2025
Recommendations for Diagnosing and Quantifying treatment outcomes in clinical trials of compulsive sexual behavior disorder
Engel J, Kraus S, McCurdy L, Potenza M. Recommendations for Diagnosing and Quantifying treatment outcomes in clinical trials of compulsive sexual behavior disorder. Addictive Behaviors Reports 2025, 21: 100610. DOI: 10.1016/j.abrep.2025.100610.Peer-Reviewed Original ResearchCompulsive sexual behaviorCompulsive sexual behavior disorderTreatment of compulsive sexual behaviourSexual behavior disorderTreatment outcome studiesMechanisms of changeNeuropsychological measuresMeasures of quality of lifeParaphilic interestsPrefrontal areasClinical interviewQuantify treatment outcomesProblem behaviorsBehavioral disordersBehavioral engagementReward systemTreatment studiesTreatment trialsOutcome studiesSexual behaviorMoral judgmentTreatment outcomesDiagnostic criteriaDisordersTreatment changesKleptomania on the impulsive–compulsive spectrum. Clinical and therapeutic considerations for women
Munguía L, Baenas-Soto I, Granero R, Fábregas-Balcells M, Gaspar-Pérez A, Rosinska M, Potenza M, Cuquerella Á, Tapia-Martínez J, Cabús-Grange R, Taranilla-Castro A, Macharé-Alberni M, Talón-Navarro M, Fernández-Aranda F, Jiménez-Murcia S. Kleptomania on the impulsive–compulsive spectrum. Clinical and therapeutic considerations for women. Scientific Reports 2025, 15: 7886. PMID: 40050325, PMCID: PMC11885670, DOI: 10.1038/s41598-025-85705-9.Peer-Reviewed Original ResearchConceptsImpulsive-compulsive spectrumDSM-5 criteriaClinical groupsDSM-5Personality featuresSemi-structured clinical interviewTreatment outcomesHarm avoidance scoresCognitive behavioral treatmentHealthy control individualsSample of female patientsImpact treatment outcomesPoor treatment outcomesCompulsive featuresBehavioral treatmentHigher impulsivityAvoidance scoresClinical interviewKleptomaniaInvestigate treatment outcomesCharacteristics of peopleFemale participantsPsychopathologyClinical samplesTreatment approachesStructural Brain Changes Associated With Risky Drinking in Late-Life Depression
Steffens D, Wang L, Manning K, Pearlson G. Structural Brain Changes Associated With Risky Drinking in Late-Life Depression. The American Journal Of Geriatric Psychiatry Open Science Education And Practice 2025, 6: 1-14. PMID: 40535612, PMCID: PMC12176382, DOI: 10.1016/j.osep.2025.01.003.Peer-Reviewed Original ResearchStructural brain changesBrain changesAlcohol useAlcohol consumptionCortical thicknessFronto-striatal circuitsInferior parietal sulcusVolumetric brain changesFrontal cortical regionsLate-life depressionDecreased depression severityModerate drinkersDecreased alcohol consumptionOlder adultsRisky drinkersRisky alcohol useImpact of alcohol useCognitive batteryDepression severityDepressive episodeDSM criteriaStudy psychiatristClinical interviewOlder depressivesPosterior cingulateA generalized reward processing deficit pathway to negative symptoms across diagnostic boundaries
Spilka M, Millman Z, Waltz J, Walker E, Levin J, Powers A, Corlett P, Schiffman J, Gold J, Silverstein S, Ellman L, Mittal V, Woods S, Zinbarg R, Strauss G. A generalized reward processing deficit pathway to negative symptoms across diagnostic boundaries. Psychological Medicine 2025, 55: e6. PMID: 39901872, PMCID: PMC11968125, DOI: 10.1017/s003329172400326x.Peer-Reviewed Original ResearchConceptsNegative symptomsDiagnostic boundariesPsychiatric diagnosisTransdiagnostic sample of youthProcessing profilesEffort-cost computationsPositive valence systemsElevated negative symptomsHelp-seeking participantsClinical high riskClinical group membershipSample of youthHedonic reactivityTransdiagnostic sampleCHR criteriaNeurobiological mechanismsPsychosis riskSubgroup of participantsBehavioral tasksClinical interviewPsychiatric disordersClinical participantsValence systemsGroup membershipDiagnostic classificationSocial functioning and frontal alpha asymmetry in schizophrenia
Farina E, Assaf M, Corbera S, Choi J, Yantz C, Chen C. Social functioning and frontal alpha asymmetry in schizophrenia. Journal Of Psychiatric Research 2025, 182: 74-82. PMID: 39799666, PMCID: PMC11830537, DOI: 10.1016/j.jpsychires.2025.01.006.Peer-Reviewed Original ResearchConceptsFrontal alpha asymmetryAutism spectrum disorderReduced social functioningSocial functioningNeurophysiological markersAlpha asymmetryPsychiatric disordersAtypical social behaviorUnique to schizophreniaSelf-report measuresHealthy controlsResting-state electroencephalogramClinical interviewPsychiatric diagnosisSchizophreniaSpectrum disorderDiagnostic groupsReduced motivationSocial behaviorDisordersEmotional tendencyAnalysis of varianceClinical manifestationsElectroencephalogramAutism
2024
Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder
Song J, Pasman J, Johansson V, Kuja-Halkola R, Harder A, Karlsson R, Lu Y, Kowalec K, Pedersen N, Cannon T, Hultman C, Sullivan P. Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder. JAMA Psychiatry 2024, 81: 1246-1252. PMID: 39196586, PMCID: PMC11359115, DOI: 10.1001/jamapsychiatry.2024.2406.Peer-Reviewed Original ResearchPolygenic risk scoresGenome-wide association studiesSwedish Twin RegistryBipolar disorderCase-control studyTwin concordanceTwin heritabilityLevels of polygenic risk scoreTwin RegistrySwedish national register dataCompare polygenic risk scoresRisk scoreNational register dataHeritable psychiatric disorderAffected co-twinsPairs of twinsPsychosis phenotypeIllness vulnerabilityClinical interviewPsychiatric disordersGenetic liabilityMain OutcomesStructural equation modelingPsychosisSchizophreniaCharacterization of pain and somatization and its relationship with psychopathology in early onset psychosis
van der Heijden H, Goldman M, Ray A, Golden E, Petty C, Deaso E, Hojlo M, Sethna N, Glahn D, Gonzalez-Heydrich J, Upadhyay J. Characterization of pain and somatization and its relationship with psychopathology in early onset psychosis. Journal Of Psychiatric Research 2024, 179: 77-82. PMID: 39260111, PMCID: PMC11531992, DOI: 10.1016/j.jpsychires.2024.09.006.Peer-Reviewed Original ResearchBrief Psychiatric Rating ScaleEarly onset psychosisDegree of psychopathologyBrief Psychiatric Rating Scale totalBrief Psychiatric Rating Scale subscalesDimensions of psychopathologyPsychiatric Rating ScaleChlorpromazine equivalent doseAntipsychotic medication usageControl of psychosisStructured Clinical InterviewAdult-onset psychosisPain catastrophizingSelf-report questionnairesCentral sensitizationPain severityFrequent cause of distressClinical interviewSomatic severityClinical presentation of painSomatic symptomsPsychopathologyPsychosisSubscale scoresRating ScaleMental Health and Social Correlates of Reincarceration of Youths as Adults.
Buchanan A, Zhou B, Rhee T, Stefanovics E, Rosenheck R. Mental Health and Social Correlates of Reincarceration of Youths as Adults. The Journal Of The American Academy Of Psychiatry And The Law 2024, 52: 294-303. PMID: 39048309, DOI: 10.29158/jaapl.240039-24.Peer-Reviewed Original ResearchSubstance use disordersU.S. prison populationIncarceration of childrenAssociated with incarcerationCriminological researchPrison populationReduce reincarcerationHeightened scrutinyReincarcerationNational Epidemiologic SurveyIncarcerationCross-sectional representative surveyPsychiatric treatmentU.S. populationBipolar disorderClinical interviewNESARC-IIIPsychometric instrumentsRepresentative surveySocial correlatesMental healthRelated conditionsDisordersU.S.AdultsEnhancing Early Diagnosis of Bipolar Disorder in Adolescents Through Multimodal Neuroimaging
Wu J, Lin K, Lu W, Zou W, Li X, Tan Y, Yang J, Zheng D, Liu X, Lam B, Xu G, Wang K, McIntyre R, Wang F, So K, Wang J. Enhancing Early Diagnosis of Bipolar Disorder in Adolescents Through Multimodal Neuroimaging. Biological Psychiatry 2024, 97: 313-322. PMID: 39069165, DOI: 10.1016/j.biopsych.2024.07.018.Peer-Reviewed Original ResearchAt-risk adolescentsBipolar disorderBehavioral assessmentBD patientsDiagnosis of bipolar disorderEarly diagnosis of bipolar disordersSevere neuropsychiatric conditionMultimodal MRIAt-riskBehavioral attributesEnhancing early diagnosisSubthreshold symptomsClinical interviewPsychiatric symptomsNeuropsychiatric conditionsStructural equation modelingMultimodal neuroimagingGlobal functioningBrain healthBD diagnosisBD DiagnosticsAdvanced imaging techniquesSubgroup distinctionsAdolescentsRetrospective cohortLuteal phase sertraline treatment of premenstrual dysphoric disorder (PMDD): Effects on markers of hypothalamic pituitary adrenal (HPA) axis activation and inflammation
Barone J, Ho A, Osborne L, Eisenlohr-Moul T, Morrow A, Payne J, Epperson C, Hantsoo L. Luteal phase sertraline treatment of premenstrual dysphoric disorder (PMDD): Effects on markers of hypothalamic pituitary adrenal (HPA) axis activation and inflammation. Psychoneuroendocrinology 2024, 169: 107145. PMID: 39096755, PMCID: PMC11381144, DOI: 10.1016/j.psyneuen.2024.107145.Peer-Reviewed Original ResearchPremenstrual dysphoric disorderSertraline treatmentMultilevel linear modelsDysphoric disorderHypothalamic pituitary gonadalHypothalamic pituitary adrenal (HPA) axisEffects of sertraline treatmentHypothalamic pituitary adrenal (HPA) axis activityPMDD patientsPMDD statusOpen-label sertralineMildly stressful tasksPremenstrual dysphoric disorder groupDaily symptom ratingsSevere affective symptomsEffect of groupPremenstrual symptom severityMenstrual cycle phaseAssociated with higher levelsALLO levelsInflammatory markersMenstrual cycleAffective symptomsAffective disordersClinical interviewIdentifying Depression Through Machine Learning Analysis of Omics Data: Scoping Review
Taylor B, Hobensack M, de Rivera S, Zhao Y, Creber R, Cato K. Identifying Depression Through Machine Learning Analysis of Omics Data: Scoping Review. JMIR Nursing 2024, 7: e54810. PMID: 39028994, PMCID: PMC11297379, DOI: 10.2196/54810.Peer-Reviewed Original ResearchConceptsProvision of mental health careCritical Appraisal Checklist for Analytical Cross-Sectional StudiesJoanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional StudiesIncreased risk of depressionShortage of providersMental health careRisk of depressionAnalytical cross-sectional studyDiagnosis of depressionCross-sectional studySymptoms of depressionSelf-reported symptomsNursing workforceIdentifying depressionPRISMA-ScRScoping reviewHealth careCritical appraisalMental disordersIncreased riskNursesAssess individualsClinical interviewDepressionScreening processA machine-learning approach for differentiating borderline personality disorder from community participants with brain-wide functional connectivity
Lahnakoski J, Nolte T, Solway A, Vilares I, Hula A, Feigenbaum J, Lohrenz T, King-Casas B, Fonagy P, Montague P, Schilbach L. A machine-learning approach for differentiating borderline personality disorder from community participants with brain-wide functional connectivity. Journal Of Affective Disorders 2024, 360: 345-353. PMID: 38806064, DOI: 10.1016/j.jad.2024.05.125.Peer-Reviewed Original ResearchBorderline personality disorderPrediction of borderline personality disorderFunctional connectivityPersonality disorderBorderline personality disorder patientsBorderline personality disorder statusBrain-wide functional connectivityBiomarkers of psychiatric disordersFunctional connectivity markersFunctional connectivity patternsSelf-reported resultsClinical interviewPsychiatric disordersSomatomotor regionsChance levelSeed ROIConnectivity markersComparison correctionSeed regionConnectivity patternsDiscrimination performanceConnectivity valuesDisordersBorderlineGeneralizabilityThe mediating role of reflective functioning and general psychopathology in the relationship between childhood conduct disorder and adult aggression among offenders.
Yirmiya K, Constantinou M, Simes E, Bateman A, Wason J, Yakeley J, McMurran M, Crawford M, Frater A, Moran P, Barrett B, Cameron A, Hoare Z, Allison E, Pilling S, Butler S, Fonagy P. The mediating role of reflective functioning and general psychopathology in the relationship between childhood conduct disorder and adult aggression among offenders. Psychological Medicine 2024, 54: 2492-2503. PMID: 38563288, DOI: 10.1017/s003329172400062x.Peer-Reviewed Original ResearchConduct disorderPsychopathological factorsMentalization-based treatmentStructure of psychopathologyChildhood conduct disorderAdult male offendersOne-factor modelConfirmatory factor analysisPsychopathological dimensionsTransdiagnostic approachDiverse psychopathologiesBifactor modelAntisocial behaviorCD symptomsClinical interviewPsychopathological structurePsychopathologyMale offendersAdult aggressionMediation modelDevelopmental trajectoriesIncreased aggressionMental statesReflective functioningAggressionClinical Interviewing: An Essential but Neglected Method of Medicine
Fava G, Sonino N, Aron D, Balon R, Montiel C, Cao J, Concato J, Eory A, Horwitz R, Rafanelli C, Schnyder U, Wang H, Wise T, Wright J, Zipfel S, Patierno C. Clinical Interviewing: An Essential but Neglected Method of Medicine. Psychotherapy And Psychosomatics 2024, 93: 94-99. PMID: 38382481, DOI: 10.1159/000536490.Peer-Reviewed Original ResearchClinical interviewIncrease patient motivationHealthy behaviorsMethods of medicineSelf-managementClinical encountersPatient motivationClinical processesPatient informationQuality of interviewsEducational trainingLack cost effectivenessClinical domainsPresenting complaintMedical historyInterviewsPhysiciansLife settingsTime pressureQuality of dataPersonal attitudesPatientsCost-effectiveExpensive testsDecision makingSustained mental health and functional responses to the COVID-19 pandemic in Black and White Veterans with psychosis or recent homelessness
Novacek D, Wynn J, McCleery A, Reavis E, Senturk D, Sugar C, Tsai J, Green M. Sustained mental health and functional responses to the COVID-19 pandemic in Black and White Veterans with psychosis or recent homelessness. Journal Of Psychiatric Research 2024, 172: 102-107. PMID: 38373371, DOI: 10.1016/j.jpsychires.2024.02.037.Peer-Reviewed Original ResearchSustain mental healthMental healthWhite veteransLack of racial disparitiesControl group of veteransGroup of veteransVeterans Health AdministrationWrap-around servicesClinical interviewPsychiatric symptomsCOVID-19 pandemicMental illnessPsychosisHealthcare servicesPsychosocial outcomesHealth AdministrationBlack veteransRacial disparitiesPsychosocial impactMinoritized statusVeteran groupsAbsence of systematic differencesVeteransTime pointsHealthBlood epigenome-wide association studies of suicide attempt in adults with bipolar disorder
Mirza S, Lima C, Del Favero-Campbell A, Rubinstein A, Topolski N, Cabrera-Mendoza B, Kovács E, Blumberg H, Richards J, Williams A, Wemmie J, Magnotta V, Fiedorowicz J, Gaine M, Walss-Bass C, Quevedo J, Soares J, Fries G. Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder. Translational Psychiatry 2024, 14: 70. PMID: 38296944, PMCID: PMC10831084, DOI: 10.1038/s41398-024-02760-y.Peer-Reviewed Original ResearchConceptsEpigenome-wide association studiesDifferentially methylated regionsDifferentially methylated positionsAssociation studiesCo-methylation network analysisBipolar disorderDNA methylation patternsSuicide attemptsReplication cohortHistory of SAGene ontology analysisSignificant CpG sitesMethylation patternsDNA methylationCpG sitesOntology analysisImmune-related genesEnrichment analysisNon-psychiatric controlsCalcium signalingGenesDNAClinical interviewSA historyNetwork analysisClinical Care of Patients with Neurocognitive Disorders: A Qualitative Study of the Psychiatric Residency Training Experience
Duong K, Khasnavis S, Welsh W, Camp M. Clinical Care of Patients with Neurocognitive Disorders: A Qualitative Study of the Psychiatric Residency Training Experience. Academic Psychiatry 2024, 48: 143-147. PMID: 38291315, DOI: 10.1007/s40596-023-01932-0.Peer-Reviewed Original ResearchFocus groupsTraining programPsychiatry residentsMental health conditionsNeurocognitive disordersCare of patientsClinical care of patientsLimited comfortHealth conditionsClinical careQualitative studyUnique participantsResident experienceCareGrounded theoryResident traineesTraining opportunitiesTraining needsExpert educatorsObjectiveFew dataClinical interviewExpressed challengesMethodsThe authorsPerceived gapThemesValidation of the EDDS-5 self-report survey against the SCID-5 diagnostic interview in US veterans
Maguen S, Batten A, Siegel S, Huggins J, Snow J, Fenn L, Dick A, Zenteno C, West A, Masheb R. Validation of the EDDS-5 self-report survey against the SCID-5 diagnostic interview in US veterans. Eating Behaviors 2024, 52: 101846. PMID: 38335645, DOI: 10.1016/j.eatbeh.2024.101846.Peer-Reviewed Original ResearchConceptsClinician-administered interviewDSM-5SCID-5Clinical interviewEating disordersEating Disorder Diagnostic ScaleStructured Clinical InterviewMental health measuresDiagnostic InterviewDiagnostic ScaleSelf-report surveyDiverse sampleVeteran populationDiverse veteransVeteransUS veteransDisordersInterviewsEatingHealth measuresSubsampleDifferences in Diagnostic Rules Used to Determine Borderline Personality Disorder Impact Prevalence and Associations with Clinically Relevant Variables: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III
Loya J, Wagner A, Pittman B, Davis M. Differences in Diagnostic Rules Used to Determine Borderline Personality Disorder Impact Prevalence and Associations with Clinically Relevant Variables: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Personality Disorders Theory Research And Treatment 2024, 15: 60-73. PMID: 38206863, PMCID: PMC10786338, DOI: 10.1037/per0000643.Peer-Reviewed Original ResearchConceptsBorderline personality disorderBorderline personality disorder diagnosisPrevalence of borderline personality disorderBorderline personality disorder statusClinically relevant variablesNational Epidemiologic SurveyRelated Conditions-IIIMental health conditionsGeneralizability of findingsPersonality disorderClinical interviewClinical variablesProblem behaviorsDisorder prevalenceConditions-IIIRelevant variablesMethodological differencesEpidemiological surveyDisordersBorderlineDiagnostic rulesPrevalence ratesU.S. adultsHealth consequencesHealth conditions
2016
Incidence and Risk for Mood and Anxiety Disorders in a Representative Sample of Ohio Army National Guard Members, 2008–2012
Fink D, Chen Q, Liu Y, Tamburrino M, Liberzon I, Shirley E, Fine T, Cohen G, Galea S, Calabrese J. Incidence and Risk for Mood and Anxiety Disorders in a Representative Sample of Ohio Army National Guard Members, 2008–2012. Public Health Reports 2016, 131: 614-622. PMID: 27453607, PMCID: PMC4937124, DOI: 10.1177/0033354916662221.Peer-Reviewed Original ResearchConceptsAlcohol use disorderNational Guard membersPsychiatric disordersMood disordersArmy National Guard membersDepressive disorderUse disorderTraumatic eventsGuard membersIncident anxietyStructured Clinical InterviewIncidence rateDiscrete-time Cox proportional hazards modelsRisk factorsAnxiety disordersMilitary sampleClinical interviewIncident disordersAnnual incidence rateHighest incidence rateCox proportional hazards modelsMoodPast-year experienceAnxietyPotential risk factors
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