2025
Assessment of test-retest reproducibility by [18F]Bavarostat for PET imaging of HDAC6
Naganawa M, Zheng M, Gallezot J, Bonomi R, Gu J, Gao H, Jacutin-Porte S, Nabulsi N, Koole M, Van Laere K, Matuskey D, Huang Y, Carson R. Assessment of test-retest reproducibility by [18F]Bavarostat for PET imaging of HDAC6. EJNMMI Research 2025, 15: 76. PMID: 40542929, PMCID: PMC12182542, DOI: 10.1186/s13550-025-01268-w.Peer-Reviewed Original ResearchAbsolute test-retest variabilityMultilinear analysis-1Time-activity curvesTest-retest variabilityRegional time-activity curvesTest-retest reproducibilityVT valuesTwo-tissue compartment modelEffect of scan durationInterscan intervalRegional VT valuesTest-retest scansScan durationArterial blood samplesBrain bindingOne-tissuePET/CT scannerCentrum semiovaleDistribution volumePET imagingAnalysis-1Blood samplesTherapeutic targetBrain regionsHDAC6 inhibitorsCortisol response patterns to stress correlated to white matter integrity and duration of illness in patients with schizophrenia
Jiang X, Gou M, Yin Y, Chen W, Li Y, Chen S, Pan S, Luo X, Tan S, Tian B, Li W, Tong J, Wang J, Li H, Yu T, Wang Z, Zhang P, Huang J, Tian L, Kochunov P, Li C, Hong L, Tan Y. Cortisol response patterns to stress correlated to white matter integrity and duration of illness in patients with schizophrenia. Psychoneuroendocrinology 2025, 179: 107501. PMID: 40479922, DOI: 10.1016/j.psyneuen.2025.107501.Peer-Reviewed Original ResearchCortisol response patternsDuration of illnessDiffusion tensor imagingCortisol levelsWM integrityPositive and Negative Syndrome ScaleResponse to acute stress exposureHC groupPaced Auditory Serial Addition TaskResponse patternsNegative Syndrome ScaleFirst-episode schizophreniaBiomarkers of schizophreniaAcute stress exposureWhite matter integrityWM microstructural integrityWM tract integritySalivary cortisol levelsSyndrome ScaleChronic schizophreniaClinical psychopathologyCortisol reactivitySchizophrenia pathogenesisWhite matterBrain regionsConnecting the dots: approaching a standardized nomenclature for molecular connectivity in positron emission tomography
Reed M, Cocchi L, Sander C, Chen J, Matheson G, Fisher P, Volpi T, Khattar N, DeLorenzo C, Gryglewski G, Silberbauer L, Murgaš M, Godbersen G, Nics L, Walter M, Hacker M, Bertoldo A, Lubberink M, Silfstein M, Ogden R, Mann J, Suhara T, Varrone A, Boellaard R, Gunn R, Hammers A, Biswal B, Rosen B, Knudsen G, Carson R, Price J, Lanzenberger R, Hahn A. Connecting the dots: approaching a standardized nomenclature for molecular connectivity in positron emission tomography. European Journal Of Nuclear Medicine And Molecular Imaging 2025, 1-11. PMID: 40455254, DOI: 10.1007/s00259-025-07357-1.Peer-Reviewed Original ResearchFunctional connectivityFMRI resting-state functional connectivityResting-state functional connectivityNeurobiological underpinningsMeasured PET signalBrain regionsConnectivity analysisPositron emission tomographyConnectivity metricsConnectivity studiesBetween-subjectsPET signalEmission tomographyBrainImaging modalitiesDiverse methodologiesMolecular connectivityMolecular covariatesFMRIPositronGreater neuroimmune system deficit in women than men with alcohol use disorder
Zakiniaeiz Y, Hillmer A, Shi H, Pittman B, Nabulsi N, Huang Y, Bonomi R, Matuskey D, Angarita G, McKee S, Cosgrove K. Greater neuroimmune system deficit in women than men with alcohol use disorder. Biological Psychiatry 2025 PMID: 40412787, DOI: 10.1016/j.biopsych.2025.05.012.Peer-Reviewed Original ResearchTranslocator protein availabilityAlcohol-induced neurodegenerationExecutive function tasksConsequences of alcohol useAlcohol use disorderBrain imaging scansTranslocator protein levelsSex-matched controlsExecutive functionLower hippocampalTSPO availabilityFrontal cortexTranslocator proteinUse disorderNeurocognitive functionBrain regionsSex differencesAlcohol useBrain-resident immune cellsNeuroimmune mechanismsFunctional tasksSystem deficitsAUDImaging scansNeuroimmune cellsEvaluation of radio-thin-layer chromatography as an alternative to radio-HPLC for [18F]SynVesT-1 metabolism analysis in rats
Balayeva T, Asch R, Tan P, Mennie W, Tong J, Chen B, Zhuang Z, Zheng C, Zheng M, Toyonaga T, Cai Z. Evaluation of radio-thin-layer chromatography as an alternative to radio-HPLC for [18F]SynVesT-1 metabolism analysis in rats. Nuclear Medicine And Biology 2025, 146: 109029. PMID: 40383020, DOI: 10.1016/j.nucmedbio.2025.109029.Peer-Reviewed Original ResearchPositron emission tomographyParent fractionSynaptic vesicle glycoprotein 2ANeuropsychiatric disordersBrain regionsRadiometabolite analysisPET imaging dataLongitudinal studyRadiometabolitesRadio-HPLCArterial blood samplesEmission tomographyBrainMetabolic correctionIntravenous infusionPlasma concentrationsPET quantificationSV2AKinetic modelBlood samplesRadio-high-performance liquid chromatographyPost-injectionRatsRadio-HPLC methodRadio thin layer chromatographyAcute Alcohol‐Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography
Raval N, Smart K, Angarita G, Miller R, Huang Y, Krystal J, Carson R, Cosgrove K, O'Malley S, Hillmer A. Acute Alcohol‐Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography. Addiction Biology 2025, 30: e70031. PMID: 40309934, PMCID: PMC12044519, DOI: 10.1111/adb.70031.Peer-Reviewed Original ResearchConceptsBlood alcohol levelsAlcohol challengeEffects of acute alcohol consumptionPeak blood alcohol levelsLaboratory alcohol challengeNon-displaceable binding potentialMetabotropic glutamate receptor 5Acute alcohol challengeGlutamate releaseAlcohol-induced changesGlutamate receptor 5Alcohol consumptionAcute alcohol consumptionMGluR5 availabilityPET scansSocial drinkersEthanol doseAlcohol effectsBrain regionsAcute alcoholBinding potentialCortical regionsClinically relevant dosesDrinking occasionsAlcohol levelsA multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder
Wang J, Liu Y, Li H, Nguyen T, Soto-Vargas J, Wilson R, Wang W, Lam T, Zhang C, Lin C, Lewis D, Glausier J, Holtzheimer P, Friedman M, Williams K, Picciotto M, Nairn A, Krystal J, Duman R, Young K, Zhao H, Girgenti M. A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder. Genome Medicine 2025, 17: 43. PMID: 40301990, PMCID: PMC12042318, DOI: 10.1186/s13073-025-01473-1.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderDorsolateral prefrontal cortexPsychiatric disordersAutism spectrum disorderPrefrontal cortexDepressive disorderStress disorderGamma-aminobutyric acidGenome-wide association studiesPTSD brainsGenome-wide measurementsStudies of postmortem brainsSubgenual prefrontal cortexDisabling psychiatric disorderMultiple psychiatric disordersPrefrontal cortical areasPTSD casesHuman brain studiesBrain regionsSpectrum disorderGABAergic processesPostmortem brainsMDDProtein co-expression modulesProteomic profilingCausal Modeling of FMRI Time-Series for Interpretable Autism Spectrum Disorder Classification
Duan P, Dvornek N, Wang J, Staib L, Duncan J. Causal Modeling of FMRI Time-Series for Interpretable Autism Spectrum Disorder Classification. 2025, 00: 1-5. DOI: 10.1109/isbi60581.2025.10980933.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingAutism spectrum disorderState-of-the-art modelsState-of-the-artFMRI time seriesDeep learning classifierDeep learning modelsTime series informationLearning classifiersClassification accuracyNon-linear interactionsMachine learningLeft precuneusRight precuneusABIDE datasetBrain regionsLearning modelsASD populationSpectrum disorderDisorder classificationASD classificationBrain signalsASD biomarkersDevelopmental disordersCorrelation-based modelsDLG2 rs11607886 polymorphism associated with schizophrenia and precuneus functional changes
Zhu H, Wu Z, Wang J, Zhang E, Zhang S, Yang Y, Li W, Shi H, Yang G, Lv L, Zhang Y. DLG2 rs11607886 polymorphism associated with schizophrenia and precuneus functional changes. Schizophrenia Research 2025, 280: 50-58. PMID: 40220608, DOI: 10.1016/j.schres.2025.04.004.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingSZ patientsPrecuneus gyrusRight middle temporal gyrusHealthy controlsMiddle temporal gyrusIncreased risk of SZSevere mental disordersRisk of SZPathogenesis of SZAssociated with SZClinical symptom assessmentSignificant main effectLeft precuneus gyrusTemporal gyrusBrain regionsMental disordersSchizophreniaCognitive functionBrain functionSZ susceptibilityMain effectGyrusMagnetic resonance imagingSingle nucleotide polymorphismsUnraveling the Neural Landscape of Mental Disorders using Double Functional Independent Primitives (dFIPs)
Soleimani N, Iraji A, Pearlson G, Preda A, Calhoun V. Unraveling the Neural Landscape of Mental Disorders using Double Functional Independent Primitives (dFIPs). Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40222638, DOI: 10.1016/j.bpsc.2025.03.015.Peer-Reviewed Original ResearchAutism spectrum disorderFunctional network connectivityBipolar disorderPsychiatric conditionsMental disordersMental illnessResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingConnectivity patternsBrain network alterationsFunctional connectivity patternsNeurobiological underpinningsDepressive disorderEmotion regulationNeural signaturesPsychiatric diagnosisConnectivity alterationsBrain regionsSpectrum disorderCognitive functionNeural landscapeCerebellar connectivitySocial behaviorNetwork alterationsSchizophreniaExtracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks
Kawiková I, Špička V, Lai J, Askenase P, Wen L, Kejík Z, Jakubek M, Valeš K, Španiel F. Extracellular vesicles as precision therapeutics for psychiatric conditions: targeting interactions among neuronal, glial, and immune networks. Frontiers In Immunology 2025, 16: 1454306. PMID: 40264776, PMCID: PMC12011847, DOI: 10.3389/fimmu.2025.1454306.Peer-Reviewed Original ResearchConceptsDevelopment of immune therapiesEVs-based therapyIatrogenic immune deficienciesRobust preclinical dataExploitation of extracellular vesiclesPsychiatric diseasesDiagnostic biomarker panelExtracellular vesiclesRecipient cell functionsImmune therapyImmune deficiencyPatient subsetsPreclinical dataFluid abnormalitiesBiomarker panelEV administrationImmune systemIntercellular communicationPrecision therapeuticsTherapyTherapeutic toolCell functionRegulatory approvalPsychiatric conditionsBrain regionsThe MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program
Harms M, Cho K, Anticevic A, Bolo N, Bouix S, Campbell D, Cannon T, Cecchi G, Goncalves M, Haidar A, Hughes D, Izyurov I, John O, Kapur T, Kim N, Kotler E, Kubicki M, Kuperman J, Laulette K, Lindberg U, Markiewicz C, Ning L, Poldrack R, Rathi Y, Romo P, Tamayo Z, Wannan C, Wickham A, Yassin W, Zhou J, Addington J, Alameda L, Arango C, Breitborde N, Broome M, Cadenhead K, Calkins M, Chen E, Choi J, Conus P, Corcoran C, Cornblatt B, Diaz-Caneja C, Ellman L, Fusar-Poli P, Gaspar P, Gerber C, Glenthøj L, Horton L, Hui C, Kambeitz J, Kambeitz-Ilankovic L, Keshavan M, Kim S, Koutsouleris N, Kwon J, Langbein K, Mamah D, Mathalon D, Mittal V, Nordentoft M, Pearlson G, Perez J, Perkins D, Powers A, Rogers J, Sabb F, Schiffman J, Shah J, Silverstein S, Smesny S, Stone W, Strauss G, Thompson J, Upthegrove R, Verma S, Wang J, Wolf D, Kahn R, Kane J, McGorry P, Nelson B, Woods S, Shenton M, Wood S, Bearden C, Pasternak O. The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program. Schizophrenia 2025, 11: 52. PMID: 40175382, PMCID: PMC11965426, DOI: 10.1038/s41537-025-00581-6.Peer-Reviewed Original ResearchClinical high riskSchizophrenia ProgramClinical high-risk cohortClinical high-risk stateResting-state fMRIFMRI scanningStudy of individualsNeuroimaging resultsBrain regionsNeuroimaging dataNeuroimaging protocolsStructural scansParticipation varianceDiffusion scansFMRIPercentage of participantsNeuroimagingVariance component analysisMulti-siteParticipantsPsychosisVarianceTime pointsDiffusion-weighted imagingHigh riskMicroglial regulation of white matter development and its disruption in autism spectrum disorder
Canada K, Evans T, Pelphrey K. Microglial regulation of white matter development and its disruption in autism spectrum disorder. Cerebral Cortex 2025, 35: bhaf109. PMID: 40302613, DOI: 10.1093/cercor/bhaf109.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderMaternal immune activationWhite matter developmentSpectrum disorderPresentation of autism spectrum disorderService of perceptionCortical brain regionsBrain-resident immune cellsWhite matterResident immune cellsSocial cognitionCore symptomsWhite matter abnormalitiesBrain regionsBrain functionNeurodevelopmental disordersOL lineage cellsImmune dysregulationEfficient neuronal signalingImmune activationImmune cellsCytokine releaseMicroglial reactivityHuman brainLineage cellsAlcohol use disorder and body mass index show genetic pleiotropy and shared neural associations
Malone S, Davis C, Piserchia Z, Setzer M, Toikumo S, Zhou H, Winterlind E, Gelernter J, Justice A, Leggio L, Rentsch C, Kranzler H, Gray J. Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations. Nature Human Behaviour 2025, 9: 1056-1066. PMID: 40164914, DOI: 10.1038/s41562-025-02148-y.Peer-Reviewed Original ResearchConceptsAlcohol use disorderUse disorderBrain regionsGenotype-Tissue ExpressionSingle-nucleotide polymorphismsPolygenic overlapAssociated with alcohol use disorderCaudate nucleus volumeBody mass indexMultiple brain regionsConjunctional false discovery rateNeurobiological overlapExecutive functionNeurobiological mechanismsNeural associationsBrain phenotypesNucleus volumeFalse discovery rate methodFalse discovery rateGenetic architectureVariant effectsMass indexGenetic pleiotropyDiscovery rateTissue enrichmentProjectome-based characterization of hypothalamic peptidergic neurons in male mice
Jiao Z, Gao T, Wang X, Wang A, Ma Y, Feng L, Gao L, Gou L, Zhang W, Biglari N, Boxer E, Steuernagel L, Ding X, Yu Z, Li M, Gao M, Hao M, Zhou H, Cao X, Li S, Jiang T, Qi J, Jia X, Feng Z, Ren B, Chen Y, Shi X, Wang D, Wang X, Han L, Liang Y, Qian L, Jin C, Huang J, Deng W, Wang C, Li E, Hu Y, Tao Z, Li H, Yu X, Xu M, Chang H, Zhang Y, Xu H, Yan J, Li A, Luo Q, Stoop R, Sternson S, Brüning J, Anderson D, Poo M, Sun Y, Xu S, Gong H, Sun Y, Xu X. Projectome-based characterization of hypothalamic peptidergic neurons in male mice. Nature Neuroscience 2025, 28: 1073-1088. PMID: 40140607, DOI: 10.1038/s41593-025-01919-0.Peer-Reviewed Original ResearchConceptsHypothalamic peptidergic neuronsMale micePeptidergic neuronsStructural basisInnate behaviorsHypothalamic functionBrain regionsPhysiological homeostasisAxonal projectionsCircuit mechanismsPeptidergic axonsHypothalamic axonsSoma distributionsHypothalamusMiceAxonsNeuropeptideTopographic organizationNeuronsMaleVoxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes
Karam G, Chen M, Zeevi D, Harms B, Berson E, Torres-Lopez V, Rivier C, Malhotra A, Qureshi A, Falcone G, Sheth K, Payabvash S. Voxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes. Stroke 2025, 56: 868-877. PMID: 40052269, PMCID: PMC11932768, DOI: 10.1161/strokeaha.124.048453.Peer-Reviewed Original ResearchConceptsImpact of intracerebral hemorrhageAssociated with worse outcomesClinical risk factorsVoxel-wise mapsMapping of brain regionsBaseline hematomaVoxel-wise analysisHematoma volumeICH locationBrain regionsValidation cohortWorse outcomesPresence of intraventricular hemorrhageRisk factorsBaseline hematoma volumeModified Rankin Scale scorePoor scan qualityMulticenter clinical trialRankin Scale scoreDeep white matterLow-risk categoryComprehensive stroke centerIntraventricular hemorrhageConsecutive patientsPatient ageBrain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease
Ramsingh N, Lin H, Ouyang Y, Ravona‐Springer R, Livny A, Soleimani L, Bendlin B, Matatov A, Niv T, Shamir T, Ganmore I, Heymann A, Sano M, Azuri J, Beeri M. Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease. International Journal Of Geriatric Psychiatry 2025, 40: e70060. PMID: 40050014, DOI: 10.1002/gps.70060.Peer-Reviewed Original ResearchConceptsSuperior longitudinal fasciculusCortical volumeCortical brain volumesWhite matterAlzheimer's Prevention studyEarly cognitive declineBrain signaturesBrain regionsCognitive changesWM microstructureMiddle-aged adultsBrain volumeLongitudinal fasciculusCognitive declinePreclinical cognitive changesOffspring of peopleBrain tractsPatient's offspringTarget individualsEarly interventionCorpus callosumParental historyBrainAlzheimer's diseaseLinear regression modelsEffects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed with PET Imaging and Neuronally Derived Exosomes
Johnson B, Allen M, Nader S, Solingapuram Sai K, Kumar A, Su Y, Singh S, Li S, Huang Y, Deep G, Nader M. Effects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed with PET Imaging and Neuronally Derived Exosomes. Biological Psychiatry 2025 PMID: 40054763, DOI: 10.1016/j.biopsych.2025.02.900.Peer-Reviewed Original ResearchLong-term cocaine self-administrationKappa-opioid receptorsCocaine self-administrationSelf-administrationKappa opioid receptor availabilityPeripheral measuresSocially housed monkeysOpioid receptorsCocaine intakeCocaine SAIntravenous cocaineCocaine misuseBrain regionsCocainePET imagingCynomolgus monkeysSocial rankPET studiesPharmacological interventionsMonkeysPET scansBrainBlood samplesDominant femalesSocialConnectomics modeling of regional networks of white-matter fractional anisotropy to predict the severity of young adult drinking
Li Y, Li G, Yang L, Yan Y, Zhang N, Gao M, Hao D, Ye-Lin Y, Li C. Connectomics modeling of regional networks of white-matter fractional anisotropy to predict the severity of young adult drinking. Quantitative Imaging In Medicine And Surgery 2025, 15: 2405419-2402419. PMID: 40160628, PMCID: PMC11948382, DOI: 10.21037/qims-24-2131.Peer-Reviewed Original ResearchConnectome-based predictive modelingSeverity of alcohol consumptionDrinking severityRule-breaking behaviorSex differencesDiffusion tensor imagingFractional anisotropyMediation analysisWhite matter FAImpact brain structureWhite matter integrityFA valuesAlcohol consumptionYoung adult drinkingHuman Connectome ProjectBrain networksBrain regionsWhite-matter fractional anisotropyBrain structuresAdult drinkingAlcohol misuseAlcohol abuseConnectome ProjectConnectome modelTensor imagingIdentifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation
Dai W, Zhang H. Identifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation. Journal Of The American Statistical Association 2025, ahead-of-print: 1-19. DOI: 10.1080/01621459.2025.2450837.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsDetect single nucleotide polymorphismsGene-based analysisControlling false discovery rateControlling false discoveriesSNP setsFunctional connectivityFalse discovery rateGenetic architectureNovel genesGenetic basisNucleotide polymorphismsGenetic variantsUK Biobank dataPsychiatric disordersDiscovery rateBrain functionFalse discoveriesBiobank dataCorrelations of neural activityBrain regionsBiological etiologyBrain connectivityEQTLNeural activity
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