2025
Risk Factors for Serious Bacterial Infections Among Young Infants With Hypothermia: Protocol for a Multicenter, Retrospective Case-Control Study
Ramgopal S, Aronson P, Lorenz D, Rogers A, Cruz A. Risk Factors for Serious Bacterial Infections Among Young Infants With Hypothermia: Protocol for a Multicenter, Retrospective Case-Control Study. JMIR Research Protocols 2025, 14: e66722. PMID: 40536806, DOI: 10.2196/66722.Peer-Reviewed Original ResearchConceptsEpidemiology of SBIHerpes simplex virusCase-control studyEmergency departmentYoung infantsMultivariable prediction modelRetrospective nested case-control studyBacterial infectionsRetrospective case-control studyManagement of young infantsNested case-control studyUrinary tract infectionOptimal cutoff valueSerious bacterial infectionsSoft tissue infectionsOutcome measuresPediatric Emergency Medicine Collaborative Research CommitteeReceiver operating characteristic curvePediatric emergency departmentOperating characteristics curveUS children's hospitalsMixed effects logistic regressionHSV-positiveBlood culturesPredicting SBIA case-control study of early-life residential exposure to tetrachloroethylene and risks of childhood cancer and birth defects
Rhee J, Michalski A, Kuliszewski M, Musco J, Adler C, Xie S, Friesen M, Insaf T, Purdue M. A case-control study of early-life residential exposure to tetrachloroethylene and risks of childhood cancer and birth defects. Environment International 2025, 201: 109600. PMID: 40516285, DOI: 10.1016/j.envint.2025.109600.Peer-Reviewed Original ResearchConceptsRisk of childhood cancerCase-control studyChildhood cancerNew York CityNew York State Cancer RegistryBureau of Vital StatisticsOdds ratioCases of childhood cancerState Cancer RegistryNon-whiteConfidence intervalsUnconditional logistic regressionComputed odds ratiosBirth Defects RegistryBirth defectsCancer RegistryExposure-response effectTetrachloroethylene exposureBirth certificatesVital statisticsResidential exposureInvestigate associationsCollege-educatedLogistic regressionStrong associationsAssociation Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition
Park J, Van Puyvelde H, Regazzetti L, Clasen J, Heath A, Eussen S, Ueland P, Johansson M, Biessy C, Zamora-Ros R, Huerta J, Sánchez M, Ocke M, Schulze M, Schiborn C, Braaten T, Skeie G, Sacerdote C, Castilla J, Karlsson T, Johansson I, Kyrø C, Tjønneland A, Tong T, Katzke V, Bajracharya R, Lasheras C, Midttun Ø, Vollset S, Vineis P, Masala G, Amiano P, Tumino R, Baldassari I, Weiderpass E, Riboli E, Gunter M, Freisling H, Rinaldi S, Muller D, Huybrechts I, Ferrari P. Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition. Nutrients 2025, 17: 1970. PMID: 40573081, PMCID: PMC12195952, DOI: 10.3390/nu17121970.Peer-Reviewed Original ResearchConceptsEuropean Prospective InvestigationDietary intakeBlood concentrationsProspective InvestigationOne-carbon metabolism-related nutrientsDietary intake of betaineNested case-control studyCancer and NutritionVitamin B6Individual dietary intakeAssociated with folateVitamin B12Vitamin supplement useWeak to moderate associationsCase-control studyCase-control statusIntake of betaineConcentrations of homocysteineSupplement useSmoking statusAssociated with methionineModerate associationBloodFolateIntakeExploring Ethnic Disparities in Hypospadias Incidence: A Meta-Analysis of Epidemiological Studies
Santoso B, Situmorang G, Wahyudi I, Rodjani A, Saraiva L, Al-Shafai K, Abbas T, Raharja P. Exploring Ethnic Disparities in Hypospadias Incidence: A Meta-Analysis of Epidemiological Studies. Journal Of Pediatric Urology 2025 DOI: 10.1016/j.jpurol.2025.06.015.Peer-Reviewed Original ResearchEthnic disparitiesMeta-analysis of epidemiological studiesMeta-analysisHypospadias incidenceImprove healthcare outcomesDiverse populationsIncidence of hypospadiasCross-sectional studyCongenital anomaly prevalenceCase-control studyHealthcare outcomesReduce disparitiesJBI toolsPerinatal determinantsNon-white groupsCitation tracingStudy selectionData extractionSystematic reviewBias riskManual searchEpidemiological studiesRisk factorsDisparitiesEthnic variationsEvaluating the association between routine pneumococcal vaccination and COVID-19 severity among older adults in the United States: A case control study
Prunas O, Tiu A, Shioda K, Bansal S, Weinberger D. Evaluating the association between routine pneumococcal vaccination and COVID-19 severity among older adults in the United States: A case control study. Vaccine X 2025, 24: 100622. DOI: 10.1016/j.jvacx.2025.100622.Peer-Reviewed Original ResearchCOVID-19 patientsCase-control studyIntensive care unitSevere respiratory symptomsPneumococcal vaccineSevere outcomesRespiratory symptomsOdds of progressionReceipt of pneumococcal vaccinationCOVID-19 severitySevere COVID-19 outcomesLogistic regression modelsSevere acute respiratory syndrome coronavirus 2Streptococcus pneumoniaeAcute respiratory syndrome coronavirus 2Non-severeRespiratory syndrome coronavirus 2Care unitControlled studiesPatientsSyndrome coronavirus 2COVID-19 outcomesSARS-CoV-2VaccineCoronavirus 2Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer
Deziel N, Wang R, Warren J, Dinauer C, Ogilvie J, Clark C, Zhong C, Wiemels J, Morimoto L, Metayer C, Ma X. Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer. Environmental Health Perspectives 2025, 133: 057026. PMID: 40209106, PMCID: PMC12121722, DOI: 10.1289/ehp14849.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAir PollutantsCaliforniaCarcinoma, PapillaryCase-Control StudiesChildChild, PreschoolEnvironmental ExposureFemaleHumansInfantInfant, NewbornLightingMaleParticulate MatterPregnancyPrenatal Exposure Delayed EffectsRisk FactorsThyroid Cancer, PapillaryThyroid NeoplasmsYoung AdultConceptsThyroid cancer riskOutdoor artificial lightAmbient fine particulate matterCancer riskOdds ratioAge groupsConfidence intervalsExposure to ambient fine particulate matterIndividual-level exposuresAssociated with thyroid cancerPediatric thyroid cancer incidenceControls frequency-matchedPapillary thyroid cancer riskThyroid cancer incidenceFine particulate matterCalifornia birth cohortOutdoor air pollutionAerodynamic diameter <Case-control studyHypothesized risk factorsStatistically significant associationCancer incidenceThyroid cancerExposure tertilesFrequency-matchedSex-specific genetic effects on susceptibility to idiopathic pulmonary fibrosis
Leavy O, Goemans A, Hernandez-Beeftink T, Stockwell A, Allen R, Guillen-Guio B, Adegunsoye A, Booth H, Fahy W, Fingerlin T, Virk H, Hall I, Hart S, Hill M, Hirani N, Kaminski N, Ma S, McAnulty R, Sheng X, Millar A, Molina-Molina M, Navaratnam V, Neighbors M, Parfrey H, Saini G, Sayers I, Strek M, Tobin M, Whyte M, Zhang Y, Maher T, Molyneaux P, Oldham J, Yaspan B, Flores C, Martinez F, Reynolds C, Schwartz D, Noth I, Jenkins R, Wain L. Sex-specific genetic effects on susceptibility to idiopathic pulmonary fibrosis. ERJ Open Research 2025, 00200-2025. DOI: 10.1183/23120541.00200-2025.Peer-Reviewed Original ResearchPolygenic risk scoresIdiopathic pulmonary fibrosis riskGenetic association signalsIdiopathic pulmonary fibrosis susceptibilitySNP-based polygenic risk scoresAssociation signalsSex-specific genetic effectsGenetic risk predictionEvaluate genetic risksSex-specific associationsStudy meta-analysisEuropean genetic ancestryCase-control studyIdiopathic pulmonary fibrosisChronic lung conditionsGenetic riskAutosomal variantsSusceptibility to idiopathic pulmonary fibrosisRisk scoreGenetic ancestryDiagnostic biasAssociation resultsClinical prediction modelGenetic variantsMeta-analysisCoronavirus Disease 2019 (COVID-19) Vaccination and Spontaneous Abortion
Sheth S, Vazquez-Benitez G, DeSilva M, Zhu J, Seburg E, Denoble A, Daley M, Getahun D, Klein N, Vesco K, Irving S, Nelson J, Williams J, Hambidge S, Donahue J, Lipkind H, Kharbanda E. Coronavirus Disease 2019 (COVID-19) Vaccination and Spontaneous Abortion. Obstetrics And Gynecology 2025, 146: 129-137. PMID: 40311142, PMCID: PMC12169859, DOI: 10.1097/aog.0000000000005904.Peer-Reviewed Original ResearchConceptsSpontaneous abortionVaccine Safety Datalink sitesLive birthsCase groupGestational ageCOVID-19 vaccineDose numberContinuous health plan enrollmentPregnancy start dateControl groupCase-control studyHealth plan enrollmentSafety of COVID-19 vaccinesConditional logistic regressionSingleton pregnanciesFetal deathPregnancy outcomesPrenatal visitEarly pregnancyMaternal agePregnancyVaccine exposureOutcome datePatientsPlan enrollmentRadiation toxicity and survival in patients with interstitial lung disease and non-small cell lung cancer: A case control study
Justet A, Jackson L, Bardon M, Lerouge D, Césaire M, Loiseau C, Bergot E, Christy F, Thariat J. Radiation toxicity and survival in patients with interstitial lung disease and non-small cell lung cancer: A case control study. Cancer/Radiothérapie 2025, 29: 104622. PMID: 40311519, DOI: 10.1016/j.canrad.2025.104622.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseNon-small cell lung cancerProgression-free survivalCell lung cancerOverall survivalLung diseaseCase-control studyLung cancerCentral reviewOligometastatic non-small cell lung cancerMedian progression-free survivalCase-control study of patientsPrevalence of interstitial lung diseaseConsecutive lung cancer patientsIntensity-modulated radiotherapyStereotactic body radiotherapyMedian overall survivalThree-dimensional radiotherapyScore of fibrosisPrognosis of patientsGround-glass patternInterstitial pulmonary fibrosisStudy of patientsLung cancer patientsCancer treatment characteristicsFish consumption and gastric cancer within the Stomach cancer Pooling (StoP) Project
Franchi C, Ardoino I, Mandelli S, Patel L, Pelucchi C, Bonzi R, Camargo M, Rabkin C, Liao L, Sinha R, Johnson K, Hu J, Zhang Z, Palli D, Ferraroni M, Negri E, Turati F, Yu G, Lunet N, Morais S, López-Carrillo L, Tsugane S, Hidaka A, Malekzadeh R, Zaridze D, Maximovitch D, Vioque J, Gonzalez-Palacios S, Ward M, Aragonés N, Castaño-Vinyals G, Curado M, Dias-Neto E, Hamada G, Hernández-Ramirez R, Pakseresht M, Pourfarzi F, Mu L, Lagiou A, Lagiou P, López-Cervantes M, Dolci A, Boccia S, Pastorino R, Boffetta P, D’Avanzo B, La Vecchia C. Fish consumption and gastric cancer within the Stomach cancer Pooling (StoP) Project. Scientific Reports 2025, 15: 13099. PMID: 40240417, PMCID: PMC12003686, DOI: 10.1038/s41598-025-96658-4.Peer-Reviewed Original ResearchConceptsRisk of gastric cancerCancer riskAssociated with gastric cancer riskFamily history of gastric cancerStomach cancer PoolingStomach cancer riskHistory of gastric cancerGastric cancer riskIncreased intake of fishBody mass indexCase-control studyIntake of fishGeographical differencesFish consumptionGastric cancerPooling ProjectFamily historyMass indexCancer deathCanned fish consumptionFish intakeEnergy intakeMeta-analysisIncreased intakeHelicobacter pylori infectionPerinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015)
Clark C, Wang R, Wiemels J, Metayer C, Deziel N, Ma X. Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015). Environmental Health 2025, 24: 6. PMID: 40055781, PMCID: PMC11887085, DOI: 10.1186/s12940-025-01159-6.Peer-Reviewed Original ResearchConceptsHispanic childrenSarcoma riskControls frequency-matched to casesFrequency-matched to casesBirth yearPopulation-based case-control studyOdds ratioPM2.5 exposureConfidence intervalsAir pollution exposureCalifornia birth cohortNon-Hispanic childrenAmbient PM2.5 exposureFine particle air pollutionCase-control studyAmbient fine particulate matterHigher PM2.5 levelsMaternal residenceCancer riskMaternal educationPotential disparitiesBirth cohortHispanic ethnicityElevated oddsLinkage studiesSociodemographic and Systems Risk Factors Associated With Nil by Mouth Noncompliance and Day-of-Procedure Cancellations: A Retrospective Multicenter Case-Control Study.
Goldstein D, Jimenez N, Faulk D, Jones J, Reece-Nguyen T, Gooden C, Markowitz D, Dalal P. Sociodemographic and Systems Risk Factors Associated With Nil by Mouth Noncompliance and Day-of-Procedure Cancellations: A Retrospective Multicenter Case-Control Study. Anesthesia & Analgesia 2025 PMID: 40036165, DOI: 10.1213/ane.0000000000007451.Peer-Reviewed Original ResearchCase-control studySystemic risk factorsRisk factorsNPO guidelinesRetrospective multicenter case-control studyMulticenter retrospective case-control studyRetrospective case-control studyMulticenter case-control studySingle-center studyDay of procedureMultivariate logistic regressionPublic health insuranceYears of ageLanguage of carePediatric patientsMulticenter studyAffected patientsNoncompliance eventsHealth insurance typeIncreased riskMultivariate analysisPrimary outcomeSecondary outcomesElective proceduresHealth insuranceEstimated Effectiveness of Nirsevimab Against Respiratory Syncytial Virus
Xu H, Aparicio C, Wats A, Araujo B, Pitzer V, Warren J, Shapiro E, Niccolai L, Weinberger D, Oliveira C. Estimated Effectiveness of Nirsevimab Against Respiratory Syncytial Virus. JAMA Network Open 2025, 8: e250380. PMID: 40063022, PMCID: PMC11894488, DOI: 10.1001/jamanetworkopen.2025.0380.Peer-Reviewed Original ResearchConceptsRSV-positive casesCase-control studyRSV infectionLRTI-associated hospitalizationsWeeks postimmunizationLong-acting monoclonal antibodiesTest-negative case-control studyClinical settingRespiratory syncytial virusMultivariate logistic regressionYale New Haven Health SystemRSV diseaseEmergency department dataState immunization registryRSV seasonSyncytial virusNirsevimabPolymerase chain reactionClinical trialsLRTIInfantsPotential confoundersMonoclonal antibodiesBroader outcomesDisease severityUsing Radiology as a Screening Tool to Identify Intimate Partner Violence
Lenehan P, Tang A, Watane G, Gujrathi R, Park H, Gosangi B, Thomas R, Franco F, Patel K, Warsofsky I, Rosner B, Khurana B. Using Radiology as a Screening Tool to Identify Intimate Partner Violence. Journal Of The American College Of Radiology 2025, 22: 395-404. PMID: 40044319, PMCID: PMC11887577, DOI: 10.1016/j.jacr.2025.01.003.Peer-Reviewed Original ResearchConceptsAdjusted incidence rate ratiosEmergency departmentRetrospective case-control studyImaging utilization patternsEvident injuriesCox proportional hazards regressionRace-matched controlsCase-control studyTime-to-event analysisProportional hazards regressionImaging utilizationIncidence rate ratiosCumulative incidenceAnatomical sitesScreening mammogramsHazards regressionOdds ratioImaging studiesIntimate partner violencePatientsInjury patternsLogistic regressionInjuryOrgan systemsPoisson regressionSolvent Exposure, Genetic Susceptibility, and Risk of Bladder Cancer.
Tadesse D, Rothman N, Xie S, Hurwitz L, Friesen M, Baris D, Schwenn M, Johnson A, Karagas M, Silverman D, Koutros S. Solvent Exposure, Genetic Susceptibility, and Risk of Bladder Cancer. Cancer Prevention Research 2025, 18: 283-290. PMID: 39995157, PMCID: PMC12045719, DOI: 10.1158/1940-6207.capr-24-0434.Peer-Reviewed Original ResearchBladder cancer riskRisk of bladder cancerNew England Bladder Cancer StudyCancer riskPopulation-based case-control studyOdds ratioIncreased bladder cancer riskIncreased risk of bladder cancerConfidence intervalsCumulative exposure to benzeneCancer susceptibility lociJob-exposure matrixCalculate odds ratiosBladder cancerLifetime occupational exposureGenetic risk variantsCase-control studyMultivariate logistic regressionBladder Cancer StudyExposure to benzeneSusceptibility lociLogistic regressionOccupational historyRisk variantsCancer studiesThe Impact of Aortic Arch Morphology on Periprocedural Stroke in Transcatheter Aortic Valve Replacement
Voss S, Rusa K, Campanella C, Georgescu T, Vitanova K, Ruge H, Amabile A, Sideris K, Krane M, Burri M. The Impact of Aortic Arch Morphology on Periprocedural Stroke in Transcatheter Aortic Valve Replacement. Journal Of Clinical Medicine 2025, 14: 1045. PMID: 40004577, PMCID: PMC11856225, DOI: 10.3390/jcm14041045.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementMulti-slice computed tomographyAortic valve replacementAortic arch morphologyArch anatomyValve replacementPeriprocedural strokeLeft common carotid arteryTransfemoral transcatheter aortic valve replacementEpi-aortic vesselsIschemic strokeArch morphologyPeriprocedural ischemic strokePropensity-matched case-control studyScore-matched studyCase-control studyCommon carotid arteryOccurrence of ischemic strokeAortic arch geometryEuroSCORE IIPropensity score matchingAortic archComparing patientsCatheter manipulationCarotid arteryIncidence and Risk Factors for Posttraumatic Osteoarthritis After Primary ACL Reconstruction in Pediatric Patients: A National Database Study
Moran J, Gouzoulis M, Kunze K, LaPrade C, Grauer J, Hewett T, Chahla J, Jimenez A, McKay S, Fabricant P, LaPrade R, Franklin C. Incidence and Risk Factors for Posttraumatic Osteoarthritis After Primary ACL Reconstruction in Pediatric Patients: A National Database Study. Orthopaedic Journal Of Sports Medicine 2025, 13: 23259671251313754. PMID: 39926589, PMCID: PMC11806457, DOI: 10.1177/23259671251313754.Peer-Reviewed Original ResearchPrimary ACLRAnterior cruciate ligament (ACL) reconstructionRisk factorsPosttraumatic osteoarthritisPediatric patientsMale sexRestorative proceduresTibial eminence avulsion fractureLysis of adhesionsYears of follow-up dataPrimary ACL reconstructionACL injury diagnosisMultiligament knee injuriesNational database studyCase-control studyConcomitant partial meniscectomyFollow-up dataMultivariate logistic regressionLevel of evidenceJuvenile idiopathic arthritisDevelopment of posttraumatic osteoarthritisInjury diagnosisKnee injuriesKnee osteoarthritisCartilage proceduresObservational and Genetic Analyses of Traumatic Experiences and Endometriosis
Koller D, Løkhammer S, Goroshchuk O, Denner V, Stiltner B, Mitjans M, He J, Taylor H, Lawn R, Koenen K, Polimanti R. Observational and Genetic Analyses of Traumatic Experiences and Endometriosis. JAMA Psychiatry 2025, 82: 386-394. PMID: 39908042, PMCID: PMC11800128, DOI: 10.1001/jamapsychiatry.2024.4694.Peer-Reviewed Original ResearchPolygenic risk scoresLatent class analysisAssociated with increased oddsTraumatic experiencesImpact of childhoodIndividual-level dataCase-control studyStressful eventsGenetic predispositionTrauma-related outcomesUnaffected womenMain OutcomesFinnGen cohortRisk scoreAssociation of endometriosisPosttraumatic stress disorderTrauma eventsMeta-analysisSexual traumaAssociated with endometriosisContact traumaPotential associationStress disorderPsychological traumaPhenotypic associationsIdentifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship
Papadimitriou N, Kazmi N, Tsilidis K, Richmond R, Lynch B, Bendinelli B, Ricceri F, Sánchez M, Trobajo-Sanmartín C, Jakszyn P, Simeon V, Severi G, Perduca V, Truong T, Ferrari P, Keski-Rahkonen P, Weiderpass E, Eichelmann F, Schulze M, Katzke V, Fortner R, Heath A, Aune D, Harewood R, Dahm C, Llorente A, Gunter M, Murphy N, Lewis S. Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship. Cancer Epidemiology Biomarkers & Prevention 2025, 34: 578-587. PMID: 39883068, PMCID: PMC11966109, DOI: 10.1158/1055-9965.epi-24-1390.Peer-Reviewed Original ResearchPhysical activityPA levelsReduced risk of colorectal cancerAssociated with CRC riskColorectal cancerRisk of colorectal cancerFalse discovery rate correctionColorectal cancer riskCancer prevention interventionsNested case-control studyMetabolomic signaturesCase-control studyCancer relationshipCRC riskBaseline questionnairePA measuresEPIC cohortPreventive interventionsInverse associationPA indexPhosphatidylcholine acyl-alkylReduced riskMediation analysisMetabolomics panelCirculating metabolomeOral microbiota among treatment-naïve adolescents with depression: A case-control study
Zeng Y, Jia X, Li H, Zhou N, Liang X, Liu K, Yang B, Xiang B. Oral microbiota among treatment-naïve adolescents with depression: A case-control study. Journal Of Affective Disorders 2025, 375: 93-102. PMID: 39855566, PMCID: PMC11934967, DOI: 10.1016/j.jad.2025.01.089.Peer-Reviewed Original ResearchMajor depressive disorderArea under the curveCognitive functionOral microbiotaCase-control studyReceiver operating characteristicAdolescent depressionDSM-5 major depressive disorderAssociated with major depressive disorderTreatment naive individualsNon-depressed individualsMorning saliva samplesHealthy control groupGroup of adolescentsDepressive disorderDSM-5Visual breadthDelayed memoryDepression groupOral healthOral bacteriaHC individualsGut microbiota changesHC groupOral microbes
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