in child and adolescent mental health during global crises: experience and recommendations of the Co-SPACE international consortium
McMahon J, March S, Oakes M, Silverman W, Creswell C, Rowe A, Rajabi M, Skripkauskaite S. Addressing international research challenges in child and adolescent mental health during global crises: experience and recommendations of the Co-SPACE international consortium. Child And Adolescent Psychiatry And Mental Health 2025, 19: 62. PMID: 40442826, PMCID: PMC12123706, DOI: 10.1186/s13034-025-00918-0.Peer-Reviewed Original ResearchMental healthFamily mental healthMental health researchMental health symptomsAdolescent mental healthPublic health crisisHealth researchHealth symptomsInternational consortiumMobilisation of resourcesLong-term trajectoriesLongitudinal researchRobust evidenceClinical practiceHealth crisisCross-culturallyCompare findingsCOVID-19 pandemicEthical reviewHealthYoung peopleResearch designCountry-level dataEffective supportPandemic impactClinical factors influencing retreatment with anti-PD-(L)1 therapies after treatment in early-stage cancers: a modified Delphi consensus study
Pusztai L, Sondak V, Aguiar-Ibáñez R, Cappuzzo F, Chouaid C, Elder C, Hirasawa Y, Ishida M, Jones R, Lee S, Mizuno R, Nagata M, Okonji D, Parente P, Shah B, Sun A, Ferreira D, Spiteri C, Lauer A, Kaliasethi A, Kao C, Kothari S, McKendrick J. Clinical factors influencing retreatment with anti-PD-(L)1 therapies after treatment in early-stage cancers: a modified Delphi consensus study. Journal For ImmunoTherapy Of Cancer 2025, 13: e011184. PMID: 40425232, PMCID: PMC12107590, DOI: 10.1136/jitc-2024-011184.Peer-Reviewed Original ResearchConceptsAnti-PD-(L)1 treatmentAnti-PD-(L)1Anti-PD-(L)1 therapyEarly-stage cancerAnti-PD-(L)1 agentsRetreatment of patientsAnti-programmed deathTreating early-stage cancersAdjuvant settingMetastatic settingNeoadjuvant settingRetreatment patientsClinical expertsAdjuvant treatmentEarly-stage treatmentRetreatment decisionsClinical factorsRepeated treatmentTherapyCancer typesCancerPatient responseClinical practicePatientsRelapseBleeding Definitions in Pediatric Extracorporeal Membrane Oxygenation (ECMO) Studies: A Systematic Review and Meta-Analysis.
Atchison C, Chegondi M, Aldairi N, Carmona C, Mahmood H, Levasseur J, Funaro M, Faustino E, Nellis M, Willems A, Labarinas S, Karam O. Bleeding Definitions in Pediatric Extracorporeal Membrane Oxygenation (ECMO) Studies: A Systematic Review and Meta-Analysis. ASAIO Journal 2025 PMID: 40397688, DOI: 10.1097/mat.0000000000002468.Peer-Reviewed Original ResearchExtracorporeal membrane oxygenationPrevalence of bleedingExtracorporeal Life Support OrganizationBleeding definitionsMembrane oxygenationChildren treated with extracorporeal membrane oxygenationPooled prevalencePediatric extracorporeal membrane oxygenationSevere cardiorespiratory failureMeta-analysisLife Support OrganizationSystematic reviewBleeding prevalenceBleeding riskCardiorespiratory failureIntracranial bleedingIntracranial hemorrhageControl bleedingBleedingDatabase inceptionClinical practicePrevalenceScreening studiesNeonatesTransfusionGovernance for anti-racist AI in healthcare: integrating racism-related stress in psychiatric algorithms for Black Americans
Fields C, Black C, Thind J, Jegede O, Aksen D, Rosenblatt M, Assari S, Bellamy C, Anderson E, Holmes A, Scheinost D. Governance for anti-racist AI in healthcare: integrating racism-related stress in psychiatric algorithms for Black Americans. Frontiers In Digital Health 2025, 7: 1492736. PMID: 40444183, PMCID: PMC12119476, DOI: 10.3389/fdgth.2025.1492736.Peer-Reviewed Original ResearchRacism-related stressBlack patientsBlack AmericansClinical algorithmAnti-Black racismHealthcare interventionsAnti-Black biasHealth outcomesHealth policySocioeconomic statusIntervention modelHistory of enslavementPatient outcomesCommunity membersHealthcareGenerational traumaHealthAmerica's historyBlack researchersSources of varianceClinical practiceEquitable outcomesSocial factorsRacial groupsAI governanceMolecular Diagnosis of Gestational Trophoblastic Disease
Hui P. Molecular Diagnosis of Gestational Trophoblastic Disease. 2025, 217-251. DOI: 10.1007/978-3-031-83545-2_14.Peer-Reviewed Original ResearchGestational trophoblastic tumorsInternational Collaboration on Cancer ReportingGestational trophoblastic diseaseHydatidiform moleDevelopment of gestational trophoblastic tumorsPolymerase chain reactionSTR genotypingSubtypes of hydatidiform moleShort tandem repeat (STRTrophoblastic tumorTrophoblastic diseaseDiagnostic workupPathological diagnosisPrognostic riskTumor developmentClinical sensitivityGerm cellsHydatidiformMolecular diagnosisAncillary toolSomatic originClinical practiceGenetic compositionSTR analysisCancer reportingAccelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers
Abraham S, Parekh J, Lee S, Afrin H, Rozenblit M, Blenman K, Perry R, Ferrucci L, Liu J, Irwin M, Lustberg M. Accelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers. Cancer Medicine 2025, 14: e70929. PMID: 40322791, PMCID: PMC12051034, DOI: 10.1002/cam4.70929.Peer-Reviewed Original ResearchConceptsBiological age of patientsLeukocyte telomere lengthInterleukin-6Treatment-related toxicityAge of patientsTherapy-induced toxicityExpression of p16INK4aPredictors of toxicityStatus of biomarkersMarkers of cellular senescenceRadiation therapyBiological ageCancer patientsCancer therapyFunctional reserveAging biomarkersPhysiological reserveCancer treatmentCancerConfirmatory studiesTherapyClinical practiceFunctional capacityPatientsFunctional statusAccuracy of Home Blood Pressure Monitoring in Youth: A Systematic Review and Meta-Analysis
Cueto V, Medvecky H, Funaro M, Nugent J. Accuracy of Home Blood Pressure Monitoring in Youth: A Systematic Review and Meta-Analysis. The Journal Of Pediatrics 2025, 284: 114633. PMID: 40334740, DOI: 10.1016/j.jpeds.2025.114633.Peer-Reviewed Original ResearchAmbulatory BP monitoringHome blood pressure monitoringBlood pressure monitoringHome BPAmbulatory BPPressure monitoringAwake ambulatory BPMeta-analysisModerate agreementWhite coat hypertensionRandom-effects weightingAsleep ambulatory BPDaytime ambulatory hypertensionAmbulatory hypertensionWeb of ScienceBP monitoringCochrane LibraryHypertensionHBPM protocolClinical practiceNocturnal home BPAssess outcomesSystematic reviewHypertension thresholdCategorical scaleClinical-genomic profiling of MDS to inform allo-HCT: recommendations from an international panel on behalf of the EBMT
Gurnari C, Robin M, Adès L, Aljurf M, Almeida A, Duarte F, Bernard E, Cutler C, Della Porta M, De Witte T, DeZern A, Drozd-Sokolowska J, Duncavage E, Fenaux P, Gagelmann N, Garcia-Manero G, Haferlach C, Haferlach T, Hasserjian R, Hellström-Lindberg E, Jacoby M, Kulasekararaj A, Lindsley R, Maciejewski J, Makishima H, Malcovati L, Mittelman M, Myhre A, Ogawa S, Onida F, Papaemmanuil E, Passweg J, Platzbecker U, Pleyer L, Raj K, Santini V, Sureda A, Tobiasson M, Voso M, Yakoub-Agha I, Zeidan A, Walter M, Kröger N, McLornan D, Cazzola M. Clinical-genomic profiling of MDS to inform allo-HCT: recommendations from an international panel on behalf of the EBMT. Blood 2025, 145: 1987-2001. PMID: 39970324, DOI: 10.1182/blood.2024025131.Peer-Reviewed Original ResearchAllo-HCTMolecular International Prognostic Scoring SystemGenomic profilingInternational Prognostic Scoring SystemAllogeneic hematopoietic cell transplantationAssociated with superior clinical outcomesMutant hematopoietic cellsNon-transplant therapiesPrognostic Scoring SystemHematopoietic cell transplantationClinical practiceTime of diagnosisSuperior clinical outcomesEstimate patient survivalIPSS-MAllo-HSCTCell transplantationExpert international panelPatient survivalPredisposition variantsTherapeutic optionsClinical outcomesCurative treatmentGenetic abnormalitiesHematopoietic cellsAdvocacy in Practice: The Role of Mental Health Providers in Creating Systems of Support for Transgender and Gender Expansive Youth
Olezeski C, Meade N, Ralston A. Advocacy in Practice: The Role of Mental Health Providers in Creating Systems of Support for Transgender and Gender Expansive Youth. Evidence-Based Practice In Child And Adolescent Mental Health 2025, ahead-of-print: 1-11. DOI: 10.1080/23794925.2025.2491062.Peer-Reviewed Original ResearchManagement of Challenging Psoriasis Clinical Scenarios
Stein Gold L, Alexis A, Glick B, Shahriari M, Song E, Strober B, Watch N, Young M. Management of Challenging Psoriasis Clinical Scenarios. Dermatology And Therapy 2025, 15: 1555-1567. PMID: 40232594, PMCID: PMC12092870, DOI: 10.1007/s13555-025-01393-3.Peer-Reviewed Original ResearchComorbidities associated with psoriasisPresentation of psoriasisSecondary treatment failureChronic inflammatory skin conditionInflammatory skin conditionTreatment failurePharmacological therapyTreat psoriasisPsoriasis treatmentSystemic diseaseTherapeutic approachesPsoriasisPsoriasis careQuality of lifeClinical practicePatientsSkin conditionsDermatology expertsComprehensive managementDarker skin tonesTreatmentAccounting for Healthcare Structures When Measuring Variation in Care
Colquhoun D, Janda A, Mentz G, Fisher C, Schonberger R, Shah N, Kheterpal S, Mathis M. Accounting for Healthcare Structures When Measuring Variation in Care. Anesthesiology 2025, 142: 793-805. PMID: 40197451, PMCID: PMC11981012, DOI: 10.1097/aln.0000000000005395.Peer-Reviewed Original ResearchConceptsHealthcare structuresOutcomes of clinical careFeatures of health systemsHealth services researchStructured healthcare systemHealth systemServices researchHealthcare systemClinical careQuality improvementOutcomes researchCarePatient outcomesAssessment of varianceClinical practiceInclusion of explanatory variablesHealthcareMixed-effects statistical modelOutcomesCliniciansPatientsPracticeHealthExplanatory variablesHospitalTreat-to-target of endoscopic remission in patients with inflammatory bowel disease in symptomatic remission on advanced therapies (QUOTIENT): rationale, design and protocol for an open-label, multicentre, pragmatic, randomised controlled trial
Singh S, Nguyen J, Fudman D, Gerich M, Shah S, Hudesman D, McConnell R, Lukin D, Flynn A, Hwang C, Sprung B, Gaidos J, Mattar M, Rubin D, Hashash J, Metwally M, Ali T, Ma C, Hoentjen F, Narula N, Bessissow T, Rosenfeld G, McCurdy J, Ananthakrishnan A, Cross R, Gaytan J, Gurrola E, Patel S, Siegel C, Melmed G, Weaver S, Power S, Zou G, Jairath V, Hou J. Treat-to-target of endoscopic remission in patients with inflammatory bowel disease in symptomatic remission on advanced therapies (QUOTIENT): rationale, design and protocol for an open-label, multicentre, pragmatic, randomised controlled trial. BMJ Open Gastroenterology 2025, 12: e001615. PMID: 40164445, PMCID: PMC11962770, DOI: 10.1136/bmjgast-2024-001615.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseAdvanced therapiesTreat-to-targetSymptomatic remissionBowel inflammationOpen-labelAsymptomatic patientsPatient-Centered Outcomes Research InstituteBowel diseaseControlled trialsSafety of switchingClinical practiceActive bowel inflammationReduced bowel inflammationDeep remissionEndoscopic remissionTreatment failurePrimary endpointRandomised controlled trialsTargeted immunomodulationRemissionTherapyPatientsGood Clinical PracticeInformed consentA systematic review of implant materials for facial reconstructive and aesthetic surgery
Kauke-Navarro M, Knoedler L, Baecher H, Sherwani K, Knoedler S, Allam O, Diatta F, Alperovich M, Safi A. A systematic review of implant materials for facial reconstructive and aesthetic surgery. Frontiers In Surgery 2025, 12: 1548597. PMID: 40225117, PMCID: PMC11985522, DOI: 10.3389/fsurg.2025.1548597.Peer-Reviewed Original ResearchPatient-specific implantsFacial implantsBone resorption ratePlastic surgery techniquesStandardized outcome reportingSystematic reviewPatient ageImplant displacementNerve injurySafety profileSurgery techniquesPostoperative recoveryFollow-upAlloplastic materialsReduce complicationsPotential complicationsWeb of SciencePatient anatomyInclusion criteriaResorption rateLong-term effectsAesthetic surgeryClinical practicePRISMA guidelinesOutcome reportingDesign and evaluation of valve interventions using ex vivo biomechanical modeling: the Stanford experience
Weininger G, Elde S, Zhu Y, Woo Y. Design and evaluation of valve interventions using ex vivo biomechanical modeling: the Stanford experience. General Thoracic And Cardiovascular Surgery 2025, 73: 375-384. PMID: 40146494, DOI: 10.1007/s11748-025-02127-0.Peer-Reviewed Original ResearchConceptsValve pathologyPrevalence of valvular heart diseaseMitral valve pathologyAortic valve pathologyValvular heart diseaseSurgical repair strategiesValve interventionRepair strategiesHeart diseaseClinical practiceHeart valvesDevice developmentSimulationPathologyStanford experienceHeart simulatorBiomechanical evaluationPsychiatric Genetics in Clinical Practice: Essential Knowledge for Mental Health Professionals.
Besterman A, Alnor M, Castaño M, DeLisi L, Grice D, Lohoff F, Middeldorp C, Müller D, Quattrone D, Nurnberger J, Nurmi E, Ross D, Soda T, Schulze T, Trost B, Vilella E, Yap C, Zai G, Moreno-De-Luca D. Psychiatric Genetics in Clinical Practice: Essential Knowledge for Mental Health Professionals. American Journal Of Psychiatry 2025, appiajp20240295. PMID: 40134266, DOI: 10.1176/appi.ajp.20240295.Peer-Reviewed Original ResearchMental health cliniciansHealth cliniciansPsychiatric geneticsHolistic model of careGenetic architecture of psychiatric disordersModels of careMental health outcomesApplication of genetic informationMental health professionalsGene-environment interactionsClinical practiceRare genetic variantsGenetics professionalsPower of geneticsHealth professionalsHealth outcomesEffective communication strategiesOngoing educationPatient educationFamilial aggregationGenetic architectureSubspecialty expertsGenetic dataNon-genetic factorsGenetic informationImplementation of a specialized neuroprognostication consultation program and associated provider attitudes: A survey-based study
Fischer D, Reyes-Esteves S, Law C, Ford A, Schwab P, Abella B, Schneider A, Kumar M. Implementation of a specialized neuroprognostication consultation program and associated provider attitudes: A survey-based study. Resuscitation Plus 2025, 23: 100932. PMID: 40235930, PMCID: PMC11999623, DOI: 10.1016/j.resplu.2025.100932.Peer-Reviewed Original ResearchCritical care providersProvider attitudesCare providersCardiac arrestSurvey assessing perceptionsLongitudinal careSurvey-based studyClinical guidelinesDisseminated surveysNovel programFisher's exact testConsultation programProvidersDisorders of consciousnessClinical practiceFavorable attitudesExact testSatisfactionContemporary controlsNeuroprognosticationNeurologistsProgramAttitudesRespondentsHistorical controls
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply