2025
Emergency Department Implementation of a Multimodal Electronic Health Record–Integrated Clinical Intervention for High-Sensitivity Troponin Testing Increases Diagnostic Efficiency
Sangal R, Iscoe M, Rothenberg C, Possick S, Taylor R, Safdar B, Desai N, Rhodes D, Venkatesh A. Emergency Department Implementation of a Multimodal Electronic Health Record–Integrated Clinical Intervention for High-Sensitivity Troponin Testing Increases Diagnostic Efficiency. Journal Of The American College Of Emergency Physicians Open 2025, 6: 100202. DOI: 10.1016/j.acepjo.2025.100202.Peer-Reviewed Original ResearchEmergency departmentAcute myocardial infarction diagnosisTroponin testingED dischargeMyocardial infarction diagnosisAssociated with lower oddsAccelerated diagnostic protocolPhysician practice variationAcute coronary syndromeInfarction diagnosisChest pain evaluationMultivariate logistic regressionSuspected acute coronary syndromePostintervention periodDownstream testingPhysician practicesPreintervention periodED dispositionLower oddsCoronary syndromeDecreased oddsIncreased oddsPractice variationED patientsHs-cTnTDifferences in In-Hospital and Post-Discharge Ischemic Stroke Care According to Prestroke Functional Status.
Wechsler P, Mistry E, Sucharew H, Robinson D, Stanton R, de Los Rios La Rosa F, Mackey J, Ferioli S, Demel S, Coleman E, Jasne A, Slavin S, Walsh K, Star M, Haverbusch M, Alwell K, Woo D, Kleindorfer D, Kissela B. Differences in In-Hospital and Post-Discharge Ischemic Stroke Care According to Prestroke Functional Status. Journal Of The American Heart Association 2025, 14: e040499. PMID: 40417811, DOI: 10.1161/jaha.124.040499.Peer-Reviewed Original ResearchConceptsIschemic stroke carePrestroke disabilityStroke careIn-hospitalGreater Cincinnati/Northern Kentucky populationAssociated with lower oddsPopulation-based dataSecondary stroke prevention treatmentPrestroke functional statusMedical decision-makingCare continuumStroke prevention treatmentRehabilitation therapyLower oddsIschemic stroke patientsFunctional statusStroke reperfusion therapyStroke patientsLogistic regressionCareDisabilityKentucky populationAcute ischemic strokeReperfusion therapyPrestrokeSpinal cord stimulator utilization trends and predictors of unsuccessful trial-to-implant conversion
Day W, Maloy G, Winter A, Chapman K, Seddio A, Doshi R, Ratnasamy P, Varthi A, Fourman M, Grauer J. Spinal cord stimulator utilization trends and predictors of unsuccessful trial-to-implant conversion. North American Spine Society Journal (NASSJ) 2025, 22: 100616. PMID: 40548099, PMCID: PMC12182330, DOI: 10.1016/j.xnsj.2025.100616.Peer-Reviewed Original ResearchSpinal cord stimulationSpinal cord stimulator trialFactors associated with failureUtilization of spinal cord stimulationSpinal cord stimulator implantationPermanent SCS implantationLower oddsMultivariate logistic regressionAssociated with lower oddsLow comorbidity burdenSCS trialSCS implantationCord stimulationNeurological painMale sexPermanent implantationAnnual incidenceComorbidity burdenClaims databaseTobacco useLogistic regressionNeuromodulatory devicesOlder ageImplantationUtilization trendsExamining measurement discrepancies in adolescent screen media activity with insights from the ABCD study
Zhao Y, Han X, Bagot K, Tapert S, Potenza M, Paulus M. Examining measurement discrepancies in adolescent screen media activity with insights from the ABCD study. Npj Mental Health Research 2025, 4: 15. PMID: 40346141, PMCID: PMC12064680, DOI: 10.1038/s44184-025-00131-z.Peer-Reviewed Original ResearchEarly spontaneous resolution of vesicoureteral reflux from voiding cystourethrogram: a comparison of contemporary prediction models
Khondker A, Kim J, Arlen A, Rickard M, Chua M, Kirsch A, Lorenzo A, Cooper C. Early spontaneous resolution of vesicoureteral reflux from voiding cystourethrogram: a comparison of contemporary prediction models. Journal Of Pediatric Urology 2025 PMID: 40368726, DOI: 10.1016/j.jpurol.2025.04.030.Peer-Reviewed Original ResearchUreteral diameter ratioFollow-up VCUGVesicoureteral reflux gradeVesicoureteral refluxAssociated with resolutionVUR resolutionSpontaneous resolution of vesicoureteral refluxResolution of vesicoureteral refluxDegree of VURResolved vesicoureteral refluxVesicoureteral reflux resolutionPrimary vesicoureteral refluxSpontaneous complete resolutionArea under the receiver-operatingImprove risk stratificationMultivariate logistic regressionAssociated with lower oddsVUR gradeVoiding cystourethrogramRenal scarringComplete resolutionRetrospective studyUreteral anomaliesClinical outcomesRisk stratification1145 Higher Proceduralist Stroke Thrombectomy Volume is Associated With Reduced Inpatient Mortality
Koo A, Renedo D, Ney J, Amllay A, Kanzler M, Stogniy S, Alawieh A, Sujijantarat N, Antonios J, Al Kasab S, Malhotra A, Hebert R, Matouk C, de Havenon A. 1145 Higher Proceduralist Stroke Thrombectomy Volume is Associated With Reduced Inpatient Mortality. Neurosurgery 2025, 71: 177-178. DOI: 10.1227/neu.0000000000003360_1145.Peer-Reviewed Original ResearchCut-pointsAbsolute risk of deathAssociated with lower oddsState Inpatient DatabasesFlorida State Inpatient DatabaseIn-hospital moralityRates of in-hospital mortalityPrimary study outcomeCare certificationRisk of deathOptimal cut-pointAssociated with reduced inpatient mortalityThrombectomy-capable stroke centersOverall careRetrospective cohort studyAIS patientsIn-hospital deathLow-volume cohortLower oddsIn-hospital mortalityPotential confoundersAbsolute riskVolume cohortsInpatient mortalityCohort studyTelemedicine Use and Hypertension Control in an Urban Community Health Center Cohort
Molina F, Westvold S, Soulos P, Brockman A, Alcaraz E, Oldfield B. Telemedicine Use and Hypertension Control in an Urban Community Health Center Cohort. Journal Of General Internal Medicine 2025, 40: 1519-1526. PMID: 39920430, PMCID: PMC12052640, DOI: 10.1007/s11606-025-09393-x.Peer-Reviewed Original ResearchBlood pressure <Safety-net primary care settingBlood pressure controlMultisite community health centerHypertension controlMain MeasuresThe primary outcomeBP controlAssociated with blood pressure controlChronic disease managementSocial deprivation indexAssociated with lower oddsCommunity health centersPrimary care settingSafety-net populationMeasuresThe primary outcomeBlack patientsMixed-effects logistic regression modelsIn-person visitsPersistent racial disparitiesAssociated with blood pressureSystolic blood pressure <Logistic regression modelsDeprivation indexDiastolic blood pressure <High deprivationThe Impact of Medical School Experiences in Global Surgery on Perceptions and Career Plans Among U.S. Medical Students
Kersh L, Serrato P, Anderson C, Raguveer V, Peck C, Ally S, Gondi I, Subhedar S, Rollins A, Hauser B, Jayaram A, Hill S, Wariso B, Rehman S, Alliance G, Clune J. The Impact of Medical School Experiences in Global Surgery on Perceptions and Career Plans Among U.S. Medical Students. Journal Of Surgical Education 2025, 82: 103441. PMID: 39894006, DOI: 10.1016/j.jsurg.2025.103441.Peer-Reviewed Original ResearchConceptsMedical school experienceGlobal surgeryMedical studentsMedical schoolsSurgical mission tripsCross-sectional survey studyAssociated with lower oddsMission tripsAssociated with increased oddsMedical school curriculumGlobal health researchU.S. medical studentsCareer planningSurgery researchGlobal surgery educationResponding medical studentsMultivariate regression modelHealth researchSurgery opportunitiesLower oddsSchool experiencesSurgeryOddsSurgery educationMedical institutionsTransient Ischemic Attack in Women: Real-World Hospitalization Incidence, Outcomes, and Risk of Hemorrhage and Stroke
Chen H, Khunte M, Colasurdo M, Majmundar S, Payabvash S, Chaturvedi S, Malhotra A, Gandhi D. Transient Ischemic Attack in Women: Real-World Hospitalization Incidence, Outcomes, and Risk of Hemorrhage and Stroke. Stroke 2025, 56: 285-293. PMID: 39869710, DOI: 10.1161/strokeaha.124.049278.Peer-Reviewed Original ResearchConceptsRates of vascular risk factorsTransient ischemic attackUS Census Bureau dataAssociated with lower oddsHigher odds of deathIschemic strokeRisk factorsAnnual incidenceTransient neurological symptomsStroke risk factorsOdds of deathLogistic regression modelsVascular risk factorsCensus Bureau dataRate of headacheRetrospective cohort studyLower oddsHigher oddsNeurological symptomsHome dischargeCohort studyIschemic attackHospital incidenceExcess hospitalizationsRisk of hemorrhageFrom Chronic Opioids for Pain to Microgram Buprenorphine: Key Factors in an Increasingly Recommended Transition.
Hickey T, Hitt J. From Chronic Opioids for Pain to Microgram Buprenorphine: Key Factors in an Increasingly Recommended Transition. Pain Physician Journal 2025, 28: 59-67. PMID: 39903018.Peer-Reviewed Original ResearchConceptsOpioid therapyBuprenorphine exposureTotal dose of opioidsVeterans Health AdministrationChronic opioid therapyDoses of opioidsChronic pain managementOutpatient opioid prescriptionsReducing opioid useFull-agonist opioidsPrescription of buprenorphineTransition to buprenorphineAssociated with lower oddsVeterans Affairs Corporate Data WarehouseBaseline opioidChronic opioidsOpioid doseAgonist opioidsOpioid exposureHealth AdministrationOpioid prescriptionsOpioid useSurrogate markerLarge-scale observational studiesBuprenorphine initiation
2024
Association of clerical burden and EHR frustration with burnout and career intentions among physician faculty in an urban academic health system
Ripp J, Pietrzak R, de Guillebon E, Peccoralo L. Association of clerical burden and EHR frustration with burnout and career intentions among physician faculty in an urban academic health system. International Journal Of Medical Informatics 2024, 195: 105740. PMID: 39644795, DOI: 10.1016/j.ijmedinf.2024.105740.Peer-Reviewed Original ResearchElectronic health recordsClerical burdenAssociated with greater likelihoodPhysician facultyHealth systemEHR timeUrban academic health systemClerical timeGreater likelihoodOdds of burnoutAssociated with lower oddsAcademic health systemMultivariate logistic regression analysisHealth recordsLogistic regression analysisHospital-based departmentsInstitution-wide surveyLower oddsHealthy workforceHealthcare systemDemographic characteristicsNew York CityBurnoutCareer intentionsPhysiciansIdentifying diagnosed major chronic diseases associated with recent housing instability among aging adults: data from the ‘All of Us’ research program
Beydoun H, Vieytes C, Beydoun M, Lampros A, Tsai J. Identifying diagnosed major chronic diseases associated with recent housing instability among aging adults: data from the ‘All of Us’ research program. Journal Of Public Health 2024, 47: 15-23. PMID: 39586798, PMCID: PMC12034092, DOI: 10.1093/pubmed/fdae300.Peer-Reviewed Original ResearchUs Research ProgramHousing instabilityAging adultsChronic diseasesOdds ratioChronic disease preventionAssociated with lower oddsPsychiatric diagnosisConfidence intervalsElectronic health recordsAssociated with psychiatric diagnosesEstimate odds ratiosCardiovascular diseaseMultivariate logistic regression modelDiverse group of adultsLogistic regression modelsTreatment of chronic diseasesCross-sectional dataHealth recordsHealthcare utilizationLower oddsGroup of adultsYears of ageDiagnosed diabetesCancer diagnosisLatent transition analysis of use frequencies for multiple nicotine and tobacco products among US adults
Mistry R, Bondarenko I, Jeon J, Brouwer A, Jimenez Mendoza E, Levy D, Elliott M, Tam J, Fleischer N, Meza R. Latent transition analysis of use frequencies for multiple nicotine and tobacco products among US adults. Addictive Behaviors 2024, 161: 108217. PMID: 39616861, PMCID: PMC12120682, DOI: 10.1016/j.addbeh.2024.108217.Peer-Reviewed Original ResearchNon-Hispanic blacksDaily cigarettesTobacco productsNon-dailyAssociated with lower oddsAssociated with higher oddsNon-Hispanic whitesFactors associated with transitionLow socioeconomic statusDaily smokeless tobaccoLatent transition analysisMultinomial logistic regressionHealth disparitiesLower educationUS adultsNon-currentSmokeless tobaccoSocioeconomic statusHigher oddsLower oddsLow-incomeLogistic regressionLatent transitionCigaretteTobaccoFactors associated with elective surgical case cancellation at a tertiary hospital in Malawi
Serrato P, Msosa V, Kondwani J, Nkhumbwah M, Mowafi H, Smith J, Mulima G, Sion M. Factors associated with elective surgical case cancellation at a tertiary hospital in Malawi. World Journal Of Surgery 2024, 48: 2990-3000. PMID: 39558490, DOI: 10.1002/wjs.12404.Peer-Reviewed Original ResearchKamuzu Central HospitalFactors associated with lower oddsLower oddsFactors associated with cancellationTertiary hospitalProcess-related factorsAssociated with lower oddsPublic tertiary hospitalCase cancellationsElective surgical case cancellationCancellation of elective surgeriesCross-sectional studyMedian waiting timeReturn for surgerySurgery completion rateMultivariate regression modelHigher cancellation rateSurgical case cancellationCancellation of surgeryCompletion ratesPatient outcomesPatient demographicsOddsElective surgeryRegression modelsBaseline predictors associated with successful weight loss among breast cancer survivors in the Lifestyle, Exercise, and Nutrition (LEAN) study
Hoobler R, Puklin L, Harrigan M, Cartmel B, Li F, Sanft T, Ferrucci L, Irwin M, Playdon M. Baseline predictors associated with successful weight loss among breast cancer survivors in the Lifestyle, Exercise, and Nutrition (LEAN) study. Journal Of Cancer Survivorship 2024, 1-9. PMID: 39528779, DOI: 10.1007/s11764-024-01702-3.Peer-Reviewed Original ResearchBreast cancer survivorsClinically meaningful weight lossCancer survivorsWeight loss interventionCancer SurvivorsBreast cancer survivorsWeight loss successConclusionBreast cancer survivorsPrevention of weight gainAssociated with lower oddsHistory of weight gainHealthy body weightMultivariate logistic regressionCancer treatmentSuccessful weight lossBreast cancer treatmentIntervention armLower oddsResultsBaseline dataDesign of programsWeight lossLogistic regressionC-statisticWeight gainSurvivorsInterventionInequalities in Treatment Utilization Among Older Medicare Beneficiaries with Newly Diagnosed Acute Myeloid Leukemia Who Are Ineligible for Induction Therapy
Zeidan A, Xu Y, Kapustyan T, Miu K, Chen C, Kamalakar R, Lin C, Ma E, Montez M, Wu Z, Yee T, Sun H, Rava A, Kim S, Huntington S. Inequalities in Treatment Utilization Among Older Medicare Beneficiaries with Newly Diagnosed Acute Myeloid Leukemia Who Are Ineligible for Induction Therapy. Blood 2024, 144: 3795-3795. DOI: 10.1182/blood-2024-200213.Peer-Reviewed Original ResearchTime to treatment initiationND-AMLAssociated with lower oddsAcute myeloid leukemiaAML treatmentVEN-HMACharlson Comorbidity IndexTargeted therapyInduction therapyFemale patientsMyeloid leukemiaTreatment initiationShorter time to treatment initiationTherapy uptakeMedicare beneficiariesNewly diagnosed acute myeloid leukemiaLower oddsOdds ratioHematopoietic stem cell transplantationTime-to-treatment initiationDiagnosed acute myeloid leukemiaIn-hospital survival rateLow-dose chemotherapyClinical performance statusStem cell transplantationSickle Pain-Related Impact (SPiRIt): A Prospective Study of Impact of Chronic Pain in Sickle Cell Disease
Jagtiani A, Sinha C, Hawk A, Gillespie S, Mirbeyk M, El Rassi F, Smith W, Krishnamurti L, Sil S, Bakshi N. Sickle Pain-Related Impact (SPiRIt): A Prospective Study of Impact of Chronic Pain in Sickle Cell Disease. Blood 2024, 144: 3899-3899. DOI: 10.1182/blood-2024-210575.Peer-Reviewed Original ResearchHigh-impact chronic painPain-related patient-reported outcomesChronic pain acceptanceSickle cell diseaseChronic painAssociated with lower oddsPain acceptancePain catastrophizingPain intensitySelf-efficacyCell diseaseManaging symptomsImpact of chronic painLower oddsHigher oddsHigher pain impactPain quality scoresDissemination strategiesHigher pain interferenceFactors associated with higher oddsFear of movementMultivariate logistic regression modelSickle cell disease clinicYoung adultsAssociated with higher oddsPrenatal Diet and Infant Growth From Birth to Age 24 Months
Hedderson M, Schuh H, Knapp E, Bekelman T, Catellier D, Westlake M, Lyall K, Schmidt R, Dunlop A, Comstock S, Chatzi L, Sauder K, Dabelea D, Switkowski K, Lin P, Avalos L, Zhu Y, Ferrara A, Smith P, Newby L, Adair L, Jacobson L, Catellier D, McGrath M, Douglas C, Duggal P, Knapp E, Kress A, Blackwell C, Mansolf M, Lai J, Ho E, Cella D, Gershon R, Macy M, Das S, Freedman J, Mallal S, McLean J, Shah R, Shilts M, Alshawabkeh A, Cordero J, Meeker J, Trasande L, Camargo C, Hasegawa K, Zhu Z, Sullivan A, Dabelea D, Perng W, Bekelman T, Wilkening G, Magzamen S, Moore B, Starling A, Rinehart D, Koinis Mitchell D, D'Sa V, Deoni S, Mueller H, Duarte C, Monk C, Canino G, Posner J, Murray T, Lugo-Candelas C, Dunlop A, Brennan P, Hockett C, Elliott A, Ferrara A, Croen L, Hedderson M, Ainsworth J, Bacharier L, Bendixsen C, Gern J, Gold D, Hartert T, Jackson D, Johnson C, Joseph C, Kattan M, Khurana Hershey G, Lemanske, Jr. R, Lynch S, Miller R, O’Connor G, Ober C, Ownby D, Rivera-Spoljaric K, Ryan P, Seroogy C, Singh A, Wood R, Zoratti E, Habre R, Farzan S, Gilliland F, Hertz-Picciotto I, Bennett D, Schweitzer J, Schmidt R, LaSalle J, Hipwell A, Keenan K, Karr C, Bush N, LeWinn K, Sathyanarayana S, Zhao Q, Tylavsky F, Carroll K, Loftus C, Leve L, Ganiban J, Neiderhiser J, Weiss S, Litonjua A, McEvoy C, Spindel E, Tepper R, Newschaffer C, Lyall K, Volk H, Landa R, Ozonoff S, Piven J, Hazlett H, Pandey J, Schultz R, Dager S, Botteron K, Messinger D, Stone W, Ames J, O'Connor T, Miller R, Oken E, Hacker M, James-Todd T, O'Shea T, Fry R, Frazier J, Singh R, Rollins C, Montgomery A, Vaidya R, Joseph R, Washburn L, Gogcu S, Bear K, Rollins J, Hooper S, Taylor G, Jackson W, Thompson A, Daniels J, Hernandez M, Lu K, Msall M, Lenski M, Obeid R, Pastyrnak S, Jensen E, Sakai C, Santos H, Kerver J, Paneth N, Barone C, Elliott M, Ruden D, Fussman C, Herbstman J, Margolis A, Schantz S, Geiger S, Aguiar A, Tabb K, Strakovsky R, Woodruff T, Morello-Frosch R, Padula A, Stanford J, Porucznik C, Giardino A, Wright R, Wright R, Collett B, Baumann-Blackmore N, Gangnon R, McKennan C, Wilson J, Altman M, Aschner J, Stroustrup A, Merhar S, Moore P, Pryhuber G, Hudak M, Reynolds Lyndaker A, Lampland A, Rochelson B, Jan S, Blitz M, Katzow M, Brown Z, Chiuzan C, Rafael T, Lewis D, Meirowitz N, Poindexter B, Gebretsadik T, Osmundson S, Straughen J, Eapen A, Cassidy-Bushrow A, Wegienka G, Sitarik A, Woodcroft K, Urquhart A, Levin A, Johnson-Hooper T, Davidson B, Ma T, Barrett E, Blaser M, Dominguez-Bello M, Horton D, Jimenez M, Rosen T, Palomares K, Avalos L, Zhu Y, Hunt K, Newman R, Bloom M, Alkis M, Roberts J, Mumford S, Burris H, DeMauro S, Yee L, Hamvas A, Olidipo A, Haddad A, Eiland L, Spillane N, Suri K, Fisher S, Goldstein J, Mithal L, DeRegnier R, Maitre N, Nguyen R, JaKa M, Sidebottom A, Paidas M, Potter J, Ruby N, Duthely L, Jayakumar A, Young K, Maldonado I, Miller M, Slaughter J, Keim S, Lynch C, Venkatesh K, Whitworth K, Symanski E, Northrup T, Mendez-Figueroa H, Mosquera R, Karagas M, Madan J, MacKenzie D, Lewis J, Rennie B, Leventhal B, Kim Y, Bishop S, Nozadi S, Luo L, Lester B, Marsit C, Everson T, Loncar C, McGowan E, Sheinkopf S, Carter B, Check J, Helderman J, Neal C, Smith L. Prenatal Diet and Infant Growth From Birth to Age 24 Months. JAMA Network Open 2024, 7: e2445771. PMID: 39570591, PMCID: PMC11582932, DOI: 10.1001/jamanetworkopen.2024.45771.Peer-Reviewed Original ResearchConceptsEmpirical dietary inflammatory patternHealthy Eating IndexEmpiric dietary inflammatory pattern scoresBirth to age 6 monthsHealthy Eating Index scoreAged 6 monthsInfant growthPrenatal dietParent-child dyadsGestational ageDietary qualityCohort studyAssociation of dietary qualityRisk factors associated with obesityFactors associated with obesityPacific Islander infantsSlow infant growthObesity prevention strategiesAssociated with SGAInfant birth weightUS Dietary GuidelinesAssociated with lower oddsAssociated with higher oddsChild Health Outcomes programLater-life obesityA real-world study of persistence and adherence to prescription medications in patients with chronic idiopathic constipation in the United States.
Cash B, Lu M, Lembo A, Feuerstadt P, Nguyen L, Terasawa E, Ayyagari R, Du S, Pi S, Westermeyer B, Terreri B, Boules M, Moshiree B. A real-world study of persistence and adherence to prescription medications in patients with chronic idiopathic constipation in the United States. Journal Of Managed Care & Specialty Pharmacy 2024, 30: 1136-1148. PMID: 39321115, PMCID: PMC11424913, DOI: 10.18553/jmcp.2024.30.10.1136.Peer-Reviewed Original ResearchConceptsChronic idiopathic constipationHazard ratioIdiopathic constipationTreatment of chronic idiopathic constipationHigher treatment persistencePrescription medicationsComparator medicationUS Food and Drug AdministrationProportion of patientsIBM MarketScan Commercial ClaimsObservational cohort studyFood and Drug AdministrationAdjusted hazard ratiosMarketScan Commercial ClaimsProportion of daysAssociated with lower oddsTreatment persistencePrucaloprideCohort studyOdds ratioPrescription fillsPrescription therapyDrug AdministrationCompare persistenceInclusion criteriaAssociation of Psychological Safety with Burnout and Intent to Leave Among Physician Faculty in New York City
de Guillebon E, He C, Akhtar S, Pietrzak R, Ripp J, Peccoralo L. Association of Psychological Safety with Burnout and Intent to Leave Among Physician Faculty in New York City. Journal Of General Internal Medicine 2024, 40: 361-367. PMID: 39354250, PMCID: PMC11803037, DOI: 10.1007/s11606-024-09034-9.Peer-Reviewed Original ResearchPhysician facultyAssociated with lower oddsAssociated with lower scoresAmbulatory care departmentPrevalence of PSClinical faculty membersStandard deviation unit increasePsychologically safe environmentMultivariate logistic regression analysisFaculty physiciansLogistic regression analysisHealth systemSeven-itemInstitution-wide surveyLower oddsConclusionsA majorityCare departmentNew York CityBurnoutPhysiciansSafe environmentFemale genderOrganization QuestionnaireLower scoresOccupational characteristics
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