2025
Structural and functional covariance architecture of major depressive disorder: A meta-analytic structural equation modeling approach to primary neuroimaging analysis
Gray J, Price L, Franklin C, Leonardo C, Chiang F, Choi K, Blangero J, Glahn D, Mayberg H, Fox P. Structural and functional covariance architecture of major depressive disorder: A meta-analytic structural equation modeling approach to primary neuroimaging analysis. Brain Organoid And Systems Neuroscience Journal 2025, 3: 96-106. DOI: 10.1016/j.bosn.2025.04.008.Peer-Reviewed Original ResearchVoxel-based morphometrySubgroup of MDD patientsSubgroups of MDDStructural equation modelingMDD patientsDepressive disorderResting-state functional magnetic resonance imagingAbnormalities of brain structureVoxel-based morphometry analysisFunctional magnetic resonance imagingMagnetic resonance imagingMDD patient groupGray matter densityBiomarkers of MDDNeuroimaging-based biomarkersClinical subgroupsMass-univariate analysesMass-univariate methodsMeta-analytic datasetNeuroimaging effectsNeuroimaging studiesMDDBrain areasBrain structuresMeta-analyticallyMultivariate associations between structural brain changes and cognitive impairment in partially or fully remitted persons with bipolar disorder
Schandorff J, Madsen A, Damgaard V, Little B, Sankar A, Macoveanu J, Frokjaer V, Kessing L, Jørgensen M, Knudsen G, Gallagher P, Miskowiak K. Multivariate associations between structural brain changes and cognitive impairment in partially or fully remitted persons with bipolar disorder. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2025, 140: 111425. PMID: 40505718, DOI: 10.1016/j.pnpbp.2025.111425.Peer-Reviewed Original ResearchBipolar disorderGray matter volumeCognitive impairmentMatter volumeBrain structuresReduced gray matter volumeExtensive cognitive test batteryLower gray matter volumeStructural magnetic resonance imagingBrain structural alterationsCognitive test batteryPosterior cingulate regionsStructural brain changesLeft caudate nucleusCanonical correlation analysisRemitted personsVerbal learningWorking memoryExecutive functionPsychomotor speedCingulate regionsCognitive domainsRight hippocampusCognitively impaired personsBrain changesImpact of Polygenic Interactions With Anticholinergic Burden on Cognition and Brain Structure in Psychosis Spectrum Disorders.
Zhang L, Ivleva E, Parker D, Hill S, Lizano P, Keefe R, Keedy S, McDowell J, Pearlson G, Clementz B, Keshavan M, Gershon E, Tamminga C, Sweeney J, Bishop J. Impact of Polygenic Interactions With Anticholinergic Burden on Cognition and Brain Structure in Psychosis Spectrum Disorders. American Journal Of Psychiatry 2025, appiajp20240709. PMID: 40432343, DOI: 10.1176/appi.ajp.20240709.Peer-Reviewed Original ResearchReduced gray matter volumePsychosis spectrum disordersGray matter volumeBrain structuresPolygenic scoresPsychotic disordersMatter volumeImpact cognitionSpectrum disorderBrief Assessment of CognitionCognitive impairmentGray matter volume reductionBipolar-Schizophrenia NetworkBrain structural outcomesAssessment of CognitionBrain structure phenotypesAnticholinergic burdenPrimary cognitive outcomeGene-by-environment interactionsModerated mediation modelBrief AssessmentBipolar disorderStructural neuroimagingPsychiatric conditionsCognitive abilitiesElevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer’s disease continuum
Nasiri H, Azargoonjahromi A, Nouri Z, Azimi S, Zand H, Shourideh A, Heydari S, Mahmoudvand B, Barabadi S, Samadpour N, Mohamadhosseini A, Khodadadi A, Shakeri S, Mayeli M, Initiative F. Elevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer’s disease continuum. Neuroscience 2025, 577: 47-53. PMID: 40348165, DOI: 10.1016/j.neuroscience.2025.05.013.Peer-Reviewed Original ResearchConceptsCognitive performanceBrain volumeMediation analysisAlzheimer's Disease Assessment Scale-cognitive subscaleReduced gray matterGray matter volumeStructural brain volumesAssociated with cognitive impairmentAlzheimer's diseaseGray matterMagnetic resonance imagingPoor cognitive outcomesAlzheimer's disease continuumMatter volumeT1-weighted magnetic resonance imagingBrain structuresCognitive outcomesCerebral volumeCognitive impairmentCognitive declineBrain atrophyAD continuumBrainSerum leucine levelsAD pathologyIncreased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7‐year period despite high levels of physical activity
Gogniat M, Khan O, Li J, Park C, Robb W, Zhang P, Sun Y, Moore E, Houston M, Pechman K, Shashikumar N, Davis L, Liu D, Landman B, Cole K, Bolton C, Gifford K, Hohman T, Full K, Jefferson A. Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7‐year period despite high levels of physical activity. Alzheimer's & Dementia 2025, 21: e70157. PMID: 40357887, PMCID: PMC12070248, DOI: 10.1002/alz.70157.Peer-Reviewed Original ResearchConceptsSedentary behaviorSedentary timeOlder adultsLevels of physical activityAPOE-e4 carrier statusReduce sedentary timeBrain structuresIncreased sedentary behaviorAPOE-e4 statusRisk factorsModifiable risk factorsLongitudinal linear regressionAlzheimer's diseaseHippocampal volume reductionPhysical activityEffect modificationAPOE-e4E4 statusEpisodic memoryNeuropsychological assessmentApolipoprotein EWorse cognitionAging adultsGenetic riskCognitive changesAlterations in Gray Matter Structure Linked to Frequency-Specific Cortico-Subcortical Connectivity in Schizophrenia via Multimodal Data Fusion
Duda M, Faghiri A, Belger A, Bustillo J, Ford J, Mathalon D, Mueller B, Pearlson G, Potkin S, Preda A, Sui J, Van Erp T, Calhoun V. Alterations in Gray Matter Structure Linked to Frequency-Specific Cortico-Subcortical Connectivity in Schizophrenia via Multimodal Data Fusion. Neuroinformatics 2025, 23: 31. PMID: 40285903, DOI: 10.1007/s12021-025-09728-3.Peer-Reviewed Original ResearchConceptsGray matter volumeJoint independent component analysisFunctional connectivityGroup differencesGray matter volume alterationsCortical gray matter volumeFunctional brain alterationsPathophysiology of SZComplex psychiatric disorderSignificant group differencesCortico-subcortical connectionsStructural brain networksFunctional network connectivityNeuroimaging-based studiesDynamic functional network connectivityGray matter structuresFunctional dysconnectivitySZ groupPsychiatric disordersBrain alterationsMatter volumeBrain networksSchizophreniaBrain structuresSensorimotor networkA genetically informed brain atlas for enhancing brain imaging genomics
Bao J, Wen J, Chang C, Mu S, Chen J, Shivakumar M, Cui Y, Erus G, Yang Z, Yang S, Wen Z, Zhao Y, Kim D, Duong-Tran D, Saykin A, Zhao B, Davatzikos C, Long Q, Shen L. A genetically informed brain atlas for enhancing brain imaging genomics. Nature Communications 2025, 16: 3524. PMID: 40229250, PMCID: PMC11997130, DOI: 10.1038/s41467-025-57636-6.Peer-Reviewed Original ResearchConceptsBrain imaging genomicsImaging genomicsComplex traits/diseasesSNP heritabilityFunctional annotationGenetic architecturePolygenic risk scoresGenomic investigationsGenetic ancestryDiscovery powerBrain atlasesHuman brain structureGenetic determinantsNeuroanatomical heterogeneityGenomeNeuroanatomical variationImaging endophenotypesBrain structuresMolecular levelBrain voxelsHeritabilityPhenotypic correlationsGiant regionGeneticsBrain conditionsMovies reveal the fine-grained organization of infant visual cortex
Ellis C, Yates T, Arcaro M, Turk-Browne N. Movies reveal the fine-grained organization of infant visual cortex. ELife 2025, 12 DOI: 10.7554/elife.92119.4.Peer-Reviewed Original ResearchBrain activityInfant visual systemMagnetic resonance imagingFunctional magnetic resonance imagingInfants' visual processingAdults' brain activityVentral visual cortexInfant brain activityShort attention spanAdult brainVisual cortexInfants' perceptionCognitive tasksBrain organizationBrain structuresInfant scansInfant mindFMRI dataInfant brain structureSensory processingNeurodevelopmental conditionsVisual processingAttention spanHomotopic areasInfant brainConnectomics modeling of regional networks of white-matter fractional anisotropy to predict the severity of young adult drinking
Li Y, Li G, Yang L, Yan Y, Zhang N, Gao M, Hao D, Ye-Lin Y, Li C. Connectomics modeling of regional networks of white-matter fractional anisotropy to predict the severity of young adult drinking. Quantitative Imaging In Medicine And Surgery 2025, 15: 2405419-2402419. PMID: 40160628, PMCID: PMC11948382, DOI: 10.21037/qims-24-2131.Peer-Reviewed Original ResearchConnectome-based predictive modelingSeverity of alcohol consumptionDrinking severityRule-breaking behaviorSex differencesDiffusion tensor imagingFractional anisotropyMediation analysisWhite matter FAImpact brain structureWhite matter integrityFA valuesAlcohol consumptionYoung adult drinkingHuman Connectome ProjectBrain networksBrain regionsWhite-matter fractional anisotropyBrain structuresAdult drinkingAlcohol misuseAlcohol abuseConnectome ProjectConnectome modelTensor imagingProtective role of parenthood on age-related brain function in mid- to late-life
Orchard E, Chopra S, Ooi L, Chen P, An L, Jamadar S, Yeo B, Rutherford H, Holmes A. Protective role of parenthood on age-related brain function in mid- to late-life. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2411245122. PMID: 39999172, PMCID: PMC11892684, DOI: 10.1073/pnas.2411245122.Peer-Reviewed Original ResearchConceptsBrain functionFunctional connectivityPatterns of brain functionAssociated with higher connectivityConsistent with animal modelsBrain structuresCaregiving environmentAssociated with patternsAge-related alterationsBrain healthAging trajectoriesLate-lifeSpatial topographyAdult brainImpact of caregivingBrainPreliminary findingsHuman parentingImpact of ageCaregiving experienceChildrenCaregiversHigher connectivityEffect of parenthoodOne-bodyModeling forebrain regional development and connectivity by human brain organoids
Choe M, Lo C, Park I. Modeling forebrain regional development and connectivity by human brain organoids. Current Opinion In Genetics & Development 2025, 91: 102324. PMID: 39983347, DOI: 10.1016/j.gde.2025.102324.Peer-Reviewed Original ResearchBrain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors
Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors. Translational Psychiatry 2025, 15: 61. PMID: 39979292, PMCID: PMC11842717, DOI: 10.1038/s41398-025-03288-5.Peer-Reviewed Original ResearchConceptsImaging-derived phenotypesBrain imaging-derived phenotypesAlcohol drinkingBrain structuresProcessing of social cuesCorrelates of smoking behaviorRelationship of brain structureSequencing Consortium of AlcoholGlobal genetic correlationsSmoking behaviorSuperior longitudinal fasciculusAssociated with smoking initiationTobacco smokeTobacco smoking behaviorLatent causal variable approachesNicotine useBrain regionsPremotor cortexSocial cuesWhite matter hyperintensitiesLongitudinal fasciculusChemosensory processingCortical thicknessMendelian randomizationPleiotropic mechanismsPolygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults
Chen Y, Li H, Luo X, Li G, Ide J, Li C. Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults. Journal Of Psychiatry And Neuroscience 2025, 50: e31-e44. PMID: 39809531, PMCID: PMC11737878, DOI: 10.1503/jpn.240087.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPolygenic risk scoresSubgenual anterior cingulate cortexAnterior cingulate cortexDepression severityCingulate cortexSubclinical depressionHealthy young adultsSomatic complaintsYoung adultsPolygenic riskAssociated with depression severitySeverity of somatic complaintsSeverity of depressive symptomsAssociated with polygenic riskWhole-brain regressionAlcohol use severityMarkers of depressionManifestations of depressionHuman Connectome ProjectDepressive disorderSubclinical populationsMode networkDepressive symptomsBrain structures
2024
Dynamics of magnetic cortico‐cortical responses evoked by single‐pulse electrical stimulation
Feys O, Schuind S, Sculier C, Rikir E, Legros B, Gaspard N, Wens V, De Tiège X. Dynamics of magnetic cortico‐cortical responses evoked by single‐pulse electrical stimulation. Epilepsia 2024, 66: 503-517. PMID: 39641210, DOI: 10.1111/epi.18183.Peer-Reviewed Original ResearchSingle-pulse electrical stimulationEpileptogenic zoneCortico-corticalRefractory focal epilepsyElectrical stimulationBrain structuresEvoked responsesEffective connectivityEpileptogenic networksFocal epilepsyIntracranial EEGCortical/subcortical structuresComplex spatiotemporal dynamicsIntracranial recordingsStimulationMEG signalsLocation of electrodesMagnetoencephalographyInter-Modality Source Coupling: A Fully-Automated Whole-Brain Data-Driven Structure-Function Fingerprint Shows Replicable Links to Reading in a Large-Scale (N8K) Analysis
Kotoski A, Liu J, Morris R, Calhoun V. Inter-Modality Source Coupling: A Fully-Automated Whole-Brain Data-Driven Structure-Function Fingerprint Shows Replicable Links to Reading in a Large-Scale (N8K) Analysis. IEEE Transactions On Biomedical Engineering 2024, 71: 3383-3389. PMID: 38968021, PMCID: PMC11700228, DOI: 10.1109/tbme.2024.3423703.Peer-Reviewed Original ResearchReading abilityBrain structuresSchool-aged childrenResting-stateStructural magnetic resonance imagingInferior frontal areasFunctional brain changesInferior parietal lobuleHigher reading abilityFunctional connectivity patternsLow reading abilityLingual gyrusNeural basisParietal lobuleReading developmentBrain changesCognitive processesReplication linksRs-fMRICortical regionsReading scoresBrain functionCognitive growthFrontal areasConnectivity patternsAssociation between cannabis use and brain structure and function: an observational and Mendelian randomisation study
Ishrat S, Levey D, Gelernter J, Ebmeier K, Topiwala A. Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study. BMJ Mental Health 2024, 27: e301065. PMID: 39477366, PMCID: PMC11529520, DOI: 10.1136/bmjment-2024-301065.Peer-Reviewed Original ResearchConceptsCannabis useBrain structuresFunctional connectivityHistory of cannabis useResting-state functional connectivityMeasures of brain structureLifetime cannabis useCentral executive networkLifetime cannabis usersWhite matter integrityGenu of the corpus callosumMendelian randomisation analysisAssociated with multiple measuresPoorer white matter integrityInvestigate potential causal relationshipsCannabis usersExecutive networkBrain regionsImaging-derived phenotypesBrain healthCannabisRandomisation analysesTwo-sample Mendelian randomisation analysisFractional anisotropyYoung adulthoodLinking neuroimaging and mental health data from the ABCD Study to UrbanSat measurements of macro environmental factors
Goldblatt R, Holz N, Tate G, Sherman K, Ghebremicael S, Bhuyan S, Al-Ajlouni Y, Santillanes S, Araya G, Abad S, Herting M, Thompson W, Thapaliya B, Sapkota R, Xu J, Liu J, Schumann G, Calhoun V. Linking neuroimaging and mental health data from the ABCD Study to UrbanSat measurements of macro environmental factors. Nature Mental Health 2024, 2: 1285-1297. DOI: 10.1038/s44220-024-00318-x.Peer-Reviewed Original ResearchSymptoms of mental illnessAdolescent Brain Cognitive DevelopmentResidential addressesAdolescent Brain Cognitive Development StudyMental illnessMental healthSubject's residential addressMental health dataDevelopmental periods of childhoodChild healthHealth dataEnvironmental factorsBaseline visitPeriod of childhoodObservational studyPopulation characteristicsHealthIndividual symptomsStudy dataUrban livingIllnessNeurobehavioral researchBrain structuresCognitive developmentAdolescentsGenomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
García-Marín L, Campos A, Diaz-Torres S, Rabinowitz J, Ceja Z, Mitchell B, Grasby K, Thorp J, Agartz I, Alhusaini S, Ames D, Amouyel P, Andreassen O, Arfanakis K, Arias-Vasquez A, Armstrong N, Athanasiu L, Bastin M, Beiser A, Bennett D, Bis J, Boks M, Boomsma D, Brodaty H, Brouwer R, Buitelaar J, Burkhardt R, Cahn W, Calhoun V, Carmichael O, Chakravarty M, Chen Q, Ching C, Cichon S, Crespo-Facorro B, Crivello F, Dale A, Smith G, de Geus E, De Jager P, de Zubicaray G, Debette S, DeCarli C, Depondt C, Desrivières S, Djurovic S, Ehrlich S, Erk S, Espeseth T, Fernández G, Filippi I, Fisher S, Fleischman D, Fletcher E, Fornage M, Forstner A, Francks C, Franke B, Ge T, Goldman A, Grabe H, Green R, Grimm O, Groenewold N, Gruber O, Gudnason V, Håberg A, Haukvik U, Heinz A, Hibar D, Hilal S, Himali J, Ho B, Hoehn D, Hoekstra P, Hofer E, Hoffmann W, Holmes A, Homuth G, Hosten N, Ikram M, Ipser J, Jack Jr C, Jahanshad N, Jönsson E, Kahn R, Kanai R, Klein M, Knol M, Launer L, Lawrie S, Hellard S, Lee P, Lemaître H, Li S, Liewald D, Lin H, Longstreth W, Lopez O, Luciano M, Maillard P, Marquand A, Martin N, Martinot J, Mather K, Mattay V, McMahon K, Mecocci P, Melle I, Meyer-Lindenberg A, Mirza-Schreiber N, Milaneschi Y, Mosley T, Mühleisen T, Müller-Myhsok B, Maniega S, Nauck M, Nho K, Niessen W, Nöthen M, Nyquist P, Oosterlaan J, Pandolfo M, Paus T, Pausova Z, Penninx B, Pike G, Psaty B, Pütz B, Reppermund S, Rietschel M, Risacher S, Romanczuk-Seiferth N, Romero-Garcia R, Roshchupkin G, Rotter J, Sachdev P, Sämann P, Saremi A, Sargurupremraj M, Saykin A, Schmaal L, Schmidt H, Schmidt R, Schofield P, Scholz M, Schumann G, Schwarz E, Shen L, Shin J, Sisodiya S, Smith A, Smoller J, Soininen H, Steen V, Stein D, Stein J, Thomopoulos S, Toga A, Tordesillas-Gutiérrez D, Trollor J, Valdes-Hernandez M, van ′t Ent D, van Bokhoven H, van der Meer D, van der Wee N, Vázquez-Bourgon J, Veltman D, Vernooij M, Villringer A, Vinke L, Völzke H, Walter H, Wardlaw J, Weinberger D, Weiner M, Wen W, Westlye L, Westman E, White T, Witte A, Wolf C, Yang J, Zwiers M, Ikram M, Seshadri S, Thompson P, Satizabal C, Medland S, Rentería M. Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. Nature Genetics 2024, 56: 2333-2344. PMID: 39433889, PMCID: PMC12088653, DOI: 10.1038/s41588-024-01951-z.Peer-Reviewed Original ResearchSubcortical brain volumesBrain volumePolygenic scoresEffects of brain volumeAttention-deficit/hyperactivity disorderIndividuals of diverse ancestryComorbid neuropsychiatric disordersSubcortical brain structuresGenome-wide association study meta-analysesBrain substratesParticipants of European ancestryAttention-deficit/hyperactivityGene expression patternsNeuropsychiatric disordersDifferentiation time pointsBrain structuresGenomic analysisDiverse ancestryBrain developmentStudy meta-analysesGenetic variantsNeural cell typesPhenotypic varianceRisk genesAging-related processesF18. ROLE OF PSYCHIATRIC-ASSOCIATED SNVS IN THE EARLY ADULTHOOD: INSIGHTS FROM LONGITUDINAL NEUROIMAGING
Ito L, Ota V, Fernandes D, Martins A, Carvalho C, Zugman A, Sato J, Bressan R, Miguel E, Pan P, Salum G, Belangero S, Santoro M. F18. ROLE OF PSYCHIATRIC-ASSOCIATED SNVS IN THE EARLY ADULTHOOD: INSIGHTS FROM LONGITUDINAL NEUROIMAGING. European Neuropsychopharmacology 2024, 87: 214-215. DOI: 10.1016/j.euroneuro.2024.08.429.Peer-Reviewed Original ResearchPost-traumatic stress disorderAttention deficit/hyperactivity disorderBrain regionsBipolar disorderMental conditionBrain structuresBrazilian High-Risk Cohort StudyPrefrontal cortex regionsFrontal pole regionsHigh Risk Cohort StudyLateral orbitofrontal regionGenome-wide association studiesSignificant main effectDepressive disorderMixed-effects modelsStress disorderDeficit/hyperactivity disorderFrontal cortexOrbitofrontal regionsBiological underpinningsGenetic influencesCortex regionsLongitudinal relationshipIntracranial volumeEarly adulthoodF85. GENETIC OVERLAP OF BRAIN STRUCTURE AND CONNECTIVITY WITH SCHIZOPHRENIA: DIFFERENT STATISTICAL METHODS PROVIDE COMPLEMENTARY INSIGHTS
Wu X, Parekh P, Lin B, Pries L, Guloksuz S, Rutten B, Andreassen O, Linden D, van der Meer D. F85. GENETIC OVERLAP OF BRAIN STRUCTURE AND CONNECTIVITY WITH SCHIZOPHRENIA: DIFFERENT STATISTICAL METHODS PROVIDE COMPLEMENTARY INSIGHTS. European Neuropsychopharmacology 2024, 87: 251. DOI: 10.1016/j.euroneuro.2024.08.496.Peer-Reviewed Original ResearchConcordant effect directionsLinkage disequilibrium score regressionGenome-wide association study dataCell adhesion molecule bindingGenetic architectureBrain measuresPolygenic scoresBrain phenotypesUnique genesGene OntologyBrain structuresConjunctional false discovery rateLinkage disequilibrium score regression analysisGenetic correlationsGenetic risk of schizophreniaComplex genetic architectureHeritable brain disorderKyoto Encyclopedia of GenesAssociated with schizophreniaInsignificant genetic correlationResting-state fMRIWhite matter integrityEncyclopedia of GenesPostsynaptic densityRisk of schizophrenia
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