2025
Exploring the Acceptability and Feasibility of a Self-directed Approach to Identifying Health Priorities in a Sample of Southern Older African American Adults with Multiple Chronic Conditions
Ejem D, Bakitas M, Durant R, Parker T, Oppong K, Esterson J, Odom J, Wells R, Boockvar K, Tinetti M. Exploring the Acceptability and Feasibility of a Self-directed Approach to Identifying Health Priorities in a Sample of Southern Older African American Adults with Multiple Chronic Conditions. Journal Of Racial And Ethnic Health Disparities 2025, 1-18. PMID: 40410637, DOI: 10.1007/s40615-025-02469-8.Peer-Reviewed Original ResearchMultiple chronic conditionsWeb-based programFamily caregiversAfrican AmericansSystem Usability ScaleChronic conditionsOlder African American adultsFamily caregivers' experiencesPrimary care clinicsPatient-clinician interactionsStudy measuresOlder African AmericansAfrican American adultsConstant comparative methodU.S. academic medical centersAcademic medical centerSelf-directed approachSouthern African AmericansFormative evaluation studyCare clinicsCare approachHealth priorityThematic analysisAmerican adultsCaregiversValidation of the WIfI Classification in the Vascular Quality Initiative database
Alameddine D, Satam K, Slade M, Cardella J, Aboian E, Guzman R, Mills J, Chaar C. Validation of the WIfI Classification in the Vascular Quality Initiative database. Journal Of Vascular Surgery 2025 PMID: 40056961, DOI: 10.1016/j.jvs.2025.03.001.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaWIfI stageWIfI scoreWIfI classificationLower extremity revascularizationPeripheral vascular interventionsMajor amputationAssociated with major amputationWIfI clinical stagePredicting major amputationPeripheral vascular interventional proceduresAssociated with increased riskVascular Quality InitiativeRegression analysisAmputation groupAmputation resultsCox regression analysisLimb-threatening ischemiaCharacteristics of patientsAfrican AmericansQuality InitiativeAmputationRisk factorsExtremity revascularizationFoot Infection classification
2024
A Mendelian randomization study of alcohol use and cardiometabolic disease risk in a multi‐ancestry population from the Million Veteran Program
Kember R, Rentsch C, Lynch J, Vujkovic M, Voight B, Justice A, Program M, Assimes T, Kranzler H. A Mendelian randomization study of alcohol use and cardiometabolic disease risk in a multi‐ancestry population from the Million Veteran Program. Alcohol Clinical And Experimental Research 2024, 48: 2256-2268. PMID: 39580711, PMCID: PMC11629435, DOI: 10.1111/acer.15445.Peer-Reviewed Original ResearchCoronary heart diseaseMR analysisMillion Veteran ProgramGenetic scoreAlcohol consumptionBody mass indexMendelian randomizationCardiometabolic diseasesVeteran ProgramAfrican AmericansAlcohol Use Disorders Identification Test-Consumption (AUDIT-C) scoresEuropean AmericansHispanic AmericansAssociation of alcohol consumptionMultivariable MR analysisAssociated with CHD riskMendelian randomization studiesRisk of cardiometabolic diseasesAssociated with alcohol consumptionCardiometabolic disease riskIncidence of coronary heart diseaseObservational studyNested case-control studyReduced risk of cardiometabolic diseasesMulti-ancestry populationPrenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort
Siwakoti R, Harris S, Ferguson K, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort. Environment International 2024, 194: 109145. PMID: 39550829, PMCID: PMC11663107, DOI: 10.1016/j.envint.2024.109145.Peer-Reviewed Original ResearchC-reactive proteinNested case-control study of preterm birthCase-control study of preterm birthInflammatory biomarkersIL-10TNF-aInterquartile range increaseNested case-control studyStudy of preterm birthPre-pregnancy BMIQuantile-based g-computation approachIL-6Prenatal PFAS exposureInflammatory processPregnancy plasma samplesMeasurement of inflammatory biomarkersBirth outcomesLinear mixed modelsInverse associationRange increaseMaternal raceMaternal demographicsTNF-a levelsAdverse pregnancyAfrican AmericansUpdated CP*Trends: An Online Tool to Compare Cohort and Period Trends across Cancer Sites
Holford T, Chen H, Kane M, Krapcho M, Annett D, Esclamado L, Melkonyan A, Feuer E. Updated CP*Trends: An Online Tool to Compare Cohort and Period Trends across Cancer Sites. American Journal Of Epidemiology 2024, kwae398. PMID: 39475089, DOI: 10.1093/aje/kwae398.Peer-Reviewed Original ResearchCancer sitesAfrican AmericansCervical cancer incidence trendsCancer incidence trendsMortality trendsCancer incidenceIncidence trendsEffect of cohortConfidence intervalsPeriod effectsInteractive websiteCohortAmericanSample sizeScoresWhiteEffects of periodMortalityCancerC-P scoreBootstrap confidence intervalsIncidenceSEERWebsitesTrendsSeeing in Color: Inclusion and Characterization of Hereditary Eye Disease in African Americans
Owete A, Ionin R, Huryn L, Cukras C, Blain D, Agather A, Hufnagel R, Brooks B, Nwanyanwu K, Zein W. Seeing in Color: Inclusion and Characterization of Hereditary Eye Disease in African Americans. Translational Vision Science & Technology 2024, 13: 4. PMID: 39226063, PMCID: PMC11373706, DOI: 10.1167/tvst.13.9.4.Peer-Reviewed Original ResearchConceptsHereditary eye diseasesEye diseaseOphthalmic genetics researchAfrican American patientsAfrican AmericansGenomic researchEra of molecular geneticsRare diseaseWeb of ScienceAmerican patientsInclusion criteriaPatientsLiterature searchInclusion of African AmericansDiverse cohortPredetermined inclusion criteriaDiseasePatient careCounseling sessionsMolecular geneticsAncestral backgroundDiverse populationsPublic perspectives on increased data sharing in health research in the context of the 2023 National Institutes of Health Data Sharing Policy
de Rivera S, Creber R, Zhao Y, Eslami S, Mangal S, Dugdale L, Turchioe M. Public perspectives on increased data sharing in health research in the context of the 2023 National Institutes of Health Data Sharing Policy. PLOS ONE 2024, 19: e0309161. PMID: 39197051, PMCID: PMC11357082, DOI: 10.1371/journal.pone.0309161.Peer-Reviewed Original ResearchConceptsNational Institutes of HealthHealthcare providersEnglish-speaking US adultsNational Institutes of Health policyNational InstitutePatient perspectivePotential unintended consequencesInstitutes of HealthUS adultsHealth researchPatient autonomyBlack participantsPatients' willingnessSexual healthParticipants' perspectivesParticipants' preferencesAfrican AmericansResearch fundersHealthRacial differencesOnline surveyParticipantsHealthcareEffective JanuaryHealth technology companies692-P: Work or Wellness? Examining Challenges of Low Wage Workers with Type 2 Diabetes
SCHLESINGER P, ASANTE P, LIPSKA K, KEENE D. 692-P: Work or Wellness? Examining Challenges of Low Wage Workers with Type 2 Diabetes. Diabetes 2024, 73 DOI: 10.2337/db24-692-p.Peer-Reviewed Original ResearchSocial determinants of healthDeterminants of healthDiabetes self-managementDiabetes outcomesDiabetes managementSelf-managementImpact of social determinants of healthAverage age of participantsExperiences of diabetes managementAge of participantsImprovement support systemDigestive and Kidney DiseasesMitigate disparitiesNational Institute of DiabetesInductive codingType 2 diabetesInterview participantsQualitative interviewsLow wage workersAfrican AmericansParticipantsAverage ageWorkplace conditionsInterviewsWork schedulesPhonological awareness mediates the relationship between DCDC2 and reading performance with home environment
Li M, DeMille M, Lovett M, Bosson-Heenan J, Frijters J, Gruen J. Phonological awareness mediates the relationship between DCDC2 and reading performance with home environment. Npj Science Of Learning 2024, 9: 36. PMID: 38702345, PMCID: PMC11068914, DOI: 10.1038/s41539-024-00247-5.Peer-Reviewed Original ResearchPhonological awarenessSocioeconomic statusDevelopment of genetic screeningReading outcomesParental educationReading performanceHome environmentPhonological processing skillsChildren aged 8Phonological processingPhonological skillsRisk of reading disabilityProficient readingAfrican AmericansAged 8Environmental factorsProcess skillsAnalyzed dataREAD1Family backgroundHomeAwarenessEducationAssociationOutcomesPredictors of stroke literacy among African Americans in the “buckle of the stroke belt”
Sunmonu N, Malek A, Jenkins C, Hyacinth H. Predictors of stroke literacy among African Americans in the “buckle of the stroke belt”. Frontiers In Stroke 2024, 3: 1331085. DOI: 10.3389/fstro.2024.1331085.Peer-Reviewed Original ResearchKnowledge of stroke signsStroke literacyStroke signsStroke BeltStroke signs and symptomsReduce stroke-related disabilityAssociated with racial disparitiesStroke-related disabilityAfrican American adultsHigh school educationStroke knowledgeHealth disparitiesAcute stroke treatmentSocioeconomic statusRacial disparitiesSocioeconomic factorsSociodemographic aspectsAmerican adultsEducation levelAdequate knowledgeAfrican AmericansEducation programsSchool educationStroke outcomeEmergency roomAssociations between Plasma Tocopherols and Lung Cancer Risk: Results from the Southern Community Cohort Study.
Yoon H, Wu J, Shidal C, Sun Y, Franke A, Yang J, Braithwaite D, Courtney R, Cai H, Blot W, Shu X, Zheng W, Cai Q. Associations between Plasma Tocopherols and Lung Cancer Risk: Results from the Southern Community Cohort Study. Cancer Epidemiology Biomarkers & Prevention 2024, 33: 480-488. PMID: 38284815, PMCID: PMC10990776, DOI: 10.1158/1055-9965.epi-23-1107.Peer-Reviewed Original ResearchLung cancer riskAssociated with lung cancer riskSouthern Community Cohort StudyCommunity Cohort StudyCancer riskAfrican AmericansIncident lung cancer casesOdds ratioCohort studyLow-income African AmericansEuropean AmericansYear of blood drawEstimate odds ratiosNested case-control studyConditional logistic regressionLung cancer preventionLung cancer casesSignificant risk reductionCase-control studyCurrent smokersCohort enrollmentInverse associationPotential confoundersCancer casesStratified analysis
2023
ASSOCIATION OF RELIGIOUS ATTENDANCE, RELIGIOSITY/SPIRITUALITY, AND C-REACTIVE PROTEIN IN MIDDLE TO OLDER ADULTS IN THE U.S
Britt K, Boateng A, Sebu J, Oh H, Lekwauwa R, Massimo L, Doolittle B. ASSOCIATION OF RELIGIOUS ATTENDANCE, RELIGIOSITY/SPIRITUALITY, AND C-REACTIVE PROTEIN IN MIDDLE TO OLDER ADULTS IN THE U.S. Innovation In Aging 2023, 7: 457-457. PMCID: PMC10737976, DOI: 10.1093/geroni/igad104.1503.Peer-Reviewed Original ResearchC-reactive proteinBody mass indexCRP levelsSystemic inflammationReligiosity/spiritualityCognitive declineCognitive healthReligious service attendanceAverage CRP levelsService attendanceBetter cognitive healthRace/ethnicityMass indexMean ageHigh riskSignificant negative associationReligious attendanceU.S. adultsHealth conditionsElevated levelsMarital statusUnderlying physiological mechanismsInflammationAdultsAfrican AmericansExamination of eQTL Polymorphisms Associated with Increased Risk of Progressive Complicated Sarcoidosis in European and African Descent Subjects.
Casanova N, Camp S, Gonzalez-Garay M, Batai K, Garman L, Montgomery C, Ellis N, Kittles R, Bime C, Hsu A, Holland S, Lussier Y, Karnes J, Sweiss N, Maier L, Koth L, Moller D, Kaminski N, Garcia J. Examination of eQTL Polymorphisms Associated with Increased Risk of Progressive Complicated Sarcoidosis in European and African Descent Subjects. European Journal Of Respiratory Medicine 2023, 5: 359-371. PMID: 38390497, PMCID: PMC10883688, DOI: 10.31488/ejrm.137.Peer-Reviewed Original ResearchExpression quantitative trait lociGenome-wide association studiesEQTL SNPsGenome-wide association study cohortsInnate immunityQuantitative trait lociAllograft rejection pathwayGWAS SNPsIndependent sarcoidosis cohortTrait lociAssociation studiesGenetic basisComplicated sarcoidosisSNPsHLA regionAfrican AmericansSarcoidosis riskSeverity of sarcoidosisGranulomatous inflammatory diseaseMHC class IISystemic granulomatous inflammatory diseaseEuropean AmericansSarcoidosis cohortVariants/genesPoolTHU313 Lactation As A Possible Protective Factor For Postpartum Diabetes In Women With Gestational Diabetes Mellitus: A Retrospective Analysis
Dávila-Parrilla V, Stanton C, Hackerson C, Song H, Hens J, Wysolmerski J, Merriam A, De Aguiar R. THU313 Lactation As A Possible Protective Factor For Postpartum Diabetes In Women With Gestational Diabetes Mellitus: A Retrospective Analysis. Journal Of The Endocrine Society 2023, 7: bvad114.747. PMCID: PMC10553496, DOI: 10.1210/jendso/bvad114.747.Peer-Reviewed Original ResearchGestational diabetes mellitusYale-New Haven HospitalInfant feeding practicesExclusive lactationFeeding practicesDiabetes mellitusRetrospective analysisOral glucose tolerance test resultsGlucose tolerance test resultsSignificant differencesExclusive formula feedingWeek postpartum visitPre-pregnancy BMITolerance test resultsDevelopment of T2DMPre-diabetic statusPopulation of womenNew Haven HospitalAfrican AmericansPossible protective factorDM statusPostpartum visitChart reviewFormula feedingDietary modificationCharacteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms
Bellamkonda K, Zogg C, Nassiri N, Sadeghi M, Zhang Y, Guzman R, Ochoa Chaar C. Characteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms. Journal Of Vascular Surgery 2023, 77: 1649-1657. PMID: 36796595, DOI: 10.1016/j.jvs.2023.02.003.Peer-Reviewed Original ResearchConceptsEndovascular aneurysm repairAbdominal aortic aneurysmRAAA casesRAAA groupElective repairAneurysm repairAortic aneurysmMyocardial infarctionVascular Quality Initiative databaseLower body mass indexSmall abdominal aortic aneurysmsMean aneurysm diameterVascular Surgery guidelinesLong-term mortalityOutcomes of patientsPerioperative myocardial infarctionOpen AAA repairBody mass indexLong-term outcomesOperative thresholdAfrican AmericansInfrarenal aneurysmsTotal morbidityAAA repairPatient characteristicsRace and Gender in Ophthalmology: A National Analysis of Medical Students with Intention to Pursue the Field
Chhoa J, Jawiche J, Uppal P, Arunachalam T, Nguyen M, Eggan B, Mason H, Busingye J. Race and Gender in Ophthalmology: A National Analysis of Medical Students with Intention to Pursue the Field. Journal Of Academic Ophthalmology 2023, 15: e24-e35. PMID: 38737154, PMCID: PMC10804828, DOI: 10.1055/s-0043-1760834.Peer-Reviewed Original ResearchUnderserved areasMultivariate logistical regressionBlack/African AmericanMethods Study participantsDiverse U.S. populationAbstract PurposeMedical careStudy participantsField of ophthalmologyNonsurgical fieldsConclusion FemalesLogistical regressionHealth experiencesU.S. populationAmerican Medical Colleges Graduation QuestionnaireOphthalmologyAfrican AmericansGlobal health experiencesNon-Hispanic white studentsNational analysisQuestionnaireAAMC Graduation QuestionnaireMedical studentsGraduation Questionnaire
2022
Radical Visions of American Medicine: Politics and Activism in the History of Medicine.
Rogers N. Radical Visions of American Medicine: Politics and Activism in the History of Medicine. Bulletin Of The History Of Medicine 2022, 96: 545-611. PMID: 38588142, DOI: 10.1353/bhm.2022.0050.Peer-Reviewed Original ResearchAmerican health policyHealth care deliveryBureaucratic maneuveringCare deliveryHealth politicsRadical visionHealth policyHealth systemHealth activitiesStudent activistsWomen's healthMedical trainingMedical schoolsAfrican AmericansIntersection examplesPoliticsActivistsAmerican physiciansHealthPhysiciansFeministPoliticiansAlternative wayHistory of medicineStrugglesAbstract 15751: Trends and Disparities in Pulmonary Arterial Hypertension Over the Past Decade: A National Inpatient Sample Database Study
Sana M, ASEMOTA I, Park D, Hammo H, Yilmaz M, Murthi M, Sharma B, Shaka H. Abstract 15751: Trends and Disparities in Pulmonary Arterial Hypertension Over the Past Decade: A National Inpatient Sample Database Study. Circulation 2022, 146: a15751-a15751. DOI: 10.1161/circ.146.suppl_1.15751.Peer-Reviewed Original ResearchDiagnosis of pulmonary arterial hypertensionPulmonary arterial hypertensionMedian household incomePrincipal diagnosisLength of hospital stayArterial hypertensionCrude admission ratesNo significant differenceInpatient mortality rateRate of pulmonary arterial hypertensionRisk of pulmonary arterial hypertensionAssociated with increased riskOutcome analysisNational Inpatient Sample databasePrimary outcome analysisSecondary outcome analysisAsian/Pacific IslanderSignificant differenceInpatient Sample databaseAdult hospitalsInpatient mortalityICD-9Household incomeCalendar yearAfrican AmericansPrediction of telomere length and telomere attrition using a genetic risk score: The multi-ethnic study of atherosclerosis (MESA)
Castro-Diehl C, Smith J, Zhao W, Wang X, Mukherjee B, Seeman T, Needham B. Prediction of telomere length and telomere attrition using a genetic risk score: The multi-ethnic study of atherosclerosis (MESA). Frontiers In Aging 2022, 3: 1021051. PMID: 36304436, PMCID: PMC9592760, DOI: 10.3389/fragi.2022.1021051.Peer-Reviewed Original ResearchMulti-Ethnic Study of AtherosclerosisGenetic risk scoreMulti-Ethnic StudyGenome-wide association studiesStudy of AtherosclerosisAssociated with TLEuropean ancestry genome-wide association studiesEuropean ancestryRisk scoreTL-associated genetic variantsShorter TLEuropean ancestry populationsPredictive of telomere lengthHispanic participantsRace/ethnic groupsLinear mixed effects modelsShorter telomere lengthMixed effects modelsAfrican AmericansTelomere attritionExam 1Association studiesRelative TLTelomere lengthT/S ratioTumor immune microenvironment of self-identified African American and non-African American triple negative breast cancer
Marczyk M, Qing T, O’Meara T, Yagahoobi V, Pelekanou V, Bai Y, Reisenbichler E, Cole KS, Li X, Gunasekharan V, Ibrahim E, Fanucci K, Wei W, Rimm DL, Pusztai L, Blenman KRM. Tumor immune microenvironment of self-identified African American and non-African American triple negative breast cancer. Npj Breast Cancer 2022, 8: 88. PMID: 35869114, PMCID: PMC9307813, DOI: 10.1038/s41523-022-00449-3.Peer-Reviewed Original ResearchTumor immune microenvironmentImmune microenvironmentTriple-negative breast cancer tissuesTriple-negative breast cancerAfrican AmericansImmune checkpoint inhibitorsTumor mutation burdenNegative breast cancerBreast cancer tissuesImmune-related pathwaysStromal TILsCheckpoint inhibitorsImmune exclusionClinical outcomesPD-L1Self-identified African AmericansCancer patientsImmune infiltrationBreast cancerMutation burdenCancer tissuesPredictive signatureMRNA expressionTherapeutic agentsPatients
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