2025
The healthcare burden of isolated aortic valve insufficiency
Sultan I, Ryan M, Gunnarsson C, Heidrich N, Vallabhajosyula P. The healthcare burden of isolated aortic valve insufficiency. Scientific Reports 2025, 15: 4771. PMID: 39922868, PMCID: PMC11807181, DOI: 10.1038/s41598-025-87179-1.Peer-Reviewed Original ResearchConceptsHealthcare utilizationSAI patientsAnnual healthcare utilizationHealth care databasesYears post-diagnosisEstimate healthcare utilizationHome healthBaseline periodCare databaseMonths of continuous enrollmentCox proportional modelsPost-diagnosisAAI patientsMeasured outcomesHealthcareAI claimEstimate mortalityHealthcare burdenContinuous enrollmentExclusion criteriaUS patientsDiagnosis of aortic stenosisAortic valve insufficiencyProportional modelAnnual cost
2024
Unveiling gender differences in psychophysiological dynamics: support for a two-dimensional autonomic space approach
Sinai Y, J. Y, Daleski M, Gannot S, Bartsch R, Gordon I. Unveiling gender differences in psychophysiological dynamics: support for a two-dimensional autonomic space approach. Frontiers In Human Neuroscience 2024, 18: 1363891. PMID: 38545517, PMCID: PMC10967661, DOI: 10.3389/fnhum.2024.1363891.Peer-Reviewed Original ResearchRespiratory sinus arrhythmiaPsychophysiological relationsPsychological constructsGender differencesEmotional contagionPre-ejection periodElectrodermal activitySelf-report questionnairesAutonomic nervous systemCardiac autonomic balanceGeneralized anxietyPsychological functioningNA scoresEC scoresPsychophysiological dynamicsAutonomic balanceSinus arrhythmiaParasympathetic dominanceSympathetic activityANS activityAssociated with sympathetic activationHealthy studentsPsychological aspectsBaseline periodPositive link
2023
Opioid prescription and risk of atrial fibrillation in younger veterans
Chui P, Khokhar A, Gordon K, Dziura J, Burg M, Brandt C, Haskell S, Malm B, Bastian L, Gandhi P. Opioid prescription and risk of atrial fibrillation in younger veterans. American Heart Journal 2023, 268: 61-67. PMID: 37949420, DOI: 10.1016/j.ahj.2023.11.001.Peer-Reviewed Original ResearchTime-updated Cox regressionIncident atrial fibrillationAtrial fibrillationOpioid exposureVeterans Health AdministrationOpioid typeCox regressionOpioid prescriptionsICD-9-CM diagnostic codesIncidence of AFDevelopment of AFPrescription opioid exposureModifiable risk factorsPrimary care visitsPrescribed opioidsCare visitsOpioid useRisk factorsDiagnostic codesTime-dependent variablesOpioidsHealth AdministrationYounger veteransBaseline periodStudy sampleNationwide projections of heat- and cold-related mortality impacts under various climate change and population development scenarios in Switzerland
de Schrijver E, Sivaraj S, Raible C, Franco O, Chen K, Vicedo-Cabrera A. Nationwide projections of heat- and cold-related mortality impacts under various climate change and population development scenarios in Switzerland. Environmental Research Letters 2023, 18: 094010. PMID: 38854588, PMCID: PMC7616072, DOI: 10.1088/1748-9326/ace7e1.Peer-Reviewed Original ResearchClimate changeCold-related mortalityTemperature dataPopulation developmentDevelopment scenariosMortality rate projectionsScenarios of climate changeScenarios of global warmingProgressive warmingWarming targetsHeat-related mortalityWarming scenariosMortality impactRCP8.5/SSP5Combination of emissionGlobal warmingWarmingTime series analysisClimateMortality trendsTemporal patternsCold temperaturesBaseline periodSeries analysisProject heatingImplementation Facilitation to Promote Emergency Department–Initiated Buprenorphine for Opioid Use Disorder
D’Onofrio G, Edelman E, Hawk K, Chawarski M, Pantalon M, Owens P, Martel S, Rothman R, Saheed M, Schwartz R, Cowan E, Richardson L, Salsitz E, Lyons M, Freiermuth C, Wilder C, Whiteside L, Tsui J, Klein J, Coupet E, O’Connor P, Matthews A, Murphy S, Huntley K, Fiellin D. Implementation Facilitation to Promote Emergency Department–Initiated Buprenorphine for Opioid Use Disorder. JAMA Network Open 2023, 6: e235439. PMID: 37017967, PMCID: PMC10077107, DOI: 10.1001/jamanetworkopen.2023.5439.Peer-Reviewed Original ResearchConceptsOpioid use disorderRate of patientsOUD treatmentImplementation facilitationED visitsObservational cohortED cliniciansX-waiverUse disordersEmergency Department-Initiated BuprenorphineUntreated opioid use disorderEvaluation periodHybrid type 3Provision of buprenorphineBaseline periodGrand roundsRates of EDPrimary outcomeWhite patientsAcademic EDBlack patientsED patientsEmergency departmentCommunity cliniciansMAIN OUTCOME
2021
Implementing a Program to Reduce Restraint and Seclusion Utilization in a Public-Sector Hospital: Clinical Innovations, Preliminary Findings, and Lessons Learned
Dike CC, Lamb-Pagone J, Howe D, Beavers P, Bugella BA, Hillbrand M. Implementing a Program to Reduce Restraint and Seclusion Utilization in a Public-Sector Hospital: Clinical Innovations, Preliminary Findings, and Lessons Learned. Psychological Services 2021, 18: 663-670. PMID: 32940500, DOI: 10.1037/ser0000502.Peer-Reviewed Original ResearchConceptsPsychiatric hospitalState Mental Health Program DirectorsTertiary care settingPublic sector psychiatric hospitalWellness Recovery Action PlanMental health settingsQuality of careTrauma-sensitive carePublic sector hospitalsEvidence-based practicePositive behavioral support plansStaff injuriesCare settingsRestraint useMedical costsRestraint hoursHealth settingsRecovery Action PlanSensory modulationCase reviewSeclusion useHospitalPrevention toolRestraint ordersBaseline periodIncreasing face-mask compliance among healthcare personnel during the coronavirus disease 2019 (COVID-19) pandemic
Datta R, Glenn K, Pellegrino A, Tuan J, Linde B, Kayani J, Patel K, Calo L, Dembry LM, Fisher A. Increasing face-mask compliance among healthcare personnel during the coronavirus disease 2019 (COVID-19) pandemic. Infection Control And Hospital Epidemiology 2021, 43: 616-622. PMID: 33938417, PMCID: PMC8144836, DOI: 10.1017/ice.2021.205.Peer-Reviewed Original Research
2020
Association of prescription opioids and incident cardiovascular risk factors among post-9/11 Veterans
Chui PW, Gordon KS, Dziura J, Burg MM, Brandt CA, Sico JJ, Leapman MS, Cavanagh CE, Rosman L, Haskell S, Becker WC, Bastian LA. Association of prescription opioids and incident cardiovascular risk factors among post-9/11 Veterans. Preventive Medicine 2020, 134: 106036. PMID: 32097753, DOI: 10.1016/j.ypmed.2020.106036.Peer-Reviewed Original ResearchConceptsCVD risk factorsLong-term opioid therapyCurrent smoking statusRisk factorsOpioid useOpioid therapySmoking statusCardiovascular diseaseHigh riskLong-term exposureIncident cardiovascular risk factorsModifiable CVD risk factorsPrevalent CVD risk factorsFirst primary care visitCardiovascular risk factorsPrimary care visitsBaseline periodElectronic health record dataMain outcome measuresHealth record dataOpioid prescriptionsCare visitsPrescription opioidsMain exposureOutcome measures
2019
Challenges encountered and lessons learned during a trial of an electronic hand hygiene monitoring system
Boyce JM, Cooper T, Yin J, Li FY, Arbogast JW. Challenges encountered and lessons learned during a trial of an electronic hand hygiene monitoring system. American Journal Of Infection Control 2019, 47: 1443-1448. PMID: 31324492, DOI: 10.1016/j.ajic.2019.05.019.Peer-Reviewed Original ResearchConceptsSurgical intensive care unitGeneral medical wardsHH complianceHand hygiene monitoring systemsIntervention periodHand hygieneCompliance rateOverall HH complianceBaseline periodIntensive care unitElectronic hand hygiene monitoring systemsMedical wardsCare unitPostintervention periodHH eventsTransient dropSignificant improvementCompliance
2017
Opioid dosing trends over eight years among US Veterans with musculoskeletal disorders after returning from service in support of recent conflicts
Han L, Allore H, Goulet J, Bathulapali H, Skanderson M, Brandt C, Haskell S, Krebs E. Opioid dosing trends over eight years among US Veterans with musculoskeletal disorders after returning from service in support of recent conflicts. Annals Of Epidemiology 2017, 27: 563-569.e3. PMID: 28890282, PMCID: PMC5647654, DOI: 10.1016/j.annepidem.2017.08.015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalgesics, OpioidChronic PainDrug PrescriptionsElectronic PrescribingFemaleHumansMaleMental HealthMiddle AgedMusculoskeletal DiseasesOpioid-Related DisordersPrescription DrugsStress Disorders, Post-TraumaticUnited StatesUnited States Department of Veterans AffairsVeteransVeterans HealthYoung AdultConceptsHigh-dose prescribingOpioid prescriptionsMental health diagnosesMusculoskeletal disordersDaily morphine equivalentsHealth diagnosisHigh-dose therapyLong-term opioidsHigh-dose prescriptionsAverage daily dosePosttraumatic stress disorderMorphine equivalentsDose therapyDaily dosePatient characteristicsChronic painUS veteransOdds ratioPrescribingStress disorderBaseline periodGeographic confoundingVeteransPrescriptionOpioidsThe Impact of Social Contagion on Physician Adoption of Advanced Imaging Tests in Breast Cancer
Pollack CE, Soulos PR, Herrin J, Xu X, Christakis NA, Forman HP, Yu JB, Killelea BK, Wang SY, Gross CP. The Impact of Social Contagion on Physician Adoption of Advanced Imaging Tests in Breast Cancer. Journal Of The National Cancer Institute 2017, 109: djw330. PMID: 28376191, PMCID: PMC6059114, DOI: 10.1093/jnci/djw330.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingBaseline usePositron emission tomography scanEnd Results-MedicareEmission tomography scanBreast cancer practiceImaging modalitiesAdvanced imaging testsHierarchical logistic regression modelsLogistic regression modelsPatient characteristicsUnproven benefitCancer practiceMRI/PETTomography scanBreast cancerMRI useImaging testsClinical practicePET useResonance imagingPET imagingPhysician peersPhysician adoptionBaseline periodStimulation of 5-HT2A Receptors Recovers Sensory Responsiveness in Acute Spinal Neonatal Rats
Swann H, Kauer S, Allmond J, Brumley M. Stimulation of 5-HT2A Receptors Recovers Sensory Responsiveness in Acute Spinal Neonatal Rats. Behavioral Neuroscience 2017, 131: 92-98. PMID: 28004950, PMCID: PMC5269442, DOI: 10.1037/bne0000176.Peer-Reviewed Original ResearchConceptsSpinal cord injurySpinal ratsTail pinchMotor activityCord injurySensory stimulationNeonatal ratsSensory afferent stimulationRecovery of functionHind limb movementsTail pinchingAfferent stimulationReceptor agonistSpinal cordRat pupsAdult rodentsMotor circuitsQuipazineSupine postureRatsBaseline periodIntact levelsLevel of activityStimulationInjury
2015
The Psychosis-like Effects of Δ9-Tetrahydrocannabinol Are Associated With Increased Cortical Noise in Healthy Humans
Cortes-Briones JA, Cahill JD, Skosnik PD, Mathalon DH, Williams A, Sewell RA, Roach BJ, Ford JM, Ranganathan M, D’Souza D. The Psychosis-like Effects of Δ9-Tetrahydrocannabinol Are Associated With Increased Cortical Noise in Healthy Humans. Biological Psychiatry 2015, 78: 805-813. PMID: 25913109, PMCID: PMC4627857, DOI: 10.1016/j.biopsych.2015.03.023.Peer-Reviewed Original ResearchConceptsPsychosis-like effectsPsychosis-like symptomsPsychotomimetic effectsNegative-like symptomsActive drug conditionsNeural noiseDose-related effectsDose-related mannerRandom neural activityDose-dependent mannerPrincipal active constituentHealthy humansPsychotic disordersCortical noiseDrug conditionsSymptomsΔ9-tetrahydrocannabinolBaseline periodDisorganization symptomsNeural activityCounterbalanced designTest dayActive constituentsOddball taskTHC
2013
Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU: A Randomized Trial
Harris AD, Pineles L, Belton B, Johnson JK, Shardell M, Loeb M, Newhouse R, Dembry L, Braun B, Perencevich EN, Hall KK, Morgan DJ, Shahryar S, Price C, Gadbaw J, Drees M, Kett D, Muñoz-Price L, Jacob J, Herwaldt L, Sulis C, Yokoe D, Maragakis L, Lissauer M, Zervos M, Warren D, Carver R, Anderson D, Calfee D, Bowling J, Safdar N. Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU: A Randomized Trial. JAMA 2013, 310: 1571-1580. PMID: 24097234, PMCID: PMC4026208, DOI: 10.1001/jama.2013.277815.Peer-Reviewed Original ResearchMeSH KeywordsAgedCross InfectionEnterococcusFemaleGloves, ProtectiveGram-Positive Bacterial InfectionsGuideline AdherenceHand DisinfectionHumansInfection ControlIntensive Care UnitsMaleMethicillin-Resistant Staphylococcus aureusMiddle AgedPersonnel, HospitalStaphylococcal InfectionsSurgical AttireVancomycin ResistanceConceptsIntensive care unitMethicillin-resistant Staphylococcus aureusVancomycin-resistant EnterococcusIntervention ICUsSurgical intensive care unitPrimary outcomeHand hygiene complianceSecondary outcomesAdverse eventsPatient contactUniversal gloveVRE acquisitionUsual careMRSA acquisitionGown useHygiene complianceAcquisition of MRSAAntibiotic-resistant bacteriaControl intensive care unitHealth care-associated infectionsStudy periodKey secondary outcomesBaseline periodCare-associated infectionsHealth care workers
1999
Effects of Hypoxia-Ischemia and Inhibition of Nitric Oxide Synthase on Cerebral Energy Metabolism in Newborn Piglets
Groenendaal F, De Graaf R, Van Vliet G, Nicolay K. Effects of Hypoxia-Ischemia and Inhibition of Nitric Oxide Synthase on Cerebral Energy Metabolism in Newborn Piglets. Pediatric Research 1999, 45: 827-833. PMID: 10367773, DOI: 10.1203/00006450-199906000-00008.Peer-Reviewed Original ResearchConceptsNitric oxide synthaseCerebral energy metabolismHypoxia-ischemiaCerebral hypoxia-ischemiaN-acetylaspartate ratiosOxide synthaseBaseline valuesNewborn pigletsInorganic phosphate ratioHypoxia groupCerebral energy statusEnergy metabolismSaline 1 hEffect of inhibitionBilateral occlusionNω-nitroCarotid arteryAcetylaspartate ratioL-arginineOld pigletsPhosphate ratioBaseline periodReperfusionNNLAPiglets
1990
Handling Preterm Infants in Hospitals: Stimulating Controversy About Timing of Stimulation
Gorski P, Huntington L, Lewkowicz D. Handling Preterm Infants in Hospitals: Stimulating Controversy About Timing of Stimulation. Clinics In Perinatology 1990, 17: 103-112. PMID: 2318011, DOI: 10.1016/s0095-5108(18)30592-x.Peer-Reviewed Original ResearchConceptsPreterm infantsPreterm infants' heart rateHospitalized preterm infantsTactile stimulationInfant heart rateCentral nervous system organizationTiming of stimulationLow PO2 levelsCaregiver interventionsPhysiologic effectsHeart rateBrain growthNervous system organizationInfantsBaseline periodPO2 levelsStimulationBradycardiaCurrent reportUnderlying vulnerabilityPhysiologic trendsMost instancesBest predictorHospital
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