2025
A network analysis of posttraumatic stress, depression, and alcohol use in U.S. veterans: Exploring differences by childhood maltreatment exposure
Vannini M, Xu B, Blais R, Pietrzak R. A network analysis of posttraumatic stress, depression, and alcohol use in U.S. veterans: Exploring differences by childhood maltreatment exposure. Journal Of Affective Disorders 2025, 389: 119662. PMID: 40505987, DOI: 10.1016/j.jad.2025.119662.Peer-Reviewed Original ResearchChildhood maltreatment experiencesPosttraumatic stressChildhood maltreatmentAlcohol useU.S. veteransAdult psychopathologyMaltreatment experiencesCo-occurring posttraumatic stressTrauma-exposed U.S. veteransImpact of childhood maltreatmentChildhood maltreatment exposureU.S. military veteransU.S. military service membersAlcohol use itemsMilitary service membersTransdiagnostic linkTransdiagnostic approachTransdiagnostic mechanismDepression itemsMaltreatment exposureTraumatized veteransMilitary veteransDepressionMaltreatmentService membersMental Health, Substance Use, and Tuberculosis Preventive Therapy in People With HIV: A Prospective Cohort Study
Johnson A, Chimoyi L, Shenoi S, Brault M, Forastiere L, Charalambous S, Chihota V, Davis J. Mental Health, Substance Use, and Tuberculosis Preventive Therapy in People With HIV: A Prospective Cohort Study. Open Forum Infectious Diseases 2025, 12: ofaf303. PMID: 40567997, PMCID: PMC12188208, DOI: 10.1093/ofid/ofaf303.Peer-Reviewed Original ResearchTuberculosis preventive therapyUnhealthy alcohol useMental healthDepressive symptomsAlcohol useTobacco useAssociation of mental healthInfluence of mental healthCohort studyMeasure symptoms of anxietyNegatively associated with adherenceDeductive content analysisMixed methods studySubstance useLongitudinal cohort studyPsychological support servicesSymptoms of anxietySymptoms of depressionPreventive therapyProspective cohort studyAntiretroviral therapyHIV mortalityMultivariate regression modelSubstance use disordersMethods studyModeration of treatment outcomes by polygenic risk for alcohol‐related traits in placebo‐controlled trials of topiramate
Kranzler H, Jinwala Z, Davis C, Xu H, Biernacka J, Zhou H, Kember R, Gelernter J, Feinn R. Moderation of treatment outcomes by polygenic risk for alcohol‐related traits in placebo‐controlled trials of topiramate. Alcohol Clinical And Experimental Research 2025, 49: 1297-1305. PMID: 40445294, PMCID: PMC12173784, DOI: 10.1111/acer.70052.Peer-Reviewed Original ResearchConceptsHeavy drinking daysAlcohol use disorderProblematic alcohol useAlcohol-related problemsPlacebo-controlled trialModerators of treatment outcomePlacebo-controlled trial of topiramateReduce heavy drinking daysTreat alcohol use disorderAlcohol-related traitsTrial of topiramateResponse to topiramateEffects of topiramateTime to relapseGenome-wide association studiesTopiramate's effectsAUD treatmentDrinking daysUse disorderTopiramate groupPolygenic riskHeavy drinkingAlcohol usePharmacogenetic approachShort IndexGreater neuroimmune system deficit in women than men with alcohol use disorder
Zakiniaeiz Y, Hillmer A, Shi H, Pittman B, Nabulsi N, Huang Y, Bonomi R, Matuskey D, Angarita G, McKee S, Cosgrove K. Greater neuroimmune system deficit in women than men with alcohol use disorder. Biological Psychiatry 2025 PMID: 40412787, DOI: 10.1016/j.biopsych.2025.05.012.Peer-Reviewed Original ResearchTranslocator protein availabilityAlcohol-induced neurodegenerationExecutive function tasksConsequences of alcohol useAlcohol use disorderBrain imaging scansTranslocator protein levelsSex-matched controlsExecutive functionLower hippocampalTSPO availabilityFrontal cortexTranslocator proteinUse disorderNeurocognitive functionBrain regionsSex differencesAlcohol useBrain-resident immune cellsNeuroimmune mechanismsFunctional tasksSystem deficitsAUDImaging scansNeuroimmune cellsCombined Smoking Cessation and Alcohol Abstinence Treatment for People Experiencing Homelessness: A Randomized Trial
Onigbogi O, Pratt R, Luo X, Everson-Rose S, Cooney N, Specker S, Thomas J, Okuyemi K. Combined Smoking Cessation and Alcohol Abstinence Treatment for People Experiencing Homelessness: A Randomized Trial. Nicotine & Tobacco Research 2025, ntaf085. PMID: 40375387, DOI: 10.1093/ntr/ntaf085.Peer-Reviewed Original ResearchPoint prevalence smoking abstinenceAlcohol useSmoking abstinenceCombined smoking cessationAlcohol abstinenceWeeks post-interventionSmoking cessationHazardous alcohol useUsual careUrban homeless shelterPost-interventionCessation outcomesBio-behavioral interventionSmoking outcomesAbstinence treatmentAbstinenceBiobehavioral interventionsHomeless sheltersHomelessnessIntervention groupPrimary hypothesisRandomized clinical trialsSmoking combustible cigarettesSecondary hypothesisAlcoholFrom embedded interprofessional clinics to expanded alcohol-associated liver disease programs.
Winder G, Arab J, Goswami Banerjee A, Bryce K, Fipps D, Hussain F, Im G, Omary L, Patel A, Patel S, Rubman S, Serper M, Shenoy A, Suzuki J, Zimbrean P, Brown K, Abouljoud M, Mellinger J. From embedded interprofessional clinics to expanded alcohol-associated liver disease programs. Liver Transplantation 2025 PMID: 40359009, DOI: 10.1097/lvt.0000000000000638.Peer-Reviewed Original ResearchAlcohol-associated liver diseaseAUD careLong-term patient relationshipsCare delivery strategiesHazardous alcohol usePatient populationInterprofessional clinicPalliative carePrimary careCare elementsCare frameworkIll patient populationPatient relationshipHealthcare systemLiver transplantationHarm reductionDisease programsCareAlcohol useLiver diseaseEnhanced supportChronic liver diseaseEating disorder treatmentCollaborative modelDisorder treatmentMulti‐ancestry genome‐wide association study of topiramate's effects on heavy alcohol use
Davis C, Jinwala Z, Justice A, Rentsch C, Kranzler H. Multi‐ancestry genome‐wide association study of topiramate's effects on heavy alcohol use. Alcohol Clinical And Experimental Research 2025, 49: 1197-1205. PMID: 40322892, PMCID: PMC12174493, DOI: 10.1111/acer.70069.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesMillion Veteran ProgramGenome-wide significancePolygenic scoresAlcohol consumptionAssociation studiesAlcohol Use Disorders Identification Test-Consumption (AUDIT-C) scoresGenome-wide association study samplesPhenome-wide association studyAlcohol useElectronic health recordsMeta-analysisGWAS meta-analysisMulti-ancestry genome-wide association studyTopiramate's effectsAlcohol use disorder diagnosisCross-ancestry meta-analysisFrequency of alcohol useCandidate gene studiesHeavy alcohol useHealth recordsVeteran ProgramAlcohol-related liver diseaseCross-ancestryTreatment responseEmergency Medicine Resident Experiences and Perceptions Regarding Medications for the Treatment of Alcohol Use Disorder
Bia J, Hawk K. Emergency Medicine Resident Experiences and Perceptions Regarding Medications for the Treatment of Alcohol Use Disorder. Journal Of Emergency Medicine 2025 DOI: 10.1016/j.jemermed.2025.05.008.Peer-Reviewed Original ResearchAlcohol use disorderTreatment of alcohol use disordersPrescribed naltrexoneUse disorderEM residentsEmergency departmentEmergency medicineResident experienceEmergency medicine resident experiencesLack of timeLack of followReducing alcohol useED patientsPrescribed treatmentAlcohol useMedicationED visitsLack of teachingNaltrexoneNumerous barriersResidents' knowledgeLack of knowledgeTraining programTreatmentHealth consequencesAlcohol use, heavy episodic drinking, and associated cardiovascular risk in Guyana
Motilal M, Gobin R, Khan R, Maharaj R. Alcohol use, heavy episodic drinking, and associated cardiovascular risk in Guyana. BULL PAN AM HEALTH ORGAN 2025, 49: 1. PMID: 40206567, PMCID: PMC11980521, DOI: 10.26633/rpsp.2025.30.Peer-Reviewed Original ResearchHeavy episodic drinkingAlcohol useWorld Health OrganizationSecondary analysisIndo-GuyaneseCardiovascular riskSecondary analysis of dataRisk factor surveyRisk of heavy episodic drinkingEpisodic drinkingPublic health interventionsOdds of alcohol useOdds of heavy episodic drinkingElevated blood pressureCardiovascular risk factorsBinary logistic regressionFactor surveyMaximum educational levelHealth interventionsYoung malesLinear regression modelsElevated triglyceridesDescriptive statisticsEducation levelAdjusted modelsAlcohol Use and the Pre-exposure Prophylaxis Continuum of Care Among Men in Rural South Africa: Results from a Longitudinal Study
Castle A, Busang J, Dreyer J, Herbst C, Okesola N, Chimbindi N, Zuma T, Jarolimova J, Hahn J, Psaros C, Shenoi S, Shahmanesh M, Siedner M. Alcohol Use and the Pre-exposure Prophylaxis Continuum of Care Among Men in Rural South Africa: Results from a Longitudinal Study. AIDS And Behavior 2025, 1-12. PMID: 40185960, DOI: 10.1007/s10461-025-04694-y.Peer-Reviewed Original ResearchPrEP initiationHazardous alcohol useRural South AfricaAlcohol useOral HIV pre-exposure prophylaxisAlcohol consumptionHIV pre-exposure prophylaxisSouth AfricaPre-exposure prophylaxisImpact of alcohol useRisk alcohol useAlcohol use levelsAUDIT-C criteriaAlcohol use groupPrEP implementation effortsContinuum of careSexual health servicesOral PrEPHIV incidenceHazardous alcohol consumptionYoung menLogistic regression modelsSecondary data analysisInitiate PrEPNo/low riskThe Longitudinal Impact of Psychosocial Syndemic Variables on Adherence to Antiretroviral Therapy Among People With HIV in Brazil, Thailand, and Zambia: An Analysis by HIV Transmission Groups in HPTN 063.
Rodríguez-Díaz C, Zangeneh S, Chen Y, Guo X, Tsuyuki K, Ransome Y, Friedman R, Srithanaviboonchai K, Roberts S, Mimiaga M, Mayer K, Safren S. The Longitudinal Impact of Psychosocial Syndemic Variables on Adherence to Antiretroviral Therapy Among People With HIV in Brazil, Thailand, and Zambia: An Analysis by HIV Transmission Groups in HPTN 063. AIDS Education And Prevention 2025, 37: 89-106. PMID: 40323670, DOI: 10.1521/aeap.2025.37.2.89.Peer-Reviewed Original ResearchConceptsSyndemic problemsSyndemic scoreART adherenceHIV transmission groupFear of discriminationOne-year longitudinal dataSuboptimal ART adherenceTransmission groupAssociated with lower ART adherenceSyndemic variableLow ART adherenceHIV preventionTransmission categoryLongitudinal dataAntiretroviral therapyAlcohol useStimulant usePolydrug useLongitudinal impactPWHAdherenceHIVZambiaCareScoresAlcohol Use and Abusive or Neglectful Behaviors Among Family Caregivers of Patients With Dementia
Chilatra J, Browning W, Yildiz M, Yefimova M, Maxwell C, Sullivan T, Pickering C. Alcohol Use and Abusive or Neglectful Behaviors Among Family Caregivers of Patients With Dementia. JAMA Network Open 2025, 8: e256211. PMID: 40261656, PMCID: PMC12015665, DOI: 10.1001/jamanetworkopen.2025.6211.Peer-Reviewed Original ResearchConceptsFamily caregivers of relativesCaregivers of relativesFamily caregiversAssociated with increased oddsCare recipientsHazardous drinkingDaily alcohol consumptionAlcohol useDaily alcohol useSample of family caregiversFamily caregivers of patientsIncreasing prevalence of dementiaAlcohol consumptionAlcohol use patternsCaregivers of patientsPrevalence of dementiaCommunity-dwelling relativeAssociated with higher oddsNeglectful behaviorsAssociated with greater oddsBaseline hazardous drinkingBaseline surveyUnpaid careLinear mixed modelsMain OutcomesExploring the Relationship Between Lifestyle and Post-COVID Psychiatric Symptoms: Findings from a Brazilian Cohort.
Borges S, Roncete G, Amendola F, Zanetti M, Miguel E, Filho G, Forlenza O, Damiano R. Exploring the Relationship Between Lifestyle and Post-COVID Psychiatric Symptoms: Findings from a Brazilian Cohort. American Journal Of Lifestyle Medicine 2025, 15598276251328022. PMID: 40161283, PMCID: PMC11948251, DOI: 10.1177/15598276251328022.Peer-Reviewed Original ResearchPost-traumatic stress disorderGeneralized anxiety disorderCommon mental disordersSuicidal ideationPsychiatric symptomsSeverity of alcohol useAssociated with suicidal ideationContext of depressionPsychiatric well-beingMonths post-hospitalizationAnxiety disordersStress disorderCOVID-19 survivorsMental disordersExtended recovery periodIncreased depressionSubstance useAlcohol useConsumption of sedativesDepressionLifestyle factorsIncreased intake of fruitsIdeationDisordersIntake of fruitsAssociations Between Internalized HIV Stigma and Cognitive Function Among Older Women With HIV
Vu T, Wise J, Jones D, Wingood G, Diaz M, Chandran A, Cohen M, Weiser S, Spence A, Wilson T, Norcini-Pala A, Sharma A, Rubin L, Turan B, Turan J, Monin J. Associations Between Internalized HIV Stigma and Cognitive Function Among Older Women With HIV. The Journals Of Gerontology Series B 2025, 80: gbaf058. PMID: 40123355, PMCID: PMC12067073, DOI: 10.1093/geronb/gbaf058.Peer-Reviewed Original ResearchConceptsInternalized HIV stigmaHIV stigmaAssociated with poorer global cognitive functionCognitive functionHIV Stigma ScalePoorer global cognitive functionStigma reduction interventionsAnnual incomeBenefit cognitive functionDomain-specific scoresFine motor functionGlobal cognitive scoreNonprescription drug useGlobal cognitive functionWomen's Interagency HIV StudyStigma ScaleMental healthReduction interventionsDepressive symptomsLinear regression modelsOlder WomenWomen ageStigmaCognitive AssessmentAlcohol usePsilocybin-assisted therapy for relapse prevention in alcohol use disorder: a phase 2 randomized clinical trial
Rieser N, Bitar R, Halm S, Rossgoderer C, Gubser L, Thévenaz M, Kreis Y, von Rotz R, Nordt C, Visentini M, Moujaes F, Engeli E, Ort A, Seifritz E, Vollenweider F, Herdener M, Preller K. Psilocybin-assisted therapy for relapse prevention in alcohol use disorder: a phase 2 randomized clinical trial. EClinicalMedicine 2025, 82: 103149. PMID: 40144690, PMCID: PMC11937691, DOI: 10.1016/j.eclinm.2025.103149.Peer-Reviewed Original ResearchAlcohol use disorderDose of psilocybinAlcohol use disorder patientsAlcohol useWithdrawal treatmentUse disorderOral doses of psilocybinTherapeutic effects of psilocybinSingle dose of psilocybinEffects of psilocybinInpatient withdrawal treatmentPsilocybin-assisted therapyDaily alcohol useReducing relapse ratesRelapse ratePsilocybin groupPsychotherapy sessionsReduce cravingFollow-upAbstinence durationRelapse preventionPlacebo groupPsilocybinPrevent relapsePsychotherapyPatterns of Alcohol Use and Daily Smoking Among Men Who Have Sex with Men in Nepal
Paudel K, Gautam K, Hossain Sujan M, Adhikari P, Bhusal S, Wickersham J, Bhakta K, Sapkota S, Dhakal M, Adhikari T, Shrestha R. Patterns of Alcohol Use and Daily Smoking Among Men Who Have Sex with Men in Nepal. Journal Of Community Health 2025, 1-8. PMID: 40042735, DOI: 10.1007/s10900-025-01456-8.Peer-Reviewed Original ResearchPatterns of alcohol useAlcohol useDaily smokingAssociated with alcohol useElevated risk of adverse health outcomesRisk of adverse health outcomesPolice detentionSex workHistory of drug useSmoking cessation programAdverse health outcomesCondomless sexDrug useMultivariate logistic regression analysisHealth outcomesBagmati ProvinceLogistic regression analysisNepalCessation programsMSMElevated riskSmokingMenIndependent correlatesRegression analysisHIV risk perception and problematic alcohol use among urban slum residents in Bangladesh: findings from a cross-sectional survey
Sujan S, Sikder T, Siddique A, Hossain J, Hossen I, Saikat E, Uddin M, Keya S, Paudel K, Gautam K, Ha T, Shrestha R. HIV risk perception and problematic alcohol use among urban slum residents in Bangladesh: findings from a cross-sectional survey. AIDS Care 2025, 37: 1076-1084. PMID: 40043190, DOI: 10.1080/09540121.2025.2473941.Peer-Reviewed Original ResearchHIV risk perceptionUrban slum residentsProblematic alcohol useSexually transmitted infectionsAlcohol useSlum residentsHigh HIV risk perceptionRisk perceptionHistory of sexually transmitted infectionsPoor mental healthUrban slum settingsParticipants' mean ageCross-sectional surveyGlobal public health issueCross-sectional studyDecreased alcohol usePublic health issueMultivariate linear regression analysisHIV perceptionMental healthSlum settingsHIV epidemicHealth issuesUrban slumsLinear regression analysisA multicenter cross-sectional study of gambling disorder among patients with methamphetamine use disorder in drug rehabilitation centers: prevalence, correlates, and network analysis
Peng P, Hao Y, Zhang X, Ma Y, Liu X, Shen D, Shen W, Zhao B, Li D, Beck S, Nunez Y, Potenza M, Gelernter J, Liu T, Yang B. A multicenter cross-sectional study of gambling disorder among patients with methamphetamine use disorder in drug rehabilitation centers: prevalence, correlates, and network analysis. Annals Of General Psychiatry 2025, 24: 12. PMID: 40033412, PMCID: PMC11877697, DOI: 10.1186/s12991-025-00546-0.Peer-Reviewed Original ResearchSemi-Structured Assessment for Drug Dependence and AlcoholismDSM-5 diagnostic criteriaGambling disorderDSM-5Antisocial personality disorderMethamphetamine use disorderSubstance use disordersDiagnostic criteriaPersonality disorderBridge symptomsDepressive episodeDrug rehabilitation centersCentral symptomsPsychiatric diagnosisGambling durationUse disorderSelf-harmChildhood experiencesMethamphetamineAlcohol useViolent experiencesDisordersManifest symptomsChinese versionMDEDiminished reward circuit response underlies pain avoidance learning deficits in problem drinkers
Le T, Oba T, Li C. Diminished reward circuit response underlies pain avoidance learning deficits in problem drinkers. NeuroImage Clinical 2025, 45: 103762. PMID: 40009903, PMCID: PMC11908557, DOI: 10.1016/j.nicl.2025.103762.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexAvoidance learningReward circuitDrinking severityReward deficiencyLearning deficitsPain avoidanceProblem drinkersAlcohol useAvoidance learning deficitMedial orbitofrontal cortexReward circuit dysfunctionVentral tegmental areaPoor avoidance learningAssociated with problem drinkingOrbitofrontal cortexTegmental areaGo/NoGo taskCingulate cortexNeural correlatesBehavioral findingsCircuit dysfunctionAdult drinkersBrain regionsNeural processesPatterns of substance-involved intimate partner violence perpetration: Findings from a daily diary study
Schick M, Clayton A, Maxwell C, Sullivan T. Patterns of substance-involved intimate partner violence perpetration: Findings from a daily diary study. Addictive Behaviors 2025, 166: 108305. PMID: 40049052, PMCID: PMC11968212, DOI: 10.1016/j.addbeh.2025.108305.Peer-Reviewed Original ResearchIntimate partner violenceSexual IPV perpetrationPsychological intimate partner violenceSexual intimate partner violenceIPV perpetrationSubstance use patternsAlcohol usePartners' IPV perpetrationDaily diary studyPatterns of substance usePatterns of IPV perpetrationReduce intimate partner violencePhysical IPV perpetrationRisk of IPV perpetrationPhysical intimate partner violenceTargeting alcohol usePartner's use of alcoholUse of alcoholPatterns of substancesDiary studyJust-in-time interventionsSubstance usePartner's useCo-usePartner violence
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