2025
The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders
Galimberti M, Overstreet C, Gupta P, Beck S, Dao C, Deak J, Zhou H, Johnson E, Agrawal A, Stein M, Levey D, Gelernter J. The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders. Nature Mental Health 2025, 3: 700-708. DOI: 10.1038/s44220-025-00440-4.Peer-Reviewed Original ResearchGenomic structural equation modelingCannabis use disorderCannabis usePsychiatric disordersUse disorderStructural equation modelingIncreased rates of psychiatric disordersIncreasing prevalence of cannabis useRates of psychiatric disordersPrevalence of cannabis useThree-factor modelEquation modelingDepressive disorderPsychiatric traitsCannabisLocal genetic correlationDisordersGenetic correlationsMendelian randomization analysisTraitsRandomization analysisSchizophreniaADHDColocalization analysisIncreased riskCannabis Use Disorder Among People With and Without HIV.
Haley D, So-Armah K, Justice A, Kidwai-Khan F, Xuan Z, Sayko Adams R, Fox M, Edelman E, Wrona A, Silverberg M, Satre D, Trickey A, Ingle S, McGinnis K. Cannabis Use Disorder Among People With and Without HIV. Journal Of Addiction Medicine 2025 PMID: 40358026, DOI: 10.1097/adm.0000000000001505.Peer-Reviewed Original ResearchCannabis use disorderNon-HispanicHIV statusElectronic health recordsBlack non-HispanicNational US cohortCannabis useUse disorderMultivariate logistic modelHealth recordsCohort of PLWHOlder PLWHPrescription medicationsInternational ClassificationUniversal screeningGeneral populationPLWHDemographic characteristicsPLWOHPotential harmAging populationAge groupsHIVRace/ethnicityTreatment advancesThe association between cannabis use and suicidal intensity in psychiatric inpatients
Oladunjoye A, Swann A, Kosten T, Patriquin M, Bigdeli T, Barr P, Wilkinson A, Harding M, Nielsen D, Graham D. The association between cannabis use and suicidal intensity in psychiatric inpatients. American Journal On Addictions 2025 PMID: 40349103, DOI: 10.1111/ajad.70047.Peer-Reviewed Original ResearchSuicidal ideation intensityCannabis usePsychiatric inpatientsPsychological flexibilityColumbia-Suicide Severity Rating ScaleAssociated with cannabis useSuicidal intensityMale psychiatric inpatientsSubstance Involvement Screening TestSeverity Rating ScaleModel of moderationEmotion regulationPsychiatric comorbidityPolygenic risk scoresPath analysis modelSuicidal ideationSuicide attemptsRating ScaleSex-specific patternsPotential mediatorsSuicideInpatientsAssociated with greater riskCannabisAdolescentsCannabis Use in Clinical High-Risk for Psychosis Across Different Legal Environments: Preliminary Findings From the Global Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) Study
Penzel N, Kelly S, Seitz-Holland J, Cho K, Corcoran C, Calkins M, Cornblatt B, Jacobs G, Kambeitz J, Lewandowski K, Mittal V, Polosecki P, Shah J, Coleman M, Bearden C, Kane J, Kahn R, McGorry P, Woods S, Shenton M, Nelson B, Pasternak O, Investigators A. Cannabis Use in Clinical High-Risk for Psychosis Across Different Legal Environments: Preliminary Findings From the Global Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) Study. Biological Psychiatry 2025, 97: s34-s35. DOI: 10.1016/j.biopsych.2025.02.099.Peer-Reviewed Original ResearchHow Cannabis Use is Associated with the Physical and Mental Health of Older Adults: A US Population-Based Study
You E, Sarkar S, Pietrzak R, Monin J, Poghosyan H. How Cannabis Use is Associated with the Physical and Mental Health of Older Adults: A US Population-Based Study. International Journal Of Mental Health And Addiction 2025, 1-22. DOI: 10.1007/s11469-025-01475-5.Peer-Reviewed Original ResearchCannabis useMental healthDaily cannabis usersPhysical healthDays of poor physical healthBehavioral Risk Factor Surveillance SystemRisk Factor Surveillance SystemIncreased oddsUS population-based studyAssociated with poor healthPhysical and Mental HealthPoor physical healthLack health insurance coverageMultivariate multinomial logistic regression analysisCannabis usersPopulation-based studyEvidence-based guidelinesMultinomial logistic regression analysisHealth insurance coverageLogistic regression analysisPoor healthOlder AdultsCannabisInsurance coveragePromote awarenessTranscriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review
Valizadeh A, Veenhuis R, Bradley B, Xu K. Transcriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review. International Journal Of Molecular Sciences 2025, 26: 2598. PMID: 40141240, PMCID: PMC11942185, DOI: 10.3390/ijms26062598.Peer-Reviewed Original ResearchConceptsSimian immunodeficiency virus (SIV)-infected macaquesPrevalence of cannabis useSIV-infected macaquesChronic immune activationHIV-infected human cellsEpithelial cell proliferationModulate immune responsesSystematic reviewSIV/HIV infectionHIV infectionPreclinical evidencePathways related to inflammationImmune activationCannabis useMicro-RNA expressionImmunomodulatory roleImmunomodulatory effectsReduce inflammationImmune responseTetrahydrocannabinolComprehensive searchCell proliferationTranscriptomic alterationsMethodological qualityPWHA randomized, placebo-controlled, double-blind, pilot study of cannabis-related driving impairment assessed by driving simulator and self-report
Meda S, Stevens M, Boer E, Pittman B, Gueorguieva R, Huestis M, Pearlson G. A randomized, placebo-controlled, double-blind, pilot study of cannabis-related driving impairment assessed by driving simulator and self-report. Journal Of Psychopharmacology 2025, 39: 364-372. PMID: 40077985, DOI: 10.1177/02698811251324379.Peer-Reviewed Original ResearchConceptsCannabis-induced impairmentBlood THC levelsDouble-blindCannabis useVaporized cannabisTHC levelsActual impairmentAcute doseWithin-subjectSelf-reportSimulated driving testDrug effectsDriving impairmentPlacebo-controlledImpairment indicatorsImpairmentCannabisAssessment daysEffect of doseParticipants' willingnessPost-doseTHCBehavioral metricsCar-followingParticipantsCannabis legalization and increasing cannabis use in the United States: Data from urine toxicology testing in emergency room patients
Fink D, Samples H, Malte C, Olfson M, Wall M, Alschuler D, Simpson T, Mannes Z, Saxon A, Hasin D. Cannabis legalization and increasing cannabis use in the United States: Data from urine toxicology testing in emergency room patients. International Journal Of Drug Policy 2025, 138: 104765. PMID: 40058102, PMCID: PMC11967342, DOI: 10.1016/j.drugpo.2025.104765.Peer-Reviewed Original ResearchConceptsUrine drug screensCannabis use disorderMedical cannabis lawsVeterans Health AdministrationCannabis useRecreational cannabis lawsRates of cannabis use disordersCannabis lawsEmergency departmentIndicators of cannabis useUrine toxicology testsIncreased cannabis useDifference-in-differences analysisLegalized cannabis useEmergency room patientsSelf-reported dataBinomial regression modelsED visitsED patientsHealth AdministrationCannabis involvementPatient samplesPatientsUse disorderCannabisPrenatal Cannabis Use and Depressive Symptoms
Pitt T, Allshouse A, Kim P, McMillin G, Silver R, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Metz T. Prenatal Cannabis Use and Depressive Symptoms. Obstetrics And Gynecology 2025, 145: 417-425. PMID: 40014863, PMCID: PMC11925678, DOI: 10.1097/aog.0000000000005860.Peer-Reviewed Original ResearchConceptsAssociated with later depressive symptomsCannabis exposureDepressive symptomsCannabis useTHC-COOHAssociated with increased depressive symptomsAssociated with greater oddsAssociated with depressive symptomsFirst-trimesterExposed to cannabisPregnancy outcome dataWeeks of gestationFirst-trimester exposureGreater oddsCannabis metabolitesSecondary analysisCannabisAssociated with increased oddsExploratory analysisUrine immunoassayTrimesterHigher levelsPrimary outcomePregnancyAcademic centersInternational perspectives on physician knowledge, attitudes, and practices related to medical cannabis
Syed S, Singh J, Elkholy H, Palavra I, Tomicevic M, Eric A, da Costa M, Guloksuz S, Radhakrishnan R. International perspectives on physician knowledge, attitudes, and practices related to medical cannabis. Frontiers In Public Health 2025, 13: 1463871. PMID: 40051509, PMCID: PMC11882600, DOI: 10.3389/fpubh.2025.1463871.Peer-Reviewed Original ResearchConceptsPhysicians' knowledgeStrength of evidenceMedical cannabisCross-sectional survey of physiciansSurvey of physiciansCross-sectional surveyYears of clinical experienceNegative health outcomesCannabis useClinical experienceRefractory chronic neuropathic painClinical decision-makingHealth outcomesPhysicians' attitudesPhysicians' willingnessChronic neuropathic painMedical use of cannabisRisk of psychosisDaily cannabis useMedication useDescriptive statisticsRisk of addictionMedical indicationsUse of cannabisPhysiciansDocumented Cannabis Use Is a Risk Factor for Nonunion After Nonoperative Management of Scaphoid Fractures: A Retrospective Review of 159 998 Patients.
Pathak N, Ratnasamy P, Oghenesume O, Luo X, Grauer J, Halim A. Documented Cannabis Use Is a Risk Factor for Nonunion After Nonoperative Management of Scaphoid Fractures: A Retrospective Review of 159 998 Patients. Hand 2025, 15589447251317225. PMID: 39968879, PMCID: PMC11840816, DOI: 10.1177/15589447251317225.Peer-Reviewed Original ResearchDocumented cannabis useCannabis useNonunion surgeryScaphoid fracturesNonunion rateNon-user groupNonoperative managementMultivariate analysisTreated with nonoperative managementIncreased riskScaphoid nonunionNon-usersPotential associationElectronic medical recordsManagement of scaphoid fracturesAcute scaphoid fracturesIndex fractureTobacco useRetrospective reviewTobacco-onlyFracture patientsAdult patientsFracture diagnosisMatched cohortCannabis-onlyMapping the exposome of mental health: exposome-wide association study of mental health outcomes among UK Biobank participants
Arias-Magnasco A, Lin B, Pries L, Guloksuz S. Mapping the exposome of mental health: exposome-wide association study of mental health outcomes among UK Biobank participants. Psychological Medicine 2025, 55: e16. PMID: 39917825, PMCID: PMC11968124, DOI: 10.1017/s0033291724003015.Peer-Reviewed Original ResearchConceptsMental health phenotypesMental health outcomesExposome-wide association studySymptom dimensionsDiagnostic domainsCommon psychiatric disordersHealth phenotypesHealth outcomesEarly life experiencesMental Health SurveyImproving mental well-beingMental health frameworkAssociation studiesUK Biobank participantsCannabis usePsychiatric disordersEating disordersChildhood adversityPublic health policiesTraumatic eventsMental well-beingMultivariate modelDifferential associationsNeurodevelopmental disordersMental healthIdentification and external validation of a problem cannabis risk network
Lichenstein S, Kiluk B, Potenza M, Garavan H, Chaarani B, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Paillère Martinot M, Artiges E, Nees F, Orfanos D, Poustka L, Hohmann S, Holz N, Baeuchl C, Smolka M, Vaidya N, Walter H, Whelan R, Schumann G, Pearlson G, Yip S. Identification and external validation of a problem cannabis risk network. Biological Psychiatry 2025 PMID: 39909136, DOI: 10.1016/j.biopsych.2025.01.022.Peer-Reviewed Original ResearchAlcohol use outcomesCannabis useNeural mechanismsSample of treatment-seeking adultsNeural mechanisms of riskTreatment-seeking adultsCannabis use disorderNon-clinical sampleMechanisms of riskFunctional connectivity dataSample of adolescentsTreatment outcomesAssociated with harmful outcomesPoor treatment outcomesAddiction severityUse disorderEmerging adulthoodWhole-brainCannabisCollege studentsBrain developmentConnectivity dataIdentified networksTreatment approachesAdultsM31 Cannabis Use and Its Association With Treatment Engagement and Other Substance use: Results From a 90-Day Daily Diary Study
Warnock C, Edelman E, Kershaw T, Muilenberg J. M31 Cannabis Use and Its Association With Treatment Engagement and Other Substance use: Results From a 90-Day Daily Diary Study. Drug And Alcohol Dependence 2025, 267: 111625. DOI: 10.1016/j.drugalcdep.2024.111625.Peer-Reviewed Original ResearchCannabis Use and Self-Reported Bothersome Symptoms in People with HIV
Wrona A, Justice A, Tate J, Rentsch C, Gordon K, Kidwai-Khan F, Silverberg M, Satre D, Marconi V, Ingle S, Sterne J, Cavassini M, Bryant K, McGinnis K. Cannabis Use and Self-Reported Bothersome Symptoms in People with HIV. Cannabis 2025, 8: 177-190. PMID: 39968492, PMCID: PMC11831903, DOI: 10.26828/cannabis/2025/000269.Peer-Reviewed Original ResearchCannabis useKaiser Permanente Northern CaliforniaSwiss HIV Cohort StudyHIV Symptom IndexSelf-reportBothersome symptomsSubstance useAssociations of self-reportedBothersome levelSelf-reported substanceMental health symptomsSymptom IndexSelf-reported informationHIV Cohort StudyPatterns of associationWeight lossPresence/absence of symptomsCross-cohort studyLogistic regression modelsHealth symptomsCannabisHealth outcomesLoss of appetiteHIV cohortStudy HIVThe relationship of medical and recreational cannabis laws with opioid misuse and opioid use disorder in the USA: Does it depend on prior history of cannabis use?
Martins S, Bruzelius E, Mauro C, Santaella-Tenorio J, Boustead A, Wheeler-Martin K, Samples H, Hasin D, Fink D, Rudolph K, Crystal S, Davis C, Cerdá M. The relationship of medical and recreational cannabis laws with opioid misuse and opioid use disorder in the USA: Does it depend on prior history of cannabis use? International Journal Of Drug Policy 2025, 136: 104687. PMID: 39793270, PMCID: PMC11821435, DOI: 10.1016/j.drugpo.2024.104687.Peer-Reviewed Original ResearchConceptsCannabis lawsCannabis useNational Survey on Drug Use and Health (NSDUHDrug Use and Health (NSDUHRecreational cannabis lawsState fixed effectsAvailability of cannabisOpioid outcomesOpioid useAssociated with changesHistory of cannabis useLawOpioid misusePast-year cannabis useLifetime cannabis useState policySensitivity to unmeasured confoundingMisuseIndividual level covariatesCannabisLogistic regression modelsAssociated with reductionsOpioidCollider biasFalse discovery rate
2024
Tobacco and Cannabis Co-Use by Sexual Minority Adults in the United States, 2022
Lee J, Hinds J, Dai H, Weinberger A. Tobacco and Cannabis Co-Use by Sexual Minority Adults in the United States, 2022. American Journal Of Preventive Medicine 2024, 68: 717-725. PMID: 39725091, PMCID: PMC12048864, DOI: 10.1016/j.amepre.2024.12.014.Peer-Reviewed Original ResearchConceptsSexual minority individualsCannabis co-useMinority individualsCo-use of tobaccoSexual identityPast-month tobaccoSexual minority adultsNational Survey on Drug Use and HealthLevels of tobaccoCo-useDrug Use and HealthLesbian femalesGay malesBisexual femalesAdult samplesHeterosexual femalesBisexual malesMinority adultsNegative health outcomesHeterosexual malesMultinomial logistic regressionCannabis useUnited StatesHigh health burdenCannabisThe association of hidradenitis suppurativa with cigarette smoking and cannabis use: a cross-sectional study in the All of Us Research Program
Chen G, Shipman W, Hodelin C, Hsia H, Cohen J, Eisenstein A. The association of hidradenitis suppurativa with cigarette smoking and cannabis use: a cross-sectional study in the All of Us Research Program. Clinical And Experimental Dermatology 2024, 50: 1042-1044. PMID: 39573984, PMCID: PMC12020478, DOI: 10.1093/ced/llae521.Peer-Reviewed Original ResearchCigarette smokingOdds of cigarette smokingElectronic health recordsHealth research programsCannabis useCross-sectional studyCross sectional studyHealth recordsSectional studySmokingHidradenitis suppurativaNational InstituteSurvey dataAssociationCannabisOddsUseCigaretteHidradenitisResearch programNationalProgramPopulationStudyCannabis Use and Cannabis Use Disorder Among U.S. Adults with Psychiatric Disorders: 2001-2002 and 2012-2013
Hasin D, Mannes Z, Livne O, Fink D, Martins S, Stohl M, Olfson M, Cerdá M, Keyes K, Keyhani S, Wisell C, Bujno J, Saxon A. Cannabis Use and Cannabis Use Disorder Among U.S. Adults with Psychiatric Disorders: 2001-2002 and 2012-2013. Substance Use & Misuse 2024, 60: 285-292. PMID: 39533528, PMCID: PMC11710973, DOI: 10.1080/10826084.2024.2423374.Peer-Reviewed Original ResearchConceptsCannabis use disorderPsychiatric disordersCannabis useNon-medical cannabis useCannabis outcomesUse disorderDSM-IV cannabis use disorderRates of cannabis use disordersRates of cannabis useCannabis use disorder prevalenceAntisocial personality disorderU.S. adultsPersonality disorderDSM-IVVeterans AdministrationPatient samplesNon-medical useDisordersPrevalence differencesU.S. general populationNationally representative sampleCannabisVA patientsAdultsDisproportionate increaseAssociation between cannabis use and brain structure and function: an observational and Mendelian randomisation study
Ishrat S, Levey D, Gelernter J, Ebmeier K, Topiwala A. Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study. BMJ Mental Health 2024, 27: e301065. PMID: 39477366, PMCID: PMC11529520, DOI: 10.1136/bmjment-2024-301065.Peer-Reviewed Original ResearchConceptsCannabis useBrain structuresFunctional connectivityHistory of cannabis useResting-state functional connectivityMeasures of brain structureLifetime cannabis useCentral executive networkLifetime cannabis usersWhite matter integrityGenu of the corpus callosumMendelian randomisation analysisAssociated with multiple measuresPoorer white matter integrityInvestigate potential causal relationshipsCannabis usersExecutive networkBrain regionsImaging-derived phenotypesBrain healthCannabisRandomisation analysesTwo-sample Mendelian randomisation analysisFractional anisotropyYoung adulthood
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