2025
The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders
Galimberti M, Overstreet C, Gupta P, Beck S, Dao C, Deak J, Zhou H, Johnson E, Agrawal A, Stein M, Levey D, Gelernter J. The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders. Nature Mental Health 2025, 3: 700-708. DOI: 10.1038/s44220-025-00440-4.Peer-Reviewed Original ResearchGenomic structural equation modelingCannabis use disorderCannabis usePsychiatric disordersUse disorderStructural equation modelingIncreased rates of psychiatric disordersIncreasing prevalence of cannabis useRates of psychiatric disordersPrevalence of cannabis useThree-factor modelEquation modelingDepressive disorderPsychiatric traitsCannabisLocal genetic correlationDisordersGenetic correlationsMendelian randomization analysisTraitsRandomization analysisSchizophreniaADHDColocalization analysisIncreased riskCannabis Use Disorder Among People With and Without HIV.
Haley D, So-Armah K, Justice A, Kidwai-Khan F, Xuan Z, Sayko Adams R, Fox M, Edelman E, Wrona A, Silverberg M, Satre D, Trickey A, Ingle S, McGinnis K. Cannabis Use Disorder Among People With and Without HIV. Journal Of Addiction Medicine 2025 PMID: 40358026, DOI: 10.1097/adm.0000000000001505.Peer-Reviewed Original ResearchCannabis use disorderNon-HispanicHIV statusElectronic health recordsBlack non-HispanicNational US cohortCannabis useUse disorderMultivariate logistic modelHealth recordsCohort of PLWHOlder PLWHPrescription medicationsInternational ClassificationUniversal screeningGeneral populationPLWHDemographic characteristicsPLWOHPotential harmAging populationAge groupsHIVRace/ethnicityTreatment advancesAssociations of Childhood Adversity and Polygenic Scores with Substance Use Initiation and Disorder Severity
SooHoo J, Davis C, Han A, Jinwala Z, Gelernter J, Feinn R, Kranzler H. Associations of Childhood Adversity and Polygenic Scores with Substance Use Initiation and Disorder Severity. Psychological Medicine 2025, 55: e132. PMID: 40314172, PMCID: PMC12094658, DOI: 10.1017/s0033291725001163.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Childhood ExperiencesAlcoholismBlack or African AmericanFemaleGene-Environment InteractionGenetic Predisposition to DiseaseHumansMaleMarijuana AbuseMiddle AgedMultifactorial InheritanceOpioid-Related DisordersSeverity of Illness IndexSubstance-Related DisordersWhiteYoung AdultConceptsSubstance use disorder severitySubstance use disordersAdverse childhood experiencesGene-by-environment interactionsSubstance use initiationPolygenic scoresOpioid use disorderUse disorderEUR individualsAssociated with AUD severityCannabis use disorderAssociated with adverse childhood experiencesSeverity of alcoholismLatent factorsSubstance use disorder riskGene-environment correlationAssociation of childhood adversityAssociation of adverse childhood experiencesAncestry groupsAUD severityDisorder severityChildhood adversityPolygenic riskChildhood experiencesEnvironmental influencesGenerating synthetic brain PET images of synaptic density based on MR T1 images using deep learning
Zheng X, Worhunsky P, Liu Q, Guo X, Chen X, Sun H, Zhang J, Toyonaga T, Mecca A, O’Dell R, van Dyck C, Angarita G, Cosgrove K, D’Souza D, Matuskey D, Esterlis I, Carson R, Radhakrishnan R, Liu C. Generating synthetic brain PET images of synaptic density based on MR T1 images using deep learning. EJNMMI Physics 2025, 12: 30. PMID: 40163154, PMCID: PMC11958861, DOI: 10.1186/s40658-025-00744-5.Peer-Reviewed Original ResearchCannabis use disorderStructural similarity indexPET imagingImages of higher qualityMR-T1 imagesMean square errorUse disorderEncoder-decoderDeep learningCross-validation processData-driven approachDiagnostic categoriesLow-dose scansPredicted imageTemporal regionsBrain disordersGround truthT1-weighted MRISynaptic densityHuman brainSimilarity indexDisordersSevere neurological disordersTranslation accuracyNoise reductionCannabis legalization and increasing cannabis use in the United States: Data from urine toxicology testing in emergency room patients
Fink D, Samples H, Malte C, Olfson M, Wall M, Alschuler D, Simpson T, Mannes Z, Saxon A, Hasin D. Cannabis legalization and increasing cannabis use in the United States: Data from urine toxicology testing in emergency room patients. International Journal Of Drug Policy 2025, 138: 104765. PMID: 40058102, PMCID: PMC11967342, DOI: 10.1016/j.drugpo.2025.104765.Peer-Reviewed Original ResearchConceptsUrine drug screensCannabis use disorderMedical cannabis lawsVeterans Health AdministrationCannabis useRecreational cannabis lawsRates of cannabis use disordersCannabis lawsEmergency departmentIndicators of cannabis useUrine toxicology testsIncreased cannabis useDifference-in-differences analysisLegalized cannabis useEmergency room patientsSelf-reported dataBinomial regression modelsED visitsED patientsHealth AdministrationCannabis involvementPatient samplesPatientsUse disorderCannabisIdentification and external validation of a problem cannabis risk network
Lichenstein S, Kiluk B, Potenza M, Garavan H, Chaarani B, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Paillère Martinot M, Artiges E, Nees F, Orfanos D, Poustka L, Hohmann S, Holz N, Baeuchl C, Smolka M, Vaidya N, Walter H, Whelan R, Schumann G, Pearlson G, Yip S. Identification and external validation of a problem cannabis risk network. Biological Psychiatry 2025 PMID: 39909136, DOI: 10.1016/j.biopsych.2025.01.022.Peer-Reviewed Original ResearchAlcohol use outcomesCannabis useNeural mechanismsSample of treatment-seeking adultsNeural mechanisms of riskTreatment-seeking adultsCannabis use disorderNon-clinical sampleMechanisms of riskFunctional connectivity dataSample of adolescentsTreatment outcomesAssociated with harmful outcomesPoor treatment outcomesAddiction severityUse disorderEmerging adulthoodWhole-brainCannabisCollege studentsBrain developmentConnectivity dataIdentified networksTreatment approachesAdults
2024
Cannabis Use and Cannabis Use Disorder Among U.S. Adults with Psychiatric Disorders: 2001-2002 and 2012-2013
Hasin D, Mannes Z, Livne O, Fink D, Martins S, Stohl M, Olfson M, Cerdá M, Keyes K, Keyhani S, Wisell C, Bujno J, Saxon A. Cannabis Use and Cannabis Use Disorder Among U.S. Adults with Psychiatric Disorders: 2001-2002 and 2012-2013. Substance Use & Misuse 2024, 60: 285-292. PMID: 39533528, PMCID: PMC11710973, DOI: 10.1080/10826084.2024.2423374.Peer-Reviewed Original ResearchConceptsCannabis use disorderPsychiatric disordersCannabis useNon-medical cannabis useCannabis outcomesUse disorderDSM-IV cannabis use disorderRates of cannabis use disordersRates of cannabis useCannabis use disorder prevalenceAntisocial personality disorderU.S. adultsPersonality disorderDSM-IVVeterans AdministrationPatient samplesNon-medical useDisordersPrevalence differencesU.S. general populationNationally representative sampleCannabisVA patientsAdultsDisproportionate increaseThe Impact of Cannabis Use Disorder on Critical Illness
Carr Z, Strand E. The Impact of Cannabis Use Disorder on Critical Illness. 2024, 95-105. DOI: 10.1007/978-3-031-67069-5_7.Peer-Reviewed Original ResearchIntensive care unitImpacts of cannabis use disordersCannabis use disorderManagement of patientsIntensive care managementIntensive care management of patientsChronic adverse effectsCannabis useClinical evidenceCare management of patientsBotanical cannabisCannabis usageCare unitUse disorderCannabisOrgan systemsAdverse effectsPatientsDownstream effectsIntensive care unit providersMedical careCare managementAssociation of multiple sclerosis with psychiatric disorders and homelessness among veterans in the United States Department of Veterans Affairs healthcare system
Silveira S, Beydoun H, Tsai J. Association of multiple sclerosis with psychiatric disorders and homelessness among veterans in the United States Department of Veterans Affairs healthcare system. CNS Spectrums 2024, 29: 433-440. PMID: 39576134, DOI: 10.1017/s1092852924002165.Peer-Reviewed Original ResearchSubstance use disordersPsychiatric disordersUse disorderMental illnessDiagnosis of cannabis use disorderAssociated with diagnosisDiagnosis of alcohol use disorderCannabis use disorderPosttraumatic stress disorderStimulant use disorderAlcohol use disorderHealthcare systemService-connected disability ratingDepartment of Veterans Affairs healthcare systemSample of veteransPrevalence of mental illnessCharlson Comorbidity IndexGroup of veteransManagement of mental illnessVeterans Affairs Healthcare SystemVA healthcare systemMS diagnosisSchizophrenia/schizoaffective disorderCorporate Data WarehouseDepressive disorderShared genetics of ADHD, cannabis use disorder and cannabis use and prediction of cannabis use disorder in ADHD
Nielsen T, Duan J, Levey D, Walters G, Johnson E, Thorgeirsson T, Werge T, Mortensen P, Stefansson H, Stefansson K, Hougaard D, Agrawal A, Gelernter J, Grove J, Børglum A, Demontis D. Shared genetics of ADHD, cannabis use disorder and cannabis use and prediction of cannabis use disorder in ADHD. Nature Mental Health 2024, 2: 1071-1083. DOI: 10.1038/s44220-024-00277-3.Peer-Reviewed Original ResearchAttention-deficit hyperactivity disorderCannabis use disorderCannabis useUse disorderPolygenic scoresComorbid cannabis use disorderStudies of attention-deficit hyperactivity disorderCross-disorder genome-wide association studySubstance-use disordersIncreased polygenic scoresBrain developmental stagesRisk genesCross-disorderConditions co-occurringPsychiatric disordersHyperactivity disorderGenome-wide significant lociSubstance useRare deleterious variantsCannabisDisordersSignificant lociDeleterious variantsSex-specific differencesBrainS13 Trends in Prevalence of Cannabis Use Disorders Among U.S. Veterans With Psychiatric Disorders Between 2005 and 2019
Livne O, Malte C, McDowell Y, Olfson M, Wall M, Keyes K, Cerda M, Martins S, Saxon A, Mannes Z, Fink D, Keyhani S, Hasin D. S13 Trends in Prevalence of Cannabis Use Disorders Among U.S. Veterans With Psychiatric Disorders Between 2005 and 2019. Drug And Alcohol Dependence 2024, 260: 110124. DOI: 10.1016/j.drugalcdep.2023.110124.Peer-Reviewed Original ResearchCross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking
Johnson E, Austin-Zimmerman I, Thorpe H, Levey D, Baranger D, Colbert S, Demontis D, Khokhar J, Davis L, Edenberg H, Di Forti M, Sanchez-Roige S, Gelernter J, Agrawal A. Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking. Neuropsychopharmacology 2024, 49: 1655-1665. PMID: 38906991, PMCID: PMC11399264, DOI: 10.1038/s41386-024-01886-3.Peer-Reviewed Original ResearchCannabis use disorderUse disorderPleiotropic lociCo-occurring substance useHeavy cannabis useInvestigation of schizophreniaSubstance use disordersGenome-wide studiesGenetic factorsMental health conditionsExecutive functionCannabis useSubstance useLead variantsSchizophreniaGenetic variantsEuropean ancestryEuropean ancestry dataRisk-takingSCZHeritable factorsCannabisDisordersTobacco smokeGenetic correlationsSex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study
Mohammad Aghaei A, Urban Spillane L, Pittman B, Flynn L, De Aquino J, Bassir Nia A, Ranganathan M. Sex differences in the acute effects of oral THC: a randomized, placebo-controlled, crossover human laboratory study. Psychopharmacology 2024, 241: 2145-2155. PMID: 38832949, DOI: 10.1007/s00213-024-06625-6.Peer-Reviewed Original ResearchRey Auditory Verbal Learning TestCannabis use disorderHuman laboratory studiesOral tetrahydrocannabinolPsychoactive effectsSex differencesAuditory Verbal Learning TestDissociative Symptoms ScalePsychotomimetic States InventoryExposure to cannabisVerbal Learning TestPlacebo-controlledIncreased cannabis useInvestigate sex differencesClinician-AdministeredVerbal learningPsychotomimetic effectsCannabinoid effectsLearning TestCannabis useTetrahydrocannabinol dosesEffects of sexUse disorderDose-related effectsIndividual vulnerabilityThe risk of cannabis use disorder is mediated by altered brain connectivity: A chronnectome study
Fazio G, Olivo D, Wolf N, Hirjak D, Schmitgen M, Werler F, Witteman M, Kubera K, Calhoun V, Reith W, Wolf R, Sambataro F. The risk of cannabis use disorder is mediated by altered brain connectivity: A chronnectome study. Addiction Biology 2024, 29: e13395. PMID: 38709211, PMCID: PMC11072977, DOI: 10.1111/adb.13395.Peer-Reviewed Original ResearchConceptsRisk of cannabis use disorderCannabis use disorderDynamic functional connectivityFunctional connectivityUse disorderTreatment of cannabis use disorderAt-risk individualsResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingCannabis-related problemsDefault-mode networkPatterns of FCCognitive-controlCUDIT-RBrain mechanismsSubcortical functionBrain networksSelf-screening questionnaireBrain connectivityBrain functionSensory-motorNeurostimulation treatmentsMagnetic resonance imagingBrainCluster statesDissecting the Relationships Between Cannabis Use Disorder and Schizophrenia Using Genome-Wide Approaches
Johnson E, Levey D, Baranger D, Colbert S, Gelernter J, Agrawal A. Dissecting the Relationships Between Cannabis Use Disorder and Schizophrenia Using Genome-Wide Approaches. Biological Psychiatry 2024, 95: s28-s29. DOI: 10.1016/j.biopsych.2024.02.075.Peer-Reviewed Original ResearchAssociation of mental health related quality of life and other factors with treatment seeking for substance use disorders: A comparison of SUDs rooted in legal, partially legal, and illegal substances
Havlik J, Rhee T, Rosenheck R. Association of mental health related quality of life and other factors with treatment seeking for substance use disorders: A comparison of SUDs rooted in legal, partially legal, and illegal substances. PLOS ONE 2024, 19: e0302544. PMID: 38683850, PMCID: PMC11057773, DOI: 10.1371/journal.pone.0302544.Peer-Reviewed Original ResearchConceptsIllicit substance use disordersCannabis use disorderSubstance use disordersMental health-related quality of lifeUse disorderTreatment usePast-year CUDRates of treatment usePast-year substance use disorderMental health-related qualityMental health related qualityBehavioral health factorsLegal statusNegative associationNESARC-IIISUD treatment useMultiple regression analysisDisordersHealth-related quality of lifeIllegal substancesHealth related qualityUnadjusted analysisQuality of lifeAUDDiagnostic factors“Weeding out” violence? Translational perspectives on the neuropsychobiological links between cannabis and aggression
Bortolato M, Braccagni G, Pederson C, Floris G, Fite P. “Weeding out” violence? Translational perspectives on the neuropsychobiological links between cannabis and aggression. Aggression And Violent Behavior 2024, 78: 101948. PMID: 38828012, PMCID: PMC11141739, DOI: 10.1016/j.avb.2024.101948.Peer-Reviewed Original ResearchCannabis use disorderCannabis useReactive aggressionPathological aggressionViolent behaviorSelf-medication strategyCannabis misuseNeurobiological mechanismsUse disorderCannabis consumptionCannabisAggressionAnimal researchSelf-perpetuating cycleBidirectional interplayLegal discussionTranslational perspectiveEnvironmental predispositionSignificant linkSocietal attitudesBiological mechanismsYoung peopleViolent reactionDisordersPolarized understandingsGenetic influences and causal pathways shared between cannabis use disorder and other substance use traits
Galimberti M, Levey D, Deak J, Zhou H, Stein M, Gelernter J. Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits. Molecular Psychiatry 2024, 29: 2905-2910. PMID: 38580809, PMCID: PMC11419938, DOI: 10.1038/s41380-024-02548-y.Peer-Reviewed Original ResearchSubstance use disordersProblematic alcohol useSubstance use traitsCannabis use disorderCannabis useOpioid use disorderUse disorderGenomic structural equation modelingSmoking initiationLifetime cannabis useLegalization of cannabis useGlobal genetic correlationsProblematic substance useStructural equation modelingNicotine dependenceGenetic influencesCannabisSubstance useFagerstrom TestAlcohol useMendelian randomizationBidirectional relationshipGenetic correlationsDisordersSmoking cessationPleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders
Koller D, Friligkou E, Stiltner B, Pathak G, Løkhammer S, Levey D, Zhou H, Hatoum A, Deak J, Kember R, Treur J, Kranzler H, Johnson E, Stein M, Gelernter J, Polimanti R. Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders. Molecular Psychiatry 2024, 29: 2021-2030. PMID: 38355787, PMCID: PMC11324857, DOI: 10.1038/s41380-024-02446-3.Peer-Reviewed Original ResearchMultisite chronic painSubstance use disordersChronic painUK BiobankUse disorderMillion Veteran ProgramSNP-based heritabilityGenome-wide association statisticsMR analysisPotential causal relationshipVeteran ProgramPleiotropy analysisTobacco usePleiotropic variantsOpioid use disorderAssociation statisticsCannabis use disorderAlcohol use disorderMeta-analysesBrain-wide analysisImaging phenotypesBi-directional relationshipPainPleiotropyBiobankGenetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders
Koller D, Mitjans M, Kouakou M, Friligkou E, Cabrera-Mendoza B, Deak J, Llonga N, Pathak G, Stiltner B, Løkhammer S, Levey D, Zhou H, Hatoum A, Kember R, Kranzler H, Stein M, Corominas R, Demontis D, Artigas M, Ramos-Quiroga J, Gelernter J, Ribasés M, Cormand B, Polimanti R. Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders. Psychiatry Research 2024, 333: 115758. PMID: 38335780, PMCID: PMC11157987, DOI: 10.1016/j.psychres.2024.115758.Peer-Reviewed Original ResearchConceptsUse disorderGenome-wide association studiesGenomic structural equation modelingCannabis use disorderAlcohol Use Disorders Identification TestAttention-deficit/hyperactivity disorderAlcohol use disorderProblematic alcohol useSubstance use disordersTwo-sample Mendelian randomization analysisLinkage disequilibrium score regression analysisDisorders Identification TestMendelian randomization analysisAssociated with increased oddsOdds of ADHDOpioid use disorderAttention-deficit/hyperactivityGWAS meta-analysesAlcohol dependenceStructural equation modelingNicotine dependenceInvestigate genetic correlationsADHDPolygenic riskStrength of evidence
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