2025
Imaging Markers of Neuroinflammation in Aging and Alzheimer's Disease and Related Dementia: A Comprehensive Review
Chaudhary S, Chao H, Agarwal K, Gupta S, Li C. Imaging Markers of Neuroinflammation in Aging and Alzheimer's Disease and Related Dementia: A Comprehensive Review. Neuroscience & Biobehavioral Reviews 2025, 176: 106270. PMID: 40578495, DOI: 10.1016/j.neubiorev.2025.106270.Peer-Reviewed Original ResearchFunctional brain changesBrain changesMagnetic resonance imagingCognitive declineWhite matter deficitsImaging marker of neuroinflammationFunctional brain impairmentAlzheimer's diseaseImpact of neuroinflammationDiffusion tensor imagingMarkers of neuroinflammationFunctional connectivityBrain impairmentAssessment of blood-brain barrierNeural markersBody of researchDevelopment of Alzheimer's diseaseTensor imagingBlood-brain barrierOlder adultsGray matterNeuroinflammatory processesMagnetization transfer imagingStructural imagingRelated dementiaSuccessful Evidence-Based Parenting Programs are Associated With Brain Changes and Improved Reward Processing in Boys With Conduct Problems
Sethi A, O’Brien S, Blair J, Viding E, Shani D, Robinson O, Mehta M, Ecker C, Petrinovic M, Catani M, Blackwood N, Doolan M, Murphy D, Scott S, Craig M. Successful Evidence-Based Parenting Programs are Associated With Brain Changes and Improved Reward Processing in Boys With Conduct Problems. Biological Psychiatry 2025 PMID: 40541593, DOI: 10.1016/j.biopsych.2025.06.008.Peer-Reviewed Original ResearchVentromedial prefrontal cortexAntisocial behaviorConduct problemsParenting behaviorsParenting interventionsAssociated with brain changesReward processing regionsReward learning taskPosterior cingulate cortexIncreased neural activityTask-based fMRIReinforcement learning parametersEarly interventionGroup parenting interventionEarly parenting interventionsReduce antisocial behaviorPersistent CPReward/punishment sensitivityInsula activationNeurocognitive mechanismsReward processingPrefrontal cortexCingulate cortexBrain changesAction biasMultivariate associations between structural brain changes and cognitive impairment in partially or fully remitted persons with bipolar disorder
Schandorff J, Madsen A, Damgaard V, Little B, Sankar A, Macoveanu J, Frokjaer V, Kessing L, Jørgensen M, Knudsen G, Gallagher P, Miskowiak K. Multivariate associations between structural brain changes and cognitive impairment in partially or fully remitted persons with bipolar disorder. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2025, 140: 111425. PMID: 40505718, DOI: 10.1016/j.pnpbp.2025.111425.Peer-Reviewed Original ResearchBipolar disorderGray matter volumeCognitive impairmentMatter volumeBrain structuresReduced gray matter volumeExtensive cognitive test batteryLower gray matter volumeStructural magnetic resonance imagingBrain structural alterationsCognitive test batteryPosterior cingulate regionsStructural brain changesLeft caudate nucleusCanonical correlation analysisRemitted personsVerbal learningWorking memoryExecutive functionPsychomotor speedCingulate regionsCognitive domainsRight hippocampusCognitively impaired personsBrain changesNeurocognitive effects of psilocybin: A systematic and comprehensive review of neuroimaging studies in humans
Berkovitch L, Fauvel B, Preller K, Gaillard R. Neurocognitive effects of psilocybin: A systematic and comprehensive review of neuroimaging studies in humans. Neuroscience & Biobehavioral Reviews 2025, 175: 106239. PMID: 40456393, DOI: 10.1016/j.neubiorev.2025.106239.Peer-Reviewed Original ResearchConceptsEffects of psilocybinPsilocybin effectsNeuroimaging studiesBrain changesNeuroimaging techniquesTherapeutic effects of psilocybinTreat various psychiatric disordersFunctional brain changesSamples of healthy volunteersSerotonergic compoundsEmotional processingNeurobiological mechanismsMode networkPsychiatric disordersCognitive tasksPsychoactive effectsBrain activityNeuroimaging dataPsilocybinSelf-experienceAssociated with acute alterationsSocial functioningTherapeutic effectBrainNeuronal networksAssociations between diffusion tensor imaging patterns and cerebrospinal fluid markers in mild cognitive impairment
Niknam N, Khaefi S, Heidarpour H, Sadeghi M, Jafari N, Mohammadi S, Ahmadi Z, Ahangar-Sirous R, Mayeli M, Seyedmirzaei H, Initiative A. Associations between diffusion tensor imaging patterns and cerebrospinal fluid markers in mild cognitive impairment. Journal Of Clinical Neuroscience 2025, 135: 111141. PMID: 40010169, DOI: 10.1016/j.jocn.2025.111141.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentDiffusion tensor imagingWhite matter tractsDiffusion tensor imaging metricsAlzheimer's Disease Neuroimaging InitiativeCognitive impairmentLeft uncinate fasciculusMild cognitive impairment groupDiffusion tensor imaging markersBrain changesUncinate fasciculusCerebrospinal fluidDTI patternsTensor imagingCerebrospinal fluid biomarkersStudy groupImpairmentIncreased water diffusionCerebrospinal fluid markersStatistically significant associationStatistically significant differenceStructural Brain Changes Associated With Risky Drinking in Late-Life Depression
Steffens D, Wang L, Manning K, Pearlson G. Structural Brain Changes Associated With Risky Drinking in Late-Life Depression. The American Journal Of Geriatric Psychiatry Open Science Education And Practice 2025, 6: 1-14. PMID: 40535612, PMCID: PMC12176382, DOI: 10.1016/j.osep.2025.01.003.Peer-Reviewed Original ResearchStructural brain changesBrain changesAlcohol useAlcohol consumptionCortical thicknessFronto-striatal circuitsInferior parietal sulcusVolumetric brain changesFrontal cortical regionsLate-life depressionDecreased depression severityModerate drinkersDecreased alcohol consumptionOlder adultsRisky drinkersRisky alcohol useImpact of alcohol useCognitive batteryDepression severityDepressive episodeDSM criteriaStudy psychiatristClinical interviewOlder depressivesPosterior cingulateStructural Brain Changes Associated With Cognitive Behavioral Therapy in Cocaine Use Disorder Treatment
McCurdy L, DeVito E, Loya J, Nich C, Kiluk B, Potenza M. Structural Brain Changes Associated With Cognitive Behavioral Therapy in Cocaine Use Disorder Treatment. Drug And Alcohol Dependence 2025, 267: 112224. DOI: 10.1016/j.drugalcdep.2024.112224.Peer-Reviewed Original ResearchPrenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways
Maurer S, Hing B, Lussier S, Radhakrishna S, Davis J, Abbott P, Michaelson J, Stevens H. Prenatal stress alters mouse offspring dorsal striatal development and placental function in sex-specific ways. Journal Of Psychiatric Research 2025, 182: 149-160. PMID: 39809011, PMCID: PMC11959308, DOI: 10.1016/j.jpsychires.2024.12.048.Peer-Reviewed Original ResearchConceptsPrenatal stressAutism spectrum disorderSex-specific wayDorsal striatumNeurodevelopmental disordersGABAergic populationEffects of prenatal stressStriatal GABAergic neuronsReversal learningVentral forebrain regionsBrain changesSpectrum disorderForebrain regionsStriatal developmentGABAergic neuronsBehavioral assaysBrain developmentPlacental transcriptomeStriatumCognitionDevelopmental originsDisordersPlacental differencesPlacental functionPlacenta function
2024
Inter-Modality Source Coupling: A Fully-Automated Whole-Brain Data-Driven Structure-Function Fingerprint Shows Replicable Links to Reading in a Large-Scale (N8K) Analysis
Kotoski A, Liu J, Morris R, Calhoun V. Inter-Modality Source Coupling: A Fully-Automated Whole-Brain Data-Driven Structure-Function Fingerprint Shows Replicable Links to Reading in a Large-Scale (N8K) Analysis. IEEE Transactions On Biomedical Engineering 2024, 71: 3383-3389. PMID: 38968021, PMCID: PMC11700228, DOI: 10.1109/tbme.2024.3423703.Peer-Reviewed Original ResearchReading abilityBrain structuresSchool-aged childrenResting-stateStructural magnetic resonance imagingInferior frontal areasFunctional brain changesInferior parietal lobuleHigher reading abilityFunctional connectivity patternsLow reading abilityLingual gyrusNeural basisParietal lobuleReading developmentBrain changesCognitive processesReplication linksRs-fMRICortical regionsReading scoresBrain functionCognitive growthFrontal areasConnectivity patternsStructural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment
McCurdy L, DeVito E, Loya J, Nich C, Zhai Z, Kiluk B, Potenza M. Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment. Drug And Alcohol Dependence Reports 2024, 11: 100246. PMID: 38966567, PMCID: PMC11222934, DOI: 10.1016/j.dadr.2024.100246.Peer-Reviewed Original ResearchCocaine use disorderCognitive behavioral therapyCocaine useBehavioral therapyBrain changesBrain structuresWhole-brain voxel-based morphometry analysisCocaine use disorder treatmentLevel of cocaine useWeeks of outpatient treatmentVoxel-based morphometry analysisDigital cognitive behavioral therapyT1-weighted magnetic resonance imaging scansRight caudate bodyAssociated with cocaine useMethadone-maintained individualsGray matter volumeStructural brain changesFunction of engagementCaudate bodyRight caudateCUD treatmentMatter volumeUse disorderBilateral cerebellumOral ketamine effects on dynamics of functional network connectivity in patients treated for chronic suicidality
Shan Z, Can A, Mohamed A, Dutton M, Hermens D, Calhoun V, Williams L, Bennett M, Lagopoulos J. Oral ketamine effects on dynamics of functional network connectivity in patients treated for chronic suicidality. European Archives Of Psychiatry And Clinical Neuroscience 2024, 1-11. PMID: 38772940, DOI: 10.1007/s00406-024-01831-x.Peer-Reviewed Original ResearchBeck Scale for Suicide IdeationBeck Scale for Suicidal Ideation scoresChronic suicidalityFollow-upPersistent respondingScale for Suicide IdeationCognitive control statesBrain statesSuicide-preventive effectsResting-state functional MRIMechanisms of ketamineDynamic functional connectivity analysisFunctional network connectivityPost-treatment patientsCharacteristics of patientsTrial's primary endpointPost-treatmentKetamine trialsBrain mechanismsKetamine effectsKetamine treatmentSuicidal ideationBrain changesFunctional MRIPrimary endpointNeuroimaging alterations and relapse in early-stage psychosis
Mihaljevic M, Nagpal A, Etyemez S, Narita Z, Ross A, Schaub R, Cascella N, Coughlin J, Nestadt G, Nucifora F, Sedlak T, Calhoun V, Faria A, Yang K, Sawa A. Neuroimaging alterations and relapse in early-stage psychosis. Journal Of Psychiatry And Neuroscience 2024, 49: e135-e142. PMID: 38569725, PMCID: PMC10980532, DOI: 10.1503/jpn.230115.Peer-Reviewed Original ResearchConceptsEarly-stage psychosisNeuroimaging alterationsResting-state functional MRI dataNo-relapse groupFunctional connectivity changesFunctional MRI dataHealthy controlsMagnetic resonance imagingRelapse groupPsychotic disordersFunctional connectivity estimatesBrain changesPsychotic eventsPsychosisConnectivity changesSymptom exacerbationConnectivity estimatesComparison correctionNo relapseLongitudinal studyThalamusNeuroimagingMRI dataClinical confounding factorsControl groupA Novel Deep Subspace Learning Framework to Automatically Uncover Assessment-Specific Independent Brain Networks
Batta I, Abrol A, Calhoun V. A Novel Deep Subspace Learning Framework to Automatically Uncover Assessment-Specific Independent Brain Networks. 2024, 00: 1-6. DOI: 10.1109/ciss59072.2024.10480204.Peer-Reviewed Original ResearchLearning frameworkBrain subsystemsSubspace learning frameworkBrain networksHigh-dimensional neuroimaging dataConvolutional neural networkLow-dimensional subspaceSupervised learning approachDeep learning frameworkStructural brain featuresPredictive performanceUnsupervised approachNeural networkAutomated frameworkDimensional subspaceAlzheimer's diseaseLearning approachBrain changesFeature importanceTraining procedureNeuroimaging dataBrain featuresSalient networkNetworkBrain disordersAndrogen deprivation increases frontopolar cortical thickness in prostate cancer patients: an effect of early neurodegeneration?
Chaudhary S, Roy A, Summers C, Ahles T, Li C, Chao H. Androgen deprivation increases frontopolar cortical thickness in prostate cancer patients: an effect of early neurodegeneration? American Journal Of Cancer Research 2024, 14: 3652-3664. PMID: 39113873, PMCID: PMC11301281, DOI: 10.62347/wola8904.Peer-Reviewed Original ResearchFrontopolar cortexCortical thicknessWorking memoryAndrogen deprivation therapyN-back performanceN-back taskProstate cancer patientsYears of educationPublished routinesNeural consequencesBrain changesBrain morphologyMediation analysisCT changesConsequences of androgen deprivation therapyMonths of androgen deprivation therapyTestosterone level changesImpact of androgen deprivation therapyCancer patientsNon-metastatic prostate cancerTestosterone levelsResponse to androgen deprivationLong duration of treatmentBrain imagingNeurodegenerative changes
2023
6 Graph Analysis of Resting State Functional Brain Networks and Associations with Cognitive Outcomes in Survivors on Pediatric Brain Tumor
Semmel E, Calhoun V, Hillary F, Morris R, King T. 6 Graph Analysis of Resting State Functional Brain Networks and Associations with Cognitive Outcomes in Survivors on Pediatric Brain Tumor. Journal Of The International Neuropsychological Society 2023, 29: 316-317. DOI: 10.1017/s135561772300437x.Peer-Reviewed Original ResearchSurvivors of pediatric brain tumorsFunctional brain networksWorking memoryBrain networksCognitive outcomesProcessing speedLong-term neuropsychological deficitsResting state functional magnetic resonance imagingFunctional magnetic resonance imagingMeasures of attentionCore cognitive skillsLong-term cognitive outcomesStructural brain changesSmall-moderate effect sizeFunctional network propertiesSurvivors of brain tumorsBrain tumor survivorsGraph metricsResting state dataGlobal efficiencyNeuropsychological deficitsNeuropsychological testsBrain changesGroup differencesIndependence in adulthoodAge-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains
Anderson J, Calhoun V, Pearlson G, Hawkins K, Stevens M. Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains. Developmental Cognitive Neuroscience 2023, 64: 101318. PMID: 37875033, PMCID: PMC10618425, DOI: 10.1016/j.dcn.2023.101318.Peer-Reviewed Original ResearchConceptsExecutive function domainsResponse inhibitionWhite matter microstructureLower response inhibitionStructure-cognition relationshipsEF abilitiesBehavioral performanceCognitive imbalanceNeurocognitive testsFunction domainTest performanceYoung adulthoodFractional anisotropyBrain changesAge 12Young adultsSS performanceWhite matter FA valuesGreater relianceWhite matter changesWhite matter microstructural differencesSubjects ages 12White matter skeletonIndependent componentsMultivariate associationsGraph analysis of resting state functional brain networks and associations with cognitive outcomes in survivors of pediatric brain tumor
Semmel E, Calhoun V, Hillary F, Morris R, King T. Graph analysis of resting state functional brain networks and associations with cognitive outcomes in survivors of pediatric brain tumor. Neuroimage Reports 2023, 3: 100178. PMID: 40568453, PMCID: PMC12172936, DOI: 10.1016/j.ynirp.2023.100178.Peer-Reviewed Original ResearchSurvivors of pediatric brain tumorsFunctional brain networksWorking memoryBrain networksFunctional magnetic resonance imagingLong-term cognitive difficultiesCognitive outcomes in adulthoodCore cognitive skillsFunctional network propertiesOutcomes in adulthoodBrain tumor survivorsGraph metricsNeuroimaging researchNeuropsychological testsBrain changesCognitive difficultiesProcessing speedCognitive outcomesHub regionsSmall-worldCognitive skillsPost hoc analysisTumor survivorsPediatric brain tumor patientsSmall-world propertiesSensorimotor Cortical Thickness Changes Following Taxane-Based Chemotherapy: Support for a CNS Role in CIPN?
Worthen-Chaudhari L, Monfort S, Chaudhari A, Lustberg M. Sensorimotor Cortical Thickness Changes Following Taxane-Based Chemotherapy: Support for a CNS Role in CIPN? Archives Of Physical Medicine And Rehabilitation 2023, 104: e51. DOI: 10.1016/j.apmr.2022.12.148.Peer-Reviewed Original ResearchChemotherapy cyclesCortical thicknessBrain changesBreast cancerSensorimotor regionsCycles of TaxolSensorimotor cortical thicknessChemotherapy-induced neuropathyFirst chemotherapy cycleBreast cancer survivorsMain outcome measuresMean cortical thicknessSensory-motor regionsBrain structural integrityTaxane exposureChemotherapy exposureCancer survivorsCentral effectsChemotherapy treatmentDesign ProspectiveOutpatient oncologyCNS roleCommencement of studyOutcome measuresGait variabilityPotential Biological Markers and Treatment Implications for Binge Eating Disorder and Behavioral Addictions
Mestre-Bach G, Potenza M. Potential Biological Markers and Treatment Implications for Binge Eating Disorder and Behavioral Addictions. Nutrients 2023, 15: 827. PMID: 36839185, PMCID: PMC9962023, DOI: 10.3390/nu15040827.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInternet gaming disorderGambling disorderVentral striatumBehavioral addictionsBinge Eating DisorderReward processingEating DisordersGaming disorderReward systemTreatment implicationsBrain regionsBrain changesTreatment-related changesAddictionDisordersBingePotential biological markersPossible biomarkersBiological markersMore evidenceSpecific roleProcessingInterventionImplicationsCircuitry
2022
Characterization of Early Stage Parkinson's Disease From Resting-State fMRI Data Using a Long Short-Term Memory Network
Guo X, Tinaz S, Dvornek N. Characterization of Early Stage Parkinson's Disease From Resting-State fMRI Data Using a Long Short-Term Memory Network. Frontiers In Neuroimaging 2022, 1: 952084. PMID: 37555151, PMCID: PMC10406199, DOI: 10.3389/fnimg.2022.952084.Peer-Reviewed Original ResearchEarly-stage Parkinson's diseaseFunctional magnetic resonance imagingParkinson's Progression Markers InitiativeParkinson's diseaseProgression Markers InitiativeDiagnosis of PDEarly-stage diseaseFunctional brain changesBrain function alterationsStage Parkinson's diseaseFunctional connectivity differencesComplex neurodegenerative disorderMagnetic resonance imagingResting-state fMRI dataStage diseaseDisease stageDisease progressionBrain changesTreatment responseMotor impairmentFC changesNew therapiesFunction alterationsResonance imagingBrain regions
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