2025
The Dyson equalizer: adaptive noise stabilization for low-rank signal detection and recovery
Landa B, Kluger Y. The Dyson equalizer: adaptive noise stabilization for low-rank signal detection and recovery. Information And Inference A Journal Of The IMA 2025, 14: iaae036. PMID: 39830802, PMCID: PMC11735832, DOI: 10.1093/imaiai/iaae036.Peer-Reviewed Original ResearchNoise varianceLow-rank signalData matrixNoisy data matrixSignal detectionImproved signal recoverySignal recoveryMP lawNoise distributionRandom matrix theory resultsSignal structureData-drivenSingular valuesNoiseDataTaskNoise characteristicsNoise levelNoise stabilitySingle-cell RNA sequencingDetectionSpatial transcriptomics dataTranscriptome dataNormalization procedureMatrix
2024
Gene trajectory inference for single-cell data by optimal transport metrics
Qu R, Cheng X, Sefik E, Stanley III J, Landa B, Strino F, Platt S, Garritano J, Odell I, Coifman R, Flavell R, Myung P, Kluger Y. Gene trajectory inference for single-cell data by optimal transport metrics. Nature Biotechnology 2024, 43: 258-268. PMID: 38580861, PMCID: PMC11452571, DOI: 10.1038/s41587-024-02186-3.Peer-Reviewed Original ResearchGene dynamicsGene programTrajectory inferenceBiological processesCell-cell graphDynamics of genesCell trajectory inferenceSingle-cell RNA sequencingSingle-cell dataCell state transitionsMyeloid lineage maturationDynamics of biological processesGene distributionRNA sequencingPseudotemporal orderingGene processingTrajectories of cellsGenesActivity of biological processesTechnical noiseGroups of cellsLineage maturationCellsConstruct cellsSequence
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