2025
The interplay between ADHD and school shift on educational outcomes in children and adolescents: a cross-sectional and longitudinal analysis
Porto I, do Amaral J, Pacheco J, Terra I, Miguel E, Pan P, Gadelha A, Rohde L, Salum G, Hoffmann M. The interplay between ADHD and school shift on educational outcomes in children and adolescents: a cross-sectional and longitudinal analysis. European Child & Adolescent Psychiatry 2025, 1-12. PMID: 40439742, DOI: 10.1007/s00787-025-02758-x.Peer-Reviewed Original ResearchSchool subjectsEducational outcomesSchool eventsADHD symptom levelsTests of readingAssociated with lower readingAttention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorder symptomsSchool systemSemi-structured interviewsEducational performanceSchool shiftEducational difficultiesWriting abilityAttend schoolSchoolYoung peopleBenefit childrenLow readingsAfternoon shiftAttention problemsReadingAssociated with circadian preferenceCognitive factorsDouble-shift school systemKappa opioid receptor antagonism restores phosphorylation, trafficking and behavior induced by a disease-associated dopamine transporter variant
Mayer F, Stewart A, Varman D, Moritz A, Foster J, Owens A, Areal L, Gowrishankar R, Velez M, Wickham K, Phelps H, Katamish R, Rabil M, Jayanthi L, Vaughan R, Daws L, Blakely R, Ramamoorthy S. Kappa opioid receptor antagonism restores phosphorylation, trafficking and behavior induced by a disease-associated dopamine transporter variant. Molecular Psychiatry 2025, 1-14. PMID: 40442453, DOI: 10.1038/s41380-025-03055-4.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderKappa-opioid receptor antagonismKappa-opioid receptorsAnomalous DA effluxDA transporterAutism spectrum disorderBipolar disorderDAT Val559D-amphetamineDA releaseAbuse liabilityTreatment of attention-deficit/hyperactivity disorderDopamine transporter variantsModulate DA releaseDA transporter functionSubstance use disordersTargeting kappa opioid receptorsKappa-opioid receptor stimulationHuman DA transporterKOR antagonismDA effluxAberrant dopamineAttention-deficit/hyperactivityDA neuronsSpectrum disorderSafety of Stimulants Across Patient Populations
Oliva H, Prudente T, Mayerson T, Mignosa M, Oliva I, Potenza M, Jegede O, Angarita G. Safety of Stimulants Across Patient Populations. JAMA Network Open 2025, 8: e259492. PMID: 40343695, PMCID: PMC12065045, DOI: 10.1001/jamanetworkopen.2025.9492.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderRandomized clinical trialsAdverse eventsStimulant medicationData extractionSafety of stimulationRisk ratioIncreased riskMethodological quality assessmentPreferred Reporting ItemsPatient populationClinical conditionsDiverse patient populationsRisk of biasSafety of stimulant medicationsUnclear risk of biasTreatment of attention-deficit/hyperactivity disorderOverall AEsRandom-effects modelWeb of ScienceBinge eating disorderStimulant use disorderComprehensive literature searchMain OutcomesReporting ItemsLongitudinal relationships between social anhedonia and internalizing symptoms in autistic children: results from the Autism Biomarkers Consortium for Clinical Trials
Gerber A, Naples A, Chawarska K, Dawson G, Kleinhans N, Jeste S, Faja S, Dziura J, Webb S, Sugar C, Shic F, Levin A, McPartland J, Trials F. Longitudinal relationships between social anhedonia and internalizing symptoms in autistic children: results from the Autism Biomarkers Consortium for Clinical Trials. Psychological Medicine 2025, 55: e104. PMID: 40170613, PMCID: PMC12094631, DOI: 10.1017/s0033291725000650.Peer-Reviewed Original ResearchConceptsSocial anhedoniaSocial anxietyInternalizing symptomsAutistic childrenAutism severityCASI-5Parent-reported social anxietyAssociated with increased internalizing symptomsAutism Diagnostic Observation ScheduleCross-lagged panel modelBidirectional relationshipAttention-deficit/hyperactivity disorderBidirectional longitudinal associationsCross-lagged modelsAnhedonia subscaleAttention-deficit/hyperactivityAnhedoniaFifth EditionReduced pleasureObservation ScheduleAutistic youthConcurrent relationshipsAutismLongitudinal relationshipDevelopmental modelMeasuring Mental Health in 2 Brazilian University Centers: Protocol for a Cohort Survey.
Di Santi T, Nascimento A, Fukuti P, Marchisio V, Araujo do Amaral G, Vaz C, Carrijo L, Oliveira L, Costa L, Mancini Marion Konieczniak E, Zuppi Garcia L, Cabrelon Jusevicius V, Humes E, Rossi Menezes P, Miguel E, Caye A. Measuring Mental Health in 2 Brazilian University Centers: Protocol for a Cohort Survey. JMIR Research Protocols 2025, 14: e63636. PMID: 40085140, PMCID: PMC11953593, DOI: 10.2196/63636.Peer-Reviewed Original ResearchConceptsINTERNATIONAL REGISTERED REPORT IDENTIFIERMental Health SurveyHealth SurveyMental healthEvaluating mental health conditionsDevelopment of targeted interventionsMeasure mental healthMental health conditionsMental health disordersMental well-beingAttention-deficit/hyperactivity disorderMental health trendsSelf-report questionnairesWeb-based mental health surveyCohort surveyAttention-deficit/hyperactivityHealth conditionsHealth disordersHealth trendsSelf-report scalesBrazilian university studentsUniversity studentsAdult Self-Report ScaleWell-beingMental well-being of university studentsEnvironMental Health: A Framework for an Emerging Field at the Intersection of the Environment and Mental Health Crises
Ratjen L, Goddard E, Gilcher E, Nguyen B, Kelley M, Feldman H, Akalaonu K, Nyhan K, Backhaus A, Lascurain M, Wyrtzen N, Smith S, Prabhu M, Lowe S, Chen K, Zimmerman J, Anastas P. EnvironMental Health: A Framework for an Emerging Field at the Intersection of the Environment and Mental Health Crises. GeoHealth 2025, 9: e2024gh001254. PMID: 39958831, PMCID: PMC11826329, DOI: 10.1029/2024gh001254.Peer-Reviewed Original ResearchCognitive healthReview of reviewsMental health conditionsMental health crisisAttention-deficit/hyperactivity disorderBehavioral healthMental healthHealth conditionsHealthPublic healthEconomic burdenWell-beingNeuropsychological healthHealth crisisSocial factorsContextual needsAttention-deficit/hyperactivityEnvironmental factorsGreen spacesHealthcareDementiaFunding strategiesConceptual frameworkFundingBurdenCo-occurring Psychopathology in Children With and Without Autism Spectrum Disorder (ASD): Differences by Sex in the ECHO Cohorts
Volk H, Fortes D, Musci R, Kim A, Bastain T, Camargo C, Croen L, Dabelea D, Duarte C, Dunlop A, Gachigi K, Ghassabian A, Hertz-Picciotto I, Huddleston K, Joseph R, Keating D, Kelly R, Kim Y, Landa R, Leve L, Lyall K, Northrup J, O’Connor T, Ozonoff S, Ross A, Schmidt R, Schweitzer J, Shuffrey L, Shuster C, Vance E, Weiss S, Wilkening G, Wright R. Co-occurring Psychopathology in Children With and Without Autism Spectrum Disorder (ASD): Differences by Sex in the ECHO Cohorts. Journal Of Autism And Developmental Disorders 2025, 1-12. PMID: 39762643, DOI: 10.1007/s10803-024-06670-2.Peer-Reviewed Original ResearchChild Behavior ChecklistAutism spectrum disorderAttention-deficit/hyperactivity disorderSocial Responsiveness ScaleEmotional problemsSpectrum disorderTotal problemsAutism diagnosisCo-occurring psychopathologyChild sexDiagnosis of autism spectrum disorderSocial Responsiveness Scale scoresDSM-oriented subscalesParent-reported depressionSocial communication deficitsChild Behavior Checklist TotalCBCL Total ProblemsProblem scale scoresNon-autistic childrenHigher CBCL scoresNational sampleAttention-deficit/hyperactivityCommunication deficitsBehavior ChecklistChild health outcomes
2024
Online social activity time predicts ADHD problems in youth from late childhood to early adolescence in the ABCD study
Deng H, Song K, Geng X, Xu L, Zhang J, Li X, He J, Potenza M, Zhang J. Online social activity time predicts ADHD problems in youth from late childhood to early adolescence in the ABCD study. European Child & Adolescent Psychiatry 2024, 1-10. PMID: 39724179, DOI: 10.1007/s00787-024-02620-6.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorder problemsAttention-deficit/hyperactivity disorderAdolescent Brain Cognitive DevelopmentEarly adolescenceRandom intercept cross-lagged panel modelDevelopment of attentional processesAdolescent Brain Cognitive Development StudyAdolescent Brain Cognitive Development dataCross-lagged panel modelLongitudinal bidirectional associationsCross-lagged effectsModerating effectPotential moderating effectsADHD problemsRI-CLPMTargeting of interventionsAttentional processesAttention-deficit/hyperactivityModeration analysisBidirectional associationsCognitive developmentLate childhoodLongitudinal associationsChild sexSocial interactionMental Health Service Referral and Treatment Following Screening and Assessment in Juvenile Detention.
Tedeschi F, Horwitz S, Surko M, Weinberger E, Bart A, Baetz C, Guo F, Alexander A, Havens J. Mental Health Service Referral and Treatment Following Screening and Assessment in Juvenile Detention. The Journal Of The American Academy Of Psychiatry And The Law 2024, 52: 460-469. PMID: 39393913, DOI: 10.29158/jaapl.240082-24.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderDSM-5 diagnosisMental health screeningDSM-5Prevalence of attention-deficit/hyperactivity disorderRates of mental health disordersPosttraumatic stress disorderProblematic substance useMental health disordersMental health service referralJuvenile detention facilitiesStress disorderAttention-deficit/hyperactivityDetained youthSubstance useNeurodevelopmental disordersHealth disordersJuvenile detentionDetention facilitiesEvaluate youthHealth screeningDisordersEmotional concernsAvailability of servicesService referralsEnhanced neurobiological biomarker differentiation for attention-deficit/hyperactivity disorder through a risk-informed design
Duarte I, Hoffmann M, Salum G, Leffa D, Belangero S, Santoro M, Ota V, Ito L, Pan P, Farhat L, Murray A, Miguel E, Kieling C, Rohde L, Caye A. Enhanced neurobiological biomarker differentiation for attention-deficit/hyperactivity disorder through a risk-informed design. European Child & Adolescent Psychiatry 2024, 1-11. PMID: 39625683, DOI: 10.1007/s00787-024-02622-4.Peer-Reviewed Original ResearchNeurobiological measuresADHD polygenic scoresBrazilian High-Risk CohortAttention-deficit/hyperactivity disorderPoorer executive functionPolygenic scoresADHD symptomsExecutive functionHigh-risk subgroupsAttention-deficit/hyperactivitySubcortical volumesHigh-risk cohortMental disordersADHD casesEffect sizeADHDMental conditionDifferential riskClinical practiceRisk cohortBiomarkers to clinical practiceLow-risk groupCalculated riskParticipantsAdolescentsGenomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries
García-Marín L, Campos A, Diaz-Torres S, Rabinowitz J, Ceja Z, Mitchell B, Grasby K, Thorp J, Agartz I, Alhusaini S, Ames D, Amouyel P, Andreassen O, Arfanakis K, Arias-Vasquez A, Armstrong N, Athanasiu L, Bastin M, Beiser A, Bennett D, Bis J, Boks M, Boomsma D, Brodaty H, Brouwer R, Buitelaar J, Burkhardt R, Cahn W, Calhoun V, Carmichael O, Chakravarty M, Chen Q, Ching C, Cichon S, Crespo-Facorro B, Crivello F, Dale A, Smith G, de Geus E, De Jager P, de Zubicaray G, Debette S, DeCarli C, Depondt C, Desrivières S, Djurovic S, Ehrlich S, Erk S, Espeseth T, Fernández G, Filippi I, Fisher S, Fleischman D, Fletcher E, Fornage M, Forstner A, Francks C, Franke B, Ge T, Goldman A, Grabe H, Green R, Grimm O, Groenewold N, Gruber O, Gudnason V, Håberg A, Haukvik U, Heinz A, Hibar D, Hilal S, Himali J, Ho B, Hoehn D, Hoekstra P, Hofer E, Hoffmann W, Holmes A, Homuth G, Hosten N, Ikram M, Ipser J, Jack Jr C, Jahanshad N, Jönsson E, Kahn R, Kanai R, Klein M, Knol M, Launer L, Lawrie S, Hellard S, Lee P, Lemaître H, Li S, Liewald D, Lin H, Longstreth W, Lopez O, Luciano M, Maillard P, Marquand A, Martin N, Martinot J, Mather K, Mattay V, McMahon K, Mecocci P, Melle I, Meyer-Lindenberg A, Mirza-Schreiber N, Milaneschi Y, Mosley T, Mühleisen T, Müller-Myhsok B, Maniega S, Nauck M, Nho K, Niessen W, Nöthen M, Nyquist P, Oosterlaan J, Pandolfo M, Paus T, Pausova Z, Penninx B, Pike G, Psaty B, Pütz B, Reppermund S, Rietschel M, Risacher S, Romanczuk-Seiferth N, Romero-Garcia R, Roshchupkin G, Rotter J, Sachdev P, Sämann P, Saremi A, Sargurupremraj M, Saykin A, Schmaal L, Schmidt H, Schmidt R, Schofield P, Scholz M, Schumann G, Schwarz E, Shen L, Shin J, Sisodiya S, Smith A, Smoller J, Soininen H, Steen V, Stein D, Stein J, Thomopoulos S, Toga A, Tordesillas-Gutiérrez D, Trollor J, Valdes-Hernandez M, van ′t Ent D, van Bokhoven H, van der Meer D, van der Wee N, Vázquez-Bourgon J, Veltman D, Vernooij M, Villringer A, Vinke L, Völzke H, Walter H, Wardlaw J, Weinberger D, Weiner M, Wen W, Westlye L, Westman E, White T, Witte A, Wolf C, Yang J, Zwiers M, Ikram M, Seshadri S, Thompson P, Satizabal C, Medland S, Rentería M. Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. Nature Genetics 2024, 56: 2333-2344. PMID: 39433889, PMCID: PMC12088653, DOI: 10.1038/s41588-024-01951-z.Peer-Reviewed Original ResearchSubcortical brain volumesBrain volumePolygenic scoresEffects of brain volumeAttention-deficit/hyperactivity disorderIndividuals of diverse ancestryComorbid neuropsychiatric disordersSubcortical brain structuresGenome-wide association study meta-analysesBrain substratesParticipants of European ancestryAttention-deficit/hyperactivityGene expression patternsNeuropsychiatric disordersDifferentiation time pointsBrain structuresGenomic analysisDiverse ancestryBrain developmentStudy meta-analysesGenetic variantsNeural cell typesPhenotypic varianceRisk genesAging-related processesT4. RELATIONSHIP OF GENETICALLY-INDEXED PHYSICAL ACTIVITY WITH MENTAL DISORDERS
Galimberti M, Gupta P, Deak J, Dao C, Nitin R, Zhou H, Harrington K, Na P, Topiwala A, Davis L, Gaziano M, Levey D, Stein M, Gelernter J. T4. RELATIONSHIP OF GENETICALLY-INDEXED PHYSICAL ACTIVITY WITH MENTAL DISORDERS. European Neuropsychopharmacology 2024, 87: 157-158. DOI: 10.1016/j.euroneuro.2024.08.314.Peer-Reviewed Original ResearchProtective effect of PAMental health traitsMillion Veteran ProgramEffects of PAGenome-wide association studiesPhysical activityLocal genetic correlationAlcohol consumptionPosttraumatic stress disorderSmoking initiationLeisure time PARelationship of PAUse disorderMental health outcomesPsychiatric disordersSelf-reported informationSubstance useAttention-deficit/hyperactivity disorderGenetic correlation analysisLocal genetic correlation analysisTime PAGenome-wide association study statisticsHealth traitsMR analysisResults PAPharmacological Interventions for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents with Tourette Disorder: A Systematic Review and Network Meta-Analysis
Farhat L, Behling E, Landeros-Weisenberger A, de Barros P, Polanczyk G, Cortese S, Bloch M. Pharmacological Interventions for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents with Tourette Disorder: A Systematic Review and Network Meta-Analysis. Journal Of Child And Adolescent Psychopharmacology 2024, 34: 373-382. PMID: 39320340, PMCID: PMC11807863, DOI: 10.1089/cap.2024.0049.Peer-Reviewed Original ResearchADHD symptomsAttention-deficit/hyperactivity disorderTic severityTourette's disorderAttention-deficit/hyperactivityRandomized controlled trialsA2 agonistPharmacological interventionsADHD symptom severityIncreased tic severityPersistent tic disordersNetwork meta-analysisStandardized mean differencePairs of medicationsEfficacy of pharmacological interventionsWorsen ticsRandom-effects network meta-analysisSymptom severityTic disordersADHDMeta-analysisNetwork meta-analysis frameworkCertainty of evidenceDisordersNetwork meta-analysesLongitudinal Association of Adolescent ADHD Symptoms in the Trajectory of Maternal Depression Symptoms
Shippen N, Felton J, Stevens A, Khaireddin M, Lejuez C, Chronis-Tuscano A, Meinzer M. Longitudinal Association of Adolescent ADHD Symptoms in the Trajectory of Maternal Depression Symptoms. Journal Of Psychopathology And Behavioral Assessment 2024, 46: 888-899. DOI: 10.1007/s10862-024-10165-w.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderMaternal depressive symptomsAttention-deficit/hyperactivity disorder symptomsAdolescent ADHD symptomsDepressive symptomsADHD symptomsMaternal depressionTrajectories of maternal depressive symptomsCommunity sample of adolescentsChild mental health symptomsSymptoms of hyperactivity/impulsivitySymptoms of inattentionChild ADHD symptomsLatent growth modelingMental health symptomsCaregiver well-beingSample of adolescentsMaternal mental healthMental health conditionsFamilies of youthHyperactivity/impulsivity symptomsAttention-deficit/hyperactivityCommunity sampleChildhood disordersHealth symptomsA randomized clinical trial to evaluate feasibility, tolerability, and preliminary target engagement for a novel executive working memory training in adolescents with ADHD
Sullivan A, Anderson J, Beatty M, Choi J, Jaccard J, Hawkins K, Pearlson G, Stevens M. A randomized clinical trial to evaluate feasibility, tolerability, and preliminary target engagement for a novel executive working memory training in adolescents with ADHD. Behaviour Research And Therapy 2024, 181: 104615. PMID: 39173523, PMCID: PMC11465636, DOI: 10.1016/j.brat.2024.104615.Peer-Reviewed Original ResearchExecutive working memoryAttention-deficit/hyperactivity disorderWorking memory trainingMemory trainingExecutive working memory taskIncreased working memory capacityMedium effect size improvementsEffect size improvementsSelf-rated motivationIntervention participantsTarget engagementTrial retentionWorking memoryAttention-deficit/hyperactivityDifficulty manipulationPlacebo-controlled studyMemory capacityTask accuracySize improvementsMemory contentIntervention tolerabilityTraining targetBehavioral changesPrimary outcome measureCoaching sessionsRare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes
Olfson E, Farhat L, Liu W, Vitulano L, Zai G, Lima M, Parent J, Polanczyk G, Cappi C, Kennedy J, Fernandez T. Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes. Nature Communications 2024, 15: 5870. PMID: 38997333, PMCID: PMC11245598, DOI: 10.1038/s41467-024-50247-7.Peer-Reviewed Original ResearchConceptsDNA sequencesRisk genesHigh-confidence risk genesWhole-exome DNA sequencingSequencing of familiesIdentified de novoLysine demethylase 5BDNA variantsTrio cohortBiological pathwaysGenesSequencing cohortGenetic factorsChildhood neurodevelopmental disordersAttention-deficit/hyperactivity disorderSequenceVariantsADHD riskNeurodevelopmental disordersKDM5BDNAMutationsFamilyLysineDiscoveryVerbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis
Kennedy E, Liebel S, Lindsey H, Vadlamani S, Lei P, Adamson M, Alda M, Alonso-Lana S, Anderson T, Arango C, Asarnow R, Avram M, Ayesa-Arriola R, Babikian T, Banaj N, Bird L, Borgwardt S, Brodtmann A, Brosch K, Caeyenberghs K, Calhoun V, Chiaravalloti N, Cifu D, Crespo-Facorro B, Dalrymple-Alford J, Dams-O’Connor K, Dannlowski U, Darby D, Davenport N, DeLuca J, Diaz-Caneja C, Disner S, Dobryakova E, Ehrlich S, Esopenko C, Ferrarelli F, Frank L, Franz C, Fuentes-Claramonte P, Genova H, Giza C, Goltermann J, Grotegerd D, Gruber M, Gutierrez-Zotes A, Ha M, Haavik J, Hinkin C, Hoskinson K, Hubl D, Irimia A, Jansen A, Kaess M, Kang X, Kenney K, Keřková B, Khlif M, Kim M, Kindler J, Kircher T, Knížková K, Kolskår K, Krch D, Kremen W, Kuhn T, Kumari V, Kwon J, Langella R, Laskowitz S, Lee J, Lengenfelder J, Liou-Johnson V, Lippa S, Løvstad M, Lundervold A, Marotta C, Marquardt C, Mattos P, Mayeli A, McDonald C, Meinert S, Melzer T, Merchán-Naranjo J, Michel C, Morey R, Mwangi B, Myall D, Nenadić I, Newsome M, Nunes A, O’Brien T, Oertel V, Ollinger J, Olsen A, de la Foz V, Ozmen M, Pardoe H, Parent M, Piras F, Piras F, Pomarol-Clotet E, Repple J, Richard G, Rodriguez J, Rodriguez M, Rootes-Murdy K, Rowland J, Ryan N, Salvador R, Sanders A, Schmidt A, Soares J, Spalleta G, Španiel F, Sponheim S, Stasenko A, Stein F, Straube B, Thames A, Thomas-Odenthal F, Thomopoulos S, Tone E, Torres I, Troyanskaya M, Turner J, Ulrichsen K, Umpierrez G, Vecchio D, Vilella E, Vivash L, Walker W, Werden E, Westlye L, Wild K, Wroblewski A, Wu M, Wylie G, Yatham L, Zunta-Soares G, Thompson P, Pugh M, Tate D, Hillary F, Wilde E, Dennis E. Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis. Brain Sciences 2024, 14: 669. PMID: 39061410, PMCID: PMC11274572, DOI: 10.3390/brainsci14070669.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderVerbal learningNeuropsychiatric conditionsTraumatic brain injuryYears of educationMild cognitive impairmentComorbid disordersAttention-deficit/hyperactivityBipolar disorderMemory deficitsMemory performanceMemory recallClinical groupsMega-analysisCognitive impairmentEffects of dementiaAssociated with dementiaMemoryBrain injurySchizophreniaMemory impactDisordersDepressionParkinson's diseaseUnique participantsThe role of genetics on behavioral outcomes in nonsyndromic sagittal synostosis.
Alper D, Almeida M, Hu K, Yang J, Timberlake A, Shah J, Persing J, Alperovich M. The role of genetics on behavioral outcomes in nonsyndromic sagittal synostosis. Journal Of Neurosurgery Pediatrics 2024, 34: 234-245. PMID: 38875721, DOI: 10.3171/2024.4.peds23510.Peer-Reviewed Original ResearchBehavioral outcomesNonsyndromic sagittal synostosisSocial Responsiveness Scale-2nd editionBehavior Rating InventoryAttention-deficit/hyperactivity disorderSagittal synostosisPly geneRelative to controlsExecutive functionAttention-deficit/hyperactivityExternalizing behaviorsExternalizing problemsLoss of functionBehavior problemsASD domainAssociated with worse scoresOutcomes of patientsRule-breakingParents of children aged 6Treating sagittal synostosisOlder ageAssociation of mutationsBehavior scoresSociodemographic factorsPly groupsThe Relationship Between Vitamin D and the Development and Treatment of Attention-Deficit Hyperactivity Disorder: An Overview of Systematic Reviews
Kitaneh R, Jalilian-Khave L, Ysrayl B, Borelli A, Funaro M, Potenza M, Angarita G. The Relationship Between Vitamin D and the Development and Treatment of Attention-Deficit Hyperactivity Disorder: An Overview of Systematic Reviews. Current Behavioral Neuroscience Reports 2024, 11: 164-181. DOI: 10.1007/s40473-024-00278-7.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorder symptomsTreatment of attention-deficit hyperactivity disorderSeverity of ADHD symptomsAttention-deficit hyperactivity disorderManagement of attention-deficit/hyperactivity disorderOutcomes of attention-deficit/hyperactivity disorderOverview of systematic reviewsADHD symptomsSerum vitamin D levelsHyperactivity disorderInclusion criteriaMeta-analysesVitamin D levelsBrain regionsMaternal serum vitamin D levelsPrenatal vitamin D levelsAssociated with improvementsNeurotransmitter regulationRisk of offspringVitamin D supplementationD levelsWell-powered randomized clinical trialsSystematic literature searchSummaryThe literatureDo psychotropic drugs cause seizures?
Gopaul M, Altalib H. Do psychotropic drugs cause seizures? Epilepsy & Behavior Reports 2024, 27: 100679. PMID: 38881884, PMCID: PMC11179069, DOI: 10.1016/j.ebr.2024.100679.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderPsychiatric comorbiditiesPsychotropic medicationsTricyclic antidepressantsCNS stimulantsSerotonin reuptake inhibitorsConcurrent psychiatric disordersSeizure riskReuptake inhibitorsAttention-deficit/hyperactivityPsychiatric disordersPsychiatric symptomsIncreased seizure riskPsychotropic drugsBidirectional associationsAnticonvulsant effectsAntidepressantsIatrogenic seizuresAntipsychoticsTreatment outcomesDisordersHigh dosesClinical decision-makingSeizure onsetEpilepsy
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