2025
The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders
Galimberti M, Overstreet C, Gupta P, Beck S, Dao C, Deak J, Zhou H, Johnson E, Agrawal A, Stein M, Levey D, Gelernter J. The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders. Nature Mental Health 2025, 3: 700-708. DOI: 10.1038/s44220-025-00440-4.Peer-Reviewed Original ResearchGenomic structural equation modelingCannabis use disorderCannabis usePsychiatric disordersUse disorderStructural equation modelingIncreased rates of psychiatric disordersIncreasing prevalence of cannabis useRates of psychiatric disordersPrevalence of cannabis useThree-factor modelEquation modelingDepressive disorderPsychiatric traitsCannabisLocal genetic correlationDisordersGenetic correlationsMendelian randomization analysisTraitsRandomization analysisSchizophreniaADHDColocalization analysisIncreased riskThe association between cannabis use and suicidal intensity in psychiatric inpatients
Oladunjoye A, Swann A, Kosten T, Patriquin M, Bigdeli T, Barr P, Wilkinson A, Harding M, Nielsen D, Graham D. The association between cannabis use and suicidal intensity in psychiatric inpatients. American Journal On Addictions 2025 PMID: 40349103, DOI: 10.1111/ajad.70047.Peer-Reviewed Original ResearchSuicidal ideation intensityCannabis usePsychiatric inpatientsPsychological flexibilityColumbia-Suicide Severity Rating ScaleAssociated with cannabis useSuicidal intensityMale psychiatric inpatientsSubstance Involvement Screening TestSeverity Rating ScaleModel of moderationEmotion regulationPsychiatric comorbidityPolygenic risk scoresPath analysis modelSuicidal ideationSuicide attemptsRating ScaleSex-specific patternsPotential mediatorsSuicideInpatientsAssociated with greater riskCannabisAdolescentsSex and Gender in Relation to use of E-cigarette Product Characteristics in United States Datasets: A Systematic Review
DeVito E, Stern E, Szpilzinger M, Petersen N, Pang R, Weinberger A. Sex and Gender in Relation to use of E-cigarette Product Characteristics in United States Datasets: A Systematic Review. Nicotine & Tobacco Research 2025, ntaf092. PMID: 40357915, DOI: 10.1093/ntr/ntaf092.Peer-Reviewed Original ResearchE-cigarette useE-cigarettesCannabis vapingAddictive potentialPrevalence of e-cigarette useE-cigarette product characteristicsCessation of tobacco productsPrevalence of nicotineSystematic reviewHarm reduction potentialGender differencesE-cigarette characteristicsE-cigarette productsCombustible cigarettesUnited StatesUnited States youthNicotineSex-specific findingsCannabisPeer-reviewed journalsGender minoritiesPrevalenceSexVapingFlavor useCannabis Use in Clinical High-Risk for Psychosis Across Different Legal Environments: Preliminary Findings From the Global Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) Study
Penzel N, Kelly S, Seitz-Holland J, Cho K, Corcoran C, Calkins M, Cornblatt B, Jacobs G, Kambeitz J, Lewandowski K, Mittal V, Polosecki P, Shah J, Coleman M, Bearden C, Kane J, Kahn R, McGorry P, Woods S, Shenton M, Nelson B, Pasternak O, Investigators A. Cannabis Use in Clinical High-Risk for Psychosis Across Different Legal Environments: Preliminary Findings From the Global Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) Study. Biological Psychiatry 2025, 97: s34-s35. DOI: 10.1016/j.biopsych.2025.02.099.Peer-Reviewed Original ResearchHow Cannabis Use is Associated with the Physical and Mental Health of Older Adults: A US Population-Based Study
You E, Sarkar S, Pietrzak R, Monin J, Poghosyan H. How Cannabis Use is Associated with the Physical and Mental Health of Older Adults: A US Population-Based Study. International Journal Of Mental Health And Addiction 2025, 1-22. DOI: 10.1007/s11469-025-01475-5.Peer-Reviewed Original ResearchCannabis useMental healthDaily cannabis usersPhysical healthDays of poor physical healthBehavioral Risk Factor Surveillance SystemRisk Factor Surveillance SystemIncreased oddsUS population-based studyAssociated with poor healthPhysical and Mental HealthPoor physical healthLack health insurance coverageMultivariate multinomial logistic regression analysisCannabis usersPopulation-based studyEvidence-based guidelinesMultinomial logistic regression analysisHealth insurance coverageLogistic regression analysisPoor healthOlder AdultsCannabisInsurance coveragePromote awarenessA randomized, placebo-controlled, double-blind, pilot study of cannabis-related driving impairment assessed by driving simulator and self-report
Meda S, Stevens M, Boer E, Pittman B, Gueorguieva R, Huestis M, Pearlson G. A randomized, placebo-controlled, double-blind, pilot study of cannabis-related driving impairment assessed by driving simulator and self-report. Journal Of Psychopharmacology 2025, 39: 364-372. PMID: 40077985, DOI: 10.1177/02698811251324379.Peer-Reviewed Original ResearchConceptsCannabis-induced impairmentBlood THC levelsDouble-blindCannabis useVaporized cannabisTHC levelsActual impairmentAcute doseWithin-subjectSelf-reportSimulated driving testDrug effectsDriving impairmentPlacebo-controlledImpairment indicatorsImpairmentCannabisAssessment daysEffect of doseParticipants' willingnessPost-doseTHCBehavioral metricsCar-followingParticipantsCannabis legalization and increasing cannabis use in the United States: Data from urine toxicology testing in emergency room patients
Fink D, Samples H, Malte C, Olfson M, Wall M, Alschuler D, Simpson T, Mannes Z, Saxon A, Hasin D. Cannabis legalization and increasing cannabis use in the United States: Data from urine toxicology testing in emergency room patients. International Journal Of Drug Policy 2025, 138: 104765. PMID: 40058102, PMCID: PMC11967342, DOI: 10.1016/j.drugpo.2025.104765.Peer-Reviewed Original ResearchConceptsUrine drug screensCannabis use disorderMedical cannabis lawsVeterans Health AdministrationCannabis useRecreational cannabis lawsRates of cannabis use disordersCannabis lawsEmergency departmentIndicators of cannabis useUrine toxicology testsIncreased cannabis useDifference-in-differences analysisLegalized cannabis useEmergency room patientsSelf-reported dataBinomial regression modelsED visitsED patientsHealth AdministrationCannabis involvementPatient samplesPatientsUse disorderCannabisPrenatal Cannabis Use and Depressive Symptoms
Pitt T, Allshouse A, Kim P, McMillin G, Silver R, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Metz T. Prenatal Cannabis Use and Depressive Symptoms. Obstetrics And Gynecology 2025, 145: 417-425. PMID: 40014863, PMCID: PMC11925678, DOI: 10.1097/aog.0000000000005860.Peer-Reviewed Original ResearchConceptsAssociated with later depressive symptomsCannabis exposureDepressive symptomsCannabis useTHC-COOHAssociated with increased depressive symptomsAssociated with greater oddsAssociated with depressive symptomsFirst-trimesterExposed to cannabisPregnancy outcome dataWeeks of gestationFirst-trimester exposureGreater oddsCannabis metabolitesSecondary analysisCannabisAssociated with increased oddsExploratory analysisUrine immunoassayTrimesterHigher levelsPrimary outcomePregnancyAcademic centersExamining concordance between emotion-dependent risk-taking in the laboratory and in the real-world
Weiss N, Schick M, Raudales A, Thomas E, Ho D, Goldstein S, Kiefer R, Newberger N, Contractor A, Sullivan T. Examining concordance between emotion-dependent risk-taking in the laboratory and in the real-world. Behaviour Research And Therapy 2025, 187: 104716. PMID: 40037003, DOI: 10.1016/j.brat.2025.104716.Peer-Reviewed Original ResearchConceptsRisk-taking behaviorRisk-taking propensityPositive emotional statesIntimate partner violenceEmotional statesBehavioral measure of risk-taking propensityMeasure of risk-taking propensityRisk-takingNeutral emotion inductionLaboratory paradigmBehavioral measuresEmotion inductionSubstance useSexual behaviorDrinking alcoholIllicit drugsPartner violenceCondomless sexParticipantsCannabisBehaviorEmotionsSubstancesAlcoholParadigmIdentification and external validation of a problem cannabis risk network
Lichenstein S, Kiluk B, Potenza M, Garavan H, Chaarani B, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Paillère Martinot M, Artiges E, Nees F, Orfanos D, Poustka L, Hohmann S, Holz N, Baeuchl C, Smolka M, Vaidya N, Walter H, Whelan R, Schumann G, Pearlson G, Yip S. Identification and external validation of a problem cannabis risk network. Biological Psychiatry 2025 PMID: 39909136, DOI: 10.1016/j.biopsych.2025.01.022.Peer-Reviewed Original ResearchAlcohol use outcomesCannabis useNeural mechanismsSample of treatment-seeking adultsNeural mechanisms of riskTreatment-seeking adultsCannabis use disorderNon-clinical sampleMechanisms of riskFunctional connectivity dataSample of adolescentsTreatment outcomesAssociated with harmful outcomesPoor treatment outcomesAddiction severityUse disorderEmerging adulthoodWhole-brainCannabisCollege studentsBrain developmentConnectivity dataIdentified networksTreatment approachesAdultsSensation Seeking, Impulsivity, and Nicotine Dependence among Adolescents and Young Adults who Vape Nicotine and Cannabis
Ouellette R, Morean M, Lee J, Kong G. Sensation Seeking, Impulsivity, and Nicotine Dependence among Adolescents and Young Adults who Vape Nicotine and Cannabis. Drug And Alcohol Dependence 2025, 267: 112209. DOI: 10.1016/j.drugalcdep.2024.112209.Peer-Reviewed Original ResearchCannabis Use and Self-Reported Bothersome Symptoms in People with HIV
Wrona A, Justice A, Tate J, Rentsch C, Gordon K, Kidwai-Khan F, Silverberg M, Satre D, Marconi V, Ingle S, Sterne J, Cavassini M, Bryant K, McGinnis K. Cannabis Use and Self-Reported Bothersome Symptoms in People with HIV. Cannabis 2025, 8: 177-190. PMID: 39968492, PMCID: PMC11831903, DOI: 10.26828/cannabis/2025/000269.Peer-Reviewed Original ResearchCannabis useKaiser Permanente Northern CaliforniaSwiss HIV Cohort StudyHIV Symptom IndexSelf-reportBothersome symptomsSubstance useAssociations of self-reportedBothersome levelSelf-reported substanceMental health symptomsSymptom IndexSelf-reported informationHIV Cohort StudyPatterns of associationWeight lossPresence/absence of symptomsCross-cohort studyLogistic regression modelsHealth symptomsCannabisHealth outcomesLoss of appetiteHIV cohortStudy HIVThe relationship of medical and recreational cannabis laws with opioid misuse and opioid use disorder in the USA: Does it depend on prior history of cannabis use?
Martins S, Bruzelius E, Mauro C, Santaella-Tenorio J, Boustead A, Wheeler-Martin K, Samples H, Hasin D, Fink D, Rudolph K, Crystal S, Davis C, Cerdá M. The relationship of medical and recreational cannabis laws with opioid misuse and opioid use disorder in the USA: Does it depend on prior history of cannabis use? International Journal Of Drug Policy 2025, 136: 104687. PMID: 39793270, PMCID: PMC11821435, DOI: 10.1016/j.drugpo.2024.104687.Peer-Reviewed Original ResearchConceptsCannabis lawsCannabis useNational Survey on Drug Use and Health (NSDUHDrug Use and Health (NSDUHRecreational cannabis lawsState fixed effectsAvailability of cannabisOpioid outcomesOpioid useAssociated with changesHistory of cannabis useLawOpioid misusePast-year cannabis useLifetime cannabis useState policySensitivity to unmeasured confoundingMisuseIndividual level covariatesCannabisLogistic regression modelsAssociated with reductionsOpioidCollider biasFalse discovery rate
2024
Tobacco and Cannabis Co-Use by Sexual Minority Adults in the United States, 2022
Lee J, Hinds J, Dai H, Weinberger A. Tobacco and Cannabis Co-Use by Sexual Minority Adults in the United States, 2022. American Journal Of Preventive Medicine 2024, 68: 717-725. PMID: 39725091, PMCID: PMC12048864, DOI: 10.1016/j.amepre.2024.12.014.Peer-Reviewed Original ResearchConceptsSexual minority individualsCannabis co-useMinority individualsCo-use of tobaccoSexual identityPast-month tobaccoSexual minority adultsNational Survey on Drug Use and HealthLevels of tobaccoCo-useDrug Use and HealthLesbian femalesGay malesBisexual femalesAdult samplesHeterosexual femalesBisexual malesMinority adultsNegative health outcomesHeterosexual malesMultinomial logistic regressionCannabis useUnited StatesHigh health burdenCannabisAlcohol use and cannabis craving in daily life: Sex differences and associations among young adults
Davis C, Ramer N, Squeglia L, Gex K, McRae‐Clark A, McKee S, Roberts W, Gray K, Baker N, Tomko R. Alcohol use and cannabis craving in daily life: Sex differences and associations among young adults. Alcohol Clinical And Experimental Research 2024, 48: 2331-2340. PMID: 39579151, PMCID: PMC11629456, DOI: 10.1111/acer.15461.Peer-Reviewed Original ResearchCannabis cravingAlcohol useMomentary levelWeeks of ecological momentary assessmentYoung adultsEcological momentary assessmentCo-used substancesFemale participantsPatterns of substance useMale participantsLevels of alcohol consumptionConditioned cuesMomentary assessmentAlcohol quantityCravingNaturalistic conditionsCannabisSubstance useSex differencesCo-useAlcohol consumptionNegative associationAlcoholParticipantsFrequent pairsThe association of hidradenitis suppurativa with cigarette smoking and cannabis use: a cross-sectional study in the All of Us Research Program
Chen G, Shipman W, Hodelin C, Hsia H, Cohen J, Eisenstein A. The association of hidradenitis suppurativa with cigarette smoking and cannabis use: a cross-sectional study in the All of Us Research Program. Clinical And Experimental Dermatology 2024, 50: 1042-1044. PMID: 39573984, PMCID: PMC12020478, DOI: 10.1093/ced/llae521.Peer-Reviewed Original ResearchCigarette smokingOdds of cigarette smokingElectronic health recordsHealth research programsCannabis useCross-sectional studyCross sectional studyHealth recordsSectional studySmokingHidradenitis suppurativaNational InstituteSurvey dataAssociationCannabisOddsUseCigaretteHidradenitisResearch programNationalProgramPopulationStudyCannabis Use and Cannabis Use Disorder Among U.S. Adults with Psychiatric Disorders: 2001-2002 and 2012-2013
Hasin D, Mannes Z, Livne O, Fink D, Martins S, Stohl M, Olfson M, Cerdá M, Keyes K, Keyhani S, Wisell C, Bujno J, Saxon A. Cannabis Use and Cannabis Use Disorder Among U.S. Adults with Psychiatric Disorders: 2001-2002 and 2012-2013. Substance Use & Misuse 2024, 60: 285-292. PMID: 39533528, PMCID: PMC11710973, DOI: 10.1080/10826084.2024.2423374.Peer-Reviewed Original ResearchConceptsCannabis use disorderPsychiatric disordersCannabis useNon-medical cannabis useCannabis outcomesUse disorderDSM-IV cannabis use disorderRates of cannabis use disordersRates of cannabis useCannabis use disorder prevalenceAntisocial personality disorderU.S. adultsPersonality disorderDSM-IVVeterans AdministrationPatient samplesNon-medical useDisordersPrevalence differencesU.S. general populationNationally representative sampleCannabisVA patientsAdultsDisproportionate increaseAssociation between cannabis use and brain structure and function: an observational and Mendelian randomisation study
Ishrat S, Levey D, Gelernter J, Ebmeier K, Topiwala A. Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study. BMJ Mental Health 2024, 27: e301065. PMID: 39477366, PMCID: PMC11529520, DOI: 10.1136/bmjment-2024-301065.Peer-Reviewed Original ResearchConceptsCannabis useBrain structuresFunctional connectivityHistory of cannabis useResting-state functional connectivityMeasures of brain structureLifetime cannabis useCentral executive networkLifetime cannabis usersWhite matter integrityGenu of the corpus callosumMendelian randomisation analysisAssociated with multiple measuresPoorer white matter integrityInvestigate potential causal relationshipsCannabis usersExecutive networkBrain regionsImaging-derived phenotypesBrain healthCannabisRandomisation analysesTwo-sample Mendelian randomisation analysisFractional anisotropyYoung adulthoodThe Impact of Cannabis Use Disorder on Critical Illness
Carr Z, Strand E. The Impact of Cannabis Use Disorder on Critical Illness. 2024, 95-105. DOI: 10.1007/978-3-031-67069-5_7.Peer-Reviewed Original ResearchIntensive care unitImpacts of cannabis use disordersCannabis use disorderManagement of patientsIntensive care managementIntensive care management of patientsChronic adverse effectsCannabis useClinical evidenceCare management of patientsBotanical cannabisCannabis usageCare unitUse disorderCannabisOrgan systemsAdverse effectsPatientsDownstream effectsIntensive care unit providersMedical careCare managementMetabotropic Glutamate Receptor 5 as a Potential Biomarker of the Intersection of Trauma and Cannabis Use
Weiss E, Davis M, Asch R, D'Souza D, Cool R, Esterlis I. Metabotropic Glutamate Receptor 5 as a Potential Biomarker of the Intersection of Trauma and Cannabis Use. The International Journal Of Neuropsychopharmacology 2024, 27: pyae044. PMID: 39320043, PMCID: PMC11969217, DOI: 10.1093/ijnp/pyae044.Peer-Reviewed Original ResearchTrauma-related psychopathologyCannabis useDepressive symptomsPositron emission tomographyCross-diagnostic sampleMetabotropic glutamate receptor 5Treatment development effortsAssociated with depressive symptomsGlutamate receptor 5CU groupSample of individualsAvailability in vivoFrontolimbic regionsGlutamatergic systemGlutamatergic neurotransmissionMGlu5PsychopathologyReceptor 5Intersection of traumaExploratory analysisCannabisEmission tomographySymptomsParticipantsVmPFC
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